Integrated NMR-based metabonomic investigation of early metabolic effects of ethylene glycol monomethyl ether (EGME) on male reproductive organs in rats

Journal of Toxicological Sciences

Volumn 32, Issue 5, 2007, Pages 515-528

  Yamamoto, Toshinori ^a,b   Horii, Ikuo ^a,b   Yoshida, Takemi ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

Ethylene glycol monomethyl ether; Hr MAS NMR; Metabonomics; Rat; Testicular toxicity

Indexed keywords

2 METHOXYETHANOL; 2 OXOGLUTARIC ACID; 3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; CITRIC ACID; CREATINE; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; KETONE BODY; LACTIC ACID; PROTEIN; SUCCINIC ACID; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BIOCHEMISTRY; BODY FLUID; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CITRIC ACID CYCLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISCRIMINANT ANALYSIS; EPIDIDYMIS; EX VIVO STUDY; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HISTOPATHOLOGY; MALE; MALE GENITAL SYSTEM; METABOLISM; METABOLITE; MULTIVARIATE ANALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; ORGAN WEIGHT; PARTIAL LEAST SQUARES REGRESSION; PLASMA; PRINCIPAL COMPONENT ANALYSIS; PROTEIN BLOOD LEVEL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SPERMATOCYTE; TESTIS; UREA NITROGEN BLOOD LEVEL; URINE;

RATTUS;

EID: 38349045405     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.32.515     Document Type: Article

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