메뉴 건너뛰기




Volumn 100, Issue 3, 2012, Pages 218-223

Cerebral ketone metabolism during development and injury

Author keywords

Brain; Development; Injury; Ketones; Metabolism; Neuroprotection

Indexed keywords

3 HYDROXYBUTYRIC ACID; GLUCOSE; KETONE; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 2;

EID: 84864102577     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2011.09.027     Document Type: Article
Times cited : (24)

References (55)
  • 1
    • 64849096855 scopus 로고    scopus 로고
    • The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat
    • Appelberg K.S., Hovda D.A., Prins M.L. The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat. J. Neurotrauma 2009, 26:497-506.
    • (2009) J. Neurotrauma , vol.26 , pp. 497-506
    • Appelberg, K.S.1    Hovda, D.A.2    Prins, M.L.3
  • 2
    • 27444445186 scopus 로고    scopus 로고
    • Upregulation of pentose phosphate pathway and preservation of tricarboxylic acid cycle flux after experimental brain injury
    • Bartnik B.L., Sutton R.L., Fukushima M., Harris N.G., Hovda D.A., Lee S.M. Upregulation of pentose phosphate pathway and preservation of tricarboxylic acid cycle flux after experimental brain injury. J. Neurotrauma 2005, 22:1052-1065.
    • (2005) J. Neurotrauma , vol.22 , pp. 1052-1065
    • Bartnik, B.L.1    Sutton, R.L.2    Fukushima, M.3    Harris, N.G.4    Hovda, D.A.5    Lee, S.M.6
  • 3
    • 0018840291 scopus 로고
    • The development of enzymes of energy metabolism in the brain of a precocial (guinea pig) and non-precocial (rat) species
    • Booth R.F.G., Patel T.B., Clark J.B. The development of enzymes of energy metabolism in the brain of a precocial (guinea pig) and non-precocial (rat) species. J. Neurochem. 1980, 34:17-25.
    • (1980) J. Neurochem. , vol.34 , pp. 17-25
    • Booth, R.F.G.1    Patel, T.B.2    Clark, J.B.3
  • 4
    • 0017177061 scopus 로고
    • Changes during development in transport processes of the blood-brain barrier
    • Cremer J.E., Braun L.D., Oldendorf W.H. Changes during development in transport processes of the blood-brain barrier. Biochim. Biophys. Acta 1976, 448:633-637.
    • (1976) Biochim. Biophys. Acta , vol.448 , pp. 633-637
    • Cremer, J.E.1    Braun, L.D.2    Oldendorf, W.H.3
  • 5
    • 0017107310 scopus 로고
    • The rat of cerebral utilization of glucose, ketone bodies, and oxygen: a comparative in vivo study of infant and adult rats
    • Dahlquist G., Persson B. The rat of cerebral utilization of glucose, ketone bodies, and oxygen: a comparative in vivo study of infant and adult rats. Pediatr. Res. 1976, 10:910-917.
    • (1976) Pediatr. Res. , vol.10 , pp. 910-917
    • Dahlquist, G.1    Persson, B.2
  • 6
    • 84864108793 scopus 로고    scopus 로고
    • Metabolic and bioenergetic changes with ketogenic diet versus standard diet after controlled cortical impact in juvenile rat brains measured by in vitro magnetic resonance spectroscopy
    • Deng-Bryant Y., Hovda D.A., Prins M.L., Harris N.G. Metabolic and bioenergetic changes with ketogenic diet versus standard diet after controlled cortical impact in juvenile rat brains measured by in vitro magnetic resonance spectroscopy. Soc. Neurotrauma 2009, 26:A80.
    • (2009) Soc. Neurotrauma , vol.26
    • Deng-Bryant, Y.1    Hovda, D.A.2    Prins, M.L.3    Harris, N.G.4
  • 7
    • 80054802883 scopus 로고    scopus 로고
    • Ketogenic Diet Prevents Alterations in Brain Metabolism in Young but not Adult Rats after Traumatic Brain Injury
    • (NEU-2011-1822.R1) in press.
    • Deng-Bryant, Y., Prins, M.L., Hovda, D.A., Harris, N.G., 2011. Ketogenic Diet Prevents Alterations in Brain Metabolism in Young but not Adult Rats after Traumatic Brain Injury. Journal of Neurotrauma (NEU-2011-1822.R1) in press.
    • (2011) Journal of Neurotrauma.
    • Deng-Bryant, Y.1    Prins, M.L.2    Hovda, D.A.3    Harris, N.G.4
  • 8
    • 43049127389 scopus 로고    scopus 로고
    • Antioxidant capacity contributes to protection of ketone bodies against oxidative damage induced during hypoglycemic conditions
    • Haces M.L., Hernández-Fonseca K., Medina-Campos O.N., Montiel T., Pedraza-Chaverri J., Massieu L. Antioxidant capacity contributes to protection of ketone bodies against oxidative damage induced during hypoglycemic conditions. Exp. Neurol. 2008, 211:85-96.
    • (2008) Exp. Neurol. , vol.211 , pp. 85-96
    • Haces, M.L.1    Hernández-Fonseca, K.2    Medina-Campos, O.N.3    Montiel, T.4    Pedraza-Chaverri, J.5    Massieu, L.6
  • 11
    • 0015020675 scopus 로고
    • Ketone-body utilization by adult and suckling rat brain in vivo
    • Hawkins R.A., Willianson D.H., Krebs H.A. Ketone-body utilization by adult and suckling rat brain in vivo. Biochem. J. 1971, 122:13-18.
    • (1971) Biochem. J. , vol.122 , pp. 13-18
    • Hawkins, R.A.1    Willianson, D.H.2    Krebs, H.A.3
  • 12
    • 67650526683 scopus 로고    scopus 로고
    • The protective effect of the ketogenic diet on traumatic brain injury-induced cell death in juvenile rats
    • Hu Z.G., Wang H.D., Qiao L., Yan W., Tan Q.F., Yin H.X. The protective effect of the ketogenic diet on traumatic brain injury-induced cell death in juvenile rats. Brain Inj. 2009, 23:459-465.
    • (2009) Brain Inj. , vol.23 , pp. 459-465
    • Hu, Z.G.1    Wang, H.D.2    Qiao, L.3    Yan, W.4    Tan, Q.F.5    Yin, H.X.6
  • 13
    • 60249102843 scopus 로고    scopus 로고
    • Ketogenic diet reduces cytochrome c release and cellular apoptosis following traumatic brain injury in juvenile rats
    • Hu Z.G., Wang H.D., Jin W., Yin H.X. Ketogenic diet reduces cytochrome c release and cellular apoptosis following traumatic brain injury in juvenile rats. Ann. Clin. Lab. Sci. 2009, 39:s76-s83.
    • (2009) Ann. Clin. Lab. Sci. , vol.39
    • Hu, Z.G.1    Wang, H.D.2    Jin, W.3    Yin, H.X.4
  • 14
    • 48249143179 scopus 로고    scopus 로고
    • The ketogenic diet increases mitochondrial glutathione levels
    • Jarrett S.G., Milder J.B., Liang L.P., Patel M. The ketogenic diet increases mitochondrial glutathione levels. J. Neurochem. 2008, 106:1044-1051.
    • (2008) J. Neurochem. , vol.106 , pp. 1044-1051
    • Jarrett, S.G.1    Milder, J.B.2    Liang, L.P.3    Patel, M.4
  • 16
    • 0347651877 scopus 로고
    • Metabolism of ketone bodies by ovine brain in vivo
    • Kammula R.G. Metabolism of ketone bodies by ovine brain in vivo. Am. J. Physiol. 1976, 231:1490-1494.
    • (1976) Am. J. Physiol. , vol.231 , pp. 1490-1494
    • Kammula, R.G.1
  • 17
    • 77953304142 scopus 로고    scopus 로고
    • Ketones Prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors
    • Kim D.Y., Vallejo J., Rho J.M. Ketones Prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors. J. Neurochem. 2010, 114(1):130-141.
    • (2010) J. Neurochem. , vol.114 , Issue.1 , pp. 130-141
    • Kim, D.Y.1    Vallejo, J.2    Rho, J.M.3
  • 18
    • 10644270649 scopus 로고    scopus 로고
    • Distance mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells
    • Kweon G., Marks J.D., Krencik R., Leung E.H., Schumacker P.T., Hyland K., Kang U. Distance mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells. J. Biol. Chem. 2004, 279:51783-51792.
    • (2004) J. Biol. Chem. , vol.279 , pp. 51783-51792
    • Kweon, G.1    Marks, J.D.2    Krencik, R.3    Leung, E.H.4    Schumacker, P.T.5    Hyland, K.6    Kang, U.7
  • 20
    • 0021362949 scopus 로고
    • Regional enzyme development in rat brain. Enzymes associated with glucose utilization
    • Leong S., Clark J. Regional enzyme development in rat brain. Enzymes associated with glucose utilization. Biochem. J. 1984, 218:131-138.
    • (1984) Biochem. J. , vol.218 , pp. 131-138
    • Leong, S.1    Clark, J.2
  • 21
    • 60749090581 scopus 로고    scopus 로고
    • The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
    • Maalouf M., Rho J.M., Mattson M.P. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res. Rev. 2009, 59:293-315.
    • (2009) Brain Res. Rev. , vol.59 , pp. 293-315
    • Maalouf, M.1    Rho, J.M.2    Mattson, M.P.3
  • 22
    • 20344408563 scopus 로고    scopus 로고
    • D-beta-hydroxybutyrate is neuroprotective against hypoxia in serum-free hippocampal primary cultures
    • Masuda R., Monahan J.W., Kashiwaya Y. D-beta-hydroxybutyrate is neuroprotective against hypoxia in serum-free hippocampal primary cultures. J. Neurosci. Res. 2005, 80:501-509.
    • (2005) J. Neurosci. Res. , vol.80 , pp. 501-509
    • Masuda, R.1    Monahan, J.W.2    Kashiwaya, Y.3
  • 23
    • 0023027650 scopus 로고
    • Regional glucose and beta-hydroxybutyrate use by developing rat brain
    • Miller A.L. Regional glucose and beta-hydroxybutyrate use by developing rat brain. Metab. Brain Dis. 1986, 1:53-61.
    • (1986) Metab. Brain Dis. , vol.1 , pp. 53-61
    • Miller, A.L.1
  • 24
    • 0017227329 scopus 로고
    • β-Hydroxybutyrate transport in rat brain: developmental and dietary modulations
    • Moore T.J., Lione A.P., Sugden M.C., Regen D.M. β-Hydroxybutyrate transport in rat brain: developmental and dietary modulations. Am. J. Physiol. 1976, 230:619-630.
    • (1976) Am. J. Physiol. , vol.230 , pp. 619-630
    • Moore, T.J.1    Lione, A.P.2    Sugden, M.C.3    Regen, D.M.4
  • 25
    • 0037141346 scopus 로고    scopus 로고
    • Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model
    • Mukherjee P., El-Abbadi M.M., Kasperzyk J.L., Ranes M.K., Seyfried T.N. Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model. Br. J. Cancer 2002, 86:1615-1621.
    • (2002) Br. J. Cancer , vol.86 , pp. 1615-1621
    • Mukherjee, P.1    El-Abbadi, M.M.2    Kasperzyk, J.L.3    Ranes, M.K.4    Seyfried, T.N.5
  • 26
    • 0023677396 scopus 로고
    • Quantitative autoradiographic measurement of local cerebral glucose utilization in freely moving rats during postnatal development
    • Nehlig A., de Vasconcelos A.P., Boyet S. Quantitative autoradiographic measurement of local cerebral glucose utilization in freely moving rats during postnatal development. J. Neurosci. 1987, 8:2321-2333.
    • (1987) J. Neurosci. , vol.8 , pp. 2321-2333
    • Nehlig, A.1    de Vasconcelos, A.P.2    Boyet, S.3
  • 27
    • 0014467001 scopus 로고
    • A simple ultramicro method for determination of pyridine nucleotides in tissues
    • Nisselbaum J.S., Green S. A simple ultramicro method for determination of pyridine nucleotides in tissues. Annal. Biochem. 1969, 27(2):212-217.
    • (1969) Annal. Biochem. , vol.27 , Issue.2 , pp. 212-217
    • Nisselbaum, J.S.1    Green, S.2
  • 29
    • 69249101222 scopus 로고    scopus 로고
    • The effects of age and ketogenic diet on local cerebral metabolic rates of glucose after controlled cortical impact injury in rats
    • Prins M., Hovda D. The effects of age and ketogenic diet on local cerebral metabolic rates of glucose after controlled cortical impact injury in rats. J. Neurotrauma 2009, 26:1083-1093.
    • (2009) J. Neurotrauma , vol.26 , pp. 1083-1093
    • Prins, M.1    Hovda, D.2
  • 30
    • 55349087208 scopus 로고    scopus 로고
    • Changes in cerebral microvessel expression of MCT1 and GLUT1 following controlled cortical impact in juvenile and adult rats
    • Prins M.L., Deng-Bryant Y., Appelberg S., Hovda D.A. Changes in cerebral microvessel expression of MCT1 and GLUT1 following controlled cortical impact in juvenile and adult rats. Soc. Neurotrauma 2007, 24:1267.
    • (2007) Soc. Neurotrauma , vol.24 , pp. 1267
    • Prins, M.L.1    Deng-Bryant, Y.2    Appelberg, S.3    Hovda, D.A.4
  • 31
    • 27644461807 scopus 로고    scopus 로고
    • Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury
    • Prins M.L., Fujima L.S., Hovda D.A. Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury. J. Neurosci. Res. 2005, 82:413-420.
    • (2005) J. Neurosci. Res. , vol.82 , pp. 413-420
    • Prins, M.L.1    Fujima, L.S.2    Hovda, D.A.3
  • 32
    • 33748186181 scopus 로고    scopus 로고
    • Induction of monocarboxylate transporter 2 expression and ketone transport following traumatic brain injury in juvenile and adult rats
    • Prins M.L., Giza C.C. Induction of monocarboxylate transporter 2 expression and ketone transport following traumatic brain injury in juvenile and adult rats. Dev. Neurosci. 2006, 28:447-456.
    • (2006) Dev. Neurosci. , vol.28 , pp. 447-456
    • Prins, M.L.1    Giza, C.C.2
  • 33
    • 3343008579 scopus 로고    scopus 로고
    • Increased cerebral uptake and oxidation of exogenous betaHB improves ATP following traumatic brain injury in adult rats
    • Prins M.L., Lee S.M., Fujima L.S., Hovda D.A. Increased cerebral uptake and oxidation of exogenous betaHB improves ATP following traumatic brain injury in adult rats. J. Neurochem. 2004, 90:666-672.
    • (2004) J. Neurochem. , vol.90 , pp. 666-672
    • Prins, M.L.1    Lee, S.M.2    Fujima, L.S.3    Hovda, D.A.4
  • 39
    • 0015950390 scopus 로고
    • Regulation of glucose and ketone-body metabolism in brain of anesthetized rats
    • Ruderman N.B., Ross P.S., Berger M., Goodman M.N. Regulation of glucose and ketone-body metabolism in brain of anesthetized rats. Biochem. J. 1974, 138:1-10.
    • (1974) Biochem. J. , vol.138 , pp. 1-10
    • Ruderman, N.B.1    Ross, P.S.2    Berger, M.3    Goodman, M.N.4
  • 40
    • 77949526140 scopus 로고    scopus 로고
    • Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet
    • Ruskin D.N., Kawamura M., Masino S.A. Reduced pain and inflammation in juvenile and adult rats fed a ketogenic diet. PLoS One 2009, 4:e8349.
    • (2009) PLoS One , vol.4
    • Ruskin, D.N.1    Kawamura, M.2    Masino, S.A.3
  • 41
    • 0019428367 scopus 로고
    • Variation in plasma ketone bodies during a 24-h fast in normal and in hypoglycemic children: relationship to age
    • Saudubray J.M., Marsac C., Limal J.M., Dumurgier E., Charpentier C., Ogier H., Coude F.X. Variation in plasma ketone bodies during a 24-h fast in normal and in hypoglycemic children: relationship to age. J. Pediatr. 1981, 98:904-908.
    • (1981) J. Pediatr. , vol.98 , pp. 904-908
    • Saudubray, J.M.1    Marsac, C.2    Limal, J.M.3    Dumurgier, E.4    Charpentier, C.5    Ogier, H.6    Coude, F.X.7
  • 42
    • 0242266477 scopus 로고    scopus 로고
    • Role of glucose and ketone bodies in the metabolic control of experimental brain cancer
    • Seyfried T.N., Sanderson T.M., El-Abbadi M.M., McGowan R., Mukherjee P. Role of glucose and ketone bodies in the metabolic control of experimental brain cancer. Br. J. Cancer 2003, 89:1375-1382.
    • (2003) Br. J. Cancer , vol.89 , pp. 1375-1382
    • Seyfried, T.N.1    Sanderson, T.M.2    El-Abbadi, M.M.3    McGowan, R.4    Mukherjee, P.5
  • 43
    • 77956465178 scopus 로고    scopus 로고
    • The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma
    • Stafford P., Abdelwahab M.G., Kim do Y., Preul M.C., Rho J.M., Sheck A.C. The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma. Nutr. Metab. (Lond.) 2010, 11(10):710-718.
    • (2010) Nutr. Metab. (Lond.) , vol.11 , Issue.10 , pp. 710-718
    • Stafford, P.1    Abdelwahab, M.G.2    Kim do, Y.3    Preul, M.C.4    Rho, J.M.5    Sheck, A.C.6
  • 45
    • 0036016029 scopus 로고    scopus 로고
    • Beta-hydroxybutyrate, a cerebral function improving agent, protects rate brain against ischemic damage caused by permanent and transient focal cerebral ischemia
    • Suzuki M., Suzuki M., Kitamura Y., Mori S., Sato K., Dohi S., Sato T., Matsuura A., Hiraide A. Beta-hydroxybutyrate, a cerebral function improving agent, protects rate brain against ischemic damage caused by permanent and transient focal cerebral ischemia. Jpn. J. Pharmacol. 2002, 89:36-43.
    • (2002) Jpn. J. Pharmacol. , vol.89 , pp. 36-43
    • Suzuki, M.1    Suzuki, M.2    Kitamura, Y.3    Mori, S.4    Sato, K.5    Dohi, S.6    Sato, T.7    Matsuura, A.8    Hiraide, A.9
  • 46
    • 0034754881 scopus 로고    scopus 로고
    • Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats
    • Suzuki M., Suzuki M., Sato K., Dohi S., Sato T., Matsuura A., Hiraide A. Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats. Jpn. J. Pharmacol. 2001, 87:143-150.
    • (2001) Jpn. J. Pharmacol. , vol.87 , pp. 143-150
    • Suzuki, M.1    Suzuki, M.2    Sato, K.3    Dohi, S.4    Sato, T.5    Matsuura, A.6    Hiraide, A.7
  • 47
    • 0033866784 scopus 로고    scopus 로고
    • Cerebral metabolic response to traumatic brain injury sustained early in development: a 2-deoxy-d-glucose autoradiographic study
    • Thomas S., Prins M.L., Samii M., Hovda D.A. Cerebral metabolic response to traumatic brain injury sustained early in development: a 2-deoxy-d-glucose autoradiographic study. J. Neurotrauma 2000, 17:649-665.
    • (2000) J. Neurotrauma , vol.17 , pp. 649-665
    • Thomas, S.1    Prins, M.L.2    Samii, M.3    Hovda, D.A.4
  • 49
    • 27744549328 scopus 로고    scopus 로고
    • A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease
    • Van der Auwera I., Wera S., Van Leuven F., Henderson S.T. A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease. Nutr. Metab. 2005, 2:28.
    • (2005) Nutr. Metab. , vol.2 , pp. 28
    • Van der Auwera, I.1    Wera, S.2    Van Leuven, F.3    Henderson, S.T.4
  • 50
    • 0142084655 scopus 로고    scopus 로고
    • Developmental switch in brain nutrient transporter expression in the rat
    • Vannucci S.J., Simpson I.A. Developmental switch in brain nutrient transporter expression in the rat. Am. J. Physiol. Endocrinol. Metab. 2003, 285:E1127-E1134.
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.285
    • Vannucci, S.J.1    Simpson, I.A.2
  • 51
    • 1042299789 scopus 로고    scopus 로고
    • The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
    • Veech R.L. The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. Prostaglandins Leukot. Essent. Fatty Acids 2004, 70:309-319.
    • (2004) Prostaglandins Leukot. Essent. Fatty Acids , vol.70 , pp. 309-319
    • Veech, R.L.1
  • 52
    • 22144477541 scopus 로고    scopus 로고
    • Ketogenic diet reduces hypoglycemia-induced neuronal death in young rats
    • Yamada K.A., Rensing N., Thio L.L. Ketogenic diet reduces hypoglycemia-induced neuronal death in young rats. Neurosci. Lett. 2005, 385:210-214.
    • (2005) Neurosci. Lett. , vol.385 , pp. 210-214
    • Yamada, K.A.1    Rensing, N.2    Thio, L.L.3
  • 53
    • 0026048155 scopus 로고
    • Dynamic changes in local cerebral glucose utilization following cerebral concussive in rats: evidence of a hyper- and subsequent hypometabolic state
    • Yoshino A., Hovda D., Kawamata T., Katayama Y., Becker D. Dynamic changes in local cerebral glucose utilization following cerebral concussive in rats: evidence of a hyper- and subsequent hypometabolic state. Brain Res. 1991, 561:106-119.
    • (1991) Brain Res. , vol.561 , pp. 106-119
    • Yoshino, A.1    Hovda, D.2    Kawamata, T.3    Katayama, Y.4    Becker, D.5
  • 54
    • 33847780073 scopus 로고    scopus 로고
    • The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer
    • Zhou W., Mukherjee P., Kiebish M.A., Markis W.T., Mantis J.G., Seyfried T.N. The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer. Nutr. Metab. 2007, 4:5.
    • (2007) Nutr. Metab. , vol.4 , pp. 5
    • Zhou, W.1    Mukherjee, P.2    Kiebish, M.A.3    Markis, W.T.4    Mantis, J.G.5    Seyfried, T.N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.