Persistence of a large population of exhausted monoclonal B cells in mixed cryoglobuliemia after the eradication of hepatitis c virus infection

Journal of Clinical Immunology

Volumn 32, Issue 4, 2012, Pages 729-735

  Visentini, Marcella ^a   Conti, Valentina ^a   Cagliuso, Maria ^a   Siciliano, Giulia ^a   Scagnolari, Carolina ^b   Casato, Milvia ^a   Fiorilli, Massimo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

B cells exhaustion; HCV. cryoglobulinemia; Toll like receptor; VH1 69

Indexed keywords

CRYOGLOBULIN; PEGINTERFERON ALPHA2B; RIBAVIRIN; TOLL LIKE RECEPTOR 9;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CELL FATE; CLINICAL ARTICLE; CRYOGLOBULINEMIA; FEMALE; HEPATITIS C; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE COUNT; MALE; PRIORITY JOURNAL; TREATMENT RESPONSE;

ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTIGENS, CD11C; B-LYMPHOCYTE SUBSETS; CRYOGLOBULINEMIA; CRYOGLOBULINS; FEMALE; HEPACIVIRUS; HEPATITIS C; HUMANS; IMMUNOGLOBULIN IDIOTYPES; MALE; MIDDLE AGED; RECEPTORS, COMPLEMENT 3D; RNA, VIRAL; TOLL-LIKE RECEPTOR 9;

EID: 84863982123     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-012-9677-0     Document Type: Article

References (25)

1. Landau DA, Saadoun D, Calabrese LH, Cacoub P. The pathophysiology of HCV induced B-cell clonal disorders. Autoimmun Rev. 2007;6:581-7. (Pubitemid 47374619)
2. Carbonari M, Caprini E, Tedesco T, Mazzetta F, Tocco V, Casato M, et al. Hepatitis C virus drives the unconstrained monoclonal expansion of VH1-69-expressing memory B cells in type II cryoglobulinemia: A model of infection-driven lymphomagenesis. J Immunol. 2005;174:6532-9. (Pubitemid 40667522)
3. Charles ED, Brunetti C,Marukian S, Ritola KD, Talal AH,Marks K, Jacobson IM, Rice CM, Dustin LB. Clonal B cells in patients with hepatitis C virus-associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset. Blood. 2011;117:5425-37.
4. Terrier B, Joly F, Vazquez T, Benech P, Rosenzwajg M, Carpentier W, Garrido M, Ghillani-Dalbin P, Klatzmann D, Cacoub P, Saadoun D. Expansion of functionally anergic CD21-/low marginal zone-like B cell clones in hepatitis C virus infection-related autoimmunity. J Immunol. 2011;187:6550-63.
5. Visentini M, Cagliuso M, Conti V, Carbonari M, Casato M, Fiorilli M. The VH1-69-expressing marginal zone B cells expanded in hepatitis C virus-associated mixed cryoglobulinemia display proliferative anergy irrespective of CD21low phenotype. Blood. 2011;118:3440-1.
6. Rakhmanov M, Keller B, Gutenberger S, et al. Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells. Proc Natl Acad Sci USA. 2009;106:13451-6.
7. Isnardi I, NgYS,Menard L,MeyersG, Saadoun D, Srdanovic I, et al. Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones. Blood. 2010;115:5026-36.
8. Visentini M, Cagliuso M, Conti V, Carbonari M, Mancaniello D, Cibati M, et al. Telomere-dependent replicative senescence of B and T cells from patients with type 1a common variable immunodeficiency. Eur J Immunol. 2011;41:854-62.
9. Moir S, Ho J, Malaspina A, Wang W, DiPoto AC, O'Shea MA, et al. Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals. J Exp Med. 2008;205:1797-805.
10. Cacoub P, Lidove O, Maisonobe T, Duhaut P, Thibault V, Ghillani P, Myers RP, Leger JM, Servan J, Piette JC. Interferon-alpha and ribavirin treatment in patients with hepatitis C virus-related systemic vasculitis. Arthritis Rheum. 2002;46:3317-26. (Pubitemid 35453543)
11. Lyons AB. Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J Immunol Methods. 2000;243:147-54.
12. Saadoun D, Resche Rigon M, Sene D, Terrier B, Karras A, Perard L, et al. Rituximab plus Peg-interferon-alpha/ribavirin compared with Peg-interferon- alpha/ribavirin in hepatitis C-related mixed cryoglobulinemia. Blood. 2010;116:326-34.
13. Radkowski M, Gallegos-Orozco JF, Jablonska J, et al. Persistence of hepatitis C virus in patients successfully treated for chronic hepatitis C. Hepatology. 2005;41:106-14. (Pubitemid 40066388)
14. Hao Z, Rajewsky K. Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow. J Exp Med. 2001;194:1151-64.
15. Pilllai S, Cariappa A, Moran ST. Marginal zone B cells. Annu Rev Immunol. 2005;23:161-6.
16. Cambier JC, Gauld SB, Merrell KT, Vilen BJ. B-cell anergy: from transgenic models to naturally occurring anergic B cells? Nat Rev Immunol. 2007;7:633-43.
17. Landau DA, Rosenzwajg M, Saadoun D, Klatzmann D, Cacoub P. The B lymphocyte stimulator receptor-ligand system in hepatitis C virus-induced B cell clonal disorders. Ann Rheum Dis. 2009;68:337-44.
18. Rifkin IR, Leadbetter EA, Beaudette BC, Kiani C, Monestier M, Shlomchik MJ, et al. Immune complexes present in the sera of autoimmune mice activate rheumatoid factor B cells. J Immunol. 2000;165:1626-33. (Pubitemid 30604601)
19. Visentini M, Cagliuso M, Conti V, Carbonari M, Cibati M, Siciliano G, Cristofoletti C, Russo G, Casato M, Fiorilli M. VH1-69-expressing B cells in HCV-associated cryoglobulinemia patients contain exhausted CD21low B cells and marginal zonelike B cells overexpressing Stra13. Eur J Immunol. In press.
20. Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature. 2002;416:603-7. (Pubitemid 34406754)
21. Lau CM, Broughton C, Tabor AS, et al. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med. 2005;202:1171-7. (Pubitemid 41586947)
22. McMurray RW, Elbourne K. Hepatitis C virus infection and autoimmunity. Semin Arthritis Rheum. 1997;26:689-701. (Pubitemid 27118536)
23. Rubtsov AV, Rubtsova K, Fischer A, et al. Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+B-cell population is important for the development of autoimmunity. Blood. 2011;118:1305-15.
24. Kardava L, Moir S, Wang W, Ho J, Buckner CM, Posada JG, O'Shea MA, Roby G, Chen J, Sohn HW, Chun TW, Pierce SK, Fauci AS. Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors. J Clin Invest. 2011;121:2614-24.
25. Gauld SB, Benschop RJ, Merrell KT, Cambier JC. Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling. Nat Immunol. 2005;6:1160-7. (Pubitemid 41541794)