Glycine suppresses TNF-alpha-induced activation of NF-κB in differentiated 3T3-L1 adipocytes

European Journal of Pharmacology

Volumn 689, Issue 1-3, 2012, Pages 270-277

  Blancas Flores, Gerardo ^a,b   Alarcón Aguilar, Francisco J ^a   García Macedo, Rebeca ^b   Almanza Pérez, Julio C ^a   Flores Sáenz, José L ^a   Román Ramos, Rubén ^a   Ventura Gallegos, José L ^c   Kumate, Jesús ^e   Zentella Dehesa, Alejandro ^c,d   Cruz, Miguel ^b  

^a DEPARTAMENTO DE QUÍMICA   (Mexico)

^b HOSPITAL DE ESPECIALIDADES   (Mexico)

^c INSTITUTO DE INVESTIGACIONES BIOMÉDICAS   (Mexico)

^d Unidad de Biología Molecular y Medicina Genómica   (Mexico)

^e Fundación IMSS A C México   (Mexico)

Author keywords

Cytokines; Glycine; I Bs; Inflammatory process; NF B

Indexed keywords

GLYCINE; I KAPPA B; I KAPPA B EPSILON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR FACTOR KAPPA B SUBUNIT P50; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG TARGETING; IMMUNOMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; GLYCINE; MICE; NF-KAPPA B; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84864276943     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.06.025     Document Type: Article

References (40)

1. I.M. Adcock, C.R. Brown, O. Kwon, and P.J. Barnes Oxidative stress induces NF kappa B DNA binding and inducible NOS mRNA in human epithelial cells Biochem. Biophys. Res. Commun. 199 1994 1518 1524 (Pubitemid 24174831)
2. A.F.J. Alarcon, P.J.C. Almanza, G. Blancas, S. Angeles, M.R. Garcia, R. Roman, and M. Cruz Glycine regulates the production of pro-inflammatory cytokines in lean and monosodium glutamate-obese mice Eur. J. Pharmacol. 599 2008 152 158
3. A. Andalibi, F. Liao, S. Imes, A.M. Fogelman, and A.J. Lusis Oxidized lipoproteins influence gene expression by causing oxidative stress and activating the transcription factor NF-kappa B Biochem. Soc. Trans. 3 1993 651 655 (Pubitemid 23265756)
4. D.S. Basseres, and A.S. Baldwin Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression Oncogene 25 2006 6817 6830 (Pubitemid 44657854)
5. S. Beinke, and S. Ley Functions of NF-kB1 and NF-kB2 in immune cell biology Biochem. J. 382 2004 393 409 (Pubitemid 39243905)
6. G. Carvajal, E. Juarez, G. Ramos, and M.E. Carvajal Inhibición de la glicosilación no enzimática de la hemoglobina en la diabetes mellitus Rev. Inst. Nal. Enf. Resp 8 1995 185 188
7. F. Chen, V. Castranova, X. Shi, and L.M. Demers New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases Clin. Chem. 45 1999 7 17 (Pubitemid 29036378)
8. L. Chen, and W. Greene Shaping the nuclear action of NF- kB Nat. Immunol. Rev. 5 2004 392 401
9. F. Chenguang, L. Qiang, Z. Yulong, L. Xiaoming, L. Meihui, A. Duane, Z. Weihong, and J.F. Engelhardt IkBa and IkBb possess injury context-specific functions that uniquely influence hepatic NF-kB induction and inflammation J. Clin. Invest. 113 2004 746 755 (Pubitemid 38544168)
10. P. Chomczynski, and N. Sacchi Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Annal. Biochem 162 1987 156 159 (Pubitemid 17064313)
11. M. Cruz, B.C. Maldonado, G.R. Mondragón, B.R. Sanchez, N. Wacher, S.G. Carvajal, and J. Kumate Glycine treatment decreases proinflammatory cytokines and increases interferon-γ in patients with type 2 diabetes Journal of Endrocrinological Investigation 31 2008 694 699
12. K. De Bosscher, B.W. Vanden, and G. Haegeman The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression Endocr. Rev 24 2003 488 522 (Pubitemid 37059110)
13. J.D. Dignam, R.M. Lebovitz, and R.G. Roeder Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei Nucleic Acid. Res 11 1983 1475 1489
14. M. Fasshauer, J. Klein, U. Lossner, and R. Paschke Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes Horm. Metab. Res. 35 2003 147 152 (Pubitemid 36577855)
15. M. Fasshauer, S. Kralisch, M. Klier, U. Lossner, M. Bluher, J. Klein, and R. Paschke Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes Biochem. Biophys. Res. Commun. 301 2003 1045 1050 (Pubitemid 36279218)
16. S.E. File, E. Fluck, and C. Fernandes Beneficial effects of glycine (bioglycin) on memory and attention in young and middle-aged adults J. Clin. Psychopharmacol. 9 1999 506 512
17. M.R. Garcia, M.F. Sanchez, P.J.C. Almanza, R.G. Duran, A.F.J. Alarcon, and M. Cruz Glycine increases mRNA adiponectin and diminishes pro-inflammatory adipokines expression in 3T3-L1 cells Eur. J. Pharmacol. 587 2008 317 321
18. S. Ghosh, and D. Baltimore Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I-kappa B Nature 344 1990 678 682
19. G. Gloire, P.S. Legrand, and J. Piette NF-kB activation by reactive oxygen species: Fifteen years later Biochem. Pharmacol. 72 2006 1493 1505 (Pubitemid 44666727)
20. H. Green, and O. Kehinde An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion Cell 5 1975 19 27
21. S. Hasegawa, T. Ichiyama, I. Sonaka, A. Ohsaki, R. Hirano, Y. Haneda, R. Fukano, M. Hara, and S. Furukawa Amino acids exhibit anti-inflammatory effects in human monocytic leukemia cell line, THP-1 cells Inflamm Res 60 2011 1013 1019
22. S. Hasegawa, T. Ichiyama, I. Sonaka, A. Ohsaki, S. Okada, H. Wakiguchi, K. Kudo, S. Kittaka, M. Hara, and S. Furukawa Cysteine, histidine and glycine exhibit anti-inflammatory effects in human coronary arterial endothelial cells Clin Exp Immunol 167 2012 269 274
23. M.S. Hayden, and S. Ghosh Signaling to NF-kappaB Genes Dev. 18 2004 2195 2224
24. L.U. Heresco, D. Javitt, M. Ermilov, C. Mordel, A. Horowitx, and D. Kelly Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia Brit. J. Psychiatry 169 1996 34 37
25. L.U. Heresco, D. Javitt, M. Ermilov, C. Mordel, G. Silipo, and M. Lichtenstein Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia Arch. Gen. Pshychiatry 56 1999 29 36 (Pubitemid 29055047)
26. K. Ikejima, Y. Iimuro, D. Forman, and R.G. Thurman A diet containing glycine improves survival in endotoxin shock in the rat Am. J. Physiol. 271 1996 G97 G103
27. M. Khan, L.R. Van Der Wieken, R.K. Riezebos, J.G. Tijssen, F. Kiemeneij, T. Slagboom, and G.J. Laarman Oral administration of glycine in the prevention of restenosis after coronary angioplasty. A double blind placebo controlled randomized feasibility trial evaluating safety and efficacy of glycine in the prevention of restenosis after angioplasty Acute Cardiac Care 8 2006 58 64
28. B.L.N. Lopez, V.F. Arechavaleta, O.F. Vadillo, S.D. Montes, G.J.L. Ventura, and D.A. Zentella NF-kappa B translocation and endothelial cell activation is potentiated by macrophage-released signals co-secreted with TNF-alpha and IL-lbeta Inflamm. Res. 53 2004 567 575
29. S. Malek, Y. Chen, T. Huxford, and G. Ghosh Ikappa B-beta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappa B dimers by masking both NF-kappa B nuclear localization sequences in resting cells J. Biol. Chem. 276 2001 45225 45235
30. M. Meyer, R. Schreck, and P.A. Baeuerle H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor EMBO J 12 1993 2005 2015 (Pubitemid 23157717)
31. T. Ogihara, T. Asano, H. Katagiri, H. Sakoda, M. Anai, N. Shojima, H. Ono, M. Fujishiro, A. Kushiyama, Y. Fukushima, M. Kikuchi, N. Noguchi, H. Aburatani, Y. Gotoh, I. Komuro, and T. Fujita Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase Diabetologia 47 2004 794 805 (Pubitemid 38756991)
32. I. Rahman, and W. MacNee Oxidative stress and regulation of glutathione in lung inflammation Eur. Respir. J. 16 2000 534 554
33. B. Scazzocchio, R. Vari, M. D'Archivio, C. Santangelo, C. Filesi, C. Giovannini, and R. Masella Oxidized LDL impair adipocyte response to insulin by activating serine/threonine kinases J. Lipid. Res. 50 2009 832 845
34. R.I. Scheinman, P.C. Cogswell, A.K. Lofquist, and A.S. Baldwin Jr Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids Science 270 1995 283 286
35. A. Spittler, C.M. Reissner, R. Oehler, A. Gornikiewicz, T. Gruenberger, N. Manhart, T. Brodowicz, M. Mittlboeck, N.G. Boltz, and E. Roth Immunomodulatory effects of glycine on LPS-treated monocytes: reduced TNF-α production and accelerated IL-10 expression FASEB J 13 1999 563 571 (Pubitemid 29115575)
36. T. Valovka, and M.O. Hottiger p65 controls NF-κB activity by regulating cellular localization of IκBβ Biochem. J. 434 2011 253 263
37. M.D. Wheeler, K. Ikejema, N. Enomoto, R.F. Stacklewitz, V. Seabra, Z. Zhong, M. Yin, P. Schemmer, M.L. Rose, I. Rusyn, B. Bradford, and R.G. Thurman Glycine; a new anti-inflammatory immunonutrient Cell. Mol. Life. Sci. 56 1999 843 856
38. M.D. Wheeler, and R.G. Thurman Production of superoxide and TNF-α from alveolar macrophages is blunted by glycine Am. J. Physiol. 277 1999 L952 L959
39. Z. Zhong, M.D. Wheeler, X. Li, M. Froh, P. Schemmer, M. Yin, H. Bunzendaul, B. Bradford, and J.J. Lemasters L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent Curr. Opin. Clin. Nutr. Metab. Care. 6 2003 229 240 (Pubitemid 40674528)
40. Q.G. Zhou, M. Zhou, A.J. Lou, D. Xie, and F.F. Hou Advanced oxidation protein products induce inflammatory response and insulin resistance in cultured adipocytes via induction of endoplasmic reticulum stress Cell. Physiol. Biochem. 26 2010 775 786