Thymic transplantation across an MHC class I barrier in swine

Journal of Immunology

Volumn 163, Issue 7, 1999, Pages 3785-3792

  Haller, Gary W ^a   Esnaola, Nestor ^a,b   Yamada, Kazuhiko ^a   Wu, Anette ^a   Shimizu, Akira ^a   Hansen, Andrew ^a   Ferrara, Vincent R ^a   Allison, Kenneth S ^a   Colvin, Robert B ^a   Sykes, Megan ^a   Sachs, David H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD1 ANTIGEN; CYCLOSPORIN A; IMMUNOGLOBULIN G; LEUKOCYTE ANTIGEN;

ALLOGENEIC RESTRICTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNE RESPONSE; IMMUNOPEROXIDASE STAINING; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; SWINE; THYMECTOMY; THYMUS TRANSPLANTATION; TISSUE TRANSPLANTATION; XENOGRAFT;

ANIMALS; CELL DIFFERENTIATION; CHIMERA; GRAFT REJECTION; GRAFT SURVIVAL; HISTOCOMPATIBILITY; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNE TOLERANCE; SKIN TRANSPLANTATION; SWINE; SWINE, MINIATURE; T-LYMPHOCYTES; THYMECTOMY; THYMUS GLAND; TISSUE DONORS;

EID: 0033215143     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Zinkernagel, R. M., A. Althage, E. Waterfield, B. Kindred, R. M. Welsh, G. Callahan, and P. Pincetl. 1980. Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts. J. Exp. Med. 151:376.
2. Sprent, J. 1993. T lymphocytes and the thymus. In Fundamental Immunology, 3rd Ed. W. E. Paul, ed. Raven Press, New York, p. 75.
3. Elliott, J. I. 1993. The identity of the cells that positively select thymocytes. Immunol. Rev. 135:215.
4. Jameson, S. C., K. A. Hogquist, and M. J. Bevan. 1995. Positive selection of thymocytes. Annu. Rev. Immunol. 13:93.
5. Ardavin, C. 1997. Thymic dendritic cells. Immunol. Today 18:350.
6. Ashton-Rickardt, P. G., A. Bandeira, J. R. Delaney, L. V. Kaer, H.-P. Pricher, R. M. Zinkernagel, and S. Tonegawa. 1994. Evidence for a differential avidity model of T cell selection in the thymus. Cell 76:651.
7. Bonomo, A., and P. Matzinger. 1993. Thymus epithelium induces tissue-specific tolerance. J. Exp. Med. 177:1153.
8. Zhao, Y., K. Swenson, J. J. Sergio, J. S. Arn, D. H. Sachs, and M. Sykes. 1996. Skin graft tolerance across a discordant xenogeneic barrier. Nat. Med. 2:1211.
9. d resulting in positive versus negative selection of the 2C transgenic T cell receptor in vivo. Immunity 7:233.
10. Tomita, Y., A. Khan, and M. Sykes. 1994. Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a non-myeloablative regimen. J. Immunol. 153: 1087.
11. Hosaka, N., M. Nose, M. Kayogoku, N. Nagata, S. Miyashima, R. A. Good, and S. Ikehara. 1996. Thymus transplantation, a critical factor for correction of autoimmune disease in aging MRL/+ mice. Proc. Natl. Acad. Sci. USA 93 :8558.
12. Aisenberg, A. C. 1970. Allogeneic thymus grafts and the restoration of immune function in irradiated thymectomized mice. J. Exp. Med. 131:275.
13. Waer, M., V. Palathumpat, H. Sobis, and M. Vandeputte. 1990. Induction of transplantation tolerance in mice across major histocompatibility barrier by using allogeneic thymus transplantation and total lymphoid irradiation. J. Immunol. 145:499.
14. Zhao, Y., J. J. Sergio, K. Swenson, J. S. Arn, D. H. Sachs, and M. Sykes. 1997. Positive and negative selection of functional mouse CD4 cells by porcine MHC in pig thymus grafts. J. Immunol. 159:2100.
15. + T cells with a mouse MHC-restricted TCR in pig thymus grafts. J. Immunol. 161:1320.
16. Zhao, Y., J. A. Fishman, J. I. Sergio, J. L. Oliveros, D. A. Pearson, G. L. Szot, R. A. Wilkinson, J. S. Arn, D. H. Sachs, and M. Sykes. 1997. Immune restoration by fetal pig thymus grafts in T cell-depleted, thymectomized mice. J. Immunol. 158:1641.
17. Markert, M. L., D. D. Kostyu, F. E. Ward, T. M. McLaughlin, T. J. Watson, R. H. Buckley, S. E. Schiff, R. M. Ungerleider, J. W. Gaynor, K. T. Oldham, et al. 1997. Successful formation of a chimeric human thymus allograft following transplantation of cultured postnatal human thymus. J. Immunol. 158:998.
18. Salaün, J., A. Bandeira, I. Khazaal, F. Calman, M. Coltey, A. Coutinho, and N. M. Le Douarin. 1990. Thymic epithelium tolerizes for histocompatibility antigens. Science 247:1471.
19. Rosengard, B. R., C. A. Ojikutu, J. Fishbein, E. O. Kortz, and D. H. Sachs. 1992. Selective breeding of miniature swine leads to an increased rate of acceptance of MHC-identical, but not of class-I disparate, renal allografts. J. Immunol. 149: 1099.
20. Rosengard, B. R., C. A. Ojikutu, P. C. Guzzetta, C. V. Smith, T. M. Sundt III, K. Nakajima, S. M. Boorstein, G. S. Hill, J. M. Fishbein, and D. H. Sachs. 1992. Induction of specific tolerance to class I disparate renal allografts in miniature swine with cyclosporine. Transplantation 54:490.
21. Sachs, D. H., G. Leight, J. Cone, S. Schwartz, L. Stuart, and S. Rosenberg. 1976. Transplantation in miniature swine. I. Fixation of the major histocompatibility complex. Transplantation 22:559.
22. Sachs, D. H. 1992. MHC homozygous miniature swine. In Swine as Models in Biomedical Research, 1st Ed. M. M. Swindle, D. C. Moody and L. D. Phillips, eds. Iowa State University Press, Ames, p. 3.
23. Pennington, L. R., J. K. Lunney, and D. H. Sachs. 1981. Transplantation in miniature swine. VIII. Recombination within the major histocompatibility complex of miniature swine. Transplantation 31:66.
24. Yamada, K., P. R. Gianello, F. L. Ierino, T. Lorf, A. Shimizu, S. Meehan, R. B. Colvin, and D. H. Sachs. 1997. Role of the thymus in transplantation tolerance in miniature swine. I. Requirement of the thymus for rapid and stable induction of tolerance to class I-mismatched renal allografts. J. Exp. Med. 186: 497.
25. Lambrigts, D., C. Franssen, H. Martens, P. Van Calster, M. Meurisse, V. Geenen, C. Charlet-Renard, A. Dewaele, F. Coignoul, M. Lamy, et al. 1996. Development of thymus autografts under the kidney capsule in the pig: a new "organ" for xenotransplantation. Xenotransplantation 3:296.
26. Pescovitz, M. D., J. R. Thistlethwaite, Jr., H. Auchincloss, Jr., S. T. Ildstad, T. G. Sharp, R. Terrill, and D. H. Sachs. 1984. Effect of class II antigen matching on renal allograft survival in miniature swine. J. Exp. Med. 160:1495.
27. Kirkman, R. L., R. B. Colvin, M. W. Flye, G. M. Williams, and D. H. Sachs. 1979. Transplantation in miniature swine. VII. Evidence for cellular immune mechanisms in hyperacute rejection of renal allografts. Transplantation 28:24.
28. Pescovitz, M. D., J. K. Lunney, and D. H. Sachs. 1985. Murine anti-swine T4 and T8 monoclonal antibodies: distribution and effects on proliferative and cytotoxic T cells. J. Immunol. 134:37.
29. Ivansoka, D., D. C. Sun, and J. K. Lunney. 1991. Production of monoclonal antibodies reactive with polymorphic and monomorphic determinants of SLA class I gene products. Immunogenetics 33:220.
30. Tuazon, T. V., E. E. Schneeberger, A. K. Bhan, R. T. McCluskey, A. B. Cosimi, R. T. Schooley, R. H. Rubin, and R. B. Colvin. 1987. Mononuclear cells in acute allograft glomerulopathy. Am. J. Pathol. 129:119.
31. Pescovitz, M. D., S. M. Hsu, S. I. Katz, J. K. Lunney, S. Shimada, and D. H. Sachs. 1990. Characterization of a porcine CD1-specific mAb that distinguishes CD4/CD8 double-positive thymic from peripheral T lymphocytes. Tissue Antigens 35:151.
32. Thistlethwaite J. R., Jr., H. Auchincloss, Jr., M. D. Pescovitz, and D. H. Sachs. 1984. Immunologic characterization of MHC recombinant swine: role of class I and II antigens in in vitro immune responses. J. Immunogenet. 11:9.
33. Gianello, P., J. M. Fishbein, and D. H. Sachs. 1993. Tolerance to primarily vascularized allografts in miniature swine. Immunol. Rev. 133:19.
34. Khan, A., J. J. Sergio, Y. Zhao, D. A. Pearson, D. H. Sachs, and M. Sykes. 1997. Discordant xenogeneic neonatal thymic transplantation can induce donor-specific tolerance. Transplantation 63:124.
35. Lee, L. A., H. A. Gritsch, J. J. Sergio, J. S. Arn, R. M. Glaser, T. Sablinski, D. H. Sachs, and M. Sykes. 1994. Specific tolerance across a discordant xenogeneic transplantation barrier. Proc. Natl. Acad. Sci. USA 91:10864.
36. Modigliani, Y., V. Thomas-Vaslin, A. Bandeira, M. Coltey, N. M. Le Douarin, A. Coutinho, and J. Salaün. 1995. Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype. Proc. Natl. Acad. Sci. USA 92:7555.
37. Le Douarin, N., C. Corbel, A. Bandeira, V. Thomas-Vaslin, Y. Modigliani, A. Coutinho, and J. Salaün. 1996. Evidence for a thymus-dependent form of tolerance that is not based on elimination or anergy of reactive T cells. Immunol. Rev. 149:35.
38. Cheney, R. T., and J. Sprent. 1985. Capacity of cyclosporine to induce autograft-versus-host disease and impair intrathymic T cell differentiation. Transplant. Proc. 17:528.
39. Beschorner, W. E., X. Yao, and J. Divic. 1995. Recruitment of semiallogeneic dendritic cells to the thymus during post-cyclosporine thymic regeneration. Transplantation 11:1326.
40. Sharabi, Y., and D. H. Sachs. 1989. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J. Exp. Med. 169:493.
41. Lambrigts, D., D. H. Sachs, and D. K. Cooper. 1998. Discordant organ xenotransplantation in primates: world experience and current status. Transplantation 66:547.