Thymic transplantation in pig-to-nonhuman primates for the induction of tolerance across xenogeneic barriers

Methods in Molecular Biology

Volumn 885, Issue , 2012, Pages 191-212

  Yamada, Kazuhiko ^a   Scalea, Joseph ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Miniature swine; T cell depletion; Thymic transplantation; Thymokidney; Thymus; Transplantation; Xenotransplantation

Indexed keywords

ANIMAL; ARTICLE; B LYMPHOCYTE; BALLOON DILATATION; CYTOTOXICITY; IMMUNOLOGY; KIDNEY TRANSPLANTATION; LYMPHOCYTE DEPLETION; METABOLISM; METHODOLOGY; MIXED LYMPHOCYTE CULTURE; PRIMATE; SWINE; T LYMPHOCYTE; THYMECTOMY; THYMUS; TRANSGENIC ANIMAL; TRANSPLANTATION; TRANSPLANTATION TOLERANCE; XENOGRAFT;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; B-LYMPHOCYTES; BALLOON DILATION; CYTOTOXICITY, IMMUNOLOGIC; KIDNEY TRANSPLANTATION; LYMPHOCYTE CULTURE TEST, MIXED; LYMPHOCYTE DEPLETION; PRIMATES; SWINE; T-LYMPHOCYTES; THYMECTOMY; THYMUS GLAND; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HETEROLOGOUS; TRANSPLANTS;

ANIMALIA; PAPIO; PRIMATES; SUIDAE; SUS;

EID: 84864135994     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-845-0_12     Document Type: Article

References (43)

1. Cooper DKC, Ye Y, Rolf LL Jr, Zuhdi N (1991) In: Cooper DKC, Kemp E, Reemtsma K, White DJG (eds) Xenotransplantation: The transplantation of organs and tissues between species. Heidelberg, Springer
2. Cooper DK, Gollackner B, Sachs DH (2002) Will the pig solve the transplantation backlog? Annu Rev Med 53:133-147
3. Yamada K, Griesemer A, Okumi M (2008) Pigs as xenogeneic donors. Transplant Rev 19:164-177
4. Sachs DH, Galli C (2009) Genetic manipulation in pigs. Curr Opin Organ Transplant 14:148-153
5. Cooper DK, Good AH, Koren E et al (1993) Identi fi cation of alpha-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: Relevance to discordant xenografting in man. Transpl Immunol 1:198-205
6. Galili U, Clark MR, Shohet SB, Buehler J, Macher BA (1987) Evolutionary relationship between the natural anti-Gal antibody and the Gal alpha 1-3Gal epitope in primates. Proc Natl Acad Sci USA 84:1369-1373
7. Galili U (1993) Evolution and pathophysiology of the human natural anti-.alpha.-galactosyl IgG (anti-Gal) antibody. Springer Semin Immunopathol 15:155-171
8. Galili U, Gregory CR, Morris RE (1996) New World monkeys as a primate model for xenografts in the absence of anti-Gal. Transplant Proc 28:567-568
9. Galili U, Shohet SB, Kobrin E, Stults CL, Macher BA (1988) Man, apes, and old world monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells. J Biol Chem 263: 17755-17762
10. Phelps CJ, Koike C, Vaught TD et al (2003) Production of alpha 1,3-galactosyltransferasede ficient pigs. Science 299:411-414
11. Kolber-Simonds D, Lai L, Watt SR et al (2004) Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fi broblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci USA 101:7335-7340
12. Lai L, Kolber-Simonds D, Park K et al (2002) Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 295:1089-1092
13. Mezrich JD, Haller GW, Arn JS et al (2003) Histocompatible miniature swine: An inbred large-animal model. Transplantation 75:904-907
14. Dor FJ, Tseng YL, Cheng J et al (2004) Alpha1,3-galactosyltransferase gene-knockout miniature swine produce natural cytotoxic anti-Gal antibodies. Transplantation 78:15-20
15. Yamada K, Yazawa K, Shimizu A et al (2005) Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3- galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 11:32-34
16. Moses RD, Pierson RN, Winn HJ, Auchincloss H Jr (1990) Xenogeneic proliferation and lymphokine production are dependent on CD4+ helper T cells and self antigen-presenting cells in the mouse. J Exp Med 172:567-575
17. Deschamps JY, Roux FA, Sai P, Gouin E (2005) History of xenotransplantation. Xenotransplantation 12:91-109
18. Yamada K, Sachs DH, DerSimonian H (1995) Human anti-porcine xenogeneic T cell response. Evidence for allelic speci fi city of mixed leukocyte reaction and for both direct and indirect pathways of recognition. J Immunol 155:5249-5256
19. Murray AG, Khodadoust MM, Pober JS, Bothwell AL (1994) Porcine aortic endothelial cells activate human T cells: Direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Immunity 1:57-63
20. Cozzi E, White DJ (1995) The generation of transgenic pigs as potential organ donors for humans. Nat Med 1:964-966
21. Mollnes TE, Fiane AE (2003) Perspectives on complement in xenotransplantation. Mol Immunol 40:135-143
22. Adams DH, Kadner A, Chen RH, Farivar RS (2001) Human membrane cofactor protein (MCP, CD 46) protects transgenic pig hearts from hyperacute rejection in primates. Xenotransplantation 8:36-40
23. Buhler L, Yamada K, Kitamura H et al (2001) Pig kidney transplantation in baboons: Anti-Gal (alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation. Transplantation 72:1743-1752
24. Chen G, Qian H, Starzl T et al (2005) Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 11:1295-1298
25. Sandberg JO, Benda B, Lycke N, Korsgren O et al (1997) Xenograft rejection of porcine islet-like cell clusters in normal, interferongamma, and interferon-gamma receptor de ficient mice. Transplantation 63:1446-1452
26. Benda B, Karlsson-Parra A, Ridderstad A, Korsgren O (1996) Xenograft rejection of porcine islet-like cell clusters in immunoglobulinor Fc-receptor gamma-de ficient mice. Transplantation 62:1207-1211
27. Zhao Y, Swenson K, Sergio JJ et al (1996) Skin graft tolerance across a discordant xenogeneic barrier. Nat Med 2:1211-1216
28. Rodriguez-Barbosa JI, ZhaoY BR et al (2001) Enhanced CD4 reconstitution by grafting neonatal porcine tissue in alternative locations is associated with donor-specific tolerance and suppression of preexisting xenoreactive T cells. Transplantation 72:1223-1231
29. Nikolic B, Gardner JP, Scadden DT et al (1999) Normal development in porcine thymus grafts and specific tolerance of human T cells to porcine donor MHC. J Immunol 162:3402-3407
30. Haller GW, Esnaola N, Yamada K et al (1999) Thymic transplantation across an MHC class I barrier in swine. J Immunol 163:3785-3792
31. Yamada K, Shimizu A, Ierino FL et al (1999) Thymic transplantation in miniature swine. I. Development and function of the "thymokidney". Transplantation 68:1684-1692
32. Yamada K, Shimizu A, Utsugi R et al (2000) Thymic transplantation in miniature swine II Induction of tolerance by transplantation of composite thymokidneys to thymectomized recipients. J Immunol 164:3079-3086
33. Yamada K, Vage fi PA, Utsugi R et al (2003) Thymic transplantation in miniature swine: III. Induction of tolerance by transplantation of composite thymokidneys across fully major histocompatibility complex-mismatched barriers. Transplantation 76:530-536
34. LaMattina JC, Kumagai N, Barth RN et al (2002) Vascularized thymic lobe transplantation in miniature swine: I. Vascularized thymic lobe allografts support thymopoiesis. Transplantation 73:826-831
35. Kamano C, Vage fi PA, Kumagai N et al (2004) Vascularized thymic lobe transplantation in miniature swine: Thymopoiesis and tolerance induction across fully MHC-mismatched barriers. Proc Natl Acad Sci USA 101:3827-3832
36. Nobori S, Shimizu A, Okumi M et al (2006) Thymic rejuvenation and the induction of tolerance by adult thymic grafts. Proc Natl Acad Sci USA 103:19081-19086
37. Griesemer AD, Hirakata A, Shimizu A et al (2009) Results of gal-knockout porcine thymokidney xenografts. Am J Transplant 9:2669-78
38. Yamada K, Gianello PR, Ierino FL et al (1997) Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts. J Exp Med 186:497-506
39. Nobori S, Samelson-Jones E, Shimizu A et al (2006) Long-term acceptance of fully allogeneic cardiac grafts by cotransplantation of vascularized thymus in miniature swine. Transplantation 81:26-35
40. Sengupta D, Harper M, Jennett B (1974) Effect of carotid ligation on cerebral blood fl ow in baboons. J Neurol Neurosurg Psychiatry 37:578-584
41. Fishman JA, Patience C (2004) Xenotransplantation: Infectious risk revisited. Am J Transplant 4:1383-1390
42. Preville X, Flacher M, LeMauff B et al (2001) Mechanisms involved in antithymocyte globulin immunosuppressive activity in a nonhuman primate model. Transplantation 71:460-468
43. Gollackner B, Mueller NJ, Houser S et al (2003) Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation. Transplantation 75:1841-1847