Cu(II)-promoted transformations of α-thienylcarbinols into spirothienooxindoles: Regioselective halogenation of dienyl sulfethers containing electron-rich aryl rings

Journal of Organic Chemistry

Volumn 77, Issue 14, 2012, Pages 6365-6370

  Yin, Biaolin ^a   Huang, Li ^a   Zhang, Xiaoyu ^a   Ji, Fanghua ^a   Jiang, Huanfeng ^a  

^a SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARYL RINGS; C-H FUNCTIONALIZATION; CARBONYL GROUPS; ELECTRON-RICH; REGIO-SELECTIVE; REGIOSELECTIVE HALOGENATION;

FRIEDEL-CRAFTS REACTION;

REGIOSELECTIVITY;

1 ETHYL 4,5,6 TRIMETHOXY 5' (NAPHTHALEN 1 YLMETHYLENE) 5'H SPIRO[INDOLINE 3,2' THIOPHEN] 2 ONE; 1 ETHYL 4,6 DIMETHOXY 5' (NAPHTHALEN 1 YLMETHYLENE) 5'H SPIRO[INDOLINE 3,2' THIOPHEN] 2 ONE; 1 ETHYL 5' (4 FLUOROBENZYLIDENE) 4,5,6 TRIMETHOXY 5'H SPIRO [INDOLINE 3,2' THIOPHEN] 2 ONE; 1 ETHYL 5' (4 FLUOROBENZYLIDENE) 4,6 DIMETHOXY 5'H SPIRO [INDOLINE 3,2' THIOPHEN] 2 ONE; 1 ETHYL 5' (4 FLUOROBENZYLIDENE) 5,6 DIMETHOXY 5'H SPIRO [INDOLINE 3,2' THIOPHEN] 2 ONE; 1 ETHYL 5,6 DIMETHOXY 5' (NAPHTHALEN 1 YLMETHYLENE) 5'H SPIRO[INDOLINE 3,2' THIOPHEN] 2 ONE; 5' (2 CHLOROBENZYLIDENE) 1 ETHYL 4,5,6 TRIMETHOXY 5'H SPIRO [INDOLINE 3,2' THIOPHEN] 2 ONE; 5' (2 CHLOROBENZYLIDENE) 1 ETHYL 5,6 DIMETHOXY 5'H SPIRO[INDOLINE 3,2' THIOPHEN] 2 ONE; 5' (4 CHLOROBENZYLIDENE) 1 ETHYL 4,5,6 TRIMETHOXY 5'H SPIRO [INDOLINE 3,2' THIOPHEN] 2 ONE; 5' (BROMO(4 CHLOROPHENYL)METHYLENE) 1 ETHYL 4,5,6 TRIMETHOXY 5'H SPIRO[INDOLINE 3,2'-THIOPHEN] 2 ONE; 5' (BROMO(4 FLUOROPHENYL)METHYLENE) 1 ETHYL 4,5,6 TRIMETHOXY 5'H SPIRO[INDOLINE 3,2' THIOPHEN] 2 ONE; 5' (BROMO(4 FLUOROPHENYL)METHYLENE) 1 ETHYL 5,6 DIMETHOXY 5'H SPIRO[INDOLINE 3,2' THIOPHEN] 2 ONE; 5' (BROMO(NAPHTHALEN 2 YL)METHYLENE) 1 ETHYL 4,5,6 TRIMETHOXY 5'H SPIRO[INDOLINE 3,2' THIOPHEN] 2 ONE; 5' (BROMO(PHENYL)METHYLENE) 1 ETHYL 4,5,6 TRIMETHOXY 5'H SPIRO[INDOLINE 3,2' THIOPHEN] 2 ONE; 5' (BROMO(PHENYL)METHYLENE) 1 ETHYL 4,6 DIMETHOXY 5'H SPIRO [INDOLINE 3,2' THIOPHEN] 2 ONE; 5' (BROMO(PHENYL)METHYLENE) 1 ETHYL 5,6 DIMETHOXY 5'H SPIRO [INDOLINE 3,2' THIOPHEN] 2 ONE; 5' (CHLORO(4 CHLOROPHENYL)METHYLENE) 1 ETHYL 4,5,6 TRIMETHOXY 5'H SPIRO[INDOLINE 3,2' THIOPHEN] 2 ONE; 5' (CHLORO(NAPHTHALEN 2 YL)METHYLENE) 1 ETHYL 4,5,6 TRIMETHOXY 5'H SPIRO[INDOLINE 3,2' THIOPHEN] 2 ONE; 5' (CHLORO(PHENYL)METHYLENE) 1 ETHYL 4,5,6 TRIMETHOXY 5'H SPIRO[INDOLINE 3,2' THIOPHEN] 2 ONE; 5' (CHLORO(PHENYL)METHYLENE) 1 ETHYL 4,6 DIMETHOXY 5'H SPIRO [INDOLINE 3,2' THIOPHEN] 2 ONE; 5' (CHLORO(PHENYL)METHYLENE) 1 ETHYL 5,6 DIMETHOXY 5'H SPIRO [INDOLINE 3,2' THIOPHEN] 2 ONE; 5' BENZYLIDENE 1 ETHYL 4,5,6 TRIMETHOXY 5'H SPIRO[INDOLINE 3,2' THIOPHEN] 2 ONE; 5' BENZYLIDENE 1 ETHYL 4,6 DIMETHOXY 5'H SPIRO[INDOLINE 3,2' THIOPHEN] 2 ONE; 5' BENZYLIDENE 1 ETHYL 5,6 DIMETHOXY 5'H SPIRO[INDOLINE 3,2' THIOPHEN] 2 ONE; ALPHA THIENYLCARBINOL DERIVATIVE; COPPER; INDOLE DERIVATIVE; METHANOL DERIVATIVE; SPIROTHIENOOXINDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; HALOGENATION;

COPPER; ELECTRONS; ETHERS; HALOGENATION; INDOLES; METHANOL; MOLECULAR STRUCTURE; SPIRO COMPOUNDS; STEREOISOMERISM;

EID: 84864058711     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo301039y     Document Type: Article

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