Photodynamic therapy-mediated DC immunotherapy is highly effective for the inhibition of established solid tumors

Cancer Letters

Volumn 324, Issue 1, 2012, Pages 58-65

  Jung, Nam Chul ^a   Kim, Hee Jung ^a   Kang, Mi Sun ^b   Lee, Jun Ho ^a   Song, Jie Young ^c   Seo, Han Geuk ^d   Bae, Yong Soo ^b,e   Lim, Dae Seog ^a  

^a CHA University   (South Korea)

^b CreaGene Inc   (South Korea)

^c Korea Institute of Radiation and Medical Science   (South Korea)

^d Konkuk University   (South Korea)

^e Sungkyunkwan University   (South Korea)

Author keywords

Dendritic cells; Heat shock proteins; Immunotherapy; Photodynamic therapy

Indexed keywords

DENDRITIC CELL VACCINE; GAMMA INTERFERON; HEAT SHOCK PROTEIN 70; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW; BREAST CANCER; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CANCER STAGING; CELL LYSATE; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; FREEZE THAWING; IMMUNE RESPONSE; IMMUNOGENICITY; IN VIVO STUDY; KIDNEY CARCINOMA; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; PROTEIN SECRETION; SOLID TUMOR; SPLEEN CELL; TH1 CELL; TH2 CELL; TUMOR CELL LYSATE; TUMOR IMMUNITY;

ANIMALS; CANCER VACCINES; DENDRITIC CELLS; FEMALE; FREEZING; HSP70 HEAT-SHOCK PROTEINS; IMMUNOTHERAPY; INTERLEUKIN-2; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, INBRED BALB C; NEOPLASMS; PHOTOCHEMOTHERAPY;

EID: 84864036920     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2012.04.024     Document Type: Article

References (40)

1. Fonteneau J.F., Kavanagh D.G., Lirvall M., Sanders C., Cover T.L., Bhardwaj N., Larsson M. Characterization of the MHC class I cross-presentation pathway for cell-associated antigens by human dendritic cells. Blood 2003, 102:4448-4455.
2. Gallucci S., Lolkema M., Matzinger P. Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 1999, 5:1249-1255.
3. Medzhitov R., Janeway C. Innate immune recognition: mechanisms and pathways. Immunol. Rev. 2000, 173:89-97.
4. Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature 1998, 392:245-252.
5. Geiger J.D., Hutchinson R.J., Hohenkirk L.F., McKenna E.A., Yanik G.A., Levine J.E., Chang A.E., Braun T.M., Mule J.J. Vaccination of pediatric solid tumor patients with tumor lysate-pulsed dendritic cells can expand specific T cells and mediate tumor regression. Cancer Res. 2001, 61:8513-8519.
6. Yu J.S., Liu G., Ying H., Yong W.H., Black K.L., Wheeler C.J. Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. Cancer Res. 2004, 64:4973-4979.
7. Lim D.S., Kim J.H., Lee D.S., Yoon C.H., Bae Y.S. DC immunotherapy is highly effective for the inhibition of tumor metastasis or recurrence, although it is not efficient for the eradication of established solid tumors. Cancer Immunol. Immunother. 2007, 56:1817-1829.
8. Chang D.H., Dhodapkar M.V. Dendritic cells and immunotherapy for cancer. Int. J. Hematol. 2003, 77:439-443.
9. Nestle F.O., Farkas A., Conrad C. Dendritic-cell-based therapeutic vaccination against cancer. Curr. Opin. Immunol. 2005, 17:163-169.
10. Hartl F.U., Hayer-Hartl M. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 2002, 295:1852-1858.
11. Asea A. Chaperokine-induced signal transduction pathways. Exerc. Immunol. Rev. 2003, 9:25-33.
12. Tamura Y., Peng P., Liu K., Daou M., Srivastava P.K. Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations. Science 1997, 278:117-120.
13. Srivastava P. Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. Annu. Rev. Immunol. 2002, 20:395-425.
14. Basu S., Srivastava P.K. Heat shock proteins: the fountainhead of innate and adaptive immune responses. Cell Stress Chaperones 2000, 5:443-451.
15. Castelli C., Ciupitu A.M., Rini F., Rivoltini L., Mazzocchi A., Kiessling R., Parmiani G. Human heat shock protein 70 peptide complexes specifically activate antimelanoma T cells. Cancer Res. 2001, 61:222-227.
16. Noessner E., Gastpar R., Milani V., Brandl A., Hutzler P.J., Kuppner M.C., Roos M., Kremmer E., Asea A., Calderwood S.K., Issels R.D. Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells. J. Immunol. 2002, 169:5424-5432.
17. Binder R.J., Srivastava P.K. Essential role of CD91 in re-presentation of gp96-chaperoned peptides. Proc. Natl. Acad. Sci. USA 2004, 101:6128-6133.
18. Becker T., Hartl F.U., Wieland F. CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes. J. Cell. Biol. 2002, 158:1277-1285.
19. Asea A., Rehli M., Kabingu E., Boch J.A., Bare O., Auron P.E., Stevenson M.A., Calderwood S.K. Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J. Biol. Chem. 2002, 277:15028-15034.
20. Berwin B., Hart J.P., Rice S., Gass C., Pizzo S.V., Post S.R., Nicchitta C.V. Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells. EMBO J. 2003, 22:6127-6136.
21. Lim D.S., Ko S.H., Lee C.H., Ahn W.S., Lee W.Y. DH-I-180-3-mediated photodynamic therapy: biodistribution and tumor vascular damage. Photochem. Photobiol. 2006, 82:600-605.
22. Lim D.S., Ko S.H., Lee W.Y. Silkworm-pheophorbide alpha mediated photodynamic therapy against B16F10 pigmented melanoma. J. Photochem. Photobiol. B 2004, 74:1-6.
23. Todryk S., Melcher A.A., Hardwick N., Linardakis E., Bateman A., Colombo M.P., Stoppacciaro A., Vile R.G. Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake. J. Immunol. 1999, 163:1398-1408.
24. Korbelik M., Sun J., Cecic I. Photodynamic therapy-induced cell surface expression and release of heat shock proteins: relevance for tumor response. Cancer Res. 2005, 65:1018-1026.
25. Yin Z., Zhang D.H., Welte T., Bahtiyar G., Jung S., Liu L., Fu X.Y., Ray A., Craft J. Dominance of IL-12 over IL-4 in gamma delta T cell differentiation leads to default production of IFN-gamma: failure to down-regulate IL-12 receptor beta 2-chain expression. J. Immunol. 2000, 164:3056-3064.
26. Gollnick S.O., Vaughan L., Henderson B.W. Generation of effective antitumor vaccines using photodynamic therapy. Cancer Res. 2002, 62:1604-1608.
27. Feng H., Zeng Y., Whitesell L., Katsanis E. Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity. Blood 2001, 97:3505-3512.
28. Flohe S.B., Bruggemann J., Lendemans S., Nikulina M., Meierhoff G., Flohe S., Kolb H. Human heat shock protein 60 induces maturation of dendritic cells versus a Th1-promoting phenotype. J. Immunol. 2003, 170:2340-2348.
29. Chen W., Syldath U., Bellmann K., Burkart V., Kolb H. Human 60-kDa heat-shock protein: a danger signal to the innate immune system. J. Immunol. 1999, 162:3212-3219.
30. More S.H., Breloer M., von Bonin A. Eukaryotic heat shock proteins as molecular links in innate and adaptive immune responses: Hsp60-mediated activation of cytotoxic T cells. Int. Immunol. 2001, 13:1121-1127.
31. Srivastava P.K., Udono H., Blachere N.E., Li Z. Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics 1994, 39:93-98.
32. Dougherty T.J., Gomer C.J., Henderson B.W., Jori G., Kessel D., Korbelik M., Moan J., Peng Q. Photodynamic therapy. J. Natl. Cancer Inst. 1998, 90:889-905.
33. van Duijnhoven F.H., Aalbers R.I., Rovers J.P., Terpstra O.T., Kuppen P.J. The immunological consequences of photodynamic treatment of cancer, a literature review. Immunobiology 2003, 207:105-113.
34. Jalili A., Makowski M., Switaj T., Nowis D., Wilczynski G.M., Wilczek E., Chorazy-Massalska M., Radzikowska A., Maslinski W., Bialy L., Sienko J., Sieron A., Adamek M., Basak G., Mroz P., Krasnodebski I.W., Jakobisiak M., Golab J. Effective photoimmunotherapy of murine colon carcinoma induced by the combination of photodynamic therapy and dendritic cells. Clin. Cancer Res. 2004, 10:4498-4508.
35. Saji H., Song W., Furumoto K., Kato H., Engleman E.G. Systemic antitumor effect of intratumoral injection of dendritic cells in combination with local photodynamic therapy. Clin. Cancer Res. 2006, 12:2568-2574.
36. O'Garra A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 1998, 8:275-283.
37. + T cell subpopulations in established pulmonary metastases. J. Immunol. 1999, 162:6671-6680.
38. Negrier S., Escudier B., Lasset C., Douillard J.Y., Savary J., Chevreau C., Ravaud A., Mercatello A., Peny J., Mousseau M., Philip T., Tursz T. Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Francais d'Immunotherapie. N. Engl. J. Med. 1998, 338:1272-1278.
39. Dranoff G., Soiffer R., Lynch T., Mihm M., Jung K., Kolesar K., Liebster L., Lam P., Duda R., Mentzer S., Singer S., Tanabe K., Johnson R., Sober A., Bhan A., Clift S., Cohen L., Parry G., Rokovich J., Richards L., Drayer J., Berns A., Mulligan R.C. A phase I study of vaccination with autologous, irradiated melanoma cells engineered to secrete human granulocyte-macrophage colony stimulating factor. Hum. Gene Ther. 1997, 8:111-123.
40. Nestle F.O., Banchereau J., Hart D. Dendritic cells: on the move from bench to bedside. Nat. Med. 2001, 7:761-765.