Expression of Ccl11 associates with immune response modulation and protection against neuroinflammation in rats

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Adzemovic, Milena Z ^a,b   Öckinger, Johan ^a   Zeitelhofer, Manuel ^a   Hochmeister, Sonja ^a,c   Beyeen, Amennainiel Daniel ^a   Paulson, Atul ^a   Gillett, Alan ^a   Hedreul, Melanie Thessen ^a   Covacu, Ruxandra ^a   Lassmann, Hans ^b   Olsson, Tomas ^a   Jagodic, Maja ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Medical University of Vienna   (Austria)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR3; EOTAXIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; MONOCYTE CHEMOTACTIC PROTEIN 5;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; BLOOD BRAIN BARRIER; CCL11 GENE; CCL2 GENE; CCL7 GENE; CCL712 GENE; CCR3 GENE; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEMYELINATION; FEMALE; GENE; GENE CLUSTER; GENE CONTROL; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC SUSCEPTIBILITY; IMMUNOMODULATION; IMMUNOREGULATION; MACROPHAGE FUNCTION; MALE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; TH2 CELL;

ANIMALS; BLOOD-BRAIN BARRIER; CHEMOKINE CCL11; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE EXPRESSION REGULATION; GENETIC LOCI; HOMEOSTASIS; HYBRIDIZATION, GENETIC; INFLAMMATION; LYMPH NODES; MACROPHAGES; MALE; MULTIGENE FAMILY; RATS; T-LYMPHOCYTES;

RATTUS;

EID: 84864000891     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039794     Document Type: Article

References (34)

1. De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, et al. (2009) Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet 41: 776-782.
2. Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, et al. (2011) Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476: 214-219.
3. De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, et al. (2009) The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A 106: 5264-5269.
4. Sawcer S, (2008) The complex genetics of multiple sclerosis: pitfalls and prospects. Brain 131: 3118-3131.
5. Storch MK, Stefferl A, Brehm U, Weissert R, Wallström E, et al. (1998) Autoimmunity to Myelin Oligodendrocyte Glycoprotein in Rats Mimics the Spectrum of Multiple Sclerosis Pathology Brain Pathol 8: 681-694.
6. O'Connor RA, Prendergast CT, Sabatos CA, Lau CW, Leech MD, et al. (2008) Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis. J Immunol 181: 3750-3754.
7. Stromnes IM, Cerretti LM, Liggitt D, Harris RA, Goverman JM, (2008) Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells. Nat Med 14: 337-342.
8. Thessen Hedreul M, Gillett A, Olsson T, Jagodic M, Harris RA, (2009) Characterization of Multiple Sclerosis candidate gene expression kinetics in rat experimental autoimmune encephalomyelitis. Journal of Neuroimmunology doi:10.1016/j.jneuroim.2009.02.010.
9. Dahlman I, Wallstrom E, Weissert R, Storch M, Kornek B, et al. (1999) Linkage analysis of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the rat identifies a locus controlling demyelination on chromosome 18. Hum Mol Genet 8: 2183-2190.
10. Jagodic M, Kornek B, Weissert R, Lassmann H, Olsson T, et al. (2001) Congenic mapping confirms a locus on rat chromosome 10 conferring strong protection against myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. Immunogenetics 53: 410-415.
11. Teuscher C, Butterfield RJ, Ma RZ, Zachary JF, Doerge RW, et al. (1999) Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis. J Immunol 163: 2262-2266.
12. Jagodic M, Becanovic K, Sheng JR, Wu X, Bäckdahl L, et al. (2004) An advanced intercross line resolves Eae18 into two narrow quantitative trait loci syntenic to multiple sclerosis candidate loci. J Immunol 173: 1366-1373.
13. Ockinger J, Stridh P, Beyeen AD, Lundmark F, Seddighzadeh M, et al. (2009) Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. Genes Immun 11: 142-154.
14. Bromley ST, Illas F, Mas-Torrent M, (2008) Dependence of charge transfer reorganization energy on carrier localisation in organic molecular crystals. Phys Chem Chem Phys 10: 121-127.
15. Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, et al. (1996) Cloning, expression, and characterization of the human eosinophil eotaxin receptor. J Exp Med 183: 2349-2354.
16. Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, et al. (1999) Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 103: 779-788.
17. Correale J, Fiol M, (2004) Activation of humoral immunity and eosinophils in neuromyelitis optica. Neurology 63: 2363-2370.
18. Hochmeister S, Grundtner R, Bauer J, Engelhardt B, Lyck R, et al. (2006) Dysferlin is a new marker for leaky brain blood vessels in multiple sclerosis. J Neuropathol Exp Neurol 65: 855-865.
19. Kniesel U, Wolburg H, (2000) Tight junctions of the blood-brain barrier. Cell Mol Neurobiol 20: 57-76.
20. Vyshkina T, Kalman B, (2005) Haplotypes within genes of beta-chemokines in 17q11 are associated with multiple sclerosis: a second phase study. Human Genetics V118: 67.
21. Vyshkina T, Shugart YY, Birnbaum G, Leist TP, Kalman B, (2004) Association of haplotypes in the [beta]-chemokine locus with multiple sclerosis. Eur J Hum Genet 13: 240.
22. Bugeja MJ, Booth D, Bennetts B, Heard R, Rubio J, et al. (2006) An investigation of polymorphisms in the 17q11.2-12 CC chemokine gene cluster for association with multiple sclerosis in Australians. BMC Med Genet 7: 64.
23. Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, et al. (1996) Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J Biol Chem 271: 7725-7730.
24. Ponath PD, Qin S, Post TW, Wang J, Wu L, et al. (1996) Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med 183: 2437-2448.
25. Gao J-L, Sen AI, Kitaura M, Yoshie O, Rothenberg ME, et al. (1996) Identification of a Mouse Eosinophil Receptor for the CC Chemokine Eotaxin. Biochemical and Biophysical Research Communications 223: 679-684.
26. Beaulieu S, Robbiani DF, Du X, Rodrigues E, Ignatius R, et al. (2002) Expression of a functional eotaxin (CC chemokine ligand 11) receptor CCR3 by human dendritic cells. J Immunol 169: 2925-2936.
27. Sallusto F, Mackay CR, Lanzavecchia A, (1997) Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science 277: 2005-2007.
28. Stevenson NJ, Addley MR, Ryan EJ, Boyd CR, Carroll HP, et al. (2009) CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression. J Leukoc Biol 85: 289-297.
29. Kroenke MA, Carlson TJ, Andjelkovic AV, Segal BM, (2008) IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J Exp Med 205: 1535-1541.
30. Thakker P, Leach MW, Kuang W, Benoit SE, Leonard JP, et al. (2007) IL-23 is critical in the induction but not in the effector phase of experimental autoimmune encephalomyelitis. J Immunol 178: 2589-2598.
31. Wainwright DA, Xin J, Mesnard NA, Beahrs TR, Politis CM, et al. (2009) Exacerbation of facial motoneuron loss after facial nerve axotomy in CCR3-deficient mice. ASN Neuro 1: e00024.
32. Darvasi A, (1998) Experimental strategies for the genetic dissection of complex traits in animal models. Nat Genet 18: 19.
33. Amor S, Groome N, Linington C, Morris MM, Dornmair K, et al. (1994) Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice. J Immunol 153: 4349-4356.
34. Bradl M, Bauer J, Flugel A, Wekerle H, Lassmann H, (2005) Complementary contribution of CD4 and CD8 T lymphocytes to T-cell infiltration of the intact and the degenerative spinal cord. Am J Pathol 166: 1441-1450.