Association of Neurexin 3 polymorphisms with smoking behavior

Genes, Brain and Behavior

Volumn 11, Issue 6, 2012, Pages 704-711

  Docampo, E ^a   Ribases M ^b,c,d   Gratacos M ^a   Bruguera, E ^d   Cabezas, C ^e   Sanchez Mora C ^b   Nieva, G ^c,d   Puente, D ^f   Argimon Pallas J M ^g   Casas, M ^c,d,h   Rabionet, R ^a   Estivill, X ^a  

^a CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

^d HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^e Direcció General d'Ordenació i Regulació Sanitària   (Spain)

^f INSTITUT UNIVERSITARI D'INVESTIGACIÓ EN ATENCIÓ PRIMÀRIA JORDI GOL   (Spain)

^g Servei Català de la Salut ^*  (Spain)

^h UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Addiction; Association; NRXN3; Smoking; SNP

Indexed keywords

NEUREXIN; NEUREXIN 3; NICOTINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BECK DEPRESSION INVENTORY; CAUCASIAN; CLINICAL ASSESSMENT; COHORT ANALYSIS; CONTROLLED STUDY; COPY NUMBER VARIATION; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; GENE DELETION; GENE EXPRESSION; GENE FREQUENCY; GENE REPLICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOMICS; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; SMOKING CESSATION; SPAIN; STATE TRAIT ANXIETY INVENTORY; TOBACCO DEPENDENCE;

ADULT; AGED; CASE-CONTROL STUDIES; COHORT STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SMOKING; SPAIN; TOBACCO USE DISORDER;

NICOTIANA TABACUM;

EID: 84864147239     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2012.00815.x     Document Type: Article

References (43)

1. Agrawal, A., Lynskey, M.T., Pergadia, M.L., Bucholz, K.K., Heath, A.C., Martin, N.G. & Madden, P.A. (2008) Early cannabis use and DSM-IV nicotine dependence: a twin study. Addiction 103, 1896-1904.
2. Barrett, J.C., Fry, B., Maller, J. & Daly, M.J. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265.
3. Beck, A.T., Ward, C.H., Mendelson, M., Mock, J. & Erbaugh, J. (1961) An inventory for measuring depression. Arch Gen Psychiatry 4, 561-571.
4. Bierut, L.J. (2011) Genetic vulnerability and susceptibility to substance dependence. Neuron 69, 618-627.
5. Bierut, L.J., Dinwiddie, S.H., Begleiter, H., Crowe, R.R., Hesselbrock, V., Nurnberger, J.I. Jr, Porjesz, B., Schuckit, M.A. & Reich, T. (1998) Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism. Arch Gen Psychiatry 55, 982-988.
6. Bierut, L.J., Madden, P.A., Breslau, N. et al. (2007) Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet 16, 24-35.
7. Conrad, D.F., Pinto, D., Redon, R. et al. (2010) Origins and functional impact of copy number variation in the human genome. Nature 464, 704-712.
8. Ching, M.S., Shen, Y., Tan, W.H. et al. (2010) Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders. Am J Med Genet B Neuropsychiatr Genet 153B, 937-947.
9. Craig, A.M., Graf, E.R. & Linhoff, M.W. (2006) How to build a central synapse: clues from cell culture. Trends Neurosci 29, 8-20.
10. Gabriel, S.B., Schaffner, S.F., Nguyen, H., Moore, J.M., Roy, J., Blumenstiel, B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M., Liu-Cordero, S.N., Rotimi, C., Adeyemo, A., Cooper, R., Ward, R., Lander, E.S., Daly, M.J. & Altshuler, D. (2002) The structure of haplotype blocks in the human genome. Science 296, 2225-2229.
11. Gauthier, J., Siddiqui, T.J., Huashan, P. et al. (2011) Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia. Hum Genet 130, 563-573.
12. Ge, D., Zhang, K., Need, A.C., Martin, O., Fellay, J., Urban, T.J., Telenti, A. & Goldstein, D.B. (2008) WGAViewer: software for genomic annotation of whole genome association studies. Genome Res 18, 640-643.
13. Gonzalez, J.R., Armengol, L., Sole, X., Guino, E., Mercader, J.M., Estivill, X. & Moreno, V. (2007) SNPassoc: an R package to perform whole genome association studies. Bioinformatics 23, 644-645.
14. Heard-Costa, N.L., Zillikens, M.C., Monda, K.L. et al. (2009) NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet 5, e1000539.
15. Heath, A.C., Martin, N.G., Lynskey, M.T., Todorov, A.A. & Madden, P.A. (2002) Estimating two-stage models for genetic influences on alcohol, tobacco or drug use initiation and dependence vulnerability in twin and family data. Twin Res 5, 113-124.
16. Heatherton, T.F., Kozlowski, L.T., Frecker, R.C. & Fagerstrom, K.O. (1991) The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire. Br J Addict 86, 1119-1127.
17. Hishimoto, A., Liu, Q.R., Drgon, T., Pletnikova, O., Walther, D., Zhu, X.G., Troncoso, J.C. & Uhl, G.R. (2007) Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms. Hum Mol Genet 16, 2880-2891.
18. Ioannidis, J.P., Patsopoulos, N.A. & Evangelou, E. (2007) Heterogeneity in meta-analyses of genome-wide association investigations. PLoS One 2, e841.
19. Julia, A., Ballina, J., Canete, J.D., Balsa, A., Tornero-Molina, J., Naranjo, A., Alperi-Lopez, M., Erra, A., Pascual-Salcedo, D., Barcelo, P., Camps, J. & Marsal, S. (2008) Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility. Arthritis Rheum 58, 2275-2286.
20. Kim, H.G., Kishikawa, S., Higgins, A.W. et al. (2008) Disruption of neurexin 1 associated with autism spectrum disorder. Am J Hum Genet 82, 199-207.
21. Kirov, G., Gumus, D., Chen, W., Norton, N., Georgieva, L., Sari, M., O'Donovan, M.C., Erdogan, F., Owen, M.J., Ropers, H.H. & Ullmann, R. (2008) Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. Hum Mol Genet 17, 458-465.
22. Lachman, H.M., Fann, C.S., Bartzis, M., Evgrafov, O.V., Rosenthal, R.N., Nunes, E.V., Miner, C., Santana, M., Gaffney, J., Riddick, A., Hsu, C.L. & Knowles, J.A. (2007) Genomewide suggestive linkage of opioid dependence to chromosome 14q. Hum Mol Genet 16, 1327-1334.
23. Lein, E.S., Hawrylycz, M.J., Ao, N. et al. (2007) Genome-wide atlas of gene expression in the adult mouse brain. Nature 445, 168-176.
24. Liu, Q.R., Drgon, T., Walther, D., Johnson, C., Poleskaya, O., Hess, J. & Uhl, G.R. (2005) Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples. Proc Natl Acad Sci U S A 102, 11864-11869.
25. Novak, G., Boukhadra, J., Shaikh, S.A., Kennedy, J.L. & Le Foll, B. (2009) Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: a preliminary study. World J Biol Psychiatry 10, 929-935.
26. Nussbaum, J., Xu, Q., Payne, T.J., Ma, J.Z., Huang, W., Gelernter, J. & Li, M.D. (2008) Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers. Hum Mol Genet 17, 1569-1577.
27. Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M.A., Bender, D., Maller, J., Sklar, P., de Bakker, P.I., Daly, M.J. & Sham, P.C. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81, 559-575.
28. Ribases, M., Bosch, R., Hervas, A. et al. (2009) Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder. Biol Psychiatry 66, 926-934.
29. Rowen, L., Young, J., Birditt, B., Kaur, A., Madan, A., Philipps, D.L., Qin, S., Minx, P., Wilson, R.K., Hood, L. & Graveley, B.R. (2002) Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity. Genomics 79, 587-597.
30. Spielberger, C.D., Gorsuch, R. L. & Lushene, R.E. (1970) Manual for the State-Trait Inventory. Consulting Psychology Press, Palo Alto .
31. Stoltenberg, S.F., Lehmann, M.K., Christ, C.C., Hersrud, S.L. & Davies, G.E. (2011) Associations among types of impulsivity, substance use problems and Neurexin-3 polymorphisms. Drug Alcohol Depend 119, e31-e38.
32. Stranger, B.E., Forrest, M.S., Clark, A.G., Minichiello, M.J., Deutsch, S., Lyle, R., Hunt, S., Kahl, B., Antonarakis, S.E., Tavare, S., Deloukas, P. & Dermitzakis, E.T. (2005) Genome-wide associations of gene expression variation in humans. PLoS Genet 1, e78.
33. Stranger, B.E., Forrest, M.S., Dunning, M., Ingle, C.E., Beazley, C., Thorne, N., Redon, R., Bird, C.P., de Grassi, A., Lee, C., Tyler-Smith, C., Carter, N., Scherer, S.W., Tavare, S., Deloukas, P., Hurles, M.E. & Dermitzakis, E.T. (2007) Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science 315, 848-853.
34. Sudhof, T.C. (2008) Neuroligins and neurexins link synaptic function to cognitive disease. Nature 455, 903-911.
35. Tabuchi, K. & Sudhof, T.C. (2002) Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing. Genomics 79, 849-859.
36. TAGconsortium (2010) Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet 42, 441-447.
37. Thorgeirsson, T.E., Geller, F., Sulem, P. et al. (2008) A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452, 638-642.
38. Ullrich, B., Ushkaryov, Y.A. & Sudhof, T.C. (1995) Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons. Neuron 14, 497-507.
39. Vaags, A.K., Lionel, A.C., Sato, D. et al. (2012) Rare deletions at the Neurexin 3 locus in autism spectrum disorder. Am J Hum Genet 90, 133-141.
40. Vink, J.M., Willemsen, G. & Boomsma, D.I. (2005) Heritability of smoking initiation and nicotine dependence. Behav Genet 35, 397-406.
41. West, R.J. & Russell, M.A. (1985) Pre-abstinence smoke intake and smoking motivation as predictors of severity of cigarette withdrawal symptoms. Psychopharmacology (Berlin) 87, 334-336.
42. WHO (2011) 2011 World Health Organization report on the global tobacco epidemic.
43. Wisniowiecka-Kowalnik, B., Nesteruk, M., Peters, S.U., Xia, Z., Cooper, M.L., Savage, S., Amato, R.S., Bader, P., Browning, M.F., Haun, C.L., Duda, A.W. 3rd, Cheung, S.W. & Stankiewicz, P. (2010) Intragenic rearrangements in NRXN1 in three families with autism spectrum disorder, developmental delay, and speech delay. Am J Med Genet B Neuropsychiatr Genet 153B, 983-993.