Continuous antigen delivery from controlled release implants induces significant and anamnestic immune responses

Vaccine

Volumn 20, Issue 7-8, 2002, Pages 1089-1098

  Kemp, J M ^a   Kajihara, M ^b   Nagahara, S ^b   Sano, A ^b   Brandon, M ^a   Lofthouse, S ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Humoral immunity; Single dose vaccine; Vaccine delivery system

Indexed keywords

ALLOANTIBODY; ALUMINUM POTASSIUM SULFATE; ANTIGEN; AVIDIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; INTERLEUKIN 1BETA;

ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG IMPLANT; DRUG RESPONSE; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; NONHUMAN; OSMOTIC PUMP; PRIORITY JOURNAL; PROVOCATION TEST; SHEEP; VACCINATION;

ANIMALS; ANTIBODY FORMATION; ANTIGENS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; FEMALE; IMMUNOGLOBULIN ISOTYPES; INFUSION PUMPS; INTERLEUKIN-1; SHEEP; VACCINATION; VACCINES;

EID: 0037081389     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(01)00444-3     Document Type: Article

References (31)

1. A single-step immunization by sustained antigen release
2. Pharmacokinetics of once-a-month injectable microspheres of leuprolide acetate
3. A biodegradable delivery system for peptides: Preclinical experience with the gonadotropin-release hormone agonist Zoladex
4. Vaccine properties of antigens trapped in microparticles produced by spray-drying technique and using various polyester polymers
5. Controlled release microparticles as a single dose diptheria toxoid vaccine: Immunogenicity in small animal models
6. Prolonged immune response evoked by a single subcutaneous injection of microcapsules having a monphasic antigen release
7. Biodegradable microspheres as a vaccine delivery system
8. Pulsed controlled-release system for potential use in vaccine delivery
9. Development of a single-shot vaccine for HIV-1.5 programmable in vivo autoboost and long lasting neutralizing response
10. Specific suppression of IgG plaque forming cells (PFC) by continuous administration of antigen from an implantable delivery system
11. Regulation of the IL-12 receptor β2 subunit by soluble antigen and IL-12 in vivo
12. Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice
13. Induction and tolerisation of anti-male CD8+ cytotoxic T lymphocytes by in vivo immunisation with an H-Y-derived peptide
14. Non-MHC-linked Th2 cell development induced by soluble protein administration predicts susceptibility to Leishmania major infection
15. Effect of the profile of antigen delivery on antibody responses in mice
16. The effects of continuous and intermittent delivery of antigens of Boophilus microplus on the development of murine antibodies
17. Development of a new drug delivery system for protein drugs using silicone(I)
18. Development of a new drug delivery system for protein drugs using silicone(II)
19. Production and in vivo use of recombinant ovine IL-1β as an immunological adjuvant
20. Compendium of vaccine adjuvants and excipients
21. Production and characterisation of monoclonal antibodies specific for sheep IgG subclasses IgG1 or IgG2
22. Induction of immunological paralysis in two zones of dosage
23. Immunological paralysis induced in adult rabbits by small amounts of a protein antigen
24. Immunologic unresponsiveness induced by protein antigens
25. Humoral and cellular responses induced by intradermally administered cytokine and conventional adjuvants
26. Sheep immunology and goat peculiarities
27. The immune system of the ruminant mammary gland and its role in the control of mastitis
28. Correlation of specific antibody titre and avidity with protection in cattle immunized against Fasciola hepatica
29. Slow maturation of IgG1 avidity and persistence of specific IgM in congenital rubella: Implications for diagnosis and immunopathology