Modelling cell polarization driven by synthetic spatially graded Rac activation

PLoS Computational Biology

Volumn 8, Issue 6, 2012, Pages

  Holmes, William R ^a   Lin, Benjamin ^b   Levchenko, Andre ^b   Edelstein Keshet, Leah ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Johns Hopkins University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; CYTOLOGY; LANTHANUM COMPOUNDS; MAMMALS; ORDINARY DIFFERENTIAL EQUATIONS;

CELL POLARIZATION; CYTOSKELETAL; GTPASES; HELA CELL; MAMMALIAN CELLS; PHOSPHOINOSITIDES; RAC ACTIVATION; REORGANISATION; SMALL GTPASE; SMALL MOLECULES;

POLARIZATION;

GUANOSINE TRIPHOSPHATASE; PHOSPHATIDYLINOSITIDE; PROTEIN CDC42; RAC PROTEIN; RHO FACTOR; PHOSPHATIDYLINOSITOL; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ALGORITHM; ARTICLE; CELL FUNCTION; CELL POLARITY; INHIBITION KINETICS; INTRACELLULAR SIGNALING; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MOLECULAR INTERACTION; MOLECULAR MODEL; POLARIZATION; POSITIVE FEEDBACK; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REACTION ANALYSIS; SEQUENCE ANALYSIS; STEADY STATE; BIOLOGICAL MODEL; BIOLOGY; CELL MEMBRANE; CELL SHAPE; COMPUTER SIMULATION; CYTOSOL; ENZYME ACTIVATION; FEEDBACK SYSTEM; HELA CELL; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

MAMMALIA;

CDC42 GTP-BINDING PROTEIN; CELL MEMBRANE; CELL POLARITY; CELL SHAPE; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; CYTOSOL; ENZYME ACTIVATION; FEEDBACK, PHYSIOLOGICAL; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; PHOSPHATIDYLINOSITOLS; RAC GTP-BINDING PROTEINS; RECEPTOR CROSS-TALK; RHO GTP-BINDING PROTEINS;

EID: 84864041617     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002366     Document Type: Article

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