Isoniazid and its toxic metabolite hydrazine induce in vitro pyrazinamide toxicity

International Journal of Antimicrobial Agents

Volumn 31, Issue 6, 2008, Pages 577-580

  Tostmann, Alma ^a   Boeree, Martin J ^a   Peters, Wilbert H M ^a   Roelofs, Hennie M J ^a   Aarnoutse, Rob E ^a   van der Ven, André J A M ^a   Dekhuijzen, P N Richard ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Adverse effects; Antitubercular agents; Hepatotoxicity; Liver; Rifampicin; Tuberculosis

Indexed keywords

DRUG METABOLITE; HYDRAZINE; ISONIAZID; MOXIFLOXACIN; PYRAZINAMIDE; RIFAMPICIN;

ANTITUBERCULOSIS DRUG INDUCED HEPATOTOXICITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG METABOLISM; HEPATOMA CELL; HUMAN; HUMAN CELL; IC 50; LIVER PROTECTION; LIVER TOXICITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TOXICITY TESTING; TUBERCULOSIS;

ANTITUBERCULAR AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; HEPATITIS, TOXIC; HUMANS; HYDRAZINES; ISONIAZID; LIVER; PYRAZINAMIDE; RIFAMPIN;

EID: 43549123035     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2008.01.022     Document Type: Article

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