Anesthetic protection of neurons injured by hypothermia and rewarming: Roles of intracellular ca2+ and excitotoxicity

Anesthesiology

Volumn 117, Issue 2, 2012, Pages 280-292

  Bickler, Philip E ^a   Warren, Daniel E ^a   Clark, John P ^b   Gabatto, Pablo ^c   Gregersen, Maren ^a   Brosnan, Heather ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAINT LOUIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ADENOSINE TRIPHOSPHATE; GLUTAMIC ACID; ISOFLURANE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PENTOBARBITAL; PROPOFOL; SEVOFLURANE; XENON;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN PROTECTION; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL HYPOXIA; CELL LOSS; CONTROLLED STUDY; DRUG EFFICACY; EXCITOTOXICITY; FLUORESCENCE; HIPPOCAMPUS; HISTOPATHOLOGY; INDUCED HYPOTHERMIA; NERVE CELL; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; RAT; WARMING;

ANALYSIS OF VARIANCE; ANESTHETICS; ANIMALS; ANOXIA; CALCIUM; CELL DEATH; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUTAMIC ACID; HIPPOCAMPUS; HYPOTHERMIA; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, INBRED SHR; RECEPTORS, N-METHYL-D-ASPARTATE; REWARMING;

EID: 84864276825     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e318260a7b9     Document Type: Article

References (40)

1. Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, Polin RA, Robertson CM, Thoresen M, Whitelaw A, Gunn AJ: Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: Multicentre randomised trial. Lancet 2005; 365:663-70.
2. Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, Fanaroff AA, Poole WK, Wright LL, Higgins RD, Finer NN, Carlo WA, Duara S, Oh W, Cotten CM, Stevenson DK, Stoll BJ, Lemons JA, Guillet R, Jobe AH, National Institute of Child Health and Human Development Neonatal Research Network: Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005; 353:1574-84.
3. Hypothermia after Cardiac Arrest Study Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346: 549-56.
4. Egerton N, Egerton WS, Kay JH: Neurologic changes following profound hypothermia. Ann Surg 1963; 157:366-74.
5. Khaladj N, Shrestha M, Meck S, Peterss S, Kamiya H, Kallenbach K, Winterhalter M, Hoy L, Haverich A, Hagl C: Hypothermic circulatory arrest with selective antegrade cerebral perfusion in ascending aortic and aortic arch surgery: A risk factor analysis for adverse outcome in 501 patients. J Thorac Cardiovasc Surg 2008; 135:908-14.
6. Watanabe Y, Kawaura Y, Iwa T: Brain damage after deep hypothermia in dogs. Jap J Surgery 1982; 12:61-70.
7. Levin DA, Seay AR, Fullerton DA, Simoes EA, Sondheimer HM: Profound hypothermia with alpha-stat pH management during open-heart surgery is associated with choreoathetosis. Pediatr Cardiol 2005; 26:34-8.
8. Visconti KJ, Rimmer D, Gauvreau K, del Nido P, Mayer JE Jr, Hagino I, Pigula FA: Regional low-flow perfusion versus circulatory arrest in neonates: One-year neurodevelopmental outcome. Ann Thorac Surg 2006; 82:2207-11; discussion 2211-3.
9. DeLeon SY, Thomas C, Roughneen PT, King N, Lehne R, DeLeon AM, Walenga J, Pifarr R: Experimental evidence of cerebral injury from profound hypothermia during cardiopulmonary bypass. Pediatr Cardiol 1998; 19:398-403.
10. Alam HB, Chen Z, Li Y, Velmahos G, DeMoya M, Keller CE, Toruno K, Mehrani T, Rhee P, Spaniolas K: Profound hypothermia is superior to ultraprofound hypothermia in improving survival in a swine model of lethal injuries. Surgery 2006; 140:307-14.
11. Lipton P: Ischemic cell death in brain neurons. Physiol Rev 1999; 79:1431-568.
12. Warren DE, Bickler PE, Clark JP, Gregersen M, Brosnan H, McKleroy W, Gabatto P: Hypothermia and rewarming injury in hippocampal neurons involves intracellular Ca2 and glutamate excitotoxicity. Neuroscience 2012; 207:316-25.
13. Sakai H, Sheng H, Yates RB, Ishida K, Pearlstein RD, Warner DS: Isoflurane provides long-term protection against focal cerebral ischemia in the rat. Anesthesiology 2007; 106:92-9.
14. Weigl M, Tenze G, Steinlechner B, Skhirtladze K, Reining G, Bernardo M, Pedicelli E, Dworschak M: A systematic review of currently available pharmacological neuroprotective agents as a sole intervention before anticipated or induced cardiac arrest. Resuscitation 2005; 65:21-39.
15. Eilers H, Bickler PE: Hypothermia and isoflurane similarly inhibit glutamate release evoked by chemical anoxia in rat cortical brain slices. Anesthesiology 1996; 85:600-7.
16. Kudo M, Aono M, Lee Y, Massey G, Pearlstein RD, Warner DS: Effects of volatile anesthetics on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cultures. Anesthesiology 2001; 95:756-65.
17. Wang J, Cottrell JE, Kass IS: Effects of desflurane and propofol on electrophysiological parameters during and recovery after hypoxia in rat hippocampal slice CA1 pyramidal cells. Neuroscience 2009; 160:140-8.
18. Bickler PE, Warner DS, Stratmann G, Schuyler JA: gamma-Aminobutyric acid-A receptors contribute to isoflurane neuroprotection in organotypic hippocampal cultures. Anesth Analg 2003; 97:564-71.
19. Bickler PE, Fahlman CS: Enhanced hypoxic preconditioning by isoflurane: Signaling gene expression and requirement of intracellular Ca2 and inositol triphosphate receptors. Brain Res 2010; 1340:86-95.
20. Bickler PE, Zhan X, Fahlman CS: Isoflurane preconditions hippocampal neurons against oxygen-glucose deprivation: Role of intracellular Ca2 and mitogen-activated protein kinase signaling. Anesthesiology 2005; 103:532-9.
21. Gray JJ, Bickler PE, Fahlman CS, Zhan X, Schuyler JA: Isoflurane neuroprotection in hypoxic hippocampal slice cultures involves increases in intracellular Ca2 and mitogen-activated protein kinases. Anesthesiology 2005; 102:606-15.
22. Kurth CD, Priestley M, Watzman HM, McCann J, Golden J: Desflurane confers neurologic protection for deep hypothermic circulatory arrest in newborn pigs. Anesthesiology 2001; 95:959-64.
23. Stoppini L, Buchs PA, Muller D: A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 1991; 37:173-82.
24. Bickler PE, Fahlman CS, Gray JJ: Hypoxic preconditioning failure in aging hippocampal neurons: Impaired gene expression and rescue with intracellular calcium chelation. J Neurosci Res 2010; 88:3520-9.
25. Laake JH, Haug FM, Weiloch T, Ottersen OP: A simple in vitro model of ischemia based on hippocampal slice cultures and propidium iodide fluorescence. Brain Res Brain Res Protoc 1999; 4:173-84.
26. Newell DW, Barth A, Papermaster V, Malouf AT: Glutamate and non-glutamate receptor mediated toxicity caused by oxygen and glucose deprivation in organotypic hippocampal cultures. J Neuroscience 1995; 15:7702-11.
27. Lacour P, Heimrich B, Prls F: Induction of cellular stress and chaperone activation in organotypic slice cultures of hippocampus. J Neurosci Methods 2007; 166:24-31.
28. Orliaguet G, Vivien B, Langeron O, Bouhemad B, Coriat P, Riou B: Minimum alveolar concentration of volatile anesthetics in rats during postnatal maturation. Anesthesiology 2001; 95:734-9.
29. Koblin DD, Fang Z, Eger EI 2nd, Laster MJ, Gong D, Ionescu P, Halsey MJ, Trudell JR: Minimum alveolar concentrations of noble gases, nitrogen, and sulfur hexafluoride in rats: Helium and neon as nonimmobilizers (nonanesthetics). Anesth Analg 1998; 87:419-24.
30. Gordan ML, Kellermann K, Blobner M, Nollert G, Kochs EF, Jungwirth B: Fast rewarming after deep hypothermic circulatory arrest in rats impairs histologic outcome and increases NFB expression in the brain. Perfusion 2010; 25:349-54.
31. Ogata J, Shiraishi M, Namba T, Smothers CT, Woodward JJ, Harris RA: Effects of anesthetics on mutant N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther 2006; 318:434-43.
32. Bickler PE, Buck LT, Hansen BM: Effects of isoflurane and hypothermia on glutamate receptor-mediated calcium influx in brain slices. Anesthesiology 1994; 81:1461-9.
33. Hogins J, Crawford DC, Jiang X, Mennerick S: Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults. Neurobiol Dis 2011; 43:516-25.
34. Nakayama M, Fujita S, Kanaya N, Tsuchida H, Namiki A: Blockade of ATP-sensitive K channel abolishes the antiischemic effects of isoflurane in dog hearts. Acta Anaesthesiol Scand 1997; 41:531-5.
35. Elmistekawy EM, Rubens FD: Deep hypothermic circulatory arrest: Alternative strategies for cerebral perfusion. A review article. Perfusion 2011; 26(Suppl 1):27-34.
36. Sundt TM, Flemming MD, Oderich GS, Torres NE, Li Z, Lenoch J, Kalra M: Spinal cord protection during open repair of thoracic and thoracoabdominal aortic aneurysms using profound hypothermia and circulatory arrest. J Am Coll Surg 2011; 212:678-83; discussion 684-5.
37. Grigore AM, Murray CF, Ramakrishna H, Djaiani G: A core review of temperature regimens and neuroprotection during cardiopulmonary bypass: Does rewarming rate matter? Anesth Analg 2009; 109:1741-51.
38. Scott BS, Fisher KC: Potassium concentration and number of neurons in cultures of dissociated ganglia. Exp Neurol 1970; 27:16-22.
39. Gallo V, Kingsbury A, Balzs R, Jrgensen OS: The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J Neurosci 1987; 7:2203-13.
40. Adolph EF: Tolerance to cold and anoxia in infant rats Am J Physiol 1948; 155:366-77