T cell subsets in HIV infected patients after successful combination antiretroviral therapy: Impact on survival after 12 years

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Rönsholt, Frederikke Falkencrone ^a   Ostrowski, Sisse Rye ^a   Katzenstein, Terese Lea ^a   Ullum, Henrik ^a   Gerstoft, Jan ^a  

^a Rigshospitalet   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD45RA ANTIGEN; CD45RO ANTIGEN; HLA DR ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AGE; ARTICLE; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HEPATITIS C; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; MORTALITY; NEOPLASM; PREMATURE AGING; SURVIVAL RATE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ADULT; ANTI-HIV AGENTS; COHORT STUDIES; DRUG COMBINATIONS; FOLLOW-UP STUDIES; HIV INFECTIONS; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; T-LYMPHOCYTE SUBSETS; TIME FACTORS;

HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 84864004637     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039356     Document Type: Article

References (34)

1. Deeks SG, (2010) HIV Infection, Inflammation, Immunosenescence, and Aging. Annu Rev Med.
2. Desai S, Landay A, (2010) Early immune senescence in HIV disease. Curr HIV/AIDS Rep 7: 4-10.
3. Fahey JL, Taylor JM, Detels R, Hofmann B, Melmed R, et al. (1990) The prognostic value of cellular and serologic markers in infection with human immunodeficiency virus type 1. N Engl J Med 322: 166-172.
4. Fahey JL, Taylor JM, Manna B, Nishanian P, Aziz N, et al. (1998) Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements. AIDS 12: 1581-1590.
5. Hazenberg MD, Otto SA, van Benthem BH, Roos MT, Coutinho RA, et al. (2003) Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS 17: 1881-1888.
6. Hunt PW, Brenchley J, Sinclair E, McCune JM, Roland M, et al. (2008) Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J Infect Dis 197: 126-133.
7. Liu Z, Cumberland WG, Hultin LE, Kaplan AH, Detels R, et al. (1998) CD8+ T-lymphocyte activation in HIV-1 disease reflects an aspect of pathogenesis distinct from viral burden and immunodeficiency. J Acquir Immune Defic Syndr Hum Retrovirol 18: 332-340.
8. Liu Z, Cumberland WG, Hultin LE, Prince HE, Detels R, et al. (1997) Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression. J Acquir Immune Defic Syndr Hum Retrovirol 16: 83-92.
9. Battegay M, Nuesch R, Hirschel B, Kaufmann GR, (2006) Immunological recovery and antiretroviral therapy in HIV-1 infection. Lancet Infect Dis 6: 280-287.
10. Steel A, John L, Shamji MH, Henderson DC, Gotch FM, et al. (2008) CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy. HIV Med 9: 118-125.
11. Mildvan D, Bosch RJ, Kim RS, Spritzler J, Haas DW, et al. (2004) Immunophenotypic markers and antiretroviral therapy (IMART): T cell activation and maturation help predict treatment response. J Infect Dis 189: 1811-1820.
12. Rodger AJ, Fox Z, Lundgren JD, Kuller LH, Boesecke C, et al. (2009) Activation and coagulation biomarkers are independent predictors of the development of opportunistic disease in patients with HIV infection. J Infect Dis 200: 973-983.
13. Deeks SG, Kitchen CM, Liu L, Guo H, Gascon R, et al. (2004) Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load. Blood 104: 942-947.
14. Hunt PW, (2003) T cell activation is associated with lower CD4+ cell gains in human immudeficiency virus-infected patientswith sustained viral supression during antiretroviral therapy. J Infect Dis 1534-1543.
15. Katzenstein TL, Ullum H, Roge BT, Wandall J, Dickmeiss E, et al. (2003) Virological and immunological profiles among patients with undetectable viral load followed prospectively for 24 months. HIV Med 4: 53-61.
16. Ostrowski SR, Katzenstein TL, Thim PT, Pedersen BK, Gerstoft J, et al. (2005) Low-level viremia and proviral DNA impede immune reconstitution in HIV-1-infected patients receiving highly active antiretroviral therapy. J Infect Dis 191: 348-357.
17. Ostrowski SR, Katzenstein TL, Pedersen BK, Gerstoft J, Ullum H, (2008) Residual viraemia in HIV-1-infected patients with plasma viral load &or = 20 copies/ml is associated with increased blood levels of soluble immune activation markers. Scand J Immunol 68: 652-660.
18. Mens H, Pedersen AG, Jorgensen LB, Hue S, Yang Y, et al. (2007) Investigating signs of recent evolution in the pool of proviral HIV type 1 DNA during years of successful HAART. AIDS Res Hum Retroviruses 23: 107-115.
19. Ostrowski SR, Ullum H, Pedersen BK, Gerstoft J, Katzenstein TL, (2005) 2B4 expression on natural killer cells increases in HIV-1 infected patients followed prospectively during highly active antiretroviral therapy. Clin Exp Immunol 141: 526-533.
20. Ostrowski SR, Katzenstein TL, Thim PT, Pedersen BK, Gerstoft J, et al. (2005) Low-level viremia and proviral DNA impede immune reconstitution in HIV-1-infected patients receiving highly active antiretroviral therapy. J Infect Dis 191: 348-357.
21. Katzenstein TL, Ullum H, Roge BT, Wandall J, Dickmeiss E, et al. (2003) Virological and immunological profiles among patients with undetectable viral load followed prospectively for 24 months. HIV Med 4: 53-61.
22. Engsig FN, Gerstoft J, Kronborg G, Larsen CS, Pedersen G, et al. (2010) Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery: a cohort study. BMC Infect Dis 10: 318.
23. Lifson AR, Belloso WH, Carey C, Davey RT, Duprez D, et al. (2008) Determination of the underlying cause of death in three multicenter international HIV clinical trials. HIV Clin Trials 9: 177-185.
24. Appay V, van Lier RA, Sallusto F, Roederer M, (2008) Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry A 73: 975-983.
25. Sallusto F, Geginat J, Lanzavecchia A, (2004) Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 22: 745-763.
26. Ostrowski SR, Gerstoft J, Pedersen BK, Ullum H, (2003) A low level of CD4+CD28+ T cells is an independent predictor of high mortality in human immunodeficiency virus type 1-infected patients. J Infect Dis 187: 1726-1734.
27. Ganesan A, Chattopadhyay PK, Brodie TM, Qin J, Gu W, et al. (2010) Immunologic and virologic events in early HIV infection predict subsequent rate of progression. J Infect Dis 201: 272-284.
28. Kaech SM, Tan JT, Wherry EJ, Konieczny BT, Surh CD, et al. (2003) Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol 4: 1191-1198.
29. Crawley AM, Angel JB, (2011) Expression of gamma-chain cytokine receptors on CD8(+) T cells in HIV infection with a focus on IL-7Ralpha (CD127). Immunol Cell Biol.
30. Hunt PW, Cao HL, Muzoora C, Ssewanyana I, Bennett J, et al. (2011) Impact of CD8+ T Cell Activation on CD4+ T Cell Recovery and Mortality in HIV-infected Ugandans Initiating Antiretroviral Therapy. AIDS.
31. Deeks SG, (2010) HIV Infection, Inflammation, Immunosenescence, and Aging. Annu Rev Med.
32. Pawelec G, Larbi A, Derhovanessian E, (2010) Senescence of the human immune system. J Comp Pathol 142: S39-S44.
33. Kalayjian RC, Landay A, Pollard RB, Taub DD, Gross BH, et al. (2003) Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes. J Infect Dis 187: 1924-1933.
34. Olsson J, Wikby A, Johansson B, Lofgren S, Nilsson BO, et al. (2000) Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev 121: 187-201.