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Volumn 27, Issue 5, 2012, Pages 296-300

Disease modifying drugs targeting Β-amyloid

Author keywords

Alzheimer's disease; Amyloid ; disease modifying; intervention; pharmacological

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; ATORVASTATIN; BAPINEUZUMAB; CELECOXIB; GLUCAGON LIKE PEPTIDE; GRL 8234; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IBUPROFEN; ISOLIQUIRITIGENIN; METHYLENE BLUE; NAPROXEN; NOOTROPIC AGENT; PLACEBO; SEMAGACESTAT; SIMVASTATIN; TAK 070; UNCLASSIFIED DRUG;

EID: 84864232926     PISSN: 15333175     EISSN: 19382731     Source Type: Journal    
DOI: 10.1177/1533317512452034     Document Type: Review
Times cited : (25)

References (40)
  • 1
    • 47749147258 scopus 로고    scopus 로고
    • Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase
    • Shen C, Chen Y, Liu H, et al. Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase. J Biol Chem. 2008 ; 283 (25). 17721-17730
    • (2008) J Biol Chem , vol.283 , Issue.25 , pp. 17721-17730
    • Shen, C.1    Chen, Y.2    Liu, H.3
  • 3
    • 77956480302 scopus 로고    scopus 로고
    • Nonpharmacological therapies in Alzheimer's disease: A systematic review of efficacy
    • Olazarán J, Reisberg B, Clare L, et al. Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy. Dement Geriatr Cogn Disord. 2010 ; 30 (2). 161-178
    • (2010) Dement Geriatr Cogn Disord , vol.30 , Issue.2 , pp. 161-178
    • Olazarán, J.1    Reisberg, B.2    Clare, L.3
  • 4
    • 79551484106 scopus 로고    scopus 로고
    • Presenilin/gamma-secretase and inflammation
    • Saura CA. Presenilin/gamma-secretase and inflammation. Front Aging Neurosci. 2010 ; 2: 16
    • (2010) Front Aging Neurosci , vol.2 , pp. 16
    • Saura, C.A.1
  • 7
    • 49449101906 scopus 로고    scopus 로고
    • Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease
    • Fleisher AS, Raman R, Siemers ER, et al. Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease. Arch Neurol. 2008 ; 65 (8). 1031-1038
    • (2008) Arch Neurol , vol.65 , Issue.8 , pp. 1031-1038
    • Fleisher, A.S.1    Raman, R.2    Siemers, E.R.3
  • 8
    • 78149474423 scopus 로고    scopus 로고
    • NerveCenter: Phase III Alzheimer trial halted: Search for therapeutic biomarkers continues
    • Samson K.. NerveCenter: Phase III Alzheimer trial halted: search for therapeutic biomarkers continues. Ann Neurol. 2010 ; 68 (4). A9 - A12
    • (2010) Ann Neurol , vol.68 , Issue.4
    • Samson, K.1
  • 9
    • 79959944588 scopus 로고    scopus 로고
    • Giardina GA. ?-Secretase inhibitors and modulators for the treatment of Alzheimer's disease: Disappointments and hopes
    • Imbimbo BP. Giardina GA. ?-Secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes. Curr Top Med Chem. 2011 ; 11 (12). 1555-1570
    • (2011) Curr Top Med Chem , vol.11 , Issue.12 , pp. 1555-1570
    • Imbimbo, B.P.1
  • 10
    • 79960566232 scopus 로고    scopus 로고
    • Dynamics of AΒ42 reduction in plasma, CSF and brain of rats treated with the ?-secretase modulator, GSM-10h
    • Hawkins J, Harrison DC, Ahmed S, et al. Dynamics of AΒ42 reduction in plasma, CSF and brain of rats treated with the ?-secretase modulator, GSM-10h. Neurodegener Dis. 2011 ; 8 (6). 455-464
    • (2011) Neurodegener Dis , vol.8 , Issue.6 , pp. 455-464
    • Hawkins, J.1    Harrison, D.C.2    Ahmed, S.3
  • 11
    • 79958261220 scopus 로고    scopus 로고
    • Treating transgenic Alzheimer mice with a Β-secretase inhibitor, what have we learned?
    • Tang J, Ghosh A. Treating transgenic Alzheimer mice with a Β-secretase inhibitor, what have we learned?. Aging (Albany NY). 2011 ; 3 (1). 14-16
    • (2011) Aging (Albany NY) , vol.3 , Issue.1 , pp. 14-16
    • Tang, J.1    Ghosh, A.2
  • 12
    • 46749092486 scopus 로고    scopus 로고
    • β-Secretase as a Therapeutic Target for Alzheimer's Disease
    • DOI 10.1016/j.nurt.2008.05.007, PII S1933721308000974
    • Ghosh AK, Gemma S, Tang J. Beta-secretase as a therapeutic target for Alzheimer's disease. Neurotherapeutics. 2008 ; 5 (3). 399-408 (Pubitemid 351952491)
    • (2008) Neurotherapeutics , vol.5 , Issue.3 , pp. 399-408
    • Ghosh, A.K.1    Gemma, S.2    Tang, J.3
  • 13
    • 79551633353 scopus 로고    scopus 로고
    • Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice
    • Chang WP, Huang X, Downs D, et al. Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice. FASEB J. 2010 ; 25 (2). 775-784
    • (2010) FASEB J , vol.25 , Issue.2 , pp. 775-784
    • Chang, W.P.1    Huang, X.2    Downs, D.3
  • 14
    • 77956048697 scopus 로고    scopus 로고
    • Inhibition of BACE1 for therapeutic use in Alzheimer's disease
    • Luo X, Yan R. Inhibition of BACE1 for therapeutic use in Alzheimer's disease. Int J Clin Exp Pathol. 2010 ; 3 (6). 618-628
    • (2010) Int J Clin Exp Pathol , vol.3 , Issue.6 , pp. 618-628
    • Luo, X.1    Yan, R.2
  • 15
    • 79951541046 scopus 로고    scopus 로고
    • Potent BACE-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies
    • John S, Thangapandian S, Sakkiah S, Lee KW.. Potent BACE-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies. BMC Bioinformatics. 2011 ; 12 (suppl 1). S28
    • (2011) BMC Bioinformatics , vol.12 , Issue.SUPPL. 1 , pp. 28
    • John, S.1    Thangapandian, S.2    Sakkiah, S.3    Lee, K.W.4
  • 16
    • 80052850006 scopus 로고    scopus 로고
    • Design, synthesis and SAR study of hydroxychalcone inhibitors of human Β-secretase (BACE1)
    • Ma L, Yang Z, Li C, Zhu Z, Shen X, Hu L. Design, synthesis and SAR study of hydroxychalcone inhibitors of human Β-secretase (BACE1). J Enzyme Inhib Med Chem. 2011 ; 26 (5). 643-648
    • (2011) J Enzyme Inhib Med Chem , vol.26 , Issue.5 , pp. 643-648
    • Ma, L.1    Yang, Z.2    Li, C.3    Zhu, Z.4    Shen, X.5    Hu, L.6
  • 17
    • 77955863408 scopus 로고    scopus 로고
    • A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease
    • Fukumoto H, Takahashi H, Tarui N, et al. A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. J Neurosci. 2010 ; 30 (33). 11157-11166
    • (2010) J Neurosci , vol.30 , Issue.33 , pp. 11157-11166
    • Fukumoto, H.1    Takahashi, H.2    Tarui, N.3
  • 18
    • 78149286187 scopus 로고    scopus 로고
    • BACE: Therapeutic target and potential biomarker for Alzheimer's disease
    • Evin G, Barakat A, Masters CL. BACE: therapeutic target and potential biomarker for Alzheimer's disease. Int J Biochem Cell Biol. 2010 ; 42 (12). 1923-1926
    • (2010) Int J Biochem Cell Biol , vol.42 , Issue.12 , pp. 1923-1926
    • Evin, G.1    Barakat, A.2    Masters, C.L.3
  • 19
    • 63949088562 scopus 로고    scopus 로고
    • Function, regulation and therapeutic properties of beta-secretase (BACE1)
    • Willem M, Lammich S, Haass C. Function, regulation and therapeutic properties of beta-secretase (BACE1). Semin Cell Dev Biol. 2009 ; 20 (2). 175-182
    • (2009) Semin Cell Dev Biol , vol.20 , Issue.2 , pp. 175-182
    • Willem, M.1    Lammich, S.2    Haass, C.3
  • 23
    • 77953282150 scopus 로고    scopus 로고
    • A single ascending dose study of bapineuzumab in patients with Alzheimer disease
    • Black RS, Sperling RA, Safirstein B, et al. A single ascending dose study of bapineuzumab in patients with Alzheimer disease. Alzheimer Dis Assoc Disord. 2010 ; 24 (2). 198-203
    • (2010) Alzheimer Dis Assoc Disord , vol.24 , Issue.2 , pp. 198-203
    • Black, R.S.1    Sperling, R.A.2    Safirstein, B.3
  • 24
    • 73349091534 scopus 로고    scopus 로고
    • A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
    • Salloway S, Sperling R, Gilman S, et al. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology. 2009 ; 73 (24). 2061-2070
    • (2009) Neurology , vol.73 , Issue.24 , pp. 2061-2070
    • Salloway, S.1    Sperling, R.2    Gilman, S.3
  • 25
    • 67349112388 scopus 로고    scopus 로고
    • Common features between diabetes mellitus and Alzheimer's disease
    • Gotz J, Ittner LM, Lim YA. Common features between diabetes mellitus and Alzheimer's disease. Cell Mol Life Sci. 2009 ; 66 (8). 1321-1325
    • (2009) Cell Mol Life Sci , vol.66 , Issue.8 , pp. 1321-1325
    • Gotz, J.1    Ittner, L.M.2    Lim, Y.A.3
  • 27
    • 77950352189 scopus 로고    scopus 로고
    • GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease
    • Li Y, Duffy KB, Ottinger MA, et al. GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. J Alzheimers Dis. 2010 ; 19 (4). 1205-1219
    • (2010) J Alzheimers Dis , vol.19 , Issue.4 , pp. 1205-1219
    • Li, Y.1    Duffy, K.B.2    Ma, O.3
  • 28
    • 0038248960 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 decreases endogenous amyloid-β peptide (Aβ) levels and protects hippocampal neurons from death induced by Aβ and iron
    • DOI 10.1002/jnr.10611
    • Perry T, Lahiri DK, Sambamurti K, et al. Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J Neurosci Res. 2003 ; 72 (5). 603-612 (Pubitemid 36578646)
    • (2003) Journal of Neuroscience Research , vol.72 , Issue.5 , pp. 603-612
    • Perry, T.1    Lahiri, D.K.2    Sambamurti, K.3    Chen, D.4    Mattson, M.P.5    Egan, J.M.6    Greig, N.H.7
  • 29
    • 58249089520 scopus 로고    scopus 로고
    • Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study
    • Haag MD, Hofman A, Koudstaal PJ, Stricker BH, Breteler MM. Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study. J Neurol Neurosurg Psychiatry. 2009 ; 80 (1). 13-17
    • (2009) J Neurol Neurosurg Psychiatry , vol.80 , Issue.1 , pp. 13-17
    • Haag, M.D.1    Hofman, A.2    Koudstaal, P.J.3    Stricker, B.H.4    Breteler, M.M.5
  • 30
    • 78549284024 scopus 로고    scopus 로고
    • Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion
    • Tamboli IY, Barth E, Christian L, et al. Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion. J Biol Chem. 2010 ; 285 (48). 37405-37414
    • (2010) J Biol Chem , vol.285 , Issue.48 , pp. 37405-37414
    • Tamboli, I.Y.1    Barth, E.2    Christian, L.3
  • 31
    • 77949908687 scopus 로고    scopus 로고
    • Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe
    • Feldman HH, Doody RS, Kivipelto M, et al. Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe. Neurology. 2010 ; 74 (12). 956-964
    • (2010) Neurology , vol.74 , Issue.12 , pp. 956-964
    • Feldman, H.H.1    Doody, R.S.2    Kivipelto, M.3
  • 33
    • 43149102747 scopus 로고    scopus 로고
    • Protective effects of NSAIDs on the development of Alzheimer disease
    • DOI 10.1212/01.wnl.0000311269.57716.63, PII 0000611420080506000006
    • Vlad SC, Miller DR, Kowall NW, Felson DT. Protective effects of NSAIDs on the development of Alzheimer disease. Neurology. 2008 ; 70 (19). 1672-1677 (Pubitemid 351644133)
    • (2008) Neurology , vol.70 , Issue.19 PART 1 , pp. 1672-1677
    • Vlad, S.C.1    Miller, D.R.2    Kowall, N.W.3    Felson, D.T.4
  • 34
    • 41949119161 scopus 로고    scopus 로고
    • Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice
    • McKee AC, Carreras I, Hossain L, et al. Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain Res. 2008 ; 1207: 225-236
    • (2008) Brain Res , vol.1207 , pp. 225-236
    • McKee, A.C.1    Carreras, I.2    Hossain, L.3
  • 35
    • 81355142062 scopus 로고    scopus 로고
    • Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease
    • Wilkinson BL, Cramer PE, Varvel NH, et al. Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease. Neurobiol Aging. 2012 ; 33 (1). 197.e21 - e32
    • (2012) Neurobiol Aging , vol.33 , Issue.1
    • Wilkinson, B.L.1    Cramer, P.E.2    Varvel, N.H.3
  • 36
    • 47549107705 scopus 로고    scopus 로고
    • Cognitive function over time in the Alzheimer's disease anti-inflammatory prevention trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib
    • DOI 10.1001/archneur.2008.65.7.nct70006
    • Martin BK, Szekely C, Brandt J, et al. Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch Neurol. 2008 ; 65 (7). 896-905 (Pubitemid 352008472)
    • (2008) Archives of Neurology , vol.65 , Issue.7 , pp. 896-905
    • Martin, B.K.1    Szekely, C.2    Brandt, J.3    Piantadosi, S.4    Breitner, J.C.S.5    Craft, S.6    Evans, D.7    Green, R.8    Mullan, M.9
  • 37
    • 79952904028 scopus 로고    scopus 로고
    • Novel ?-secretase modulators: A review of patents from 2008 to 2010
    • Pettersson M, Kauffman GW, am Ende CW, et al. Novel ?-secretase modulators: a review of patents from 2008 to 2010. Expert Opin Ther Pat. 2011 ; 21 (2). 205-226
    • (2011) Expert Opin Ther Pat , vol.21 , Issue.2 , pp. 205-226
    • Pettersson, M.1    Kauffman, G.W.2    Am Ende, C.W.3
  • 38
    • 58549113365 scopus 로고    scopus 로고
    • Something old... something blue
    • Scheindlin S. Something old... something blue. Mol Interv. 2008 ; 8 (6). 268-273
    • (2008) Mol Interv , vol.8 , Issue.6 , pp. 268-273
    • Scheindlin, S.1
  • 39
    • 0033948654 scopus 로고    scopus 로고
    • Pharmacokinetics and organ distribution of intravenous and oral methylene blue
    • DOI 10.1007/s002280000124
    • Peter C, Hongwan D, Küpfer A, Lauterburg BH. Pharmacokinetics and organ distribution of intravenous and oral methylene blue. Eur J Clin Pharmacol. 2000 ; 56 (3). 247-250 (Pubitemid 30456685)
    • (2000) European Journal of Clinical Pharmacology , vol.56 , Issue.3 , pp. 247-250
    • Peter, C.1    Hongwan, D.2    Kupfer, A.3    Lauterburg, B.H.4
  • 40
    • 79251555689 scopus 로고    scopus 로고
    • Methylene blue reduces aΒ levels and rescues early cognitive deficit by increasing proteasome activity
    • Medina DX, Caccamo A, Oddo S. Methylene blue reduces aΒ levels and rescues early cognitive deficit by increasing proteasome activity. Brain Pathol. 2011 ; 21 (2). 140-149
    • (2011) Brain Pathol , vol.21 , Issue.2 , pp. 140-149
    • Medina, D.X.1    Caccamo, A.2    Oddo, S.3


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