Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion

Neuroscience Letters

Volumn 308, Issue 2, 2001, Pages 91-94

  Liu, Xin Feng ^a,b   Fawcett, John R ^a   Thorne, Robert G ^a,b   Frey Ii, William H ^a,b  

^a REGIONS HOSPITAL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cerebral ischemia, focal; Insulin like growth factor I; Intranasal delivery; Middle cerebral artery occlusion; Neurological deficits; Neuroprotection

Indexed keywords

SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BODY POSTURE; BRAIN EDEMA; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; FLEXOR REFLEX; INFARCTION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVOUS SYSTEM FUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; REFLEX; STROKE; TEST STRIP;

ADMINISTRATION, INTRANASAL; ANIMALS; BRAIN; BRAIN EDEMA; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; INFARCTION, MIDDLE CEREBRAL ARTERY; INSULIN-LIKE GROWTH FACTOR I; MALE; MOVEMENT DISORDERS; NEUROPROTECTIVE AGENTS; OLFACTORY MUCOSA; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION;

EID: 0035800541     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)01982-6     Document Type: Article

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