Transient opening of the perineurial barrier for analgesic drug delivery

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 29, 2012, Pages

  Hackel, Dagmar ^a,b   Krug, Susanne M ^b   Sauer, Reine Solange ^a   Mousa, Shaaban A ^b   Böcker, Alexander ^a   Pflücke, Diana ^a   Wrede, Esther Johanna ^b   Kistner, Katrin ^c   Hoffmann, Tali ^c   Niedermirtl, Benedikt ^a   Sommer, Claudia ^a   Bloch, Laura ^d   Huber, Otmar ^d   Blasig, Ingolf E ^e   Amasheh, Salah ^b   Reeh, Peter W ^c   Fromm, Michael ^b   Brack, Alexander ^a,b   Rittner, Heike L ^a,b  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^e LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

Blood nerve barrier; C fiber; Regional anesthesia; Two path impedance spectroscopy

Indexed keywords

ANTINOCICEPTIVE AGENT; BUPIVACAINE; CALCITONIN GENE RELATED PEPTIDE; CLAUDIN 1; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GELATINASE B; HEMOPEXIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; POLYETHYLENEIMINE; PROTOXIN; SMALL INTERFERING RNA; SODIUM CHANNEL NAV1.7; SODIUM CHLORIDE;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD NERVE BARRIER; CONTROLLED STUDY; DOWN REGULATION; DRUG DELIVERY SYSTEM; ENZYME ACTIVATION; INFLAMMATION; MALE; MOTOR DYSFUNCTION; NERVE SHEATH; NONHUMAN; PERINEURIUM; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; SCIATIC NERVE; TIGHT JUNCTION;

ANALGESICS; ANIMALS; BLOTTING, WESTERN; DIELECTRIC SPECTROSCOPY; DRUG DELIVERY SYSTEMS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; MATRIX METALLOPROTEINASE 9; MEMBRANE PROTEINS; PAIN THRESHOLD; PERIPHERAL NERVES; PHOSPHORYLATION; RATS; RNA, SMALL INTERFERING; SALINE SOLUTION, HYPERTONIC;

RATTUS;

EID: 84863938267     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1120800109     Document Type: Article

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