Pseudomonas aeruginosa exotoxin Y is a promiscuous cyclase that increases endothelial tau phosphorylation and permeability

Journal of Biological Chemistry

Volumn 287, Issue 30, 2012, Pages 25407-25418

  Ochoa, Cristhiaan D ^a   Alexeyev, Mikhail ^a,b   Pastukh, Viktoriya ^a   Balczon, Ron ^a,b   Stevens, Troy ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; CELL GAPS; CONDITIONAL EXPRESSIONS; CYCLASES; EDEMA FACTORS; ENZYMATIC ACTIVITIES; GAP FORMATION; GUANYLYL CYCLASE; HYPERPHOSPHORYLATED; HYPERPHOSPHORYLATION; INTRACELLULAR CAMP; MICROVASCULAR ENDOTHELIAL CELLS; NEURODEGENERATIVE; PATHOPHYSIOLOGICAL; PSEUDOMONAS AERUGINOSA; SODIUM NITROPRUSSIDE; TAUOPATHIES; TYPE III SECRETION SYSTEM; WILD TYPES;

AMINO ACIDS; BACTERIA; ENDOTHELIAL CELLS; ENZYME ACTIVITY; MACROMOLECULES; NEURODEGENERATIVE DISEASES; SODIUM;

PHOSPHORYLATION;

ADENYLATE CYCLASE; CYCLIC AMP; CYCLIC GMP; EXOTOXIN; EXOTOXIN Y; GUANYLATE CYCLASE; NITROPRUSSIDE SODIUM; SERINE; TAU PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MACROMOLECULE; MICROVASCULAR ENDOTHELIAL CELL; MUTANT; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PSEUDOMONAS AERUGINOSA; WILD TYPE;

ADENYLATE CYCLASE; ALZHEIMER DISEASE; BACTERIAL TOXINS; CELL LINE; CELL MEMBRANE PERMEABILITY; CYCLIC AMP; CYCLIC GMP; ENDOTHELIAL CELLS; EXOTOXINS; GUANYLATE CYCLASE; HUMANS; PHOSPHORYLATION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; SECOND MESSENGER SYSTEMS; SUBSTRATE SPECIFICITY; TAU PROTEINS;

PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 84864081350     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.301440     Document Type: Article

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