메뉴 건너뛰기




Volumn 18, Issue 14, 2012, Pages 3856-3867

Anti-myeloma effects of the novel anthracycline derivative INNO-206

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE DERIVATIVE; BORTEZOMIB; DOXORUBICIN; INNO 206; NEW DRUG; UNCLASSIFIED DRUG;

EID: 84863979870     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-11-3130     Document Type: Article
Times cited : (15)

References (49)
  • 2
    • 34250194653 scopus 로고    scopus 로고
    • A phase I/II study of arsenic trioxide/bortezomib/ascorbic acid combination therapy for the treatment of relapsed or refractory multiple myeloma
    • DOI 10.1158/1078-0432.CCR-06-1812
    • Berenson JR, Matous J, Swift RA, Mapes R, Morrison B, Yeh HS. A phase I/II study of arsenic trioxide/bortezomib/ascorbic acid combination therapy for the treatment of relapsed or refractory multiple myeloma. Clin Cancer Res 2007;13:1762-8. (Pubitemid 46952943)
    • (2007) Clinical Cancer Research , vol.13 , Issue.6 , pp. 1762-1768
    • Berenson, J.R.1    Matous, J.2    Swift, R.A.3    Mapes, R.4    Morrison, B.5    Yeh, H.S.6
  • 3
    • 0021322023 scopus 로고
    • Effective treatment of advanced multiple myeloma refractory to alkylating agents
    • Barlogie B, Smith L, Alexanian R. Effective treatment of advanced multiple myeloma refractory to alkylating agents. N Engl J Med 1984;310:1353-6. (Pubitemid 14149087)
    • (1984) New England Journal of Medicine , vol.310 , Issue.21 , pp. 1353-1356
    • Barlogie, B.1    Smith, L.2    Alexanian, R.3
  • 4
    • 0026714331 scopus 로고
    • The anthracyclines: Will we ever find a better doxorubicin?
    • Weiss RB. The anthracyclines: will we ever find a better doxorubicin? Semin Oncol 1992;19:670-86. (Pubitemid 23004844)
    • (1992) Seminars in Oncology , vol.19 , Issue.6 , pp. 670-686
    • Weiss, R.B.1
  • 5
    • 0032563825 scopus 로고    scopus 로고
    • Doxorubicin-induced cardiomyopathy
    • DOI 10.1056/NEJM199809243391307
    • Singal PK, Iliskovic N. Doxorubicin-induced cardiomyopathy. N Engl J Med 1998;339:900-5. (Pubitemid 28446849)
    • (1998) New England Journal of Medicine , vol.339 , Issue.13 , pp. 900-905
    • Singal, P.K.1    Iliskovic, N.2
  • 7
    • 2642566088 scopus 로고    scopus 로고
    • Anthracyclines: Molecular advances and pharmacologie developments in antitumor activity and cardiotoxicity
    • DOI 10.1124/pr.56.2.6
    • Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 2004;56:185-229. (Pubitemid 38720829)
    • (2004) Pharmacological Reviews , vol.56 , Issue.2 , pp. 185-229
    • Minotti, G.1    Menna, P.2    Salvatorelli, E.3    Cairo, G.4    Gianni, L.5
  • 8
    • 32544446935 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin, vincristine, and dexamethasone provide significant reduction in toxicity compared with doxorubicin, vincristine, and dexamethasone in patients with newly diagnosed multiple myeloma: A phase III multicenter randomized trial
    • DOI 10.1002/cncr.21662
    • Rifkin RM, Gregory SA, Mohrbacher A, Hussein MA. Pegylated liposomal doxorubicin, vincristine, and dexamethasone provide significant reduction in toxicity compared with doxorubicin, vincristine, and dexamethasone in patients with newly diagnosed multiple myeloma: a Phase III multicenter randomized trial. Cancer 2006;106:848-58. (Pubitemid 43238452)
    • (2006) Cancer , vol.106 , Issue.4 , pp. 848-858
    • Rifkin, R.M.1    Gregory, S.A.2    Mohrbacher, A.3    Hussein, M.A.4
  • 12
    • 77649092410 scopus 로고    scopus 로고
    • Phase II trial of combination therapy with bortezomib, pegylated liposomal doxorubicin, and dexamethasone in patients with newly diagnosed myeloma
    • Jakubowiak AJ, Kendall T, Al-Zoubi A, Khaled Y, Mineishi S, Ahmed A, et al. Phase II trial of combination therapy with bortezomib, pegylated liposomal doxorubicin, and dexamethasone in patients with newly diagnosed myeloma. J Clin Oncol 2009;27:5015-22.
    • (2009) J Clin Oncol , vol.27 , pp. 5015-5022
    • Jakubowiak, A.J.1    Kendall, T.2    Al-Zoubi, A.3    Khaled, Y.4    Mineishi, S.5    Ahmed, A.6
  • 13
    • 33747121704 scopus 로고    scopus 로고
    • LAGlambda-1: A clinically relevant drug resistant human multiple myeloma tumor murine model that enables rapid evaluation of treatments for multiple myeloma
    • Campbell RA, Manyak SJ, Yang HH, Sjak-Shie NN, Chen H, Popoviciv L. LAGlambda-1: a clinically relevant drug resistant human multiple myeloma tumor murine model that enables rapid evaluation of treatments for multiple myeloma. Int J Oncol 2006;28:1409-17.
    • (2006) Int J Oncol , vol.28 , pp. 1409-1417
    • Campbell, R.A.1    Manyak, S.J.2    Yang, H.H.3    Sjak-Shie, N.N.4    Chen, H.5    Popoviciv, L.6
  • 14
    • 78751574225 scopus 로고    scopus 로고
    • A modified regimen of pegylated liposomal doxorubicin, bortezomib, and dexamethasone is effective and well tolerated in the treatment of relapsed or refractory multiple myeloma
    • Waterman GN, Yellin O, Swift RA, Mapes R, Eades B, AckermanE, et al. A modified regimen of pegylated liposomal doxorubicin, bortezomib, and dexamethasone is effective and well tolerated in the treatment of relapsed or refractory multiple myeloma. Ann Hematol 2011;90: 193-200.
    • (2011) Ann Hematol , vol.90 , pp. 193-200
    • Waterman, G.N.1    Yellin, O.2    Swift, R.A.3    Mapes, R.4    Eades, B.5    Ackerman, E.6
  • 15
    • 81155139575 scopus 로고    scopus 로고
    • A modified regimen of pegylated liposomal doxorubicin, bortezomib, and dexamethasone (DVD) is effective and well tolerated for previously untreated multiple myeloma patients
    • Berenson JR, Yellin O, Chen C-S, Patel R, Bessudo A, Boccia RV, et al. A modified regimen of pegylated liposomal doxorubicin, bortezomib, and dexamethasone (DVD) is effective and well tolerated for previously untreated multiple myeloma patients. Br J Haematol 2011;155:580-7.
    • (2011) Br J Haematol , vol.155 , pp. 580-587
    • Berenson, J.R.1    Yellin, O.2    Chen, C.-S.3    Patel, R.4    Bessudo, A.5    Boccia, R.V.6
  • 16
    • 33745765108 scopus 로고    scopus 로고
    • Reduced dose PAD combination therapy (PS-341/bortezomib, Adriamycin and dexamethasone) for previously untreated patients with multiple myeloma
    • Abstract nr 2554
    • Popat R, Oakervee HE, Curry N, Foot N, Morris C, Drake M, et al. Reduced dose PAD combination therapy (PS-341/bortezomib, Adriamycin and dexamethasone) for previously untreated patients with multiple myeloma. Blood 2005;106:717a. Abstract nr 2554.
    • (2005) Blood , vol.106
    • Popat, R.1    Oakervee, H.E.2    Curry, N.3    Foot, N.4    Morris, C.5    Drake, M.6
  • 17
    • 35048875691 scopus 로고    scopus 로고
    • Evaluation of HIF-1 inhibitors as anticancer agents
    • DOI 10.1016/j.drudis.2007.08.006, PII S1359644607003248
    • Semenza GL. Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov Today 2007;12:853-9. (Pubitemid 47554628)
    • (2007) Drug Discovery Today , vol.12 , Issue.19-20 , pp. 853-859
    • Semenza, G.L.1
  • 18
    • 58149232648 scopus 로고    scopus 로고
    • Evolution of bevacizumab-based therapy in the management of breast cancer
    • Sachdev JC, Jahanzeb M. Evolution of bevacizumab-based therapy in the management of breast cancer. Clin Breast Cancer 2008;8:402-10
    • (2008) Clin Breast Cancer , vol.8 , pp. 402-410
    • Sachdev, J.C.1    Jahanzeb, M.2
  • 19
    • 67449138856 scopus 로고    scopus 로고
    • Targeting angiogenesis via a c-Myc/hypoxia-inducible factor-1a-dependent pathway in multiple myeloma
    • Zhang J, Sattler M, Tonon G, Grabher C, Lababidi S, Zimmerhackl A, et al. Targeting angiogenesis via a c-Myc/hypoxia-inducible factor-1a-dependent pathway in multiple myeloma. Cancer Res 2009;69: 5082-90.
    • (2009) Cancer Res , vol.69 , pp. 5082-5090
    • Zhang, J.1    Sattler, M.2    Tonon, G.3    Grabher, C.4    Lababidi, S.5    Zimmerhackl, A.6
  • 20
    • 77953219207 scopus 로고    scopus 로고
    • A novel angiogenesis model for screening anti-angiogenic compounds: The chorioallantoic membrane/feather bud assay
    • Chen H, Wang CS, Li M, Sanchez E, Li J, Berenson A, et al. A novel angiogenesis model for screening anti-angiogenic compounds: the chorioallantoic membrane/feather bud assay. Int J Oncol 2010;37: 71-9.
    • (2010) Int J Oncol , vol.37 , pp. 71-79
    • Chen, H.1    Wang, C.S.2    Li, M.3    Sanchez, E.4    Li, J.5    Berenson, A.6
  • 23
    • 23844551832 scopus 로고    scopus 로고
    • Myeloma bone disease: Pathophysiology and management
    • DOI 10.1093/annonc/mdi235
    • Terpos E, Dimopulous MA. Myeloma bone disease: pathophysiology and management. Ann Oncol 2005;16:1223-31. (Pubitemid 41158467)
    • (2005) Annals of Oncology , vol.16 , Issue.8 , pp. 1223-1231
    • Terpos, E.1    Dimopoulos, M.-A.2
  • 25
    • 0035425227 scopus 로고    scopus 로고
    • Biology of osteoclast activation in cancer
    • Roodman DG. Biology of osteoclast activation in cancer. J Clin Oncol 2001;19:3562-71.
    • (2001) J Clin Oncol , vol.19 , pp. 3562-3571
    • Roodman, D.G.1
  • 26
    • 0024461376 scopus 로고
    • Osteoclastic bone resorption by a polarized vacuolar proton pump
    • Blair HC, Teitelbaum SL, Ghiselli R, Gluck S. Osteoclast bone resorption by a polarized vacuolar proton pump. Science 1989;245:855-7. (Pubitemid 19223662)
    • (1989) Science , vol.245 , Issue.4920 , pp. 855-857
    • Blair, H.C.1    Teitelbaum, S.L.2    Ghiselli, R.3    Gluck, S.4
  • 27
    • 0024990332 scopus 로고
    • Evidence for the presence of a proton pump of the vacuolar H-ATPase type in the ruffled borders of osteoclasts
    • Vaananen HK, Karhukorpi E-K, Sundquist K, Wallmark B, Roininen I, Hentunen T, et al. Evidence for the presence of a proton pump of the vacuolar H-ATPase type in the ruffled borders of osteoclasts. J Cell Biol 1990;11:1305-11.
    • (1990) J Cell Biol , vol.11 , pp. 1305-1311
    • Vaananen, H.K.1    Karhukorpi, E.-K.2    Sundquist, K.3    Wallmark, B.4    Roininen, I.5    Hentunen, T.6
  • 29
    • 0000641883 scopus 로고
    • Alterations in the pH of osteoclast resorbing fluid reflects changes in bone degradative activity
    • Fallon MD. Alterations in the pH of osteoclast resorbing fluid reflects changes in bone degradative activity. Calcif Tissue Int 1984;36:458.
    • (1984) Calcif Tissue Int , vol.36 , pp. 458
    • Fallon, M.D.1
  • 30
    • 0030895688 scopus 로고    scopus 로고
    • Trafficking of matrix collagens through bone-resorbing osteoclasts
    • DOI 10.1126/science.276.5310.266
    • Nesbitt SA, Horton MA. Trafficking of matrix collagens through bone-resorbing osteoclasts. Science 1997;276:266-9. (Pubitemid 27172687)
    • (1997) Science , vol.276 , Issue.5310 , pp. 266-269
    • Nesbitt, S.A.1    Horton, M.A.2
  • 31
    • 0031002026 scopus 로고    scopus 로고
    • Removal of osteoclast bone resorption products by transcytosis
    • DOI 10.1126/science.276.5310.270
    • Salo J, Lehenkari P, Mulari M, Metsikko K, Vaananen HK. Removal of osteoclast bone resorption products by transcytosis. Science 1997;276:270-3. (Pubitemid 27172688)
    • (1997) Science , vol.276 , Issue.5310 , pp. 270-273
    • Salo, J.1    Lehenkari, P.2    Mulari, M.3    Metsikko, K.4    Vaananen, H.K.5
  • 33
    • 77950501364 scopus 로고    scopus 로고
    • Proton pump inhibitor-induced tumor cell death by inhibition of a detoxification mechanism
    • Fais S. Proton pump inhibitor-induced tumor cell death by inhibition of a detoxification mechanism. J Intern Med 2010;267:515-25.
    • (2010) J Intern Med , vol.267 , pp. 515-525
    • Fais, S.1
  • 34
    • 0029751950 scopus 로고    scopus 로고
    • A reaction-diffusion model of cancer invasion
    • Gatenby RA, Gawlinski ET. A reaction-diffusion model of cancer invasion. Cancer Res 1996;56:5745-53. (Pubitemid 26422183)
    • (1996) Cancer Research , vol.56 , Issue.24 , pp. 5745-5753
    • Gatenby, R.A.1    Gawlinski, E.T.2
  • 35
    • 0030942009 scopus 로고    scopus 로고
    • Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan
    • Vukovic V, Tannock IF. Influence of low pHon cytotoxicity of paclitaxel, mitoxantrone and topotecan. Br J Cancer 1997;75:1167-72. (Pubitemid 27140029)
    • (1997) British Journal of Cancer , vol.75 , Issue.8 , pp. 1167-1172
    • Vukovic, V.1    Tannock, I.F.2
  • 36
    • 74149085146 scopus 로고    scopus 로고
    • INNO-206, the (6-maleimidocaproyl hydrazone derivative of doxorubicin), shows superior antitumor efficacy compared to doxorubicin in different tumor xenograft models and in an orthotopic pancreas carcinoma model
    • Graeser R, Esser N, Unger H, Fitchner I, Zhu A, Unger C, et al. INNO-206, the (6-maleimidocaproyl hydrazone derivative of doxorubicin), shows superior antitumor efficacy compared to doxorubicin in different tumor xenograft models and in an orthotopic pancreas carcinoma model. Invest New Drugs 2010;28:14-9.
    • (2010) Invest New Drugs , vol.28 , pp. 14-19
    • Graeser, R.1    Esser, N.2    Unger, H.3    Fitchner, I.4    Zhu, A.5    Unger, C.6
  • 37
    • 33847029969 scopus 로고    scopus 로고
    • Acute and repeat-dose toxicity studies of the (6-maleimidocaproyl) hydrazone derivative of doxorubicin (DOXO-EMCH), an albumin-binding prodrug of the anticancer agent doxorubicin
    • Kratz F, Ehling G, Kauffmann HM, Unger C. Acute and repeat-dose toxicity studies of the (6-maleimidocaproyl) hydrazone derivative of doxorubicin (DOXO-EMCH), an albumin-binding prodrug of the anticancer agent doxorubicin. Hum Exp Toxicol 2007;26:19-35.
    • (2007) Hum Exp Toxicol , vol.26 , pp. 19-35
    • Kratz, F.1    Ehling, G.2    Kauffmann, H.M.3    Unger, C.4
  • 38
    • 34548106304 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the (6-maleimidocaproyl)hydrazone derivative of doxorubicin
    • DOI 10.1158/1078-0432.CCR-06-2776
    • Unger C, Haring B, Medinger M, Drevs J, Steinbild S, Kratz F, et al. Phase 1 and pharmacokinetic study of the (6-maleimidocaproyl) hydrazone derivative of doxorubicin. Clin Cancer Res 2007;13: 4858-66. (Pubitemid 47294793)
    • (2007) Clinical Cancer Research , vol.13 , Issue.16 , pp. 4858-4866
    • Unger, C.1    Haring, B.2    Medinger, M.3    Drevs, J.4    Steinbild, S.5    Kratz, F.6    Mross, K.7
  • 39
    • 57349195605 scopus 로고    scopus 로고
    • Animal models of multiple myeloma and their utility in drug discovery
    • Unite 14.9. Hoboken, NJ: John Wiley & Sons, Inc.;
    • Campbell RA, Berenson JR. Animal models of multiple myeloma and their utility in drug discovery. In: Current protocols in pharmacology. Vol 40. Unite 14.9. Hoboken, NJ: John Wiley & Sons, Inc.; 2008. p. 14.9.1-14.9.22.
    • (2008) Current Protocols in Pharmacology , vol.40
    • Campbell, R.A.1    Berenson, J.R.2
  • 40
    • 0001363919 scopus 로고
    • Protein transfer in tumor-bearing rats
    • Babson AL, Winnick T. Protein transfer in tumor-bearing rats. Cancer Res 1954;14:606-11.
    • (1954) Cancer Res , vol.14 , pp. 606-611
    • Babson, A.L.1    Winnick, T.2
  • 41
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986;46:6387-92. (Pubitemid 17221789)
    • (1986) Cancer Research , vol.46 , Issue.12 I , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 42
    • 33846594736 scopus 로고    scopus 로고
    • The 6-maleimidocaproyl hydrazone derivative of doxorubicin (DOXO-EMCH) is superior to free doxorubicin with respect to cardiotoxicity and mitochondrial damage
    • DOI 10.1002/ijc.22409
    • Lebrecht D, Geist A, Ketelsen UP, Haberstroh J, Setzer B, Kratz F, et al. The 6-maleimidocaproyl hydrazone derivative of doxorubicin (DOXOEMCH) is superior to free doxorubicin with respect to cardiotoxicity and mitochondrial damage. Int J Cancer 2007;120:927-34. (Pubitemid 46175416)
    • (2007) International Journal of Cancer , vol.120 , Issue.4 , pp. 927-934
    • Lebrecht, D.1    Geist, A.2    Ketelsen, U.-P.3    Haberstroh, J.4    Setzer, B.5    Kratz, F.6    Walker, U.A.7
  • 43
    • 0021806570 scopus 로고
    • Experimental systemic toxicology of 4'-epidoxorubicin, a new, less cardiotoxic anthracycline antitumor agent
    • DOI 10.1016/0041-008X(85)90139-5
    • Bertazzoli C, Rovero C, Ballerini L, Lux B, Balconi F, Antongiovanni V. Experimental systemic toxicology of 40-epidoxorubicin, a new, less cardiotoxic anthracycline antitumor agent. Toxicol Appl Pharmacol 1985;79:412-22. (Pubitemid 15059421)
    • (1985) Toxicology and Applied Pharmacology , vol.79 , Issue.3 , pp. 412-422
    • Bertazzoli, C.1    Rovero, C.2    Ballerini, L.3
  • 46
    • 0027213484 scopus 로고
    • Arrest of human lung tumor xenograft growth in severe combined immunodeficient mice using doxorubicin encapsulated in sterically stabilized liposomes
    • Williams SS, Alosco TR, Mayhew E, Lasic DD, Martin FJ, Bankert RB. Arrest of human lung tumor xenograft growth in severe combined immunodeficient mice using doxorubicin encapsulated in sterically stabilized liposomes. Cancer Res 1993;53:3964-67. (Pubitemid 23267696)
    • (1993) Cancer Research , vol.53 , Issue.17 , pp. 3964-3967
    • Williams, S.S.1    Alosco, T.R.2    Mayhew, E.3    Lasic, D.D.4    Martin, F.J.5    Bankert, R.B.6
  • 47
    • 0016804136 scopus 로고
    • A clinical staging system for multiple myeloma: Correlation of measured myeloma cell mass with presenting clinical features, response to treatment and survival
    • Durie BG, Salmon SE. A clinical staging system for multiple myeloma: correlation of measured myeloma cell mass with presenting clinical features, response to treatment and survival. Cancer 1975; 36:842-54.
    • (1975) Cancer , vol.36 , pp. 842-854
    • Durie, B.G.1    Salmon, S.E.2
  • 48
    • 56949084877 scopus 로고    scopus 로고
    • Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles
    • Kratz F. Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. J Control Release 2008;32:171-83.
    • (2008) J Control Release , vol.32 , pp. 171-183
    • Kratz, F.1
  • 49
    • 77950788603 scopus 로고    scopus 로고
    • Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma
    • Cirstea D, Hideshima T, Rodig S, Santo L, Pozzi S, Vallet S, et al. Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma. Mol Cancer Ther 2010;9: 963-75.
    • (2010) Mol Cancer Ther , vol.9 , pp. 963-975
    • Cirstea, D.1    Hideshima, T.2    Rodig, S.3    Santo, L.4    Pozzi, S.5    Vallet, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.