A review of recently published radiotherapy treatment guidelines for bone metastases: Contrasts or convergence?

Journal of Bone Oncology

Volumn 1, Issue 1, 2012, Pages 18-23

  Lutz, Stephen ^a   Chow, Edward ^b  

^a Blanchard Valley Regional Cancer Center   (United States)

^b DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

Author keywords

Bone metastases; Fractionation; Palliative care; Quality measures; Radiotherapy; Treatment guidelines

Indexed keywords

RADIOISOTOPE; RADIUM 223; SAMARIUM 153; STRONTIUM 89; UNCLASSIFIED DRUG;

AMERICAN SOCIETY FOR RADIATION ONCOLOGY; BONE METASTASIS; BREAST CANCER; CANCER PAIN; CANCER PALLIATIVE THERAPY; CLINICAL DECISION MAKING; CONSENSUS; CYBERKNIFE; DECOMPRESSION SURGERY; EXTERNAL BEAM RADIOTHERAPY; HEALTH CARE ORGANIZATION; HUMAN; INTENSITY MODULATED RADIATION THERAPY; KIDNEY CANCER; KYPHOPLASTY; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; METASTATIC BONE PAIN; MULTIPLE MYELOMA; NATIONAL COMPREHENSIVE CANCER NETWORK; PATIENT CARE; PERCUTANEOUS VERTEBROPLASTY; PRACTICE GUIDELINE; PROSTATE CANCER; PROTON THERAPY; PUBLICATION; RADIATION DOSE FRACTIONATION; RADIOTHERAPY; REVIEW; SPINAL CORD COMPRESSION; STEREOTACTIC ABLATIVE BODY RADIOTHERAPY; STEREOTACTIC BODY RADIATION THERAPY; STEREOTACTIC PROCEDURE; THYROID CANCER; TOMOTHERAPY;

EID: 84864248169     PISSN: 22121374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbo.2012.04.002     Document Type: Review

References (49)

1. Janjan N, Lutz S, Bedwinek J, Hartsell W, Ng A, Pieters R, et al. Therapeutic guidelines for the treatment of bone metastasis: a report from the American College of Radiology Appropriateness Criteria Expert Panel on Radiation Oncology. Journal of Palliative Medicine 2009;12(5):417-26.
2. Lutz S, Berk L, Chang E, et al. Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline. International Journal of Radiation Oncology, Biology, Physics 2011;79(4):965-76.
3. Wu JS, Wong RK, Lloyd NS, Johnston M, Bezjak A, Whelan T. Radiotherapy fractionation for the palliation of uncomplicated painful bone metastases- an evidence-based practice guideline. BMC Cancer 2004;4:71.
4. Chow E, Harris K, Fan G, Tsao M, Sze W. Palliative radiotherapy trials for bone metastases: A systematic review. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 2007;25:1423-36. (Pubitemid 46706892)
5. Hanks G, Maher G, Coia L. An overview of the first International Consensus Workshop on radiation therapy in the treatment of metastatic and locally advanced cancer. International Journal of Radiation Oncology, Biology, Physics 1992;23:201.
6. Hoskin P, Yarnold J, Roos D, Bentzen S. Radiotherapy for bone metastases. Clinical Oncology 2001;13:88-90. (Pubitemid 32377505)
7. Lutz S, Lo S, Howell D, et al. American College of Radiology ACR Appro- [28 priateness Criteriaâ® NON-SPINE BONE METASTASES expert panel on radiation oncology-bone metastases. Journal of Palliative Medicine 2011.
8. Lo S, Teh B, Mayr N, Olencki T, Wang J, Grecula J, et al. Stereotactic body [29 radiation therapy for oligometastases. Discovery Medicine 2010;10(52) 247-254.
9. Mirels H. Metastatic disease in long bones. A proposed scoring system [30 for diagnosing impending pathologic fractures. Clinical Orthopaedics and Related Research 1989;249:256-64.
10. Harrington KD. Impending pathologic fractures from metastatic malignancy: [31 evaluation and management. Instructional Course Lectures 1986;35: 357-81.
11. Brown JE, Cook RJ, Lipton A, Costa L, Coleman RE. Prognostic factors for [32 skeletal complications from metastatic bone disease in breast cancer. Breast Cancer Research and Treatment 2010;123(3):767-79.
12. van der Linden Y, Kroon H, Dijkstra S, Lok J, Noordijk E, Leer J, et al. Simple radiographic parameter predicts fracturing in metastatic femoral bone lesions: results from a randomised trial. Radiotherapy and Oncology 2003;69(1):21-31. (Pubitemid 37346185)
13. Chow E, Hoskin P, Wu J, Roos D, van der Linden Y, Hartsell W, et al. A phase III international randomised trial comparing single with multiple fractions for re-irradiation of painful bone metastases: National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) SC 20. Clinical Oncology (Royal College of Radiologists (Great Britain)) 2006;18(2):125-8. (Pubitemid 43169140)
14. Hayashi S, Hoshi H, Iida T. Reirradiation with local-field radiotherapy for painful bone metastases. Radiation Medicine 2002;20(5):231-6. (Pubitemid 35428964)
15. Jeremic B, Shibamoto Y, Igrutinovic I. Single 4 Gy re-irradiation for painful bone metastasis following single fraction radiotherapy. Radiotherapy and Oncology 1999;52(2):123-7. (Pubitemid 29461079)
16. Mithal NP, Needham PR, Hoskin PJ. Retreatment with radiotherapy for painful bone metastases. International Journal of Radiation Oncology, Biology, Physics 1994;29(5):1011-4. (Pubitemid 24278968)
17. Uppelschoten JM, Wanders SL, de Jong JM. Single-dose radiotherapy (6 Gy): [37 palliation in painful bone metastases. Radiotherapy and Oncology 1995;36(3): 198-202.
18. van der Linden Y, LokJ, Steenland E, Martijn H, van Houwelingen H, Marijnen C, et al. Single fraction radiotherapy is efficacious: a further analysis of the [38 Dutch Bone Metastasis Study controlling for the influence of retreatment. International Journal of Radiation Oncology, Biology, Physics 2004;59(2) 528-537. (Pubitemid 38622611)
19. RTOG 0433 A phase III international randomized trial of single versus multiple fractions for re-irradiation of painful bone metastases. Available from: [40
20. Lutz S, Spence C, Chow E, Janjan N, Connor S. Survey on use of palliative radiotherapy in hospice care. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 2004;22(17):3581-6. (Pubitemid 41103665)
21. Hird A, Chow E, Zhang L, Wong R, Wu J, Sinclair E, et al. Determining the [42 incidence of pain flare following palliative radiotherapy for symptomatic bone metastases: results from three Canadian cancer centers. International Journal of Radiation Oncology, Biology, Physics 2009;75(1):193-7.
22. Chow E, Harris K, Fan G, Tsao M, Sze WM. Palliative radiotherapy trials for bone metastases: a systematic review. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 2007;25(11): 1423-36. (Pubitemid 46706892)
23. Wu J, Wong R, Johnston M, Bezjak A, Whelan T. Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases. International Journal of Radiation Oncology, Biology, Physics 2003;55: 594-605. (Pubitemid 36170000)
24. Chow E, Hoskin P, Mitera G, Zeng L, Lutz S, Roos D, et al. Update of the international consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases. International Journal of Radiation Oncology, Biology, Physics 2011.
25. Fairchild A, Barnes E, Ghosh S, Ben-Josef E, Roos D, Hartsell W, et al. International patterns of practice in palliative radiotherapy for painful bone [47 metastases: evidence-based practice? International Journal of Radiation Oncology, Biology, Physics 2009;75:1281-628.
26. Hartsell W, Scott CB, Bruner D, Scarantino C, Ivker R, Roach M, et al. Randomized trial of short- versus long-course radiotherapy for palliation of painful bone metastases. Journal of the National Cancer Institute 2005;97(11):798-804. (Pubitemid 40909122)
27. Sahgal A, Larson D, Chang E. Stereotactic body radiosurgery for spinal metastases: a critical review. International Journal of Radiation Oncology, Biology, Physics 2008;71(3):652-65. (Pubitemid 351749532)
28. Chang E, Shiu A, Mendel E, Mathews L, Mahajan A, Allen P, et al. Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. Journal of Neurosurgery 2007;7:151-60. (Pubitemid 47219748)
29. Chang E, Shiu A, Lii M, Rhines L, Mendel E, Mahajan A, et al. Phase I clinical evaluation for spinal metastases. InternationalJournal ofRadiation Oncology, Biology, Physics 2004;59:1288-94.
30. Gibbs I, Kamnerdsupaphon P, Ryu M, Dodd R, Kiernan M, Chang S, et al. Image-guided robotic radiosurgery for spinal metastases. Radiotherapy and Oncology 2007;82:185-90.
31. Gerszten P, Burton S, Ozhasoglu C, Welch W. Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution. Spine 2007;32:193-9. (Pubitemid 46105806)
32. Sahgal A, Ma L, Weinberg V, Gibbs IC, Chao S, Chang UK, et al. Reirradiation human spinal cord tolerance for stereotactic body radiotherapy. International Journal of Radiation Oncology, Biology, Physics 2012;82:107-16.
33. Patchell R, Tibbs P, Regine F, Payne R, Saris S, Kryscio R, et al. Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet 2005;366:643e648.
34. Radiopharmaceuticals for the palliation of painful bone metastases: Cancer Guideline Report 14-1. Available from: < https://www.cancercare.on.ca/ common/ pages/UserFile.aspx?serverId=6&path=/File%20Database/CCO%20Files/ PEBC/ pebc14-1f.pdf); 2012 [accessed 04.02.12].
35. Van Poznak C, Temin S, Yee G, Janjan N, Barlow W, Biermann J, et al. American Society of Clinical Oncology executive summary of the clinical practice guideline update on the role of bone-modifying agents in metastatic breast cancer. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 2011;29(9):1221-7.
36. Cheung G, Chow E, Holden L, Vidmar M, Danjoux C, Yee A, et al. Percutaneous vertebroplasty in patients with intractable pain from osteoporotic or metastatic fractures: a prospective study using quality-of-life assessment. Interventional Radiology 2006;57:13-21. (Pubitemid 43793307)
37. Chow E, Hird A, Velikova G, Johnson C, Dewolf L, Bezjak A, et al. The European Organisation for Research and Treatment of Cancer Quality of life questionnaire for patients with bone metastases: the EORTC QLQ-BM22. European Journal of Cancer (Oxford, England: 1990) 2009;45:1146-52.
38. National Comprehensive Cancer Network Guidelines and Clinical Resources. Available from:
39. National Comprehensive Cancer Network Guidelines: Non-Small Cell Lung Cancer. Available from:
40. National Comprehensive Cancer Network Guidelines: Small Cell Lung Cancer. Available from: < http://www.nccn.org/professionals/physician-gls/pdf/sclc. pdf); 2012 [accessed 04.02.12].
41. National Comprehensive Cancer Network Guidelines: Kidney Cancer. Available from: http://www.nccn.org/professionals/physician-gls/pdf/kidney. pdf); 2012 [accessed 04.02.12].
42. National Comprehensive Cancer Network Guidelines: Multiple Myeloma. Available from: < http://guidelines.nccn.org/epc-guideline/guideline/id/AB9C B2A2-ABDF-9C66-6D92-8F8FD1F26358?jumpTo=false#;history=2-gls%40CC5C 60B1-6CE6-CA93-10C8-5D1D5F409079-empty-1); 2012 [accessed 04.02.12].
43. National Comprehensive Cancer Network Guidelines: Prostate Cancer. Available from: http://guidelines.nccn.org/epc-guideline/guideline/id/0E460A39- A272-4B7A-D97E-DDB246FFC11F?jumpTo=false#); 2012 [accessed 04.02.12].
44. National Comprehensive Cancer Network Guidelines: Thyroid Cancer. Available from: http://www.nccn.org/professionals/physician-gls/pdf/thyroid. pdf); 2012 [accessed 04.02.12].
45. National Comprehensive Cancer Network Guidelines: Adult Cancer Pain. Available from:
46. National Comprehensive Cancer Network Guidelines: Breast Cancer. Available from: < http://www.nccn.org/professionals/physician-gls/pdf/breast. pdf); 2012 [accessed 04.02.12].
47. National Comprehensive Cancer Network Guidelines: Palliative Care. Available from: < http://www.nccn.org/professionals/physician-gls/pdf/ palliative. pdf); 2012 [accessed 04.02.12].
48. Science direct: top 25 hottest articles, International Journal of Radiation Oncology, Biology, and Physics (January to December 2011 full year). Available from: http://top25.sciencedirect.com/subject/medicine-and-dentistry/ 17/journal/international-journal-of-radiation-oncologybiologyphysics/03603016/ archive/36/); 2012 [accessed 27.02.12].
49. National Quality Forum. Available from: http://www.qualityforum.org/Home. aspx); 2012 [accessed 04.02.12].