Metabolic activation and major protein target of a 1-benzyl-3- carboxyazetidine sphingosine-1-phosphate-1 receptor agonist

Chemical Research in Toxicology

Volumn 25, Issue 7, 2012, Pages 1412-1422

  Aloysius, Herve ^a   Tong, Vincent W ^a   Yabut, Jocelyn ^a   Bradley, Scott A ^a,b   Shang, Jackie ^a   Zou, Yan ^a   Tschirret Guth, Richard A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [4 [(4 PHENYL 5 TRIFLUOROMETHYL 2 THIENYL)METHOXY]BENZYL]AZETIDINE 3 CARBOXYLIC ACID; 1 AMINOBENZOTRIAZOLE; ACYL COENZYME A; AMINO ACID; AZETIDINE; CARBOXYLIC ACID DERIVATIVE; CYSTEINE; IMINE; IMMUNOSUPPRESSIVE AGENT; LIVER PROTEIN; LONG CHAIN FATTY ACID COENZYME A LIGASE; LYSINE; PROTEIN; PROTEIN HYDROLYSATE; SERINE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONJUGATE; CONTROLLED STUDY; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG TISSUE LEVEL; ENZYME ACTIVITY; FATTY ACID OXIDATION; HETERONUCLEAR MULTIPLE BOND CORRELATION; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER HOMOGENATE; MALE; MASS SPECTROMETRY; METABOLIC ACTIVATION; MICROSOME; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN TARGETING; PROTON NUCLEAR MAGNETIC RESONANCE; RADIOACTIVITY; RAT; ULTRAVIOLET SPECTROSCOPY;

ADMINISTRATION, ORAL; ANIMALS; AZETIDINES; BIOTRANSFORMATION; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEPATOCYTES; HUMANS; ISOTOPE LABELING; KIDNEY; LIVER; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; PEPTIDES; PROTEINS; RATS; RECEPTORS, LYSOSPHINGOLIPID; THIOPHENES;

RATTUS;

EID: 84863959036     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx300017s     Document Type: Article

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