Would eating carrots protect your liver? A new role involving NKT cells for retinoic acid in hepatitis

European Journal of Immunology

Volumn 42, Issue 7, 2012, Pages 1677-1680

  Nagy, Laszlo ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Hepatitis; NKT cells; RAR; Retinoids

Indexed keywords

CONCANAVALIN A; RETINOIC ACID; RETINOIC ACID RECEPTOR;

ANTIINFLAMMATORY ACTIVITY; B LYMPHOCYTE; CARROT; CELL HOMING; CELL INFILTRATION; CELL PROTECTION; CELL SURVIVAL; CELL TYPE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG TARGETING; HEPATITIS; HUMAN; IMMUNE SYSTEM; IMMUNOMODULATION; IMMUNOREGULATION; KUPFFER CELL; MACROPHAGE; METABOLIC REGULATION; NATURAL KILLER T CELL; NONHUMAN; NOTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; WRINKLE;

ANIMALS; DAUCUS CAROTA; DIET; HEPATITIS; MICE; NATURAL KILLER T-CELLS; TRETINOIN;

EID: 84864021598     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242705     Document Type: Note

References (29)

1. Nagy, L., Szanto, A., Szatmari, I. and Szeles, L., Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response. Physiol. Rev. 2012. 92: 739-789.
2. Duester, G., Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid. Eur. J. Biochem. 2000. 267: 4315-4324.
3. Szatmari, I. and Nagy, L., Nuclear receptor signalling in dendritic cells connects lipids, the genome and immune function. EMBO J. 2008. 27: 2353-2362.
4. Pino-Lagos, K., Benson, M. J. and Noelle, R. J., Retinoic acid in the immune system. Ann. NY Acad. Sci. 2008. 1143: 170-187.
5. Underwood, B. A. and Arthur, P., The contribution of vitamin A to public health. FASEB J. 1996. 10: 1040-1048.
6. Tsai, S., Bartelmez, S., Heyman, R., Damm, K., Evans, R. and Collins, S. J., A mutated retinoic acid receptor-alpha exhibiting dominant-negative activity alters the lineage development of a multipotent hematopoietic cell line. Genes Dev. 1992. 6: 2258-2269.
7. Tsai, S. and Collins, S. J., A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage. Proc. Natl. Acad. Sci. USA 1993. 90: 7153-7157.
8. Labbaye, C., Valtieri, M., Testa, U., Giampaolo, A., Meccia, E., Sterpetti, P., Parolini, I. et al., Retinoic acid downmodulates erythroid differentiation and GATA1 expression in purified adult-progenitor culture. Blood 1994. 83: 651-656.
9. Mehta, K., McQueen, T., Tucker, S., Pandita, R. and Aggarwal, B. B., Inhibition by all-trans-retinoic acid of tumor necrosis factor and nitric oxide production by peritoneal macrophages. J. Leukoc. Biol. 1994. 55: 336-342.
10. Wang, X., Allen, C. and Ballow, M., Retinoic acid enhances the production of IL-10 while reducing the synthesis of IL-12 and TNF-alpha from LPS-stimulated monocytes/macrophages. J. Clin. Immunol. 2007. 27: 193-200.
11. Na, S. Y., Kang, B. Y., Chung, S. W., Han, S. J., Ma, X., Trinchieri, G., Im, S. Y. et al., Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFkappaB. J. Biol. Chem. 1999. 274: 7674-7680.
12. Yamada, H., Mizuno, S., Ross, A. C. and Sugawara, I., Retinoic acid therapy attenuates the severity of tuberculosis while altering lymphocyte and macrophage numbers and cytokine expression in rats infected with mycobacterium tuberculosis. J. Nutr. 2007. 137: 2696-2700.
13. Iwata, M., Hirakiyama, A., Eshima, Y., Kagechika, H., Kato, C. and Song, S. Y., Retinoic acid imprints gut-homing specificity on T cells. Immunity 2004. 21: 527-538.
14. Coombes, J. L., Siddiqui, K. R., Arancibia-Carcamo, C. V., Hall, J., Sun, C. M., Belkaid, Y. and Powrie, F., A functionally specialized population of mucosal CD103+ DCs induces Foxp3 +regulatory T cells via a TGF-{beta} and retinoic acid dependent mechanism. J. Exp. Med. 2007. 204: 1757-1764.
15. Guilliams, M., Crozat, K., Henri, S., Tamoutounour, S., Grenot, P., Devilard, E., de Bovis, B. et al., Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells. Blood 2010.115: 1958-1968.
16. Mora, J. R., Homing imprinting and immunomodulation in the gut: role of dendritic cells and retinoids. Inflamm. Bowel Dis. 2008. 14: 275-289.
17. Mora, J. R., Iwata, M., Eksteen, B., Song, S. Y., Junt, T., Senman, B., Otipoby, K. L. et al., Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science 2006. 314: 1157-1160.
18. Szatmari, I., Pap, A., Ruhl, R., Ma, J. X., Illarionov, P. A., Besra, G. S., Rajnavolgyi, E. et al., PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J. Exp. Med. 2006. 203: 2351-2362.
19. Sun, C. M., Hall, J. A., Blank, R. B., Bouladoux, N., Oukka, M., Mora, J. R. and Belkaid, Y., Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 2007. 204:1775-1785.
20. Benson, M. J., Pino-Lagos, K., Rosemblatt, M. and Noelle, R. J., All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J. Exp. Med. 2007. 204: 1765-1774.
21. Curotto de Lafaille, M. A. and Lafaille, J. J., Natural and adaptive Foxp3+ regulatory T cells: more of the same or a division of labor? Immunity 2009. 30: 626-635.
22. Kang, S. G., Lim, H. W., Andrisani, O. M., Broxmeyer, H. E. and Kim, C. H., Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J. Immunol. 2007. 179: 3724-3733.
23. Mucida, D., Pino-Lagos, K., Kim, G., Nowak, E., Benson, M. J., Kronenberg, M., Noelle, R. J. et al., Retinoic acid can directly promote TGF-beta-mediated Foxp3(+) Treg cell conversion of naive T cells. Immunity 2009. 30: 471-472.
24. Hall, J. A., Cannons, J. L., Grainger, J. R., Dos Santos, L. M., Hand, T. W., Naik, S., Wohlfert, E. A. et al., Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity 2011. 34: 435-447.
25. Lee, K.-A., Song, Y. C., Kim, G.-T., Choi, G., Lee, Y.-S., Lee, J.-M. and Kang, C.-Y., Retinoic acid alleviates Con A-induced hepatitis and differentially regulates effector production in NKT cells. Eur. J. Immunol. 2012. 42: 1685-1694.
26. Tiegs, G., Hentschel, J. and Wendel, A., A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest. 1992. 90: 196-203.
27. Takeda, K., Hayakawa, Y., Van Kaer, L., Matsuda, H., Yagita, H. and Okumura, K., Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc. Natl. Acad. Sci. USA 2000. 97: 5498-5503.
28. Toyabe, S., Seki, S., Iiai, T., Takeda, K., Shirai, K., Watanabe, H., Hiraide, H. et al., Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice. J. Immunol. 1997. 159: 1537-1542.
29. Biburger, M. and Tiegs, G., Alpha-galactosylceramide-induced liver injury in mice is mediated by TNF-alpha but independent of Kupffer cells. J. Immunol. 2005. 175: 1540-1550.