Synthesis and biological properties of C-2 triazolylinosine derivatives

Journal of Organic Chemistry

Volumn 77, Issue 14, 2012, Pages 5870-5883

  Lakshman, Mahesh K ^a   Kumar, Amit ^a   Balachandran, Raghavan ^b   Day, Billy W ^b   Andrei, Graciela ^c   Snoeck, Robert ^c   Balzarini, Jan ^c  

^a CITY COLLEGE OF NEW YORK   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL DERIVATIVES; ANTIPROLIFERATIVE ACTIVITIES; ANTIVIRAL ACTIVITIES; AZIDO DERIVATIVES; BIOLOGICAL ASSAYS; BIOLOGICAL PROPERTIES; BROAD SPECTRUM; COLORECTAL CARCINOMA; DEALLYLATION; DIAZOTIZATION; GUANOSINES; INHIBITORY ACTIVITY; IR BANDS; RNA VIRUS; SILYL GROUP; SOLVENT POLARITY; TETRAZOLES;

ACETYLENE; CELL CULTURE; COPPER COMPOUNDS; RNA; SOLVENTS; VIRUSES;

BIOMOLECULES;

2 (4 BUTYL 1,2,3 TRIAZOL 1H YL) 2' DEOXYINOSINE; 2 (4 BUTYL 1,2,3 TRIAZOL 1H YL)INOSINE; 2 (4 FERROCENYL 1,2,3 TRIAZOL 1H YL) 2' DEOXYINOSINE; 2 (4 FERROCENYL 1,2,3 TRIAZOL 1H YL)INOSINE; 2 (4 PHENYL 1,2,3 TRIAZOL 1H YL) 2' DEOXYINOSINE; 2 (4 PHENYL 1,2,3 TRIAZOL 1H YL)INOSINE; 2 [4 (4 FLUOROPHENYL) 1,2,3 TRIAZOL 1H YL]INOSINE; 2 [4 (4 METHOXYPHENYL) 1,2,3 TRIAZOL 1H YL] 2' DEOXYINOSINE; 2 [4 (4 METHOXYPHENYL) 1,2,3 TRIAZOL 1H YL]INOSINE; 2 [4 (4 METHYLPHENYL) 1,2,3 TRIAZOL 1H YL]INOSINE; 2 [4 (HYDROXYMETHYL) 1,2,3 TRIAZOL 1H YL] 2' DEOXYINOSINE; 2 [4 (HYDROXYMETHYL) 1,2,3 TRIAZOL 1H YL]INOSINE; 2 [4 (N PHTHALIMIDOMETHYL) 1,2,3 TRIAZOL 1H YL] 2' DEOXYINOSINE; 2 [4 (N PHTHALIMIDOMETHYL) 1,2,3 TRIAZOL 1H YL]INOSINE; 6 (MORPHOLIN 4 YL) 2 (4 PHENYL 1,2,3 TRIAZOL 1H YL) 9 (BETA DEXTRO RIBOFURANOSYL)PURINE; 6 (MORPHOLIN 4 YL) 2 (4 PHENYL 1,2,3 TRIAZOL 1H YL) 9 [2',3' 5' TRI O (TERT BUTYLDIMETHYLSILYL) BETA DEXTRO RIBOFURANOSYL]PURINE; 6 N BENZYL 2 (4 PHENYL 1,2,3 TRIAZOL 1H YL) 2',3' 5' TRI O (TERT BUTYLDIMETHYLSILYL)ADENOSINE; 6 N BENZYL 2 (4 PHENYL 1,2,3 TRIAZOL 1H YL)ADENOSINE; ADENOSINE DERIVATIVE; ALKYNE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; AZIDE; COPPER CHLORIDE; NUCLEOSIDE DERIVATIVE; O 6 (1 BENZOTRIAZOL 1H YL) 2 (4 PHENYL 1,2,3 TRIAZOL 1H YL) 2',3' 5' TRI O (TERT BUTYLDIMETHYLSILYL)INOSINE; PACLITAXEL; PURINE NUCLEOSIDE DERIVATIVE; TERT BUTYL ALCOHOL; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ALLYLATION; ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOSTASIS; CYTOTOXICITY; DEPROTECTION REACTION; DNA VIRUS; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; NONHUMAN; REACTION OPTIMIZATION; RNA VIRUS; VESICULAR STOMATITIS VIRUS;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CELL PROLIFERATION; DNA VIRUSES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; INOSINE; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; RNA VIRUSES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; TUMOR CELLS, CULTURED;

EID: 84864050587     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo300628y     Document Type: Article

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