Rapamycin induces heme oxygenase-1 in liver but inhibits bile flow recovery after ischemia

Journal of Surgical Research

Volumn 176, Issue 2, 2012, Pages 468-475

  Kist, Alwine ^a   Wakkie, Joris ^a   Madu, Max ^a   Versteeg, Ruth ^a   Ten Berge, Judith ^a   Nikolic, Andrej ^a   Nieuwenhuijs, Vincent B ^b   Porte, Robert J ^b   Padbury, Robert T A ^c   Barritt, Greg J ^a  

^a FLINDERS UNIVERSITY   (Australia)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c FLINDERS UNIVERSITY   (Australia)

Author keywords

bile flow; heme oxygenase 1; ischemia reperfusion injury; isolated hepatocytes; liver; quantitative PCR; rapamycin; rat

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; COBALT PROPORPHYRIN IX CHLORIDE; HEME OXYGENASE 1; INDOCYANINE GREEN; LACTATE DEHYDROGENASE; MESSENGER RNA; PEROXIREDOXIN 1; PORPHYRIN DERIVATIVE; RAPAMYCIN; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE FLOW; BILIRUBIN BLOOD LEVEL; CELL ISOLATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; ENZYME INDUCTION; GRAVIMETRY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER; LIVER CELL; LIVER FUNCTION; LIVER ISCHEMIA; LIVER PROTECTION; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; WESTERN BLOTTING;

ANIMALS; ANTI-BACTERIAL AGENTS; BILE; BILIRUBIN; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME OXYGENASE-1; HEPATOCYTES; LIVER; LIVER TRANSPLANTATION; MALE; PRIMARY CELL CULTURE; PROTOPORPHYRINS; RATS; RATS, WISTAR; REPERFUSION INJURY; SIROLIMUS;

EID: 84863988859     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2011.10.033     Document Type: Article

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