메뉴 건너뛰기




Volumn 14, Issue 10, 2003, Pages 3977-3988

SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-β-signaling system

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CALCIUM BINDING PROTEIN; OSTEONECTIN; SMAD PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; THROMBOSPONDIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 0141541761     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E03-01-0001     Document Type: Article
Times cited : (139)

References (45)
  • 1
    • 0036051343 scopus 로고    scopus 로고
    • Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β
    • Abreu, J.G., Ketpura, N.I., Reversade, B., and De Robertis, E.M. (2002). Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β. Nat. Cell Biol. 4, 599-604.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 599-604
    • Abreu, J.G.1    Ketpura, N.I.2    Reversade, B.3    De Robertis, E.M.4
  • 2
    • 0033621614 scopus 로고    scopus 로고
    • Induction of TGF-β by the matricellular protein SPARC in a rat model of glomerulonephritis
    • Bassuk, J.A., et al. (2000). Induction of TGF-β by the matricellular protein SPARC in a rat model of glomerulonephritis. Kidney Int. 57, 117-128.
    • (2000) Kidney Int. , vol.57 , pp. 117-128
    • Bassuk, J.A.1
  • 3
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor β in human disease
    • Blobe, G.C., Schiemann, W.P., and Lodish, H.F. (2000). Role of transforming growth factor β in human disease. N. Engl. J. Med. 342, 1350-1358.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 4
    • 0024538265 scopus 로고
    • Transforming growth factor-β inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor
    • Boyd, F.T., and Massague, J. (1989). Transforming growth factor-β inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor. J. Biol. Chem. 264, 2272-2278.
    • (1989) J. Biol. Chem. , vol.264 , pp. 2272-2278
    • Boyd, F.T.1    Massague, J.2
  • 5
    • 0032930174 scopus 로고    scopus 로고
    • Primary mesenchymal cells isolated from SPARC-null mice exhibit altered morphology and rates of proliferation
    • Bradshaw, A.D., Francki, A., Motamed, K., Howe, C., and Sage, E.H. (1999). Primary mesenchymal cells isolated from SPARC-null mice exhibit altered morphology and rates of proliferation. Mol. Biol. Cell 10, 1569-1579.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 1569-1579
    • Bradshaw, A.D.1    Francki, A.2    Motamed, K.3    Howe, C.4    Sage, E.H.5
  • 6
    • 0035022957 scopus 로고    scopus 로고
    • SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury
    • Bradshaw, A.D., and Sage, E.H. (2001). SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury. J. Clin. Investig. 107, 1049-1054.
    • (2001) J. Clin. Investig. , vol.107 , pp. 1049-1054
    • Bradshaw, A.D.1    Sage, E.H.2
  • 8
    • 0028972072 scopus 로고
    • Transforming growth factor-β (TGF-β)-induced down-regulation of cyclin A expression requires a functional TGF-β receptor complex. Characterization of chimeric and truncated type I and type II receptors
    • Feng, X.H., Filvaroff, E.H., and Derynck, R. (1995). Transforming growth factor-β (TGF-β)-induced down-regulation of cyclin A expression requires a functional TGF-β receptor complex. Characterization of chimeric and truncated type I and type II receptors. J. Biol. Chem. 270, 24237-24245.
    • (1995) J. Biol. Chem. , vol.270 , pp. 24237-24245
    • Feng, X.H.1    Filvaroff, E.H.2    Derynck, R.3
  • 9
    • 0027308138 scopus 로고
    • Modulation of SPARC expression during butyrate-induced terminal differentiation of cultured human keratinocytes: Regulation via a TGF-β-dependent pathway
    • Ford, R., Wang, G., Jannati, P., Adler, D., Racanelli, P., Higgins, P.J., and Staiano-Coico, L. (1993). Modulation of SPARC expression during butyrate-induced terminal differentiation of cultured human keratinocytes: regulation via a TGF-β-dependent pathway. Exp. Cell Res. 206, 261-275.
    • (1993) Exp. Cell Res. , vol.206 , pp. 261-275
    • Ford, R.1    Wang, G.2    Jannati, P.3    Adler, D.4    Racanelli, P.5    Higgins, P.J.6    Staiano-Coico, L.7
  • 10
    • 0033527654 scopus 로고    scopus 로고
    • SPARC regulates the expression of collagen type I and transforming growth factor-β1 in mesangial cells
    • Francki, A., Bradshaw, A.D., Bassuk, J.A., Howe, C.C., Couser, W.G., and Sage, E.H. (1999). SPARC regulates the expression of collagen type I and transforming growth factor-β1 in mesangial cells. J. Biol. Chem. 274, 32145-32152.
    • (1999) J. Biol. Chem. , vol.274 , pp. 32145-32152
    • Francki, A.1    Bradshaw, A.D.2    Bassuk, J.A.3    Howe, C.C.4    Couser, W.G.5    Sage, E.H.6
  • 11
    • 0025921473 scopus 로고
    • The Ca2(+)-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells
    • Funk, S.E., and Sage, E.H. (1991). The Ca2(+)-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells. Proc. Natl. Acad. Sci. USA 88, 2648-2652.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 2648-2652
    • Funk, S.E.1    Sage, E.H.2
  • 12
    • 0027339116 scopus 로고
    • Differential effects of SPARC and cationic SPARC peptides on DNA synthesis by endothelial cells and fibroblasts
    • Funk, S.E., and Sage, E.H. (1993). Differential effects of SPARC and cationic SPARC peptides on DNA synthesis by endothelial cells and fibroblasts. J. Cell. Physiol. 154, 53-63.
    • (1993) J. Cell. Physiol. , vol.154 , pp. 53-63
    • Funk, S.E.1    Sage, E.H.2
  • 13
    • 0033539514 scopus 로고    scopus 로고
    • BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells
    • Ghaffari, S., Wu, H., Gerlach, M., Han, Y., Lodish, H.F., and Daley, G.Q. (1999). BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells. Proc. Natl. Acad. Sci. USA 96, 13186-13190.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 13186-13190
    • Ghaffari, S.1    Wu, H.2    Gerlach, M.3    Han, Y.4    Lodish, H.F.5    Daley, G.Q.6
  • 15
    • 0025772967 scopus 로고
    • SPARC induces the expression of type 1 plasminogen activator inhibitor in cultured bovine aortic endothelial cells
    • Hasselaar, P., Loskutoff, D.J., Sawdey, M., and Sage, E.H. (1991). SPARC induces the expression of type 1 plasminogen activator inhibitor in cultured bovine aortic endothelial cells. J. Biol. Chem. 266, 13178-13184.
    • (1991) J. Biol. Chem. , vol.266 , pp. 13178-13184
    • Hasselaar, P.1    Loskutoff, D.J.2    Sawdey, M.3    Sage, E.H.4
  • 16
    • 0026638285 scopus 로고
    • SPARC antagonizes the effect of basic fibroblast growth factor on the migration of bovine aortic endothelial cells
    • Hasselaar, P., and Sage, E.H. (1992). SPARC antagonizes the effect of basic fibroblast growth factor on the migration of bovine aortic endothelial cells. J. Cell. Biochem. 49, 272-283.
    • (1992) J. Cell. Biochem. , vol.49 , pp. 272-283
    • Hasselaar, P.1    Sage, E.H.2
  • 17
    • 0036143018 scopus 로고    scopus 로고
    • Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation
    • Huynh, M.L., Fadok, V.A., and Henson, P.M. (2002). Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation. J. Clin. Invest. 109, 41-50.
    • (2002) J. Clin. Invest. , vol.109 , pp. 41-50
    • Huynh, M.L.1    Fadok, V.A.2    Henson, P.M.3
  • 18
    • 0033386176 scopus 로고    scopus 로고
    • TGF-β: From latent to active
    • Khalil, N. (1999). TGF-β: from latent to active. Microbes Infect. 1, 1255-1263.
    • (1999) Microbes Infect. , vol.1 , pp. 1255-1263
    • Khalil, N.1
  • 20
    • 0032491588 scopus 로고    scopus 로고
    • SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells
    • Kupprion, C., Motamed, K., and Sage, E.H. (1998). SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells. J. Biol. Chem. 273, 29635-29640.
    • (1998) J. Biol. Chem. , vol.273 , pp. 29635-29640
    • Kupprion, C.1    Motamed, K.2    Sage, E.H.3
  • 21
    • 0026742984 scopus 로고
    • Regulation of gene expression by SPARC during angiogenesis in vitro. Changes in fibronectin, thrombospondin-1, and plasminogen activator inhibitor-1
    • Lane, T.F., Iruela-Arispe, M.L., and Sage, E.H. (1992). Regulation of gene expression by SPARC during angiogenesis in vitro. Changes in fibronectin, thrombospondin-1, and plasminogen activator inhibitor-1. J. Biol. Chem. 267, 16736-16745.
    • (1992) J. Biol. Chem. , vol.267 , pp. 16736-16745
    • Lane, T.F.1    Iruela-Arispe, M.L.2    Sage, E.H.3
  • 22
    • 23444459571 scopus 로고
    • The biology of SPARC, a protein that modulates cell-matrix interactions
    • Lane, T.F., and Sage, E.H. (1994). The biology of SPARC, a protein that modulates cell-matrix interactions. FASEB J. 8, 163-173.
    • (1994) FASEB J. , vol.8 , pp. 163-173
    • Lane, T.F.1    Sage, E.H.2
  • 23
    • 0030886204 scopus 로고    scopus 로고
    • Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells
    • Liu, X., Sun, Y., Constantinescu, S.N., Karam, E., Weinberg, R.A., and Lodish, H.F. (1997). Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc. Natl. Acad. Sci. USA 94, 10669-10674.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10669-10674
    • Liu, X.1    Sun, Y.2    Constantinescu, S.N.3    Karam, E.4    Weinberg, R.A.5    Lodish, H.F.6
  • 24
    • 0031685620 scopus 로고    scopus 로고
    • TGF-β signal transduction
    • Massague, J. (1998). TGF-β signal transduction. Annu. Rev. Biochem. 67, 753-791.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 753-791
    • Massague, J.1
  • 25
    • 0036151842 scopus 로고    scopus 로고
    • Inhibition of PDGF-stimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors
    • Motamed, K., Funk, S.E., Koyama, H., Ross, R., Raines, E.W., and Sage, E.H. (2002). Inhibition of PDGF-stimulated and matrix-mediated proliferation of human vascular smooth muscle cells by SPARC is independent of changes in cell shape or cyclin-dependent kinase inhibitors. J. Cell. Biochem. 84, 759-771.
    • (2002) J. Cell. Biochem. , vol.84 , pp. 759-771
    • Motamed, K.1    Funk, S.E.2    Koyama, H.3    Ross, R.4    Raines, E.W.5    Sage, E.H.6
  • 26
    • 0032531268 scopus 로고    scopus 로고
    • SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway
    • Motamed, K., and Sage, E.H. (1998). SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway. J. Cell. Biochem. 70, 543-552.
    • (1998) J. Cell. Biochem. , vol.70 , pp. 543-552
    • Motamed, K.1    Sage, E.H.2
  • 27
    • 0033820374 scopus 로고    scopus 로고
    • Glucose stimulation of transforming growth factor-β bioactivity in mesangial cells is mediated by thrombospondin-1
    • Poczatek, M.H., Hugo, C., Darley-Usmar, V., and Murphy-Ullrich, J.E. (2000). Glucose stimulation of transforming growth factor-β bioactivity in mesangial cells is mediated by thrombospondin-1. Am. J. Pathol. 157, 1353-1363.
    • (2000) Am. J. Pathol. , vol.157 , pp. 1353-1363
    • Poczatek, M.H.1    Hugo, C.2    Darley-Usmar, V.3    Murphy-Ullrich, J.E.4
  • 28
    • 0028110212 scopus 로고
    • Inhibition of G1 phase cyclin dependent kinases by transforming growth factor β1
    • Reddy, K.B., Hocevar, B.A., and Howe, P.H. (1994). Inhibition of G1 phase cyclin dependent kinases by transforming growth factor β1. J. Cell. Biochem. 56, 418-425.
    • (1994) J. Cell. Biochem. , vol.56 , pp. 418-425
    • Reddy, K.B.1    Hocevar, B.A.2    Howe, P.H.3
  • 29
    • 0028175379 scopus 로고
    • TGF-β1 induces the expression of type I collagen and SPARC, and enhances contraction of collagen gels, by fibroblasts from young and aged donors
    • Reed, M.J., Vernon, R.B., Abrass, I.B., and Sage, E.H. (1994). TGF-β1 induces the expression of type I collagen and SPARC, and enhances contraction of collagen gels, by fibroblasts from young and aged donors. J. Cell. Physiol. 158, 169-179.
    • (1994) J. Cell. Physiol. , vol.158 , pp. 169-179
    • Reed, M.J.1    Vernon, R.B.2    Abrass, I.B.3    Sage, E.H.4
  • 30
    • 0030614715 scopus 로고    scopus 로고
    • The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2
    • Reynisdottir, I., and Massague, J. (1997). The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev. 11, 492-503.
    • (1997) Genes Dev. , vol.11 , pp. 492-503
    • Reynisdottir, I.1    Massague, J.2
  • 31
    • 0033532054 scopus 로고    scopus 로고
    • The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-β
    • Ribeiro, S.M., Poczatek, M., Schultz-Cherry, S., Villain, M., and Murphy-Ullrich, J.E. (1999). The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-β. J. Biol. Chem. 274, 13586-13593.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13586-13593
    • Ribeiro, S.M.1    Poczatek, M.2    Schultz-Cherry, S.3    Villain, M.4    Murphy-Ullrich, J.E.5
  • 32
    • 0026893632 scopus 로고
    • Secretion of SPARC by endothelial cells transformed by polyoma middle T oncogene inhibits the growth of normal endothelial cells in vitro
    • Sage, E.H. (1992). Secretion of SPARC by endothelial cells transformed by polyoma middle T oncogene inhibits the growth of normal endothelial cells in vitro. Biochem. Cell Biol. 70, 579-592.
    • (1992) Biochem. Cell Biol. , vol.70 , pp. 579-592
    • Sage, E.H.1
  • 33
    • 16944363757 scopus 로고    scopus 로고
    • Terms of attachment: SPARC and tumorigenesis
    • Sage, E.H. (1997). Terms of attachment: SPARC and tumorigenesis. Nat. Med. 3, 144-146.
    • (1997) Nat. Med. , vol.3 , pp. 144-146
    • Sage, E.H.1
  • 34
    • 0028897670 scopus 로고
    • Inhibition of endothelial cell proliferation by SPARC is mediated through a Ca(2+)-binding EF-hand sequence
    • Sage, E.H., Bassuk, J.A., Yost, J.C., Folkman, M.J., and Lane, T.F. (1995). Inhibition of endothelial cell proliferation by SPARC is mediated through a Ca(2+)-binding EF-hand sequence. J. Cell. Biochem. 57, 127-140.
    • (1995) J. Cell. Biochem. , vol.57 , pp. 127-140
    • Sage, E.H.1    Bassuk, J.A.2    Yost, J.C.3    Folkman, M.J.4    Lane, T.F.5
  • 35
    • 0024395113 scopus 로고
    • SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix
    • Sage, H., Vernon, R.B., Funk, S.E., Everitt, E.A., and Angello, J. (1989). SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix. J. Cell Biol. 109, 341-356.
    • (1989) J. Cell Biol. , vol.109 , pp. 341-356
    • Sage, H.1    Vernon, R.B.2    Funk, S.E.3    Everitt, E.A.4    Angello, J.5
  • 36
    • 0037178816 scopus 로고    scopus 로고
    • Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion: Fibulin-5 is induced by TGF-β and affects protein kinase cascades
    • Schiemann, W.P., Blobe, G.C., Kalume, D.E., Pandey, A., and Lodish, H.F. (2002). Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion: fibulin-5 is induced by TGF-β and affects protein kinase cascades. J. Biol. Chem. 277, 27367-27377.
    • (2002) J. Biol. Chem. , vol.277 , pp. 27367-27377
    • Schiemann, W.P.1    Blobe, G.C.2    Kalume, D.E.3    Pandey, A.4    Lodish, H.F.5
  • 37
    • 0032878291 scopus 로고    scopus 로고
    • A deletion in the gene for transforming growth factor β type I receptor abolishes growth regulation by transforming growth factor β in a cutaneous T-cell lymphoma
    • Schiemann, W.P., Pfeifer, W.M., Levi, E., Kadin, M.E., and Lodish, H.F. (1999). A deletion in the gene for transforming growth factor β type I receptor abolishes growth regulation by transforming growth factor β in a cutaneous T-cell lymphoma. Blood 94, 2854-2861.
    • (1999) Blood , vol.94 , pp. 2854-2861
    • Schiemann, W.P.1    Pfeifer, W.M.2    Levi, E.3    Kadin, M.E.4    Lodish, H.F.5
  • 38
    • 0032728956 scopus 로고    scopus 로고
    • Regulation of extracellular matrix proteins by transforming growth factor β1 in cultured pulmonary endothelial cells
    • Shanker, G., Olson, D., Bone, R., and Sawhney, R. (1999). Regulation of extracellular matrix proteins by transforming growth factor β1 in cultured pulmonary endothelial cells. Cell Biol. Int. 23, 61-72.
    • (1999) Cell Biol. Int. , vol.23 , pp. 61-72
    • Shanker, G.1    Olson, D.2    Bone, R.3    Sawhney, R.4
  • 39
    • 15444345967 scopus 로고    scopus 로고
    • Differential effects of various growth factors and cytokines on the syntheses of D.N.A., type I collagen, laminin, fibronectin, osteonectin/ secreted protein, acidic and rich in cysteine (SPARC), and alkaline phosphatase by human pulp cells in culture
    • Shiba, H., et al. (1998). Differential effects of various growth factors and cytokines on the syntheses of D.N.A., type I collagen, laminin, fibronectin, osteonectin/secreted protein, acidic and rich in cysteine (SPARC), and alkaline phosphatase by human pulp cells in culture. J. Cell. Physiol. 174, 194-205.
    • (1998) J. Cell. Physiol. , vol.174 , pp. 194-205
    • Shiba, H.1
  • 40
    • 0031684855 scopus 로고    scopus 로고
    • Extracellular matrix-associated transforming growth factor-β: Role in cancer cell growth and invasion
    • Taipale, J., Saharinen, J., and Keski-Oja, J. (1998). Extracellular matrix-associated transforming growth factor-β: role in cancer cell growth and invasion. Adv. Cancer Res. 75, 87-134.
    • (1998) Adv. Cancer Res. , vol.75 , pp. 87-134
    • Taipale, J.1    Saharinen, J.2    Keski-Oja, J.3
  • 42
    • 0025808612 scopus 로고
    • Regulation of the expression of a secreted acidic protein rich in cysteine (SPARC) in human fibroblasts by transforming growth factor β. Comparison of transcriptional and post-transcriptional control with fibronectin and type I collagen
    • Wrana, J.L., Overall, C.M., and Sodek, J. (1991). Regulation of the expression of a secreted acidic protein rich in cysteine (SPARC) in human fibroblasts by transforming growth factor β. Comparison of transcriptional and post-transcriptional control with fibronectin and type I collagen. Eur. J. Biochem. 197, 519-528.
    • (1991) Eur. J. Biochem. , vol.197 , pp. 519-528
    • Wrana, J.L.1    Overall, C.M.2    Sodek, J.3
  • 43
    • 0032712968 scopus 로고    scopus 로고
    • SPARC, a matricellular glycoprotein with important biological functions
    • Yan, Q., and Sage, E.H. (1999). SPARC, a matricellular glycoprotein with important biological functions. J. Histochem. Cytochem. 47, 1495-1506.
    • (1999) J. Histochem. Cytochem. , vol.47 , pp. 1495-1506
    • Yan, Q.1    Sage, E.H.2
  • 44
    • 0027491595 scopus 로고
    • Specific interaction of SPARC with endothelial cells is mediated through a carboxyl-terminal sequence containing a calcium-binding EF hand
    • Yost, J.C., and Sage, E.H. (1993). Specific interaction of SPARC with endothelial cells is mediated through a carboxyl-terminal sequence containing a calcium-binding EF hand. J. Biol. Chem. 268, 25790-25796.
    • (1993) J. Biol. Chem. , vol.268 , pp. 25790-25796
    • Yost, J.C.1    Sage, E.H.2
  • 45
    • 0034613385 scopus 로고    scopus 로고
    • Requirement of Ras/MAPK pathway activation by transforming growth factor β for transforming growth factor β1 production in a Smad-dependent pathway
    • Yue, J., and Mulder, K.M. (2000). Requirement of Ras/MAPK pathway activation by transforming growth factor β for transforming growth factor β1 production in a Smad-dependent pathway. J. Biol. Chem. 275, 30765-30773.
    • (2000) J. Biol. Chem. , vol.275 , pp. 30765-30773
    • Yue, J.1    Mulder, K.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.