The tetrodotoxin-resistant Na+ channel Nav 1.8 reduces the potency of local anesthetics in blocking C-fiber nociceptors

Pflugers Archiv European Journal of Physiology

Volumn 459, Issue 5, 2010, Pages 751-763

  Kistner, Katrin ^a   Zimmermann, Katharina ^a   Ehnert, Corina ^b   Reeh, Peter W ^a   Leffler, Andreas ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Pain lidocaine neuropathic pain; Sensory neuron; Sodium channel; Tetrodotoxin

Indexed keywords

LIDOCAINE; LOCAL ANESTHETIC AGENT; SODIUM CHANNEL BLOCKING AGENT; SODIUM CHANNEL NAV1.8; TETRODOTOXIN;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; COLD EXPOSURE; CONTROLLED STUDY; DRUG MECHANISM; HYPERPOLARIZATION; KNOCKOUT MOUSE; MOUSE; NOCICEPTIVE RECEPTOR; NONHUMAN; PATCH CLAMP; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSORY NERVE CELL; SKIN NERVE; SODIUM CURRENT; SPINAL GANGLION; WILD TYPE;

ANESTHETICS, LOCAL; ANIMALS; LIDOCAINE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NOCICEPTORS; SODIUM CHANNELS; TETRODOTOXIN;

EID: 77950953931     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-010-0785-5     Document Type: Article

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