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Volumn 12, Issue SUPPL. 13, 2011, Pages

Near-membrane ensemble elongation in the proline-rich LRP6 intracellular domain may explain the mysterious initiation of the Wnt signaling pathway

Author keywords

[No Author keywords available]

Indexed keywords

3D STRUCTURE; COMPUTATIONAL SIMULATION; CONFORMATIONAL CHANGE; CONFORMATIONAL SPACE; CONTROL SIMULATION; INTRACELLULAR DOMAIN; MEMBRANE PROTEINS; MOLECULAR COMPLEXES; PHOSPHORYLATION SITES; PROLINE-RICH SEQUENCES; SEQUENCE-DEPENDENT; SPATIAL CONSTRAINTS; WNT SIGNALING PATHWAYS;

EID: 84864064041     PISSN: None     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/1471-2105-12-S13-S13     Document Type: Article
Times cited : (8)

References (40)
  • 1
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • 10.1146/annurev.cellbio.20.010403.113126, 15473860
    • Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annual review of cell and developmental biology 2004, 20:781-810. 10.1146/annurev.cellbio.20.010403.113126, 15473860.
    • (2004) Annual review of cell and developmental biology , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 2
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • 10.1016/j.cell.2006.10.018, 17081971
    • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006, 127(3):469-480. 10.1016/j.cell.2006.10.018, 17081971.
    • (2006) Cell , vol.127 , Issue.3 , pp. 469-480
    • Clevers, H.1
  • 3
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • 10.1038/nrc2389, 18432252
    • Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nature reviews Cancer 2008, 8(5):387-398. 10.1038/nrc2389, 18432252.
    • (2008) Nature reviews Cancer , vol.8 , Issue.5 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 4
    • 77649129121 scopus 로고    scopus 로고
    • GSK3: a multifaceted kinase in Wnt signaling
    • 10.1016/j.tibs.2009.10.002, 2834833, 19884009
    • Wu D, Pan W. GSK3: a multifaceted kinase in Wnt signaling. Trends in biochemical sciences 2010, 35(3):161-168. 10.1016/j.tibs.2009.10.002, 2834833, 19884009.
    • (2010) Trends in biochemical sciences , vol.35 , Issue.3 , pp. 161-168
    • Wu, D.1    Pan, W.2
  • 9
    • 33845351956 scopus 로고    scopus 로고
    • Beta-catenin destruction complex: insights and questions from a structural perspective
    • 10.1038/sj.onc.1210055, 17143292
    • Kimelman D, Xu W. beta-catenin destruction complex: insights and questions from a structural perspective. Oncogene 2006, 25(57):7482-7491. 10.1038/sj.onc.1210055, 17143292.
    • (2006) Oncogene , vol.25 , Issue.57 , pp. 7482-7491
    • Kimelman, D.1    Xu, W.2
  • 10
    • 4344562126 scopus 로고    scopus 로고
    • Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
    • 10.1016/j.molcel.2004.08.010, 15327768
    • Ha N-C, Tonozuka T, Stamos JL, Choi H-J, Weis WI. Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Molecular cell 2004, 15(4):511-521. 10.1016/j.molcel.2004.08.010, 15327768.
    • (2004) Molecular cell , vol.15 , Issue.4 , pp. 511-521
    • Ha, N.-C.1    Tonozuka, T.2    Stamos, J.L.3    Choi, H.-J.4    Weis, W.I.5
  • 11
    • 0037155691 scopus 로고    scopus 로고
    • Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    • 10.1016/S0092-8674(02)00685-2, 11955436
    • Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 2002, 108(6):837-847. 10.1016/S0092-8674(02)00685-2, 11955436.
    • (2002) Cell , vol.108 , Issue.6 , pp. 837-847
    • Liu, C.1    Li, Y.2    Semenov, M.3    Han, C.4    Baeg, G.H.5    Tan, Y.6    Zhang, Z.7    Lin, X.8    He, X.9
  • 12
  • 15
    • 2342430345 scopus 로고    scopus 로고
    • LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way
    • He X, Semenov M, Tamai K, Zeng X. LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. Development (Cambridge, England) 2004, 131(8):1663-1677.
    • (2004) Development (Cambridge, England) , vol.131 , Issue.8 , pp. 1663-1677
    • He, X.1    Semenov, M.2    Tamai, K.3    Zeng, X.4
  • 16
    • 0032491379 scopus 로고    scopus 로고
    • An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components
    • 10.1006/jmbi.1998.2115, 9790844
    • Springer TA. An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components. Journal of molecular biology 1998, 283(4):837-862. 10.1006/jmbi.1998.2115, 9790844.
    • (1998) Journal of molecular biology , vol.283 , Issue.4 , pp. 837-862
    • Springer, T.A.1
  • 17
    • 0035013711 scopus 로고    scopus 로고
    • Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair
    • 10.1038/88556, 11373616
    • Jeon H, Meng W, Takagi J, Eck MJ, Springer TA, Blacklow SC. Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair. Nature structural biology 2001, 8(6):499-504. 10.1038/88556, 11373616.
    • (2001) Nature structural biology , vol.8 , Issue.6 , pp. 499-504
    • Jeon, H.1    Meng, W.2    Takagi, J.3    Eck, M.J.4    Springer, T.A.5    Blacklow, S.C.6
  • 19
    • 0035954281 scopus 로고    scopus 로고
    • Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6
    • 10.1016/S0960-9822(01)00290-1, 11448771
    • Semënov MV, Tamai K, Brott BK, Kühl M, Sokol S, He X. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Current biology : CB 2001, 11(12):951-961. 10.1016/S0960-9822(01)00290-1, 11448771.
    • (2001) Current biology : CB , vol.11 , Issue.12 , pp. 951-961
    • Semënov, M.V.1    Tamai, K.2    Brott, B.K.3    Kühl, M.4    Sokol, S.5    He, X.6
  • 20
    • 3042848976 scopus 로고    scopus 로고
    • Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins
    • 10.1038/sj.onc.1207642, 2494703, 15064719
    • Brennan K, Gonzalez-Sancho JM, Castelo-Soccio LA, Howe LR, Brown AMC. Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins. Oncogene 2004, 23(28):4873-4884. 10.1038/sj.onc.1207642, 2494703, 15064719.
    • (2004) Oncogene , vol.23 , Issue.28 , pp. 4873-4884
    • Brennan, K.1    Gonzalez-Sancho, J.M.2    Castelo-Soccio, L.A.3    Howe, L.R.4    Brown, A.M.C.5
  • 21
    • 77954685213 scopus 로고    scopus 로고
    • Regulation of Lrp6 phosphorylation
    • 10.1007/s00018-010-0329-3, 20229235
    • Niehrs C, Shen J. Regulation of Lrp6 phosphorylation. Cellular and molecular life sciences : CMLS 2010, 67(15):2551-2562. 10.1007/s00018-010-0329-3, 20229235.
    • (2010) Cellular and molecular life sciences : CMLS , vol.67 , Issue.15 , pp. 2551-2562
    • Niehrs, C.1    Shen, J.2
  • 22
    • 28644439005 scopus 로고    scopus 로고
    • A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
    • 10.1038/nature04185, 2100418, 16341017
    • Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, Okamura H, Woodgett J, He X. A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 2005, 438(7069):873-877. 10.1038/nature04185, 2100418, 16341017.
    • (2005) Nature , vol.438 , Issue.7069 , pp. 873-877
    • Zeng, X.1    Tamai, K.2    Doble, B.3    Li, S.4    Huang, H.5    Habas, R.6    Okamura, H.7    Woodgett, J.8    He, X.9
  • 23
    • 28644444440 scopus 로고    scopus 로고
    • Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction
    • 10.1038/nature04170, 16341016
    • Davidson G, Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature 2005, 438(7069):867-872. 10.1038/nature04170, 16341016.
    • (2005) Nature , vol.438 , Issue.7069 , pp. 867-872
    • Davidson, G.1    Wu, W.2    Shen, J.3    Bilic, J.4    Fenger, U.5    Stannek, P.6    Glinka, A.7    Niehrs, C.8
  • 25
    • 0035902050 scopus 로고    scopus 로고
    • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • 10.1038/35077108, 11357136
    • Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 2001, 411(6835):321-325. 10.1038/35077108, 11357136.
    • (2001) Nature , vol.411 , Issue.6835 , pp. 321-325
    • Mao, B.1    Wu, W.2    Li, Y.3    Hoppe, D.4    Stannek, P.5    Glinka, A.6    Niehrs, C.7
  • 26
    • 18244427021 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
    • 10.1016/S1097-2765(01)00224-6, 11336703
    • Mao J, Wang J, Liu B, Pan W, Farr GH, Flynn C, Yuan H, Takada S, Kimelman D, Li L, et al. Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Molecular cell 2001, 7(4):801-809. 10.1016/S1097-2765(01)00224-6, 11336703.
    • (2001) Molecular cell , vol.7 , Issue.4 , pp. 801-809
    • Mao, J.1    Wang, J.2    Liu, B.3    Pan, W.4    Farr, G.H.5    Flynn, C.6    Yuan, H.7    Takada, S.8    Kimelman, D.9    Li, L.10
  • 27
    • 0042131956 scopus 로고    scopus 로고
    • A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor
    • 10.1128/MCB.23.16.5825-5835.2003, 166321, 12897152
    • Liu G, Bafico A, Harris VK, Aaronson SA. A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor. Molecular and cellular biology 2003, 23(16):5825-5835. 10.1128/MCB.23.16.5825-5835.2003, 166321, 12897152.
    • (2003) Molecular and cellular biology , vol.23 , Issue.16 , pp. 5825-5835
    • Liu, G.1    Bafico, A.2    Harris, V.K.3    Aaronson, S.A.4
  • 28
    • 1642564513 scopus 로고    scopus 로고
    • A mechanism for Wnt coreceptor activation
    • 10.1016/S1097-2765(03)00484-2, 14731402
    • Tamai K, Zeng X, Liu C, Zhang X, Harada Y, Chang Z, He X. A mechanism for Wnt coreceptor activation. Molecular cell 2004, 13(1):149-156. 10.1016/S1097-2765(03)00484-2, 14731402.
    • (2004) Molecular cell , vol.13 , Issue.1 , pp. 149-156
    • Tamai, K.1    Zeng, X.2    Liu, C.3    Zhang, X.4    Harada, Y.5    Chang, Z.6    He, X.7
  • 29
    • 58149185151 scopus 로고    scopus 로고
    • Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling
    • 10.1371/journal.pone.0004046, 2603313, 19107203
    • Piao S, Lee S-H, Kim H, Yum S, Stamos JL, Xu Y, Lee S-J, Lee J, Oh S, Han J-K, et al. Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PloS one 2008, 3(12):e4046. 10.1371/journal.pone.0004046, 2603313, 19107203.
    • (2008) PloS one , vol.3 , Issue.12
    • Piao, S.1    Lee, S.-H.2    Kim, H.3    Yum, S.4    Stamos, J.L.5    Xu, Y.6    Lee, S.-J.7    Lee, J.8    Oh, S.9    Han, J.-K.10
  • 30
    • 0034193509 scopus 로고    scopus 로고
    • A fast method to sample real protein conformational space
    • 10.1002/(SICI)1097-0134(20000501)39:2<112::AID-PROT2>3.0.CO;2-B, 10737933
    • Feldman HJ, Hogue CW. A fast method to sample real protein conformational space. Proteins 2000, 39(2):112-131. 10.1002/(SICI)1097-0134(20000501)39:2<112::AID-PROT2>3.0.CO;2-B, 10737933.
    • (2000) Proteins , vol.39 , Issue.2 , pp. 112-131
    • Feldman, H.J.1    Hogue, C.W.2
  • 31
    • 20744437001 scopus 로고    scopus 로고
    • RONN: the bio-basis function neural network technique applied to the detection of natively disordered regions in proteins
    • Yang ZR, Thomson R, McNeil P, Esnouf RM. RONN: the bio-basis function neural network technique applied to the detection of natively disordered regions in proteins. Bioinformatics (Oxford, England) 2005, 21(16):3369-3376.
    • (2005) Bioinformatics (Oxford, England) , vol.21 , Issue.16 , pp. 3369-3376
    • Yang, Z.R.1    Thomson, R.2    McNeil, P.3    Esnouf, R.M.4
  • 32
    • 24044538903 scopus 로고    scopus 로고
    • IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content
    • Dosztányi Z, Csizmok V, Tompa P, Simon I. IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content. Bioinformatics (Oxford, England) 2005, 21(16):3433-3434.
    • (2005) Bioinformatics (Oxford, England) , vol.21 , Issue.16 , pp. 3433-3434
    • Dosztányi, Z.1    Csizmok, V.2    Tompa, P.3    Simon, I.4
  • 33
    • 0042622240 scopus 로고    scopus 로고
    • GlobPlot: exploring protein sequences for globularity and disorder
    • 10.1093/nar/gkg519, 169197, 12824398
    • Linding R, Russell RB, Neduva V, Gibson TJ. GlobPlot: exploring protein sequences for globularity and disorder. Nucleic acids research 2003, 31(13):3701-3708. 10.1093/nar/gkg519, 169197, 12824398.
    • (2003) Nucleic acids research , vol.31 , Issue.13 , pp. 3701-3708
    • Linding, R.1    Russell, R.B.2    Neduva, V.3    Gibson, T.J.4
  • 36
    • 0034624753 scopus 로고    scopus 로고
    • Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein
    • 10.1038/35004513, 10724160
    • Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK. Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature 2000, 404(6774):151-158. 10.1038/35004513, 10724160.
    • (2000) Nature , vol.404 , Issue.6774 , pp. 151-158
    • Kim, A.S.1    Kakalis, L.T.2    Abdul-Manan, N.3    Liu, G.A.4    Rosen, M.K.5
  • 37
    • 32644451364 scopus 로고    scopus 로고
    • CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling
    • 10.1101/gad.1394306, 22013590
    • Price MA. CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling. Genes & development 2006, 20(4):399-410. 10.1101/gad.1394306, 22013590.
    • (2006) Genes & development , vol.20 , Issue.4 , pp. 399-410
    • Price, M.A.1


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