Normal development in porcine thymus grafts and specific tolerance of human T cells to porcine donor MHC

Journal of Immunology

Volumn 162, Issue 6, 1999, Pages 3402-3407

  Nikolic, Boris ^a   Gardner, Jason P ^a,b   Scadden, David T ^a   Arn, J Scott ^a   Sachs, David H ^a   Sykes, Megan ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLONAL ANERGY; CONTROLLED STUDY; FETUS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENCE; IMMUNOLOGICAL TOLERANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; SWINE; T LYMPHOCYTE; THYMUS GRAFT; XENOTRANSPLANTATION;

ANIMALS; CELL DIFFERENTIATION; CLONE CELLS; FEMALE; FETUS; HUMANS; IMMUNE TOLERANCE; LIVER TRANSPLANTATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, SCID; SPECIES SPECIFICITY; SWINE; T-LYMPHOCYTES; THYMUS GLAND; TRANSPLANTATION, HETEROLOGOUS;

EID: 0033559498     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Sachs, D. H., M. Sykes, J. L. Greenstein, and A. B. Cosimi. 1995. Tolerance and xenograft survival. Nat. Med. 1:969.
2. Auchincloss, H. A. 1995. Why is cell-mediated xenograft rejection so strong? Xeno 3:19.
3. Lee, L. A., H. A. Gritsch, J. J. Sergio, J. S. Arn, R. M. Glaser, T. Sablinski, D. H. Sachs, and M. Sykes. 1994. Specific tolerance across a discordant xenogeneic transplantation barrier. Proc. Natl. Acad. Sci. USA 91:10864.
4. Zhao, Y., K. Swenson, J. J. Sergio, J. S. Arn, D. H. Sachs, and M. Sykes. 1996. Skin graft tolerance across a discordant xenogeneic barrier. Nat. Med. 2:1211.
5. Sachs, D. H. 1992. MHC-homozygous miniature swine. In Swine as Models in Biomedical Research. M. M. Swindle, D. C. Moody, and L. D. Phillips, eds. Iowa State University Press, Ames, p. 3.
6. Kalams, S. A., P. R. Johnson, A. K. Trocha, M. J. Dynan, S. Ngo, R. T. D'Aquila, J. T. Kurnick, and B. D. Walker. 1994. Longitudinal analysis of T cell receptor (TCR) gene usage by HIV-1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire. J. Exp. Med. 179:1261.
7. α mediates epidermal growth factor-elicited stimulation of rat cardiac adenylate cyclase. J. Biol. Chem. 265:21317.
8. McCune, J. M., R. Namikawa, H. Kaneshima, L. D. Shultz, M. Lieberman, and I. L. Weissman. 1988. The SCID-hu mouse: Murine model for the analysis of human hematolymphoid differentiation and function. Science 241:1632.
9. Peault, B., R. Namikawa, J. Krowka, and J. M. McCune. 1992. Fetal tissue transplants in medicine. In Fetal Tissue Transplants in Medicine. R. G. Edwards, ed. Cambridge University Press, Cambridge, p. 77.
10. Bart, A., B. A. E. Vanderckhove, R. Namikawa, R. Bacchetta, and M.-G. Roncarolo. 1992. Human hematopoietic cells and thymic epithelial cells induce tolerance via different mechanisms in the SCID-hu mouse thymus. J. Exp. Med. 175:1033.
11. Vanderckhove, B. A. E., R. Baccala, D. Jones, D. H. Kono, A. N. Theofilopouslos, and M.-G. Roncarolo. 1992. Thymic selection of the human T cell receptor Vβ repertoire in SCID-hu mice. J. Exp. Med. 176:1619
12. + cells in maintaining deletional tolerance in xenogeneic rat-mouse bone marrow chimeras. Transplantation 65:1216.
13. Speiser, D. E., H. Pircher, P. S. Ohashi, D. Kyburz, H. Hengartner, and R. M. Zinkernagel. 1992. Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny. J. Exp. Med. 175:1277.
14. Guery, J.-C., and L. Adorini. 1995. Dendritic cells are the most efficient in presenting endogenous naturally processed self peptides to class II-restricted T cells. J. Immunol. 154:536.
15. Schols, D., B. Vandekerckhove, D. Jones, and M.-G. Roncarolo, 1994. IL-2 reverses human T cell unresponsiveness induced by thymic epithelium in SCID-hu mice. J. Immunol. 152:2198.
16. + T-lymphocyte regeneration after intensive chemotherapy. N. Engl. J. Med. 332:143.
17. +) T helper cells after allogeneic bone marrow transplantation. Blood 90:850.
18. Nikolic, B., and M. Sykes. 1997. Bone marrow chimerism and transplantation tolerance. Curr. Opin. Immunol. 9:634.
19. Markert, L. M., D. D. Kostyu, E. F. Ward, M. T. McLaughlin, J. T. Watson, H. R. Buckley, E. S. Schiff, M. R. Ungerleider, W. J. Gaynor, T. K. Oldham, et al. 1997. Successful formation of a chimeric human thymus allograft following transplantation of cultured postnatal human thymus. J. Immunol. 158:998.
20. Hong, R., M. Santosham, H. Schulte-Wisserman, S. Horowitz, S. H. Hsu, and J. A. Winkelstein. 1976. Reconstitution of B and T lymphocyte function in SCID after transplantation with thymic epithelium. Lancet 2:1270.
21. Bradley, S. M., A. M. Kruisbeek, and A. Singer. 1982. Cytotoxic T lymphocyte response in allogeneic radiation bone marrow chimeras: the chimeric host strictly dictates the self-repertoire of la-restricted T cells but not K/D-restricted T cells. J. Exp. Med. 156:1650.
22. Zhao, Y., J. A. Fishman, J. J. Sergio, J. L. Oliveros, D. A. Pearson, G. L. Szot, R. A. Wilkinson, J. S. Am. D. H. Sachs, and M. Sykes. 1997. Immune restoration by fetal pig thymus grafts in T cell-depleted, thymectomized mice. J. Immunol. 158:1641.
23. Patience, C., Y. Takeuchi, and R. A. Weiss. 1997. Infection of human cells by an endogenous retrovirus of pigs. Nat. Med. 3:282.
24. Le Tissier, P., J. P. Stoye, Y. Takeuchi, C. Patience, and R. A. Weiss. 1997. Two sets of human-tropic pig retrovirus. Nature 389:681.
25. Grody, W. W., S. Fligiel, and F. Naeim. 1985. Thymus involution in the acquired immunodeficiency syndrome. Am. J. Clin. Pathol. 84:85.
26. Joshi, V. V., J. M. Oleske, S. C. Gadol, K. Conner, R. Bobila, and A. B. Minnefor. 1986. Thymus biopsy in children with acquired immunodeficiency syndrome. Arch. Pathol. Lab. Med. 110:837.
27. Aldrovandi, G. M., G. Feuer, L. Gao, B. Jamieson, M. Kristeva, I. S. Y. Chen, and J. A. Zack. 1993. The SCID-hu mouse as a model for HIV infection. Nature 363:732.
28. Stanley, S. K., J. M. McCune, H. Kaneshima, J. S. Justement, M. Sullivan, E. Boone, M. Baseler, J. Adelsberger, M. Bonyhadi, J. Orenstein, C. H. Fox, and A. S. Fauci. 1993. Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse. J. Exp. Med. 178:1151.
29. Gaulton, G. V., J. V. Scobie, and M. Rosenzweig. 1997. HIV-1 and the thymus. AIDS 11:403.
30. Emery, S., and C. H. Lane. 1997. Immune reconstitution in HIV infection. Curr. Opin. Immunol. 9:568.
31. Hellerstein, M. K., and J. M. McCune. 1997. T cell turnover in HIV-1 disease. Immunity 7:583.
32. Sykes, M., G. L. Szot, K. Swenson, and D. A. Pearson. 1997. Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning. Nat. Med. 3:783.