Hemodynamics of dexamethasone-induced hypertension in the rat

Hypertension Research

Volumn 32, Issue 10, 2009, Pages 889-894

  Ong, Sharon Leng Hong ^a   Zhang, Yi ^a   Sutton, Matthew ^a   Whitworth, Judith Ann ^a  

^a Australian National University   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; MINOXIDIL; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOPPLER FLOWMETER; DRUG EFFECT; DRUG MECHANISM; HEART INDEX; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEMATOCRIT; HEMODYNAMIC MONITORING; HEMODYNAMICS; HYPERTENSION; KIDNEY CIRCULATION; MALE; MEAN ARTERIAL PRESSURE; MESENTERIC ARTERY; NONHUMAN; ORGAN WEIGHT; RAT; SYSTEMIC CIRCULATION; SYSTOLIC BLOOD PRESSURE; THYMUS WEIGHT; VASCULAR RESISTANCE; WEIGHT CHANGE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BODY FLUIDS; BODY WEIGHT; CARDIAC OUTPUT; DEXAMETHASONE; HEART RATE; HEMATOCRIT; HEMODYNAMICS; HYPERTENSION; LASER-DOPPLER FLOWMETRY; MALE; MINOXIDIL; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; STROKE VOLUME; THYMUS GLAND; VASCULAR RESISTANCE;

EID: 70349982086     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2009.118     Document Type: Article

References (25)

1. Ong SLH, Zhang Y, Whitworth JA. Mechanism of dexamethasone-induced hypertension. Curr Hypertens Rev 2009; 5: 61-74.
2. Whitworth JA, Gordon D, Andrews J, Scoggins BA. The hypertensive effect of synthetic glucocorticoids in man: Role of sodium and volume. J Hypertens 1989; 7: 537-549.
3. Macefield VG, Williamson PM, Wilson LR, Kelly JJ, Gandevia SC, Whitworth JA. Muscle sympathetic vasoconstrictor activity in hydrocortisone-induced hypertension in humans. Blood Press 1998; 7: 215-222.
4. Wallerath T, Godecke A, Molojavyi A, Li H, Schrader J, Forstermann U. Dexamethasone lacks effect on blood pressure in mice with a disrupted endothelial NO synthase gene. Nitric Oxide 2004; 10: 36-41.
5. Hu L, Zhang Y, Lim PS, Miao Y, Tan C, McKenzie KUS, Schyvens CG, Whitworth JA. Apocynin but not L-arginine prevents and reverses dexamethasone-induced hypertension in the rat. Am J Hypertens 2006; 19: 413-418.
6. Pirpiris M, Sudhir K, Yeung S, Jennings G, Whitworth JA. Pressor responsiveness in corticosteroid-induced hypertension in humans. Hypertension 1992; 19: 567-574.
7. Nakamoto H, Suzuki H, Kageyama Y, Ohishi A, Murakami M, Naitoh M, Saruta T. Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs. Clin Exp Hypertens A 1991; 13: 587-606.
8. Whitworth JA, Schyvens CG, Zhang Y, Mangos GJ, Kelly JJ. Glucocorticoid-induced hypertension: From mouse to man. Clin Exp Pharmacol Physiol 2001; 28: 993-996.
9. Whitworth JA, Zhang Y, Mangos G, Kelly JJ. Species variability in cardiovascular research: The example of adrenocorticotrophin-induced hypertension. Clin Exp Pharmacol Physiol 2006; 33: 887-891.
10. Wen C, Li M, Whitworth JA. Validation of transonic small animal flowmeter for measurement of cardiac output and regional blood flow in the rat. J Cardiovasc Pharmacol 1996; 27: 482-486.
11. Wen C, Fraser T, Li M, Turner SW, Whitworth JA. Haemodynamic mechanisms of corticotropin (ACTH)-induced hypertension in the rat. J Hypertens 1999; 17: 1715-1723.
12. Nakamoto H, Suzuki H, Kageyama Y, Murakami M, Naitoh M, Saruta T. Central nervous system mediates an antihypertensive property in glucocorticoid hypertension in dogs. J Hypertens 1995; 13: 1169-1179.
13. Tonolo G, Fraser R, Connell JM, Kenyon CJ. Chronic low-dose infusions of dexamethasone in rats: Effects on blood pressure, body weight and plasma atrial natriuretic peptide. J Hypertens 1988; 6: 25-31.
14. Mangos G, Walker B, Williamson P, Whitworth J, Kelly J. Effect of synthetic corticosteroids on vascular reactivity in the human forearm. Clin Exp Hypertens 2006; 28: 707-718.
15. Wallerath T, Witte K, Schafer SC, Schwarz PM, Prellwitz W, Wohlfart P, Kleinert H, Lehr H-A, Lemmer B, Forstermann U. Down-regulation of the expression of endothelial NO synthase is likely to contribute to glucocorticoid-mediated hypertension. Proc Natl Acad Sci USA 1999; 96: 13357-13362.
16. Handa M, Kondo K, Suzuki H, Saruta T. Dexamethasone hypertension in rats: Role of prostaglandins and pressor sensitivity to norepinephrine. Hypertension 1984; 6: 236-241.
17. Gardiner SM, Kemp PA, March JE, Bennett T. Effects of dexamethasone and SB 209670 on the regional haemodynamic responses to lipopolysaccharide in conscious rats. Br J Pharmacol 1996; 118: 141-149.
18. Chabria NL, Gaitonde BB. Effect of dexamethasone on urine output and electrolyte excretion in rats. Arch Int Pharmacodyn Ther 1966; 162: 364-370.
19. Fraser TB, Turner SW, Mangos GJ, Ludbrook J, Whitworth JA. Comparison of telemetric and tail-cuff blood pressure monitoring in adrenocorticotrophic hormone-treated rats. Clin Exp Pharmacol Physiol 2001; 28: 831-835.
20. Janssen BJA, De Celle T, Debets JJM, Brouns AE, Callahan MF, Smith TL. Effects of anesthetics on systemic hemodynamics in mice. Am J Physiol Heart Circ Physiol 2004; 287: H1618-H1624.
21. Koeppen BM, Katz AI, Lindheimer MD. Effect of general anaesthesia on renal haemodynamics in the rat. Clin Sci (Lond) 1979; 57: 469-471.
22. Sellden H, Sjovall H, Ricksten SE. Sympathetic nerve activity and central haemodynamics during mechanical ventilation with positive end-expiratory pressure in rats. Acta Physiol Scand 1986; 127 51-60.
23. Leenen FH, Prowse S. Time-course of changes in cardiac hypertrophy and pressor mechanisms in two-kidney, one clip hypertensive rats during treatment with minoxidil, enalapril or after uninephrectomy. J Hypertens 1987; 5: 73-83.
24. Tsoporis J, Fields N, Lee RM, Leenen FH. Arterial vasodilation and cardiovascular structural changes in normotensive rats. Am J Physiol Heart Circ Physiol 1991; 260: H1944-H1952.
25. Sanz E, Lopez Novoa JM, Linares M, Digiuni E, Caramelo CA. Intravascular and interstitial fluid dynamics in rats treated with minoxidil. J Cardiovasc Pharmacol 1990; 15: 485-492.