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Volumn 6, Issue 1, 2012, Pages 146-155

The function of SPARC as a mediator of fibrosis

Author keywords

Collagen; Disease; Extracellular matrix; Matricellular protein

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA CATENIN; BLEOMYCIN; MEDIATOR COMPLEX; MESSENGER RNA; OSTEONECTIN; SMALL INTERFERING RNA;

EID: 84863922620     PISSN: None     EISSN: 18743129     Source Type: Journal    
DOI: 10.2174/1874312901206010146     Document Type: Review
Times cited : (71)

References (64)
  • 1
    • 0036775425 scopus 로고    scopus 로고
    • Matricellular proteins: Extracellular modulators of cell function
    • Bornstein P, Sage EH. Matricellular proteins: extracellular modulators of cell function. Curr Opin Cell Biol 2002; 14(5): 608-16.
    • (2002) Curr Opin Cell Biol , vol.14 , Issue.5 , pp. 608-616
    • Bornstein, P.1    Sage, E.H.2
  • 2
    • 0024617070 scopus 로고
    • SPARC: A Ca2+-binding extracellular protein associated with endothelial cell injury and proliferation
    • Sage H, Decker J, Funk S, Chow M. SPARC: a Ca2+-binding extracellular protein associated with endothelial cell injury and proliferation. J Mol Cell Cardiol 1989; 21 (Suppl 1): 13-22.
    • (1989) J Mol Cell Cardiol , vol.21 , Issue.SUPPL. 1 , pp. 13-22
    • Sage, H.1    Decker, J.2    Funk, S.3    Chow, M.4
  • 3
    • 0025808612 scopus 로고
    • Regulation of the expression of a secreted acidic protein rich in cysteine (SPARC) in human fibroblasts by transforming growth factor beta. Comparison of transcriptional and post-transcriptional control with fibronectin and type I collagen
    • Wrana JL, Overall CM, Sodek J. Regulation of the expression of a secreted acidic protein rich in cysteine (SPARC) in human fibroblasts by transforming growth factor beta. Comparison of transcriptional and post-transcriptional control with fibronectin and type I collagen. Eur J Biochem 1991; 197(2): 519-28.
    • (1991) Eur J Biochem , vol.197 , Issue.2 , pp. 519-528
    • Wrana, J.L.1    Overall, C.M.2    Sodek, J.3
  • 4
    • 79960239007 scopus 로고    scopus 로고
    • SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-beta1 activity
    • Rivera LB, Brekken RA. SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-beta1 activity. J Cell Biol 2011; 193(7): 1305-19.
    • (2011) J Cell Biol , vol.193 , Issue.7 , pp. 1305-1319
    • Rivera, L.B.1    Brekken, R.A.2
  • 5
    • 0028915961 scopus 로고
    • SPARC, an extracellular matrix glycoprotein containing the follistatin module, is expressed by astrocytes in synaptic enriched regions of the adult brain
    • Mendis DB, Malaval L, Brown IR. SPARC, an extracellular matrix glycoprotein containing the follistatin module, is expressed by astrocytes in synaptic enriched regions of the adult brain. Brain Res 1995; 676(1): 69-79.
    • (1995) Brain Res , vol.676 , Issue.1 , pp. 69-79
    • Mendis, D.B.1    Malaval, L.2    Brown, I.R.3
  • 6
    • 0027099860 scopus 로고
    • Comparison of gene expression of extracellular matrix molecules in brain microvascular endothelial cells and astrocytes
    • Webersinke G, Bauer H, Amberger A, Zach O, Bauer HC. Comparison of gene expression of extracellular matrix molecules in brain microvascular endothelial cells and astrocytes. Biochem Biophys Res Commun 1992; 189(2): 877-84.
    • (1992) Biochem Biophys Res Commun , vol.189 , Issue.2 , pp. 877-884
    • Webersinke, G.1    Bauer, H.2    Amberger, A.3    Zach, O.4    Bauer, H.C.5
  • 7
    • 0031965271 scopus 로고    scopus 로고
    • SPARC is expressed by ganglion cells and astrocytes in bovine retina
    • Yan Q, Sage EH, Hendrickson AE. SPARC is expressed by ganglion cells and astrocytes in bovine retina. J Histochem Cytochem 1998; 46(1): 3-10.
    • (1998) J Histochem Cytochem , vol.46 , Issue.1 , pp. 3-10
    • Yan, Q.1    Sage, E.H.2    Hendrickson, A.E.3
  • 8
    • 0023374396 scopus 로고
    • In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization
    • Holland PW, Harper SJ, McVey JH, Hogan BL. In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization. J Cell Biol 1987; 105(1): 473-82.
    • (1987) J Cell Biol , vol.105 , Issue.1 , pp. 473-482
    • Holland, P.W.1    Harper, S.J.2    McVey, J.H.3    Hogan, B.L.4
  • 10
    • 81255214580 scopus 로고    scopus 로고
    • SPARC oppositely regulates inflammation and fibrosis in bleomycin-induced lung damage
    • Sangaletti S, Tripodo C, Cappetti B, et al. SPARC oppositely regulates inflammation and fibrosis in bleomycin-induced lung damage. Am J Pathol 2011; 179(6): 3000-10.
    • (2011) Am J Pathol , vol.179 , Issue.6 , pp. 3000-3010
    • Sangaletti, S.1    Tripodo, C.2    Cappetti, B.3
  • 11
    • 0024395113 scopus 로고
    • SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix
    • Sage H, Vernon RB, Funk SE, Everitt EA, Angello J. SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix. J Cell Biol 1989; 109(1): 341-56.
    • (1989) J Cell Biol , vol.109 , Issue.1 , pp. 341-356
    • Sage, H.1    Vernon, R.B.2    Funk, S.E.3    Everitt, E.A.4    Angello, J.5
  • 12
    • 0141541761 scopus 로고    scopus 로고
    • SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system
    • Schiemann BJ, Neil JR, Schiemann WP. SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system. Mol Biol Cell 2003; 14(10): 3977-88.
    • (2003) Mol Biol Cell , vol.14 , Issue.10 , pp. 3977-3988
    • Schiemann, B.J.1    Neil, J.R.2    Schiemann, W.P.3
  • 13
    • 0036151842 scopus 로고    scopus 로고
    • Inhibition of PDGF-stimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors
    • Motamed K, Funk SE, Koyama H, Ross R, Raines EW, Sage EH. Inhibition of PDGF-stimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors. J Cell Biochem 2002; 84(4): 759-71.
    • (2002) J Cell Biochem , vol.84 , Issue.4 , pp. 759-771
    • Motamed, K.1    Funk, S.E.2    Koyama, H.3    Ross, R.4    Raines, E.W.5    Sage, E.H.6
  • 14
    • 9244265468 scopus 로고    scopus 로고
    • SPARC is expressed by mesangial cells in experimental mesangial proliferative nephritis and inhibits platelet-derived-growth-factor-medicated mesangial cell proliferation in vitro
    • Pichler RH, Bassuk JA, Hugo C, et al. SPARC is expressed by mesangial cells in experimental mesangial proliferative nephritis and inhibits platelet-derived-growth-factor-medicated mesangial cell proliferation in vitro. Am J Pathol 1996; 148(4): 1153-67.
    • (1996) Am J Pathol , vol.148 , Issue.4 , pp. 1153-1167
    • Pichler, R.H.1    Bassuk, J.A.2    Hugo, C.3
  • 15
    • 0032536897 scopus 로고    scopus 로고
    • Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40/SPARC/osteonectin
    • Sasaki T, Hohenester E, Gohring W, Timpl R. Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40/SPARC/osteonectin. EMBO J 1998; 17(6): 1625-34.
    • (1998) EMBO J , vol.17 , Issue.6 , pp. 1625-1634
    • Sasaki, T.1    Hohenester, E.2    Gohring, W.3    Timpl, R.4
  • 16
    • 71049118163 scopus 로고    scopus 로고
    • Crystallographic insight into collagen recognition by discoidin domain receptor 2
    • Carafoli F, Bihan D, Stathopoulos S, et al. Crystallographic insight into collagen recognition by discoidin domain receptor 2. Structure 2009; 17(12): 1573-81.
    • (2009) Structure , vol.17 , Issue.12 , pp. 1573-1581
    • Carafoli, F.1    Bihan, D.2    Stathopoulos, S.3
  • 18
    • 34547575826 scopus 로고    scopus 로고
    • SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts
    • Rentz TJ, Poobalarahi F, Bornstein P, Sage EH, Bradshaw AD. SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts. J Biol Chem 2007; 282(30): 22062-71.
    • (2007) J Biol Chem , vol.282 , Issue.30 , pp. 22062-22071
    • Rentz, T.J.1    Poobalarahi, F.2    Bornstein, P.3    Sage, E.H.4    Bradshaw, A.D.5
  • 19
    • 0033527654 scopus 로고    scopus 로고
    • SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells
    • Francki A, Bradshaw AD, Bassuk JA, Howe CC, Couser WG, Sage EH. SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells. J Biol Chem 1999; 274(45): 32145-52.
    • (1999) J Biol Chem , vol.274 , Issue.45 , pp. 32145-32152
    • Francki, A.1    Bradshaw, A.D.2    Bassuk, J.A.3    Howe, C.C.4    Couser, W.G.5    Sage, E.H.6
  • 20
    • 12344316708 scopus 로고    scopus 로고
    • Small interfering RNA inhibition of SPARC attenuates the profibrotic effect of transforming growth factor beta1 in cultured normal human fibroblasts
    • Zhou X, Tan FK, Guo X, et al. Small interfering RNA inhibition of SPARC attenuates the profibrotic effect of transforming growth factor beta1 in cultured normal human fibroblasts. Arthritis Rheum 2005; 52(1): 257-61.
    • (2005) Arthritis Rheum , vol.52 , Issue.1 , pp. 257-261
    • Zhou, X.1    Tan, F.K.2    Guo, X.3
  • 21
    • 0031737501 scopus 로고    scopus 로고
    • SPARC deficiency leads to early-onset cataractogenesis
    • Norose K, Clark JI, Syed NA, et al. SPARC deficiency leads to early-onset cataractogenesis. Invest Ophthalmol Vis Sci 1998; 39(13): 2674-80.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , Issue.13 , pp. 2674-2680
    • Norose, K.1    Clark, J.I.2    Syed, N.A.3
  • 22
    • 0037791886 scopus 로고    scopus 로고
    • SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strength
    • Bradshaw AD, Puolakkainen P, Dasgupta J, Davidson JM, Wight TN, Helene SE. SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strength. J Invest Dermatol 2003; 120(6): 949-55.
    • (2003) J Invest Dermatol , vol.120 , Issue.6 , pp. 949-955
    • Bradshaw, A.D.1    Puolakkainen, P.2    Dasgupta, J.3    Davidson, J.M.4    Wight, T.N.5    Helene, S.E.6
  • 23
  • 24
    • 59849090694 scopus 로고    scopus 로고
    • Pressure overloadinduced alterations in fibrillar collagen content and myocardial diastolic function: Role of secreted protein acidic and rich in cysteine (SPARC) in post-synthetic procollagen processing
    • Bradshaw AD, Baicu CF, Rentz TJ, et al. Pressure overloadinduced alterations in fibrillar collagen content and myocardial diastolic function: role of secreted protein acidic and rich in cysteine (SPARC) in post-synthetic procollagen processing. Circulation 2009; 119(2): 269-80.
    • (2009) Circulation , vol.119 , Issue.2 , pp. 269-280
    • Bradshaw, A.D.1    Baicu, C.F.2    Rentz, T.J.3
  • 25
    • 74949090210 scopus 로고    scopus 로고
    • Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: Role of SPARC in post-synthetic procollagen processing
    • Bradshaw AD, Baicu CF, Rentz TJ, Van Laer AO, Bonnema DD, Zile MR. Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing. Am J Physiol Heart Circ Physiol 2010; 298(2): H614-22.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298 , Issue.2
    • Bradshaw, A.D.1    Baicu, C.F.2    Rentz, T.J.3    Van Laer, A.O.4    Bonnema, D.D.5    Zile, M.R.6
  • 26
    • 77957299067 scopus 로고    scopus 로고
    • SPARC/osteonectin Functions to Maintain Homeostasis of the Collagenous Extracellular Matrix in the Periodontal Ligament
    • Trombetta JM, Bradshaw AD. SPARC/osteonectin Functions to Maintain Homeostasis of the Collagenous Extracellular Matrix in the Periodontal Ligament. J Histochem Cytochem 2010; 58(10): 871-9.
    • (2010) J Histochem Cytochem , vol.58 , Issue.10 , pp. 871-879
    • Trombetta, J.M.1    Bradshaw, A.D.2
  • 27
    • 77649274059 scopus 로고    scopus 로고
    • Cardiac extracellular matrix remodeling: Fibrillar collagens and secreted protein acidic and rich in cysteine (SPARC)
    • McCurdy S, Baicu CF, Heymans S, Bradshaw AD. Cardiac extracellular matrix remodeling: fibrillar collagens and secreted protein acidic and rich in cysteine (SPARC). J Mol Cell Cardiol 2010; 48(3): 544-9.
    • (2010) J Mol Cell Cardiol , vol.48 , Issue.3 , pp. 544-549
    • McCurdy, S.1    Baicu, C.F.2    Heymans, S.3    Bradshaw, A.D.4
  • 29
    • 75849141781 scopus 로고    scopus 로고
    • Modulation of matrix remodeling by SPARC in neoplastic progression
    • Chlenski A, Cohn SL. Modulation of matrix remodeling by SPARC in neoplastic progression. Semin Cell Dev Biol 2010; 21(1): 55-65.
    • (2010) Semin Cell Dev Biol , vol.21 , Issue.1 , pp. 55-65
    • Chlenski, A.1    Cohn, S.L.2
  • 30
    • 0028792096 scopus 로고
    • Immunolocalization of SPARC, tenascin, and thrombospondin in pulmonary fibrosis
    • Kuhn C, Mason RJ. Immunolocalization of SPARC, tenascin, and thrombospondin in pulmonary fibrosis. Am J Pathol 1995; 147(6): 1759-69.
    • (1995) Am J Pathol , vol.147 , Issue.6 , pp. 1759-1769
    • Kuhn, C.1    Mason, R.J.2
  • 31
    • 77950896262 scopus 로고    scopus 로고
    • SPARC suppresses apoptosis of idiopathic pulmonary fibrosis fibroblasts through constitutive activation of beta-catenin
    • Chang W, Wei K, Jacobs SS, Upadhyay D, Weill D, Rosen GD. SPARC suppresses apoptosis of idiopathic pulmonary fibrosis fibroblasts through constitutive activation of beta-catenin. J Biol Chem 2010; 285(11): 8196-206.
    • (2010) J Biol Chem , vol.285 , Issue.11 , pp. 8196-8206
    • Chang, W.1    Wei, K.2    Jacobs, S.S.3    Upadhyay, D.4    Weill, D.5    Rosen, G.D.6
  • 32
    • 0032887716 scopus 로고    scopus 로고
    • Collagen accumulation is decreased in SPARC-null mice with bleomycininduced pulmonary fibrosis
    • Strandjord TP, Madtes DK, Weiss DJ, Sage EH. Collagen accumulation is decreased in SPARC-null mice with bleomycininduced pulmonary fibrosis. Am J Physiol 1999; 277(3 Pt 1): L628-35.
    • (1999) Am J Physiol , vol.277 , Issue.3 PART 1
    • Strandjord, T.P.1    Madtes, D.K.2    Weiss, D.J.3    Sage, E.H.4
  • 33
  • 34
    • 77950528143 scopus 로고    scopus 로고
    • Attenuation of fibrosis in vitro and in vivo with SPARC siRNA
    • Wang JC, Lai S, Guo X, et al. Attenuation of fibrosis in vitro and in vivo with SPARC siRNA. Arthritis Res Ther 2010; 12(2): R60.
    • (2010) Arthritis Res Ther , vol.12 , Issue.2
    • Wang, J.C.1    Lai, S.2    Guo, X.3
  • 35
    • 0036435916 scopus 로고    scopus 로고
    • Localization of SPARC in developing, mature, and chronically injured human allograft kidneys
    • Alpers CE, Hudkins KL, Segerer S, et al. Localization of SPARC in developing, mature, and chronically injured human allograft kidneys. Kidney Int 2002; 62(6): 2073-86.
    • (2002) Kidney Int , vol.62 , Issue.6 , pp. 2073-2086
    • Alpers, C.E.1    Hudkins, K.L.2    Segerer, S.3
  • 36
    • 0033838265 scopus 로고    scopus 로고
    • Secreted protein acidic and rich in cysteine (SPARC) in patients with diabetic nephropathy and tubulointerstitial injury
    • Kanauchi M, Nishioka M, Dohi K. Secreted protein acidic and rich in cysteine (SPARC) in patients with diabetic nephropathy and tubulointerstitial injury. Diabetologia 2000; 43(8): 1076-7.
    • (2000) Diabetologia , vol.43 , Issue.8 , pp. 1076-1077
    • Kanauchi, M.1    Nishioka, M.2    Dohi, K.3
  • 37
    • 10544241188 scopus 로고    scopus 로고
    • SPARC is expressed in renal interstitial fibrosis and in renal vascular injury
    • Pichler RH, Hugo C, Shankland SJ, et al. SPARC is expressed in renal interstitial fibrosis and in renal vascular injury. Kidney Int 1996; 50(6): 1978-89.
    • (1996) Kidney Int , vol.50 , Issue.6 , pp. 1978-1989
    • Pichler, R.H.1    Hugo, C.2    Shankland, S.J.3
  • 38
    • 0030728133 scopus 로고    scopus 로고
    • Secreted protein acidic and rich in cysteine expression after subtotal nephrectomy and blockade of the renin-angiotensin system
    • Wu LL, Cox A, Roe CJ, Dziadek M, Cooper ME, Gilbert RE. Secreted protein acidic and rich in cysteine expression after subtotal nephrectomy and blockade of the renin-angiotensin system. J Am Soc Nephrol 1997; 8(9): 1373-82.
    • (1997) J Am Soc Nephrol , vol.8 , Issue.9 , pp. 1373-1382
    • Wu, L.L.1    Cox, A.2    Roe, C.J.3    Dziadek, M.4    Cooper, M.E.5    Gilbert, R.E.6
  • 39
    • 35348852466 scopus 로고    scopus 로고
    • Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension
    • Socha MJ, Manhiani M, Said N, Imig JD, Motamed K. Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension. Am J Pathol 2007; 171(4): 1104-12.
    • (2007) Am J Pathol , vol.171 , Issue.4 , pp. 1104-1112
    • Socha, M.J.1    Manhiani, M.2    Said, N.3    Imig, J.D.4    Motamed, K.5
  • 40
    • 65649088692 scopus 로고    scopus 로고
    • SPARC accelerates disease progression in experimental crescentic glomerulonephritis
    • Sussman AN, Sun T, Krofft RM, Durvasula RV. SPARC accelerates disease progression in experimental crescentic glomerulonephritis. Am J Pathol 2009; 174(5): 1827-36.
    • (2009) Am J Pathol , vol.174 , Issue.5 , pp. 1827-1836
    • Sussman, A.N.1    Sun, T.2    Krofft, R.M.3    Durvasula, R.V.4
  • 41
    • 0037378070 scopus 로고    scopus 로고
    • Amelioration of diabetic nephropathy in SPARC-null mice
    • Taneda S, Pippin JW, Sage EH, et al. Amelioration of diabetic nephropathy in SPARC-null mice. J Am Soc Nephrol 2003; 14(4): 968-80.
    • (2003) J Am Soc Nephrol , vol.14 , Issue.4 , pp. 968-980
    • Taneda, S.1    Pippin, J.W.2    Sage, E.H.3
  • 43
    • 0030982436 scopus 로고    scopus 로고
    • Osteonectin (SPARC) expression in human liver and in cultured human liver myofibroblasts
    • Blazejewski S, Le Bail B, Boussarie L, et al. Osteonectin (SPARC) expression in human liver and in cultured human liver myofibroblasts. Am J Pathol 1997; 151(3): 651-7.
    • (1997) Am J Pathol , vol.151 , Issue.3 , pp. 651-657
    • Blazejewski, S.1    Le Bail, B.2    Boussarie, L.3
  • 44
    • 0028967282 scopus 로고
    • Expression of SPARC in normal and fibrotic livers
    • Frizell E, Liu SL, Abraham A, et al. Expression of SPARC in normal and fibrotic livers. Hepatology 1995; 21(3): 847-54.
    • (1995) Hepatology , vol.21 , Issue.3 , pp. 847-854
    • Frizell, E.1    Liu, S.L.2    Abraham, A.3
  • 45
    • 0036445817 scopus 로고    scopus 로고
    • Expression of SPARC by activated hepatic stellate cells and its correlation with the stages of fibrogenesis in human chronic hepatitis
    • Nakatani K, Seki S, Kawada N, et al. Expression of SPARC by activated hepatic stellate cells and its correlation with the stages of fibrogenesis in human chronic hepatitis. Virchows Arch 2002; 441(5): 466-74.
    • (2002) Virchows Arch , vol.441 , Issue.5 , pp. 466-474
    • Nakatani, K.1    Seki, S.2    Kawada, N.3
  • 46
    • 52649175992 scopus 로고    scopus 로고
    • Adenovirusmediated inhibition of SPARC attenuates liver fibrosis in rats
    • Camino AM, Atorrasagasti C, Maccio D, et al. Adenovirusmediated inhibition of SPARC attenuates liver fibrosis in rats. J Gene Med 2008; 10(9): 993-1004.
    • (2008) J Gene Med , vol.10 , Issue.9 , pp. 993-1004
    • Camino, A.M.1    Atorrasagasti, C.2    Maccio, D.3
  • 47
    • 79955567950 scopus 로고    scopus 로고
    • SPARC downregulation attenuates the profibrogenic response of hepatic stellate cells induced by TGF-beta1 and PDGF
    • Atorrasagasti C, Aquino JB, Hofman L, et al. SPARC downregulation attenuates the profibrogenic response of hepatic stellate cells induced by TGF-beta1 and PDGF. Am J Physiol Gastrointest Liver Physiol 2011; 300(5): G739-48.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300 , Issue.5
    • Atorrasagasti, C.1    Aquino, J.B.2    Hofman, L.3
  • 48
    • 80855147490 scopus 로고    scopus 로고
    • SPARC promotes cathepsin B-mediated melanoma invasiveness through a collagen I/alpha2beta1 integrin axis
    • Girotti MR, Fernandez M, Lopez JA, et al. SPARC promotes cathepsin B-mediated melanoma invasiveness through a collagen I/alpha2beta1 integrin axis. J Invest Dermatol 2011; 131(12): 2438-47.
    • (2011) J Invest Dermatol , vol.131 , Issue.12 , pp. 2438-2447
    • Girotti, M.R.1    Fernandez, M.2    Lopez, J.A.3
  • 49
    • 79551521517 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) in kidney fibrosis: Fact or fantasy?
    • Kriz W, Kaissling B, Le Hir M. Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy? J Clin Invest 2011; 121(2): 468-74.
    • (2011) J Clin Invest , vol.121 , Issue.2 , pp. 468-474
    • Kriz, W.1    Kaissling, B.2    Le Hir, M.3
  • 50
    • 79951805332 scopus 로고    scopus 로고
    • Epithelial-mesenchymal interactions in pulmonary fibrosis
    • Chapman HA. Epithelial-mesenchymal interactions in pulmonary fibrosis. Annu Rev Physiol 2011; 73: 413-35.
    • (2011) Annu Rev Physiol , vol.73 , pp. 413-435
    • Chapman, H.A.1
  • 51
    • 79251649154 scopus 로고    scopus 로고
    • Systemic sclerosis-a systematic overview: Part 1-disease characteristics and classification, pathophysiologic concepts, and recommendations for diagnosis and surveillance
    • Klein WP, Opitz C, Riemekasten G. Systemic sclerosis-a systematic overview: part 1-disease characteristics and classification, pathophysiologic concepts, and recommendations for diagnosis and surveillance. Vasa 2011; 40(1): 6-19.
    • (2011) Vasa , vol.40 , Issue.1 , pp. 6-19
    • Klein, W.P.1    Opitz, C.2    Riemekasten, G.3
  • 52
    • 79251602656 scopus 로고    scopus 로고
    • Systemic sclerosis-a systematic overview: Part 2-immunosuppression, treatment of SSc-associated vasculopathy, and treatment of pulmonary arterial hypertension
    • Opitz C, Klein WPF, Riemekasten G. Systemic sclerosis-a systematic overview: part 2-immunosuppression, treatment of SSc-associated vasculopathy, and treatment of pulmonary arterial hypertension. Vasa 2011; 40(1): 20-30.
    • (2011) Vasa , vol.40 , Issue.1 , pp. 20-30
    • Opitz, C.1    Klein, W.P.F.2    Riemekasten, G.3
  • 53
    • 0036897408 scopus 로고    scopus 로고
    • Increased circulating concentrations of the counteradhesive proteins SPARC and thrombospondin-1 in systemic sclerosis (scleroderma). Relationship to platelet and endothelial cell activation
    • Macko RF, Gelber AC, Young BA, et al. Increased circulating concentrations of the counteradhesive proteins SPARC and thrombospondin-1 in systemic sclerosis (scleroderma). Relationship to platelet and endothelial cell activation. J Rheumatol 2002; 29(12): 2565-70.
    • (2002) J Rheumatol , vol.29 , Issue.12 , pp. 2565-2570
    • Macko, R.F.1    Gelber, A.C.2    Young, B.A.3
  • 54
    • 0038284890 scopus 로고    scopus 로고
    • SPARC-null mice exhibit increased adiposity without significant differences in overall body weight
    • Bradshaw AD, Graves DC, Motamed K, Sage EH. SPARC-null mice exhibit increased adiposity without significant differences in overall body weight. Proc Natl Acad Sci USA 2003; 100(10): 6045-50.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.10 , pp. 6045-6050
    • Bradshaw, A.D.1    Graves, D.C.2    Motamed, K.3    Sage, E.H.4
  • 55
    • 0026021461 scopus 로고
    • Expression of osteonectin, decorin, and transforming growth factor-beta 1 genes in fibroblasts cultured from patients with systemic sclerosis and morphea
    • Vuorio T, Kahari VM, Black C, Vuorio E. Expression of osteonectin, decorin, and transforming growth factor-beta 1 genes in fibroblasts cultured from patients with systemic sclerosis and morphea. J Rheumatol 1991; 18(2): 247-51.
    • (1991) J Rheumatol , vol.18 , Issue.2 , pp. 247-251
    • Vuorio, T.1    Kahari, V.M.2    Black, C.3    Vuorio, E.4
  • 56
    • 33746945984 scopus 로고    scopus 로고
    • Attenuation of collagen production with small interfering RNA of SPARC in cultured fibroblasts from the skin of patients with scleroderma
    • Zhou X, Tan FK, Guo X, Arnett FC. Attenuation of collagen production with small interfering RNA of SPARC in cultured fibroblasts from the skin of patients with scleroderma. Arthritis Rheum 2006; 54(8): 2626-31.
    • (2006) Arthritis Rheum , vol.54 , Issue.8 , pp. 2626-2631
    • Zhou, X.1    Tan, F.K.2    Guo, X.3    Arnett, F.C.4
  • 57
    • 43049124446 scopus 로고    scopus 로고
    • Indomethacin and retinoic acid modify mouse intestinal inflammation and fibrosis: A role for SPARC
    • Klopcic B, Appelbee A, Raye W, et al. Indomethacin and retinoic acid modify mouse intestinal inflammation and fibrosis: a role for SPARC. Dig Dis Sci 2008; 53(6): 1553-63.
    • (2008) Dig Dis Sci , vol.53 , Issue.6 , pp. 1553-1563
    • Klopcic, B.1    Appelbee, A.2    Raye, W.3
  • 58
    • 79551715582 scopus 로고    scopus 로고
    • SPARC is expressed in scars of the Tenon's capsule and mediates scarring properties of human Tenon's fibroblasts in vitro
    • Fuchshofer R, Kottler UB, Ohlmann AV, et al. SPARC is expressed in scars of the Tenon's capsule and mediates scarring properties of human Tenon's fibroblasts in vitro. Mol Vis 2011; 17: 177-85.
    • (2011) Mol Vis , vol.17 , pp. 177-185
    • Fuchshofer, R.1    Kottler, U.B.2    Ohlmann, A.V.3
  • 59
    • 84861559414 scopus 로고    scopus 로고
    • In vitro analyses of the antifibrotic effect of SPARC silencing in human Tenon's fibroblasts: Comparisons with mitomycin-C
    • Seet LF, Su R, Toh LZ, Wong TT. In vitro analyses of the antifibrotic effect of SPARC silencing in human Tenon's fibroblasts: comparisons with mitomycin-C. J Cell Mol Med 2011; 16: 1245-59.
    • (2011) J Cell Mol Med , vol.16 , pp. 1245-1259
    • Seet, L.F.1    Su, R.2    Toh, L.Z.3    Wong, T.T.4
  • 60
    • 77949661954 scopus 로고    scopus 로고
    • SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery
    • Seet LF, Su R, Barathi VA, et al. SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery. PLoS One 2010; 5(2): e9415.
    • (2010) PLoS One , vol.5 , Issue.2
    • Seet, L.F.1    Su, R.2    Barathi, V.A.3
  • 61
    • 80052949838 scopus 로고    scopus 로고
    • The regulatory function of SPARC in vascular biology
    • Rivera LB, Bradshaw AD, Brekken RA. The regulatory function of SPARC in vascular biology. Cell Mol Life Sci 2011; 68(19): 3165-73.
    • (2011) Cell Mol Life Sci , vol.68 , Issue.19 , pp. 3165-3173
    • Rivera, L.B.1    Bradshaw, A.D.2    Brekken, R.A.3
  • 63
    • 53049109673 scopus 로고    scopus 로고
    • The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinase
    • Weaver MS, Workman G, Sage EH. The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinase. J Biol Chem 2008; 283(33): 22826-37.
    • (2008) J Biol Chem , vol.283 , Issue.33 , pp. 22826-22837
    • Weaver, M.S.1    Workman, G.2    Sage, E.H.3
  • 64
    • 0037373277 scopus 로고    scopus 로고
    • Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome
    • Neptune ER, Frischmeyer PA, Arking DE, et al. Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome. Nat Genet 2003; 33(3): 407-11.
    • (2003) Nat Genet , vol.33 , Issue.3 , pp. 407-411
    • Neptune, E.R.1    Frischmeyer, P.A.2    Arking, D.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.