Intranasal administration of PACAP: Uptake by brain and regional brain targeting with cyclodextrins

Peptides

Volumn 36, Issue 2, 2012, Pages 168-175

  Nonaka, Naoko ^a   Farr, Susan A ^b,c   Nakamachi, Tomoya ^a   Morley, John E ^b,c   Nakamura, Masanori ^a   Shioda, Seiji ^a   Banks, William A ^d,e  

^a SHOWA UNIVERSITY   (Japan)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Blood brain barrier; Cyclodextrin; Intranasal; Memory; Pituitary adenylate cyclase activating polypeptide

Indexed keywords

2 HYDROPROPYL BETA CYCLODEXTRIN; ALPHA CYCLODEXTRIN; BETA CYCLODEXTRIN; BETA CYCLODEXTRIN DERIVATIVE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; BRAIN REGION; CORPUS STRIATUM; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG POTENTIATION; DRUG TARGETING; HYPOTHALAMUS; MALE; MEMORY; MOUSE; NONHUMAN; OCCIPITAL CORTEX; OLFACTORY BULB; PRIORITY JOURNAL; THALAMUS;

ADMINISTRATION, INTRANASAL; ALPHA-CYCLODEXTRINS; ANIMALS; BETA-CYCLODEXTRINS; BLOOD-BRAIN BARRIER; BRAIN; CYCLODEXTRINS; HYPOTHALAMUS; MALE; MICE; MICE, INBRED ICR; OLFACTORY BULB; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE;

MUS;

EID: 84864153252     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2012.05.021     Document Type: Article

References (46)

1. A. Arimura, A. Somogyvari-Vigh, C. Weill, R.C. Fiore, I. Tatsuno, and V. Bay PACAP functions as a neurotrophic factor Ann NY Acad Sci 739 1994 228 243
2. W.A. Banks, M.J. During, and M.L. Niehoff Brain uptake of glucagon-like peptide-1 antagonist exendin (9-39) after intranasal administration J Pharmacol Exp Ther 309 2004 469 475
3. W.A. Banks, S.A. Farr, W. Butt, V.B. Kumar, M.W. Franko, and J.E. Morley Delivery across the blood-brain barrier of antisense directed againt amyloid: reversal of learning and memory deficits in mice overexpressing amyloid precursor protein J Pharmacol Exp Ther 297 2001 1113 1121
4. W.A. Banks, S.A. Farr, J.E. Morley, K.M. Wolf, V. Geylis, and M. Steinitz Anti-amyloid beta protein antibody passage across the blood-brain barrier in the SAMP8 mouse model of Alzheimer's disease: an age related selective uptake with reversal of learning impairment Exp Neurol 206 2007 248 256
5. W.A. Banks, A.J. Kastin, G. Komaki, and A. Arimura Passage of pituitary adenylate cyclase activating polypeptide 1-27 and pituitary adenylate cyclase activating polypeptide 1-38 across the blood-brain barrier J Pharmacol Exp Ther 267 1993 690 696
6. W.A. Banks, and J.E. Morley Memories are made of this: recent advances in understanding cognitive impairments and dementia J Gerontol 58A 2003 M314 M321
7. C. Benedict, M. Hallschmid, A. Hatke, B. Schultes, H.L. Fehm, and J. Born Intranasal insulin improves memory in humans Psychoneuroendocrinology 29 2004 1326 1334
8. J. Born, T. Lange, W. Kern, G.P. McGregor, U. Bickel, and H.L. Fehm Sniffing neuropeptides: a transnasal approach to the human brain Nat Neurosci 5 2002 514 516
9. D. Dogrukol-Ak, V.B. Kumar, J.S. Ryerse, S.A. Farr, S. Verma, and K. Nonaka Isolation of peptide transport system-6 from brain endothelial cells: therapeutic effects with antisense inhibition in Alzheimer's and stroke models J Cereb Blood Flow Metab 29 2009 411 422
10. C. Dufes, J.C. Olivier, F. Gaillard, A. Gaillard, W. Couet, and J.M. Muller Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats Int J Pharm 255 2003 87 97
11. M.J. During, L. Cao, D.S. Zuzga, J.S. Francis, H.L. Fitzsimons, and X. Jiao Glucagon-like peptide-1 receptor is involved in learning and neuroprotection Nat Med 9 2003 1173 1179
12. R.H. Ehrensing, and A.J. Kastin Dose-related biphasic effect of prolyl-leucyl-glycinamide (MIF-1) in depression Am J Psychiatry 135 1978 562 566
13. M.A. Erickson, M.L. Niehoff, S.A. Farr, J.E. Morley, L.A. Dillman, and K.M. Lynch Peripheral administration of antisense targeting the amyloid beta protein precursor reverses ABPP and LRP-1 overexpression in aged SAMP8 mouse brain J Alzheimers Dis 28 4 2012 951 960
14. S.A. Farr, W.A. Banks, M.E. La Scola, J.F. Flood, and J.E. Morley Permanent and tempory inactivation of the hippocampus impairs T-maze footshock avoidance acquisition and retention Brain Res 872 2000 242 249
15. S.A. Farr, W.A. Banks, K. Uezu, E.O. Freed, V.B. Kumar, and J.E. Morley Mechanisms of HIV-1 induced cognitive impairment: evidence for hippocampal cholinergic involvement with overstimulation of the VIPergic system by the viral coat protein core AIDS Res Hum Retroviruses 18 2002 1189 1195
16. S.A. Farr, W.A. Banks, K. Uezu, A. Sano, F.S. Gaskin, and J.E. Morley Antibody to beta-amyloid protein increases acetylcholine in the hippocampus of 12 month SAMP8 male mice Life Sci 73 2003 555 562
17. S.A. Farr, J.F. Flood, and J.E. Morley The effect of cholinergic, GABAergic, serotonergic and glutamatergic receptor modulation on post-trial memory processing in the hippocampus Neurobiol Learn Mem 73 2000 150 167
18. S.A. Farr, K. Uezu, J.F. Flood, and J.E. Morley Septo-hippocampal drug interactions in post-trial memory processing Brain Res 847 1999 221 230
19. J.F. Flood, and J.E. Morley Age-related changes in the pharmacological improvement of retention in SAMP8 mice T. Takeda, The SAM model of senescence 1994 Excerpta Medica Kyoto 89 94
20. J.F. Flood, and J.E. Morley Learning and memory in the SAMP8 mouse Neurosci Biobehav Rev 22 1998 1 20
21. J.F. Flood, P.M. Morley, and J.E. Morley Age-related changes in learning, memory, and lipofuscin as a function of the percentage of SAMP8 genes Physiol Behav 58 1995 819 822
22. W.H. Frey II Bypassing the blood-brain barrier to deliver therapeutic agents to the brain and spinal cord Drug Deliv Technol 2 2002 46 49
23. J. Glowinski, and L.L. Iversen Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain J Neurochem 13 1966 655 669
24. C.L. Graff, and G.M. Pollack P-glycoprotein attenuates brain uptake of substrates after nasal installation Pharm Res 20 2003 1225 1230
25. A.J. Kastin, W.A. Banks, J.E. Zadina, M.V. Graf, and Minireview: Brain peptides: the dangers of constricted nomenclatures Life Sci 32 1983 295 301
26. V.B. Kumar, S.A. Farr, J.F. Flood, V. Kamlesh, M. Franko, and W.A. Banks Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice Peptides 21 2000 1769 1775
27. V.B. Kumar, K. Vyas, M. Franko, V. Choudhary, C. Buddhiraju, and J. Alvarez Molecular cloning, expression and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8) Biochem Cell Biol 79 2000 57 67
28. X.F. Liu, J.R. Fawcett, R.G. Thorne, and W.H. Frey Non-invasive intranasal insulin-like growth factor-1 reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion Neurosci Lett 308 2001 91 94
29. J.J. Lochhead, and R.G. Thorne Intranasal delivery of biologics to the central nervous system Adv Drug Deliv Rev 2011
30. T. Loftsson, and M.E. Brewster Pharmaceutical applications of cyclodextrins: basic science and product development J Pharm Pharmacol 62 2010 1607 1621
31. J.E. Morley The SAMP8 mouse: a model of Alzheimer's disease? Biogerontology 31 2002 57 60
32. J.E. Morley, S.A. Farr, and J.F. Flood Antibody to amyloid beta protein alleviates impaired acquisition, retention, and memory processing in SAMP8 mice Neurobiol Learn Mem 78 2002 125 138
33. J.E. Morley, S.A. Farr, V.B. Kumar, and W.A. Banks Alzheimer's disease through the eye of a mouse: Acceptance lecture for the 2001 Gayle A. Olson and Richard D. Olson prize Peptides 23 2002 589 599
34. N. Nonaka, W.A. Banks, H. Mizushima, S. Shioda, and J.E. Morley Regional differences in PACAP transport across the blood-brain barrier in mice: a possible influence of strain, amyloid protein, and age Peptides 23 2002 2197 2202
35. N. Nonaka, S.A. Farr, H. Kageyama, S. Shioda, and W.A. Banks Delivery of galanin-like peptide to the brain: Targeting with intranasal delivery and cyclodextrins J Pharmacol Exp Ther 325 2008 513 519
36. H. Ohtaki, T. Nakamachi, K. Dohi, Y. Aizawa, A. Takaki, and K. Hodoyama Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with interleukin-6 (IL-6) signaling Proc Natl Acad Sci USA 103 2006 7488 7493
37. H.F. Poon, A. Castegna, S.A. Farr, V. Thongboonkerd, B.C. Lynn, and W.A. Banks Quantitative proteomics analysis of specific protein expression and oxidative modification in aged senescence-accelerated-prone 8 mice brain Neuroscience 126 2004 915 926
38. M.A. Reger, G.S. Watson, P.S. Green, L.D. Baker, B. Cholerton, and M.A. Fishel Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired adults J Alzheimers Dis 13 2008 323 331
39. D. Reglodi, P. Kiss, A. Lubics, and A. Tamas Review on the protective effects of PACAP in models of neurodegenerative diseases in vitro and in vivo Curr Pharm Des 17 2011 962 972
40. T.M. Ross, P.M. Martinez, J.C. Renne, R.G. Thorne, L.R. Hanson, and W.H. Frey Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis J Neuroimmunol 151 2004 66 77
41. A. Somogyvari-Vigh, W. Pan, D. Reglodi, A.J. Kastin, and A. Arimura Effect of middle cerebral artery occulsion on the passage of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier in the rat Regul Pept 91 2000 89 95
42. R. Strong, V. Reddy, and J.E. Morley Cholinergic deficits in the septal-hippocampal pathway of the SAM-P8 senescence accelerated mouse Brain Res 966 2003 150 156
43. R.G. Thorne, G.J. Pronk, V. Padmanabhan, and W.H. Frey II Delivery of insulin-like growth factor-1 to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration Neuroscience 127 2004 481 496
44. D. Uchida, A. Arimura, A. Somogyvari-Vigh, S. Shioda, and W.A. Banks Prevention of ischemia-induced death of hippocampal neurons by pituitary adenylate cyclase activating polypeptide Brain Res 736 1996 280 286
45. D. Uchida, S. Shloda, A. Takaki, and A. Arimura Cytoprotective action of pituitary adenylate cyclase activating polypeptide (PACAP) in ischemia-induced neuronal cell death in rat hippocampus Soc Neurosci Abst 193.10 1994 442
46. G.H.C. Varca, N. Andreo-Fiho, P.S. Lopes, and H.G. Ferraz Cycldextrins: an overview of the complexation of pharmaceutical proteins Curr Protein Pept Sci 11 2010 255 263