SKI-II, an inhibitor of sphingosine kinase, ameliorates antigen- induced bronchial smooth muscle hyperresponsiveness, but not airway inflammation, in mice

Journal of Pharmacological Sciences

Volumn 114, Issue 3, 2010, Pages 304-310

  Chiba, Yoshihiko ^a   Takeuchi, Hiroki ^a   Sakai, Hiroyasu ^a   Misawa, Miwa ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Airway hyperresponsiveness; Allergic bronchial asthma; Bronchial smooth muscle; Sphingosine kinase; Sphingosine 1 phosphate

Indexed keywords

4 [4 (4 CHLOROPHENYL)THIAZOL 2 YLAMINO]PHENOL; ACETYLCHOLINE; ANTIINFLAMMATORY AGENT; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; OVALBUMIN; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; BRONCHUS MUSCLE; CELL COUNT; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HISTOPATHOLOGY; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; RESPIRATORY TRACT INFLAMMATION; SMOOTH MUSCLE CONTRACTION; SYSTEMIC THERAPY; UPREGULATION;

EID: 78649403525     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.10202FP     Document Type: Article

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