Effects of acute treatment with dexamethasone on hemodynamic and histopathological changes in rats

Biotechnic and Histochemistry

Volumn 87, Issue 6, 2012, Pages 385-396

  Ekerbicer N ^a   Inan, S ^a   Tarakc F ^a   Barut, T ^a   Gurpnar T ^a   Ozbek, M ^a  

^a CELAL BAYAR UNIVERSITY   (Turkey)

Author keywords

Dexamethasone; Hemodynamic changes; Histopathologic changes; Immunoreactivity; Rat

Indexed keywords

DEXAMETHASONE; INTERLEUKIN 1BETA; NITRIC OXIDE SYNTHASE; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN A;

ANIMAL; ARTICLE; BLOOD PRESSURE; DRUG EFFECT; HEART RATE; HEMODYNAMICS; LUNG; MALE; METABOLISM; PATHOLOGY; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; BLOOD PRESSURE; DEXAMETHASONE; HEART RATE; HEMODYNAMICS; INTERLEUKIN-1BETA; LUNG; MALE; NITRIC OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ANIMALIA; RATTUS; TULIP BREAKING VIRUS;

EID: 84863960993     PISSN: 10520295     EISSN: 14737760     Source Type: Journal    
DOI: 10.3109/10520295.2012.672651     Document Type: Article

References (39)

1. Ata KA, Lennmyr F, Funa K, Olsson Y, Terent A (1999) Expression of transforming growth factor-beta 1, 2, 3 isoforms and type I and II receptors in acute focal cerebral ischemia: an immunohistochemical study in rat after transient and permanent occlusion of middle cerebral artery. Acta Neuropathol. (Berl.) 97: 447-455. (Pubitemid 29195107)
2. Besedovsky H, del Rey A, Sorkin E, Dinarello CA (1986) Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233: 652-654. (Pubitemid 16011614)
3. Bobadilla NA, Tapia E, Jim é nez F, S á nchez-Lozada LG, Santamar í a J, Monjard í n A, Bolio A, Gamba G, Herrera-Acosta J (1999) Dexamethasone increases eNOS gene expression and prevents renal vasoconstriction induced by cyclosporin. Am. J. Physiol. 277: F464-F471. (Pubitemid 29459659)
4. Brem AS, Bina RB, Mehta S, Marshall J (1999) Glucocorticoids inhibit the expression of calcium-dependent potassium channels in vascular smooth muscle. Mol. Gen. Metab. 67: 53-57. (Pubitemid 29393253)
5. Chaney MA, Nikolov MP, Blakeman BP, Bakhos M, Slogoff (1999) Hemodynamic effects of methylprednisolone in patients undergoing cardiac operation and early extubation. Ann. Thorac. Surg. 67: 1006-1011. (Pubitemid 29238288)
6. Clifton VL, Wallace EM, Smith R (2002) Shortterm effects of glucocorticoids in the human fetalplacental circulation in vitro. J. Clin. Endocrinol. Metab. 87: 2838-2842. (Pubitemid 34655352)
7. De Matteo R, May CN (1999) Inhibition of prostaglandin and nitric oxide synthesis prevents cortisol induced renal vasodilation in sheep. Am. J. Physiol. 276: R1125-R1131. (Pubitemid 29214186)
8. Dhandapani KM, Brann DW (2003) Transforming growth factor beta: a neuroprotective factor in cerebral ischemia. Cell Biochem. Biophys. 39: 13-22. (Pubitemid 41270804)
9. Dinarello CA (1984) Interleukin-1. Rev. Infect. Dis. 6: 51-95.
10. Guan J, Miller OT, Waugh KM, McCarthy DC, Gluckman PD, Gunn AJ (2004) TGF beta-1 and neurological function after hypoxia-ischemia in adult rats. Neuroreport 29: 961-964. (Pubitemid 38591243)
11. Gude NM, Rice GE, King RG, Boura AL, Brennecke SP (1990) Analysis of the responses of the fetal vessels of human perfused placental lobules to acute infusions of arachidonic acid. Reprod. Fertil. Dev. 2: 591-596. (Pubitemid 20373719)
12. Hafezi-Moghadam A, Simoncini T, Yang Z, Limbourg FP, Plumier JC, Rebsamen MC, Hsieh CM, Chui DS, Thomas KL, Prorock AJ, Laubach VE, Moskowitz MA, French BA, Ley K, Liao JK (2002) Acute cardiovascular protective effects of corticosteroids are mediated by nontranscriptional activation of endothelial nitric oxide synthase. Nature Med. 8: 473-479. (Pubitemid 34546749)
13. Hayashi T, Nakai T, Miyabo S (1991) Glucocorticoids increase Ca 2+ uptake and [3H]dihydropyridine binding in A7r5 vascular smooth muscle cells. Am. J. Physiol. 261: C106-C114.
14. Heiss JD, Papavassiliou E, Merrill MJ, Nieman L, Knightly JJ, Walbridge S, Edwards NA, Oldfi eld EH (1996) Mechanism of dexamethasone suppression of brain tumor-associated vascular permeability in rats. Involvement of the glucocorticoid receptor and vascular permeability factor. J. Clin. Invest. 98: 140-1408.
15. Herrera EA, Verkerk MM, Derks JB, Giussani DA (2010) Antioxidant treatment alters peripheral vascular dysfunction induced by postnatal glucocorticoid therapy in rats. PLoS One. 5:e9250.
16. Iwai A, Fujii Y, Kawakami S, Takazawa R, Kageyama Y, Yoshida MA, Kihara K (2004) Down-regulation of vascular endothelial growth factor in renal cell carcinoma cells by glucocorticoids. Molec. Cell. Endocrinol. 226: 11-17. (Pubitemid 39369818)
17. Kato H, Hayashi T, Koshino Y, Kutsumi Y, Nakai T (1992) Glucocorticoids increase Ca 2+ infl ux through dihydropyridine-sensitive channels linked to activation of protein kinase C in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 188: 934-941.
18. Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, Connolly DT (1989) Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246: 1309-1312. (Pubitemid 20066717)
19. Kluger MJ (1991) Fever: role of pyrogens and cryogens. Physiol. Rev. 71: 93-127.
20. Koedam JA, Smink JJ, van Buul-Offers SC (2002) Glucocorticoids inhibit vascular endothelial growth factor expression in growth plate chondrocytes. Molec. Cell. Endocrinol. 197: 35-44. (Pubitemid 35304775)
21. Koshino Y, Hayashi T, Matsukawa S, Asazuma K, Eguchi K, Kato H, Nakai T, Miyamori I (1998) Dexamethasone modulates the expression of endothelin-1 and-A receptors in A7r5 vascular smooth muscle cells. J. Cardiovasc. Pharmacol. 2: 665-672. (Pubitemid 28440971)
22. Lu YZ, Lin CH, Cheng FC, Hsueh CM (2005) Molecular mechanisms responsible for microglia-derived protection of Sprague-Dawley rat brain cells during in vitro ischemia. Neurosci. Lett. 373: 159-164.
23. Machein MR, Kullmer J, R ö nicke V, Machein U, Krieg M, Damert A, Breier G, Risau W, Plate KH (1999) Differential downregulation of vascular endothelial growth factor by dexamethasone in normoxic and hypoxic rat glioma cells. Neuropathol. Appl. Neurobiol. 25: 104-112. (Pubitemid 29221760)
24. Mangos G, Walker B, Kelly J, Lawson J, Webb D, Whitworth J (2000) Cortisol inhibits cholinergic vasodilation in the human forearm. Am. J. Hypertens. 13: 1155-1160.
25. Martinez G, Di Giacomo C, Sorrenti V, Carnazza ML, Ragusa N, Barcellona ML (2001) Fibroblast growth factor-2 and transforming growth factor-beta-1 immunostaining in rat brain after cerebral postischemic reperfusion. J. Neurosci. Res. 15: 136-142. (Pubitemid 32041864)
26. Mathewson AM, Wadsworth RM (2004) Induction of iNOS restricts functional activity of both eNOS and nNOS in pig cerebral artery. Nitric Oxide 11: 331-339. (Pubitemid 39626586)
27. Nishimura K, Nonomura N, Yasunaga Y, Takaha N, Inoue H, Sugao H, Yamaguchi S, Ukimura O, Miki T, Okuyama A (2000) Low doses of oral dexamethasone for hormone-refractory prostate carcinoma. Cancer 89: 2570-2576. (Pubitemid 32011601)
28. Ong SL, Zhang Y, Sutton M, Whitworth JA (2009) Hemodynamics of dexamethasone-induced hypertension in the rat. Hypertens. Res. 32: 889-894.
29. Rosenstock M, Katz S, Danon A (1997) Glucocorticoids regulate both phorbol ester and calcium ionophoreinduced endothelial prostacyclin synthesis. Prostagland. Leuk. Essen. Fatty Acids 56: 1-8. (Pubitemid 27073568)
30. Steiner A, Locher R, Sachinidis A, Vetter W (1989) Cortisol-stimulated phosphoinositide metabolism in vascular. J. Hypertens. Suppl. 7: S140-S141.
31. Storlie JA, Buckner JC, Wiseman GA, Burch PA, Hartmann LC, Richardson RL (1995) Prostate specifi c antigen levels and clinical response to low dose dexamethasone for hormone-refractory metastatic prostate carcinoma. Cancer 76: 96-100.
32. Takimoto K, Li D, Nerbonne JM, Levitan ES (1997) Distribution, splicing and glucocorticoid-induced expression of cardiac and voltage gated Ca 2+ channels. J. Mol. Cell. Cardiol. 29: 3035-3042. (Pubitemid 27510770)
33. Tatsuo Watanabe, Nobusuke Tan, Yukio Saiki, Toshirou Makisumi and Shoji Nakamura (1996) Possible involvement of glucocorticoids in the modulation of interleukin-1-induced cardiovascular responses in rats. J. Physiol. 491: 231-239.
34. Thiemermann C (1997) Nitric oxide and septic shock. Gen. Pharmacol. 29: 159-166. (Pubitemid 27312364)
35. Tillie-Leblond I, Pugin J, Marquette CH, Lamblin C, Saulnier F, Brichet A, Wallaert B, Tonnel AB, Gosset P (1999) Balance between proinfl ammatory cytokines and their inhibitors in bronchial lavage from patients with status asthmaticus. Am. J. Resp. Crit. Care Med. 159: 487-494. (Pubitemid 29084870)
36. Vivien D, Bernaudin M, Buisson A, Divoux D, MacKenzie ET, Nouvelot A (1998) Evidence of type I and type II transforming growth factor-beta receptors in central nervous tissues: changes induced by focal cerebral ischemia. J. Neurochem. 70: 2296-2304. (Pubitemid 28252355)
37. Wallace EM, Baker LS (1999) Effect of antenatal betamethasone administration on placental vascular resistance. Lancet 353: 1404-1407. (Pubitemid 29192413)
38. Whitworth JA, Brown MA, Kelly JJ, Williamson PM (1995) Experimental studies on cortisol-induced hypertension in humans. J. Hum. Hyperten. 9: 395-399.
39. Zhou H, Gao Y, Raj JU (1996) Antenatal betamethasone therapy augments nitric oxide-mediated relaxation of preterm ovine pulmonary veins. J. Appl. Physiol. 80:390-396. (Pubitemid 26061437)