Association of estrogen receptor-α gene polymorphisms with bone mineral density in postmenopausal Korean women

Journal of Bone and Mineral Metabolism

Volumn 23, Issue 1, 2005, Pages 84-89

  Nam, Hae Sung ^a   Shin, Min Ho ^b   Kweon, Sun Seog ^b   Park, Kyeong Soo ^b   Sohn, Seok Jun ^c   Rhee, Jung Ae ^c   Choi, Jin Su ^c   Son, Myuug Ho ^b  

^a Chungnam National University   (South Korea)

^b Seonam University   (South Korea)

^c Chonnam National University Medical School   (South Korea)

Author keywords

Bone mineral density (BMD); Estrogen receptor; Polymorphism; Population based study

Indexed keywords

ESTROGEN RECEPTOR ALPHA;

ADULT; AGED; ARTICLE; BONE DENSITY; DNA POLYMORPHISM; FEMALE; FEMUR; GENE FUNCTION; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; HUMAN; INTRON; LUMBAR SPINE; MORPHOMETRICS; NORMAL HUMAN; POLYMERASE CHAIN REACTION; POPULATION GENETICS; POPULATION RESEARCH; POSTMENOPAUSE; PRIORITY JOURNAL; RESTRICTION MAPPING; SMOKING; STATISTICAL MODEL;

AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; BONE DENSITY; ESTROGEN RECEPTOR ALPHA; FEMALE; HAPLOTYPES; HIP FRACTURES; HUMANS; KOREA; MIDDLE AGED; OSTEOPOROSIS; POLYMORPHISM, GENETIC; POSTMENOPAUSE; SPINAL FRACTURES;

EID: 12444263286     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-004-0545-8     Document Type: Article

References (32)

1. Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S (1987) Genetic determinants of bone mass in adults. A twin study. J Clin Invest 80:706-710
2. Jouanny P, Guillemin F, Kuntz C, Jeandel C, Pourel J (1995) Environmental and genetic factors affecting bone mass. Similarity of bone density among members of healthy families. Arthritis Rheum 38:61-67
3. Deng HW, Li J, Li JL, Johnson M, Gong G, Recker RR (1999) Association of VDR and estrogen receptor genotypes with bone mass in postmenopausal Caucasian women: different conclusions with different analyses and the implications. Osteoporos Int 9:499-507
4. Ralston SH (2003) Genetic determinants of susceptibility to osteoporosis. Curr Opin Pharmacol 3:286-290
5. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV, Sambrook PN, Eisman JA (1994) Prediction of bone density from vitamin D receptor alleles. Nature 367:284-287
6. Kobayashi S, Inoue S, Hosoi T, Ouchi Y, Shiraki M, Orimo H (1996) Association of bone mineral density with polymorphism of the estrogen receptor gene. J Bone Miner Res 11:306-311
7. Grant SF, Reid DM, Blake G, Herd R, Fogelman I, Ralston SH (1996) Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene. Nat Genet 14:203-205
8. Langdahl BL, Knudsen JY, Jensen HK, Gregersen N, Eriksen EF (1997) A sequence variation: 713-8delC in the transforming growth factor-beta 1 gene has higher prevalence in osteoporotic women than in normal women and is associated with very low bone mass in osteoporotic women and increased bone turnover in both osteoporotic and normal women. Bone 20:289-294
9. Ferrari SL, Garnero P, Emond S, Montgomery H, Humphries SE, Greenspan SL (2001) A functional polymorphic variant in the interleukin-6 gene promoter associated with low bone resorption in postmenopausal women. Arthritis Rheum 44:196-201
10. Lorentzon M, Lorentzon R, Nordstorm P (2001) Vitamin D receptor gene polymorphism is related to bone density, circulating osteocalcin, and parathyroid hormone in healthy adolescent girls. J Bone Miner Metab 19:302-307
11. Katsumata K, Nishizawa K, Unno A, Fujita Y, Tokita A (2002) Association of gene polymorphisms and bone density in Japanese girls. J Bone Miner Metab 20:164-169
12. Laaksonen M, Karkkainen M, Outila T, Vanninen T, Ray C, Lamberg-Allardt C (2002) Vitamin D receptor gene BsmI-polymorphism in Finnish premenopausal and postmenopausal women: its association with bone mineral density, markers of bone turnover, and intestinal calcium absorption, with adjustment for lifestyle factors. J Bone Miner Metab 20:383-390
13. Strandberg S, Nordstrom P, Lorentzon R, Lorentzon M (2003) Vitamin D receptor start codon polymorphism (FokI) is related to bone mineral density in healthy adolescent boys. J Bone Miner Metab 21:109-113
14. Ioannidis JP, Stavrou I, Trikalinos TA, Zois C, Brandi ML, Gennari L, Albagha O, Ralston SH, Tsatsoulis A (2002) Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density and fracture risk in women: a meta-analysis. J Bone Miner Res 17:2048-2060
15. Gennari L, Becherini L, Falchetti A, Masi L, Massart F, Brandi ML (2002) Genetics of osteoporosis: role of steroid hormone receptor gene polymorphisms. J Steroid Biochem Mol Biol 81:1-24
16. Mizunuma H, Hosoi T, Okano H, Soda M, Tokizawa T, Kagami I, Miyamoto S, Ibuki Y, Inoue S, Shiraki M, Ouchi Y (1997) Estrogen receptor gene polymorphism and bone mineral density at the lumbar spine of pre- and postmenopausal women. Bone 21:379-383
17. Kim JG, Lim KS, Kim EK, Choi YM, Lee JY (2001) Association of vitamin D receptor and estrogen receptor gene polymorphisms with bone mass in postmenopausal Korean women. Menopause 8:222-228
18. Kobayashi N, Fujino T, Shirogane T, Furuta I, Kobamatsu Y, Yaegashi M, Sakuragi N, Fujimoto S (2002) Estrogen receptor alpha polymorphism as a genetic marker for bone loss, vertebral fractures and susceptibility to estrogen. Maturitas 41:193-201
19. Han KO, Moon IG, Kang YS, Chung HY, Min HK, Han IK (1997) Nonassociation of estrogen receptor genotypes with bone mineral density and estrogen responsiveness to hormone replacement therapy in Korean postmenopausal women. J Clin Endocrinol Metab 82:991-995
20. Han K, Choi J, Moon I, Yoon H, Han I, Min H, Kim Y, Choi Y (1999) Non-association of estrogen receptor genotypes with bone mineral density and bone turnover in Korean pre-, peri-, and postmenopausal women. Osteoporos Int 9:290-295
21. Bagger YZ, Jorgensen HL, Heegaard AM, Bayer L, Hansen L, Hassager C (2000) No major effect of estrogen receptor gene polymorphisms on bone mineral density or bone loss in postmenopausal Danish women. Bone 26:111-116
22. Yamada Y, Ando F, Niino N, Ohta S, Shimokata H (2002) Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density of the femoral neck in elderly Japanese women. J Mol Med 80:452-460
23. Becherini L, Gennari L, Masi L, Mansani R, Massart F, Morelli A, Falchetti A, Gonnelli S, Fiorelli G, Tanini A, Brandi ML (2000) Evidence of a linkage disequilibrium between polymorphisms in the human estrogen receptor alpha gene and their relationship to bone mass variation in postmenopausal Italian women. Hum Mol Genet 9:2043-2050
24. Langdahl BL, Lokke E, Carstens M, Stenkjaer LL, Eriksen EF (2000) A TA repeat polymorphism in the estrogen receptor gene is associated with osteoporotic fractures but polymorphisms in the first exon and intron are not. J Bone Miner Res 15:2222-2230
25. Long JR, Zhang YY, Liu PY, Liu YJ, Shen H, Dvornyk V, Zhao LJ, Deng HW (2004) Association of estrogen receptor alpha and vitamin D receptor gene polymorphisms with bone mineral density in Chinese males. Calcif Tissue Int 74:270-276
26. Albagha OM, McGuigan FE, Reid DM, Ralston SH (2001) Estrogen receptor alpha gene polymorphisms and bone mineral density: haplotype analysis in women from the United Kingdom. J Bone Miner Res 16:128-134
27. Sapir-Koren R, Livshits G, Landsman T, Kobyliansky E (2001) Bone mineral density is associated with estrogen receptor gene polymorphism in men. Anthropol Anz 59:343-353
28. Ushiroyama T, Heishi M, Higashio S, Ikeda A, Ueki M (2001) The association between postmenopausal vertebral bone mineral density and estrogen receptor gene alleles in ethnic Japanese living in western Japan. Res Commun Mol Pathol Pharmacol 109:15-24
29. Zhang YY, Long JR, Liu PY,. Liu YJ, Shen H, Zhao LJ, Deng HW (2003) Estrogen receptor alpha and vitamin D receptor gene polymorphisms and bone mineral density: association study of healthy pre- and postmenopausal Chinese women. Biochem Biophys Res Commun 308:777-783
30. Korea, Ministry of Health and Welfare (2002) 2001 Korea National Health and Nutrition Survey (in Korean). Ministry of Health and Welfare, Seoul, pp 107-110, 304
31. Sharkey JR, Branch LG, Zohoori N, Giuliani C, Busby-Whitehead J, Haines PS (2002) Inadequate nutrient intakes among homebound elderly and their correlation with individual characteristics and health-related factors. Am J Clin Nutr 76:1435-1445
32. Winzenberg TM, Riley M, Frendin S, Oldenburg B, Jones G (2003) Sociodemographic factors associated with calcium intake in premenopausal women: cross-sectional study. Asia Pac J Clin Nutr 12(Suppl):S25