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Volumn 23, Issue 8, 2012, Pages 860-866

Chemopreventive effects of the dietary histone deacetylase inhibitor tributyrin alone or in combination with vitamin A during the promotion phase of rat hepatocarcinogenesis

Author keywords

Chemoprevention; Epigenetic; Hepatocarcinogenesis; Tributyrin; Vitamin A

Indexed keywords

BUTYRIC ACID; CELLULAR RETINOL BINDING PROTEIN 1; DIETHYLNITROSAMINE; PROTEIN P21; RETINOID; RETINOL; RETINOL PALMITATE; TRIBUTYRIN;

EID: 84864000201     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2011.04.010     Document Type: Article
Times cited : (19)

References (54)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • El-Serag H.B., Rudolph K.L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007, 132:2557-2576.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 2
    • 62849105898 scopus 로고    scopus 로고
    • Strategy and mechanism for the prevention of hepatocellular carcinoma: phosphorylated retinoid × receptor alpha is a critical target for hepatocellular carcinoma chemoprevention
    • Shimizu M., Takai K., Moriwaki H. Strategy and mechanism for the prevention of hepatocellular carcinoma: phosphorylated retinoid × receptor alpha is a critical target for hepatocellular carcinoma chemoprevention. Cancer Sci 2009, 100:369-374.
    • (2009) Cancer Sci , vol.100 , pp. 369-374
    • Shimizu, M.1    Takai, K.2    Moriwaki, H.3
  • 3
    • 56249130451 scopus 로고    scopus 로고
    • Targeting epigenetic mechanisms: potential of natural products in cancer chemoprevention
    • Hauser A.T., Jung M. Targeting epigenetic mechanisms: potential of natural products in cancer chemoprevention. Planta Med 2008, 74:1593-1601.
    • (2008) Planta Med , vol.74 , pp. 1593-1601
    • Hauser, A.T.1    Jung, M.2
  • 4
    • 34548456881 scopus 로고    scopus 로고
    • Dietary histone deacetylase inhibitors: from cells to mice to man
    • Dashwood R.H., Ho E. Dietary histone deacetylase inhibitors: from cells to mice to man. Semin Cancer Biol 2007, 17:363-369.
    • (2007) Semin Cancer Biol , vol.17 , pp. 363-369
    • Dashwood, R.H.1    Ho, E.2
  • 5
    • 78049429911 scopus 로고    scopus 로고
    • Cancer chemoprevention by dietary polyphenols: promising role for epigenetics
    • Link A., Balaguer F., Goel A. Cancer chemoprevention by dietary polyphenols: promising role for epigenetics. Biochem Pharmacol 2010, 80:1771-1792.
    • (2010) Biochem Pharmacol , vol.80 , pp. 1771-1792
    • Link, A.1    Balaguer, F.2    Goel, A.3
  • 6
    • 77957378106 scopus 로고    scopus 로고
    • Diet, epigenetic, and cancer prevention
    • Chen J., Xu X. Diet, epigenetic, and cancer prevention. Adv Genet 2010, 71:237-255.
    • (2010) Adv Genet , vol.71 , pp. 237-255
    • Chen, J.1    Xu, X.2
  • 7
    • 39749091215 scopus 로고    scopus 로고
    • Molecular basis of sodium butyrate- dependent proapoptotic activity in cancer cells
    • Pajak B., Orzechowski A., Gajkowska B. Molecular basis of sodium butyrate- dependent proapoptotic activity in cancer cells. Adv Med Sci 2007, 52:838-888.
    • (2007) Adv Med Sci , vol.52 , pp. 838-888
    • Pajak, B.1    Orzechowski, A.2    Gajkowska, B.3
  • 8
    • 0023515476 scopus 로고
    • Clinical pharmacology of sodium butyrate in patients with acute leukemia
    • Miller A.A., Kurschel E., Osieka R., Schmidt C.G. Clinical pharmacology of sodium butyrate in patients with acute leukemia. Eur J Cancer Clin Oncol 1987, 23:1283-1287.
    • (1987) Eur J Cancer Clin Oncol , vol.23 , pp. 1283-1287
    • Miller, A.A.1    Kurschel, E.2    Osieka, R.3    Schmidt, C.G.4
  • 9
    • 0033654178 scopus 로고    scopus 로고
    • Apoptosis cascade proteins are regulated in vivo by high intracolonic butyrate concentration: correlation with colon cancer inhibition
    • Avivi-Green C., Polak-Charcon S., Madar Z., Schwartz B. Apoptosis cascade proteins are regulated in vivo by high intracolonic butyrate concentration: correlation with colon cancer inhibition. Oncol Res 2000, 12:83-95.
    • (2000) Oncol Res , vol.12 , pp. 83-95
    • Avivi-Green, C.1    Polak-Charcon, S.2    Madar, Z.3    Schwartz, B.4
  • 10
    • 0032893270 scopus 로고    scopus 로고
    • Plasma pharmacokinetics of butyrate after intravenous administration of sodium butyrate or oral administration of tributyrin or sodium butyrate to mice and rats
    • Egorin M.J., Yuan Z.M., Sentz D.L., Plaisance K., Eiseman J.L. Plasma pharmacokinetics of butyrate after intravenous administration of sodium butyrate or oral administration of tributyrin or sodium butyrate to mice and rats. Cancer Chemother Pharmacol 1999, 43:445-453.
    • (1999) Cancer Chemother Pharmacol , vol.43 , pp. 445-453
    • Egorin, M.J.1    Yuan, Z.M.2    Sentz, D.L.3    Plaisance, K.4    Eiseman, J.L.5
  • 11
    • 0031255806 scopus 로고    scopus 로고
    • Hydrolysis characteristics of bovine milk fat and monoacid triglycerides mediated by pregastric lipase from goats and kids
    • Lai D.T., Mackenzie A.D., O'Connor C.J., Turner K.W. Hydrolysis characteristics of bovine milk fat and monoacid triglycerides mediated by pregastric lipase from goats and kids. J Dairy Sci 1997, 80:2249-2257.
    • (1997) J Dairy Sci , vol.80 , pp. 2249-2257
    • Lai, D.T.1    Mackenzie, A.D.2    O'Connor, C.J.3    Turner, K.W.4
  • 12
    • 0030914275 scopus 로고    scopus 로고
    • Cows' milk fat components as potential anticarcinogenic agents
    • Parodi P.W. Cows' milk fat components as potential anticarcinogenic agents. J Nutr 1997, 127:1055-1060.
    • (1997) J Nutr , vol.127 , pp. 1055-1060
    • Parodi, P.W.1
  • 13
    • 64249133886 scopus 로고    scopus 로고
    • Chemoprevention of rat hepatocarcinogenesis with histone deacetylase inhibitors: efficacy of tributyrin, a butyric acid prodrug
    • Kuroiwa-Trzmielina J., de Conti A., Scolastici C., Pereira D., Horst M.A., Purgatto E., et al. Chemoprevention of rat hepatocarcinogenesis with histone deacetylase inhibitors: efficacy of tributyrin, a butyric acid prodrug. Int J Cancer 2009, 124:2520-2527.
    • (2009) Int J Cancer , vol.124 , pp. 2520-2527
    • Kuroiwa-Trzmielina, J.1    de Conti, A.2    Scolastici, C.3    Pereira, D.4    Horst, M.A.5    Purgatto, E.6
  • 14
    • 0035749803 scopus 로고    scopus 로고
    • The promise of retinoids to fight against cancer
    • Altucci L., Gronemeyer H. The promise of retinoids to fight against cancer. Nat Rev Cancer 2001, 1:181-193.
    • (2001) Nat Rev Cancer , vol.1 , pp. 181-193
    • Altucci, L.1    Gronemeyer, H.2
  • 16
    • 27744597910 scopus 로고    scopus 로고
    • All- trans and 9-cis retinoic acids, retinol and beta-carotene chemopreventive activities during the initial phases of hepatocarcinogenesis involve distinct actions on glutathione S-transferase positive preneoplastic lesions remodeling and DNA damage
    • Fonseca E.M.A.V., Chagas C.E., Mazzantini R.P., Heidor R., Ong T.P., Moreno F.S. All- trans and 9-cis retinoic acids, retinol and beta-carotene chemopreventive activities during the initial phases of hepatocarcinogenesis involve distinct actions on glutathione S-transferase positive preneoplastic lesions remodeling and DNA damage. Carcinogenesis 2005, 26:1940-1946.
    • (2005) Carcinogenesis , vol.26 , pp. 1940-1946
    • Fonseca, E.M.A.V.1    Chagas, C.E.2    Mazzantini, R.P.3    Heidor, R.4    Ong, T.P.5    Moreno, F.S.6
  • 17
    • 0036949793 scopus 로고    scopus 로고
    • Inhibitory effects of beta-carotene and vitamin A during the progression phase of hepatocarcinogenesis involve inhibition of cell proliferation but not alterations in DNA methylation
    • Moreno F.S., S-Wu T., Naves M.M., Silveira E.R., Oloris S.C., da Costa M.A., et al. Inhibitory effects of beta-carotene and vitamin A during the progression phase of hepatocarcinogenesis involve inhibition of cell proliferation but not alterations in DNA methylation. Nutr Cancer 2002, 44:80-88.
    • (2002) Nutr Cancer , vol.44 , pp. 80-88
    • Moreno, F.S.1    S-Wu, T.2    Naves, M.M.3    Silveira, E.R.4    Oloris, S.C.5    da Costa, M.A.6
  • 18
    • 0141889047 scopus 로고    scopus 로고
    • Retinoids and epigenetic silencing in cancer
    • Johanning G.L., Piyathilake C.J. Retinoids and epigenetic silencing in cancer. Nutr Rev 2003, 61:84-89.
    • (2003) Nutr Rev , vol.61 , pp. 84-89
    • Johanning, G.L.1    Piyathilake, C.J.2
  • 19
    • 33644518439 scopus 로고    scopus 로고
    • The role of stem cells and gap junctions as targets for cancer chemoprevention and chemotherapy.
    • Trosko J.E. The role of stem cells and gap junctions as targets for cancer chemoprevention and chemotherapy. Biomed Pharmacother 2005, 59:S326-S331.
    • (2005) Biomed Pharmacother , vol.59
    • Trosko, J.E.1
  • 20
    • 34248191307 scopus 로고    scopus 로고
    • Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells.
    • De los Santos M., Zambrano A., Aranda A. Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells. Mol Cancer Ther 2007, 6:1425-1432.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1425-1432
    • De los Santos, M.1    Zambrano, A.2    Aranda, A.3
  • 21
    • 69149109317 scopus 로고    scopus 로고
    • Response of retinoic acid-resistant KG1 cells to combination of retinoic acid with diverse histone deacetylase inhibitors
    • Savickiene J., Treigyte G., Magnusson K.E., Navakauskiene R. Response of retinoic acid-resistant KG1 cells to combination of retinoic acid with diverse histone deacetylase inhibitors. Ann N Y Acad Sci 2009, 1171:321-333.
    • (2009) Ann N Y Acad Sci , vol.1171 , pp. 321-333
    • Savickiene, J.1    Treigyte, G.2    Magnusson, K.E.3    Navakauskiene, R.4
  • 22
    • 29744454120 scopus 로고    scopus 로고
    • The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia
    • Kuendgen A., Schmid M., Schlenk R., Knipp S., Hildebrandt B., Steidl C., et al. The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia. Cancer 2006, 106:112-119.
    • (2006) Cancer , vol.106 , pp. 112-119
    • Kuendgen, A.1    Schmid, M.2    Schlenk, R.3    Knipp, S.4    Hildebrandt, B.5    Steidl, C.6
  • 23
    • 0023520880 scopus 로고
    • Alternative methods of selecting rat hepatocellular nodules resistant to 2-acetylaminofluorene
    • Semple-Roberts E., Hayes M.A., Armstrong D., Becker R.A., Racz W.J., Farber E. Alternative methods of selecting rat hepatocellular nodules resistant to 2-acetylaminofluorene. Int J Cancer 1987, 40:643-645.
    • (1987) Int J Cancer , vol.40 , pp. 643-645
    • Semple-Roberts, E.1    Hayes, M.A.2    Armstrong, D.3    Becker, R.A.4    Racz, W.J.5    Farber, E.6
  • 24
    • 0001276586 scopus 로고
    • Experimental pathology of the liver: restoration of the liver of the white rat following partial surgical removal
    • Higgins G.M., Anderson R.M. Experimental pathology of the liver: restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931, 12:186-202.
    • (1931) Arch Pathol , vol.12 , pp. 186-202
    • Higgins, G.M.1    Anderson, R.M.2
  • 25
    • 0016685925 scopus 로고
    • Report of a workshop on classification of specific hepatocellular lesions in rats
    • Squire R.A., Levitt M.H. Report of a workshop on classification of specific hepatocellular lesions in rats. Cancer Res 1975, 35:3214-3223.
    • (1975) Cancer Res , vol.35 , pp. 3214-3223
    • Squire, R.A.1    Levitt, M.H.2
  • 26
    • 0032804577 scopus 로고    scopus 로고
    • Resistance to the promotion of glutathione S- transferase 7-7-positive liver lesions in Copenhagen rats
    • Wood G.A., Sarma D.S., Archer M.C. Resistance to the promotion of glutathione S- transferase 7-7-positive liver lesions in Copenhagen rats. Carcinogenesis 1999, 20:1169-1175.
    • (1999) Carcinogenesis , vol.20 , pp. 1169-1175
    • Wood, G.A.1    Sarma, D.S.2    Archer, M.C.3
  • 27
    • 0029010526 scopus 로고
    • Inhibition of apoptosis during 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated tumor promotion in rat liver
    • Stinchcombe S., Buchmann A., Bock K.W., Schwarz M. Inhibition of apoptosis during 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated tumor promotion in rat liver. Carcinogenesis 1995, 16:1271-1275.
    • (1995) Carcinogenesis , vol.16 , pp. 1271-1275
    • Stinchcombe, S.1    Buchmann, A.2    Bock, K.W.3    Schwarz, M.4
  • 28
    • 33745728931 scopus 로고    scopus 로고
    • Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase
    • Ong T.P., Heidor R., de Conti A., Dagli M.L.Z., Moreno F.S. Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase. Carcinogenesis 2005, 27:1194-1203.
    • (2005) Carcinogenesis , vol.27 , pp. 1194-1203
    • Ong, T.P.1    Heidor, R.2    de Conti, A.3    Dagli, M.L.Z.4    Moreno, F.S.5
  • 29
    • 0030038548 scopus 로고    scopus 로고
    • Importance of and approaches to quantification of hepatocyte apoptosis
    • Goldsworthy T.L., Fransson-Steen R., Maronpot R.R. Importance of and approaches to quantification of hepatocyte apoptosis. Toxicol Pathol 1996, 24:24-35.
    • (1996) Toxicol Pathol , vol.24 , pp. 24-35
    • Goldsworthy, T.L.1    Fransson-Steen, R.2    Maronpot, R.R.3
  • 30
    • 38649108511 scopus 로고    scopus 로고
    • Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-κB pathways
    • Mazzantini R.P., de Conti A., Moreno F.S. Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-κB pathways. J Cell Biochem 2008, 103:538-546.
    • (2008) J Cell Biochem , vol.103 , pp. 538-546
    • Mazzantini, R.P.1    de Conti, A.2    Moreno, F.S.3
  • 31
    • 0027175112 scopus 로고
    • Separation of β-carotene and lycopene geometrical isomers in biological samples
    • Stahl M., Sundquist A.R., Hanusch M., Schwarz W., Sie H. Separation of β-carotene and lycopene geometrical isomers in biological samples. Clin Chem 1993, 39:810-814.
    • (1993) Clin Chem , vol.39 , pp. 810-814
    • Stahl, M.1    Sundquist, A.R.2    Hanusch, M.3    Schwarz, W.4    Sie, H.5
  • 32
    • 0028174443 scopus 로고
    • Inhibition of microsomal 17 hydroxysteroid oxyreduction activities in rat liver by all-trans-, 9-cis-,and 13-cis-retinoic acid
    • Murray M., Butler A.M., Martini R. Inhibition of microsomal 17 hydroxysteroid oxyreduction activities in rat liver by all-trans-, 9-cis-,and 13-cis-retinoic acid. Biochim Biophys Acta 1994, 1222:227-233.
    • (1994) Biochim Biophys Acta , vol.1222 , pp. 227-233
    • Murray, M.1    Butler, A.M.2    Martini, R.3
  • 33
    • 0034975536 scopus 로고    scopus 로고
    • New method for histological microdissection utilizing an ultrasonically oscillating needle demonstrated by differential mRNA expression in human lung carcinoma tissue
    • Harsch M., Bendrat K., Hofmeier G., Branscheid D., Niendorf A.A. new method for histological microdissection utilizing an ultrasonically oscillating needle demonstrated by differential mRNA expression in human lung carcinoma tissue. Am J Pathol 2001, 158:1985-1990.
    • (2001) Am J Pathol , vol.158 , pp. 1985-1990
    • Harsch, M.1    Bendrat, K.2    Hofmeier, G.3    Branscheid, D.4    Niendorf, A.A.5
  • 34
    • 0037108867 scopus 로고    scopus 로고
    • Hypermethylation-associated inactivation of the cellular retinol-binding-protein 1 gene in human cancer
    • Esteller M., Guo M., Moreno V., Peinado M.A., Capella G., Galm O. Hypermethylation-associated inactivation of the cellular retinol-binding-protein 1 gene in human cancer. Cancer Res 2002, 62:5902-5905.
    • (2002) Cancer Res , vol.62 , pp. 5902-5905
    • Esteller, M.1    Guo, M.2    Moreno, V.3    Peinado, M.A.4    Capella, G.5    Galm, O.6
  • 37
    • 0026758142 scopus 로고
    • A retinoic acid response element from the rat CRBPI promoter is activated by an RAR/RXR heterodimer
    • Husmann M., Hoffmann B., Stump D.G., Chytil F., Pfahl M. A retinoic acid response element from the rat CRBPI promoter is activated by an RAR/RXR heterodimer. Biochem Biophys Res Commun 1992, 30:1558-1564.
    • (1992) Biochem Biophys Res Commun , vol.30 , pp. 1558-1564
    • Husmann, M.1    Hoffmann, B.2    Stump, D.G.3    Chytil, F.4    Pfahl, M.5
  • 40
    • 0023124846 scopus 로고
    • Hepatocarcinogenesis: a dynamic cellular perspective
    • Farber E., Sarma D.S. Hepatocarcinogenesis: a dynamic cellular perspective. Lab Invest 1987, 56:4-22.
    • (1987) Lab Invest , vol.56 , pp. 4-22
    • Farber, E.1    Sarma, D.S.2
  • 41
    • 0030331755 scopus 로고    scopus 로고
    • Inhibition of tumorigenesis in animals
    • Wattenberg L.W. Inhibition of tumorigenesis in animals. IARC Sci Publ 1996, 139:151-158.
    • (1996) IARC Sci Publ , vol.139 , pp. 151-158
    • Wattenberg, L.W.1
  • 42
    • 0142089014 scopus 로고    scopus 로고
    • A retinoid/ butyric acid prodrug overcomes retinoic acid resistance in leukemias by induction of apoptosis. Mol
    • Mann K.K., Rephaeli A., Colosimo A.L., Diaz Z., Nudelman A., Levovich I., et al. A retinoid/ butyric acid prodrug overcomes retinoic acid resistance in leukemias by induction of apoptosis. Mol. Cancer Res 2003, 1:903-912.
    • (2003) Cancer Res , vol.1 , pp. 903-912
    • Mann, K.K.1    Rephaeli, A.2    Colosimo, A.L.3    Diaz, Z.4    Nudelman, A.5    Levovich, I.6
  • 43
    • 36448988881 scopus 로고    scopus 로고
    • A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors
    • Epping M.T., Wang L., Plumb J.A., Lieb M., Gronemeyer H., Brown R., et al. A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors. Proc Natl Acad Sci U S A 2007, 104:17777-17782.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 17777-17782
    • Epping, M.T.1    Wang, L.2    Plumb, J.A.3    Lieb, M.4    Gronemeyer, H.5    Brown, R.6
  • 44
    • 70349960028 scopus 로고    scopus 로고
    • Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells
    • Tatebe H., Shimizu M., Shirakami Y., Sakai H., Yasuda Y., Tsurumi H., et al. Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells. Cancer Lett 2009, 285:210-217.
    • (2009) Cancer Lett , vol.285 , pp. 210-217
    • Tatebe, H.1    Shimizu, M.2    Shirakami, Y.3    Sakai, H.4    Yasuda, Y.5    Tsurumi, H.6
  • 45
    • 1542588471 scopus 로고    scopus 로고
    • Second generation hybrid polar compounds are potent inducers of transformed cell differentiation
    • Richon V.M., Webb Y., Merger R., Sheppard T., Jursic B., Ngo L., et al. Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. Proc Natl Acad Sci U S A 1996, 93:5705-5708.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 5705-5708
    • Richon, V.M.1    Webb, Y.2    Merger, R.3    Sheppard, T.4    Jursic, B.5    Ngo, L.6
  • 47
    • 0024502238 scopus 로고
    • The effect of dietary fatty acid composition on liver retinyl ester (vitamin A ester) composition in the rat
    • Furr H.C., Clifford A.J., Smith L.M., Olson J.A. The effect of dietary fatty acid composition on liver retinyl ester (vitamin A ester) composition in the rat. J Nutr 1989, 119:581-585.
    • (1989) J Nutr , vol.119 , pp. 581-585
    • Furr, H.C.1    Clifford, A.J.2    Smith, L.M.3    Olson, J.A.4
  • 48
    • 0021361687 scopus 로고
    • Retinyl palmitate, retinyl phosphate, and dolichyl phosphate of postnuclear membrane fraction from hepatoma, host liver, and regenerating liver: marginal vitamin A status of hepatoma tissue
    • De Luca L.M., Brugh M., Silverman-Jones C.S. Retinyl palmitate, retinyl phosphate, and dolichyl phosphate of postnuclear membrane fraction from hepatoma, host liver, and regenerating liver: marginal vitamin A status of hepatoma tissue. Cancer Res 1984, 44:224-232.
    • (1984) Cancer Res , vol.44 , pp. 224-232
    • De Luca, L.M.1    Brugh, M.2    Silverman-Jones, C.S.3
  • 49
    • 0025838837 scopus 로고
    • Reduced retinoid content in hepatocellular carcinoma with special reference to alcohol consumption
    • Adachi S., Moriwaki H., Muto Y., Yamada Y., Fukutomi Y., Shimazaki M., et al. Reduced retinoid content in hepatocellular carcinoma with special reference to alcohol consumption. Hepatology 1991, 14:776-780.
    • (1991) Hepatology , vol.14 , pp. 776-780
    • Adachi, S.1    Moriwaki, H.2    Muto, Y.3    Yamada, Y.4    Fukutomi, Y.5    Shimazaki, M.6
  • 50
    • 2942538294 scopus 로고    scopus 로고
    • Downregulation appears to be an evolutionarily conserved (human and mouse) and oncogene-specific phenomenon in breast cancer
    • Arapshian A., Bertran S., Kuppumbatti Y.S., Nakajo S., Mira-y-Lopez R., Epigenetic C.R.B.P. downregulation appears to be an evolutionarily conserved (human and mouse) and oncogene-specific phenomenon in breast cancer. Mol Cancer 2004, 27:3-13.
    • (2004) Mol Cancer , vol.27 , pp. 3-13
    • Arapshian, A.1    Bertran, S.2    Kuppumbatti, Y.S.3    Nakajo, S.4    Mira-y-Lopez, R.5    Epigenetic, C.R.B.P.6
  • 51
    • 0345214518 scopus 로고    scopus 로고
    • Identification of a mechanism to localize generation of retinoic acid in rat embryos
    • Bavik C., Ward S.J., Ong D.E. Identification of a mechanism to localize generation of retinoic acid in rat embryos. Mech Dev 1997, 69:155-167.
    • (1997) Mech Dev , vol.69 , pp. 155-167
    • Bavik, C.1    Ward, S.J.2    Ong, D.E.3
  • 52
    • 0024430480 scopus 로고
    • Levels of vitamin A and cellular retinol binding protein in human hepatocellular carcinoma and adjacent normal tissue
    • Kanematsu T., Kawano T., Takenaka K., Matsumata T., Sugimachi K., Kuwano M. Levels of vitamin A and cellular retinol binding protein in human hepatocellular carcinoma and adjacent normal tissue. Nutr Cancer 1989, 12:311-319.
    • (1989) Nutr Cancer , vol.12 , pp. 311-319
    • Kanematsu, T.1    Kawano, T.2    Takenaka, K.3    Matsumata, T.4    Sugimachi, K.5    Kuwano, M.6
  • 53
    • 2542458379 scopus 로고    scopus 로고
    • Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer
    • Boorjian S., Tickoo S.K., Mongan N.P., Yu H., Bok D., Rando R.R., et al. Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer. Clin Cancer Res 2004, 10:3429-3437.
    • (2004) Clin Cancer Res , vol.10 , pp. 3429-3437
    • Boorjian, S.1    Tickoo, S.K.2    Mongan, N.P.3    Yu, H.4    Bok, D.5    Rando, R.R.6
  • 54
    • 51849099492 scopus 로고    scopus 로고
    • The short chain fatty acid butyrate induces promoter demethylation and reactivation of RARβ2 in colon cancer cells
    • Spurling C.C., Suhl J.A., Boucher N., Nelson C.E., Rosenberg D.W., Giardina C. The short chain fatty acid butyrate induces promoter demethylation and reactivation of RARβ2 in colon cancer cells. Nutr Cancer 2008, 60:692-702.
    • (2008) Nutr Cancer , vol.60 , pp. 692-702
    • Spurling, C.C.1    Suhl, J.A.2    Boucher, N.3    Nelson, C.E.4    Rosenberg, D.W.5    Giardina, C.6


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