Apocynin attenuates lipopolysaccharide-induced lung injury in an isolated and perfused rat lung model

Shock

Volumn 38, Issue 2, 2012, Pages 196-202

  Chian, Chih Feng ^a   Chiang, Chi Huei ^b,c   Yuan Jung, Chu ^b   Chuang, Chiao Hui ^b   Liu, Shiou Ling ^b   Yi Han, Jheng ^b   Zhang, Haibo ^d,e   Ryu, Jay H ^f  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d ST MICHAEL'S HOSPITAL   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f MAYO CLINIC   (United States)

Author keywords

Apocynin; ARDS; inflammation; LPS; MAPK; NADPH; NF B

Indexed keywords

ALBUMIN; APOCYNIN; CASPASE 3; CD31 ANTIGEN; GLUTATHIONE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOPEROXIDASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; HISTOPATHOLOGY; INFLAMMATION; ISOLATED LUNG; LUNG HEMODYNAMICS; LUNG INJURY; LUNG LAVAGE; LUNG PERFUSION; LUNG WEIGHT; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; WEIGHT GAIN;

ACETOPHENONES; ANIMALS; ANTIGENS, CD31; ANTIOXIDANTS; APOPTOSIS; CYTOKINES; DOWN-REGULATION; GLUTATHIONE; HYDROGEN PEROXIDE; LIPOPOLYSACCHARIDES; LUNG INJURY; MALE; MAP KINASE SIGNALING SYSTEM; NF-KAPPA B; PERMEABILITY; PEROXIDASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PULMONARY EDEMA; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84863980304     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31825a1982     Document Type: Article

References (35)

1. Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD: Incidence and outcomes of acute lung injury. N Engl J Med 353:1685-1693, 2005. (Pubitemid 41464707)
2. The Acute Respiratory Distress Syndrome Network: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301-1308, 2000.
3. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M: Early Goal-Directed Therapy Collaborative Group: early goaldirected therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368-1377, 2001.
4. Martin GS, Mannino DM, Eaton S, Moss M: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348:1546-1554, 2003 (Pubitemid 36437931)
5. Riedemann NC, Guo RF, Ward PA: Novel strategies for the treatment of sepsis. Nat Med 9:517-524, 2003. (Pubitemid 36597096)
6. Akira S, Takeda K: Toll-like receptor signalling. Nat Rev Immunol 4:499-511, 2004. (Pubitemid 38931765)
7. Fink MP: Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: potential benefits of resuscitation with Ringer's ethyl pyruvate solution. Curr Opin Clin Nutr Metab Care 5:167-174, 2002.
8. Lorne E, Zmijewski JW, Zhao X, Liu G, Tsuruta Y, Park YJ, Dupont H, Abraham E: Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production. Am J Physiol Cell Physiol 294:C985YC993, 2008. (Pubitemid 351507911)
9. Mitra S, Abraham E: Participation of superoxide in neutrophil activation and cytokine production. Biochim Biophys Act 1762:732-741, 2006. (Pubitemid 44293376)
10. Kolls JK: Oxidative stress in sepsis: a redox redux. J Clin Invest 116:860-863, 2006.
11. Lambeth JD: NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol 4:181-189, 2004. (Pubitemid 38339084)
12. Droge W: Free radicals in the physiological control of cell function. Physiol Rev 82:47-95, 2002. (Pubitemid 34654215)
13. Park HS, Jung HY, Park EY, Kim J, Lee WJ, Bae YS: Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B. J Immunol 173:3589-3593, 2004. (Pubitemid 39280716)
14. Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, Ermolaeva M, Veldhuizen R, Leung YH, Wang H, et al.: Identification of oxidative stress and toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell 133:235-249, 2008. (Pubitemid 351512299)
15. Stefanska J, Pawliczak R: Apocynin: molecular aptitudes. Mediators Inflamm 2008:106507, 2008.
16. Wang W, Suzuki Y, Tanigaki T, Rank DR, Raffin TA: Effect of the NADPH oxidase inhibitor apocynin on septic lung injury in guinea pigs. Am J Respir Crit Care Med 150:1449-1452, 1994. (Pubitemid 24356666)
17. Chiang CH, Pai HI, Liu SL: Ventilator-induced lung injury (VILI) promotes ischemia/reperfusion lung injury (I/R) and NF-kappa B antibody attenuates both injuries. Resuscitation 79:147-154, 2008.
18. Drake R, Gaar KA, Taylor AE: Estimation of the filtration coefficient of pulmonary exchange vessels. Am J Physiol 234:H266YH274, 1978. (Pubitemid 9154162)
19. Chiang CH, Chuang CH, Liu SL: Apocynin attenuates ischemia-reperfusion lung injury in an isolated and perfused rat lung model. Transl Res 158:17-29, 2011.
20. Chiang CH, Hsu K, Yan HC, Harn HJ, Chang DM: PGE1, dexamethasone, U-74389G, or Bt2-cAMP as an additive to promote protection by UW solution in I/R injury. J Appl Physiol 83:583-590, 1997. (Pubitemid 27332777)
21. Hagiwara S, Iwasaka H, Hasegawa A, Oyama M, Imatomi R, Uchida T, Noguchi T: Adenosine diphosphate receptor antagonist clopidogrel sulfate attenuates LPS-induced systemic inflammation in a rat model. Shock 35:289-292, 2011.
22. Webster NR, Galley HF: Immunomodulation in the critically ill. Br J Anaesth 103:70-81, 2009.
23. Kozar RA, Weibel CJ, Cipolla J, Klein AJ, Haber MM, Abedin MZ, Trooskin SZ: Antioxidant enzymes are induced during recovery from acute lung injury. Crit Care Med 28:2486-2491, 2000. (Pubitemid 30604458)
24. Stolk J, Hiltermann TJ, Dijkman JH, Verhoeven AJ: Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxysubstituted catechol. Am J Respir Cell Mol Biol 11:95-102, 1994.
25. Muijsers RB, van Den Worm E, Folkerts G, Beukelman CJ, Koster AS, Postma DS, Nijkamp FP: Apocynin inhibits peroxynitrite formation by murine macrophages. Br J Pharmacol 130:932-936, 2000. (Pubitemid 30389075)
26. Johnson DK, Schillinger KJ, Kwait DM, Hughes CV, McNamara EJ, Ishmael F, O'Donnell RW, Chang MM, Hogg MG, Dordick JS: Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols. Endothelium 9:191-203, 2002. (Pubitemid 35021589)
27. Abdelrahman M, Mazzon E, Bauer M, Bauer I, Delbosc S, Cristol JP, Patel NS, Cuzzocrea S, Thiemermann C: Inhibitors of NADPH oxidase reduce the organ injury in hemorrhagic shock. Shock 23:107-114, 2005. (Pubitemid 40222945)
28. Heumü ller S, Wind S, Barbosa-Sicard E, Schmidt HH, Busse R, Schröder K, Brandes RP: Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 51:211-217, 2008.
29. McClung JM, Van Gammeren D, Whidden MA, Falk DJ, Kavazis AN, Hudson MB, Gayan-Ramirez G, Decramer M, DeRuisseau KC, Powers SK: Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilation. Crit Care Med 37:1373-1379, 2009.
30. Sakon S, Xue X, Takekawa M, Sasazuki T, Okazaki T, Kojima Y, Piao JH, Yagita H, Okumura K, Doi T, et al.: NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J 22:3898-3909, 2003. (Pubitemid 36975716)
31. Touyz RM, Schiffrin EL: Reactive oxygen species and hypertension: a complex association. Antioxid Redox Signal 10:1041-1044, 2008. (Pubitemid 351451716)
32. Viaková D, Pekarová M, Crhák T, Bú csaiová M, Matiaxovic J, Lojek A, Kubala L: Redox-sensitive regulation of macrophage-inducible nitric oxide synthase expression in vitro does not correlate with the failure of apocynin to prevent lung inflammation induced by endotoxin. Immunobiology 216:457-465, 2011.
33. Chiang CH, Chuang CH, Liu SL, Lee TS, Kou YR, Zhang H: Apocynin attenuates ventilator-induced lung injury in an isolated and perfused rat lung model. Intensive Care Med 37:1360-1367, 2011.
34. Zhu H, Shan L, Peng T: Rac1 mediates sex difference in cardiac tumor necrosis factor-alpha expression via NADPH oxidaseYERK1/2/p38 MAPK pathway in endotoxemia. J Mol Cell Cardiol 47:264-274, 2009.
35. Ben-Shaul V, Lomnitski L, Nyska A, Zurovsky Y, Bergman M, Grossman S: The effect of natural antioxidants, NAO and apocynin, on oxidative stress in the rat heart following LPS challenge. Toxicol Lett 123:1-10, 2001. (Pubitemid 32763083)