Synthesis and biological evaluation of neopeltolide and analogs

Journal of Organic Chemistry

Volumn 77, Issue 5, 2012, Pages 2225-2235

  Cui, Yubo ^a   Balachandran, Raghavan ^a   Day, Billy W ^a   Floreancig, Paul E ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL EVALUATION; CELL LINES; MACROCYCLES; MACROLIDE CORE; NEOPELTOLIDE; SIDE-CHAINS;

CHEMISTRY; ORGANIC COMPOUNDS;

CELL CULTURE;

8 HYDROXY 9 EPI NEOPELTOLIDE; 8 HYDROXYNEOPELTOLIDE; 8,9 DEHYDRONEOPELTOLIDE; 8,9 DIHYDROXYNEOPELTOLIDE; 8,9 EPOXYNEOPELTOLIDE; 9 EPI NEOPELTOLIDE; ALCOHOL; AMIDE; ANTINEOPLASTIC AGENT; MACROCYCLIC COMPOUND; MACROLIDE; NEOPELTOLIDE DERIVATIVE; OXAZOLE; PACLITAXEL; PROTEIN P53; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN HCT116; CELL STRAIN MCF 7; CHEMICAL STRUCTURE; CLINICAL PROTOCOL; CONTROLLED STUDY; CYCLIZATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROBORATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MACROLIDES; MOLECULAR CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857888778     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo2023685     Document Type: Article

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