Overexpression of scavenger receptor LOX-1 in endothelial cells promotes atherogenesis in the ApoE -/- mouse model

Cardiovascular Pathology

Volumn 20, Issue 6, 2011, Pages 369-373

  White, Stephen J ^a   Sala Newby, Graciela B ^a   Newby, Andrew C ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Atherogenesis; LOX 1; LOXIN; OLR1; Splice variant

Indexed keywords

ADENOVIRUS VECTOR; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1 LOXIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; CAROTID ATHEROSCLEROSIS; COMMON CAROTID ARTERY; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; IMMUNOHISTOCHEMISTRY; LIPID DIET; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOVIRIDAE; ANIMALS; APOLIPOPROTEINS E; CAROTID ARTERY DISEASES; CAROTID ARTERY, COMMON; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FEMALE; GENETIC VECTORS; HYPERLIPIDEMIAS; MICE; MICE, KNOCKOUT; SCAVENGER RECEPTORS, CLASS E; TIME FACTORS; TRANSDUCTION, GENETIC; UP-REGULATION;

EID: 80054911616     PISSN: 10548807     EISSN: 18791336     Source Type: Journal    
DOI: 10.1016/j.carpath.2010.08.007     Document Type: Article

References (21)

1. Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, and Aiba Y An endothelial receptor for oxidised low-density lipoprotein Nature 386 1997 73 77 (Pubitemid 27130922)
2. Kataoka H, Kume N, Miyamoto S, Minami M, Moriwaki H, and Murase T Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions Circulation 99 24 1999 3110 3117 (Pubitemid 29289075)
3. Chui PC, Guan HP, Lehrke M, and Lazar MA PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1 J Clin Invest 115 8 2005 2244 2256 (Pubitemid 41134167)
4. Kakutani M, Masaki T, and Sawamura T A platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1 Proc Natl Acad Sci U S A 97 1 2000 360 364 (Pubitemid 30055836)
5. Akagi M, Nishimura S, Yoshida K, Kakinuma T, Sawamura T, and Munakata H Cyclic tensile stretch load and oxidized low density lipoprotein synergistically induce lectin-like oxidized LDL receptor-1 in cultured bovine chondrocytes, resulting in decreased cell viability and proteoglycan synthesis J Orthop Res 24 8 2006 1782 1790 (Pubitemid 44203310)
6. Mehta JL, Chen J, Hermonat PL, Romeo F, and Novelli G Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders Cardiovasc Res 69 1 2006 36 45 (Pubitemid 41814809)
7. Oka K, Sawamura T, Kikuta K-I, Itokawa S, Kume N, and Kita T Lectin-like oxidised low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells Proc Natl Acad Sci U S A 95 1998 9535 9540 (Pubitemid 28506266)
8. Hayashida K, Kume N, Minami M, and Kita T Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) supports adhesion of leukocytes under both static and flow conditions Circulation 104 17 2001 443
9. Cominacini L, Pasini AF, Garbin U, Davoli A, Tosetti ML, and Campagnola M Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species J Biol Chem 275 17 2000 12633 12638 (Pubitemid 30241412)
10. Morawietz H LOX-1 and atherosclerosis: proof of concept in LOX-1-knockout mice Circ Res 100 11 2007 1534 1536 (Pubitemid 46897254)
11. Mehta JL, Sanada N, Hu CP, Chen J, Dandapat A, and Sugawara F Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet Circ Res 100 11 2007 1634 1642 (Pubitemid 46897266)
12. Inoue K, Arai Y, Kurihara H, Kita T, and Sawamura T Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice Circ Res 97 2 2005 176 184 (Pubitemid 41033474)
13. Ishigaki Y, Katagiri H, Gao J, Yamada T, Imai J, and Uno K Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis Circulation 118 1 2008 75 83
14. Mango R, Biocca S, del Vecchio F, Clementi F, Sangiuolo F, and Amati F In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction Circ Res 97 2 2005 152 158 (Pubitemid 41033471)
15. Biocca S, Filesi I, Mango R, Maggiore L, Baldini F, and Vecchione L The splice variant LOXIN inhibits LOX-1 receptor function through hetero-oligomerization J Mol Cell Cardiol 44 3 2008 561 570
16. Wilkinson GWG, and Akrigg A Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector Nucleic Acids Res 20 1992 2233 2239
17. -/- mice Faseb Journal 15 12 2001 U19 U37
18. Pajusola K, Gruchala M, Joch H, Luscher TF, Yla-Herttuala S, and Bueler H Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection of endothelial cells J Virol 76 22 2002 11530 11540 (Pubitemid 35231309)
19. Chen M, Kakutani M, Minami M, Kataoka H, Kume N, and Narumiya S Increased expression of lectinlike oxidised low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits Arterioscler Thromb Vasc Biol 20 2000 1107 1115 (Pubitemid 30207590)
20. Neish AS, Williams AJ, Palmer HJ, Whitley MZ, and Collins T Functional-analysis of the human vascular cell-adhesion molecule-1 promoter J Exp Med 176 6 1992 1583 1593
21. Cybulsky MI, Iiyama K, Li H, Zhu S, Chen M, and Iiyama M A major role for VCAM-1, but not ICAM-1, in early atherosclerosis J Clin Invest 107 10 2001 1255 1262 (Pubitemid 32494542)