Identification and structural characterization of in vivo metabolites of ketorolac using liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS)

Journal of Mass Spectrometry

Volumn 47, Issue 7, 2012, Pages 919-931

  Raju, B ^a   Ramesh, M ^a   Borkar, Roshan M ^a   Padiya, Raju ^a   Banerjee, Sanjay K ^a   Srinivas, R ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

accurate mass measurements; ketorolac; LC ESI MS MS; metabolites; online H D exchange experiments

Indexed keywords

ACCURATE MASS; DRUG METABOLITES; GLUCURONIDATION; GLUCURONIDES; H/D EXCHANGE; HIGH-RESOLUTION TANDEM MASS SPECTROMETRIES; HYDROGEN/DEUTERIUM EXCHANGE; IN-VIVO; ION ELECTROSPRAY IONIZATION; KETOROLAC; LC-MS/MS; LC/ESI-MS/MS; LIQUID CHROMATOGRAPHY ELECTROSPRAY; LIQUID SEPARATION; ORAL ADMINISTRATION; PHASE I; PHASE II; PLASMA SAMPLES; PROTEIN PRECIPITATION; SAMPLE PREPARATION; SOLID-PHASE EXTRACTION; SPRAGUE-DAWLEY RATS; STRUCTURAL CHARACTERIZATION; URINE SAMPLE;

CHARACTERIZATION; ELECTROSPRAY IONIZATION; EXPERIMENTS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PRECIPITATION (CHEMICAL);

BIOMOLECULES;

GLUCURONIDE; KETOROLAC; SULFATE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CARBONYLATION; CONTROLLED STUDY; DRUG GLUCURONIDATION; DRUG HYDROXYLATION; DRUG IDENTIFICATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FECES ANALYSIS; FREEZING; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; RAT; SOLID PHASE EXTRACTION; URINALYSIS;

ANIMALS; CHROMATOGRAPHY, LIQUID; DEUTERIUM EXCHANGE MEASUREMENT; FECES; KETOROLAC; MALE; MODELS, MOLECULAR; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 84863904356     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.3043     Document Type: Article

References (23)

1. B. Prasad, S. Singh,. In vitro and in vivo investigation of metabolic fate of rifampicin using an optimized sample preparation approach and modern tools of liquid chromatography mass spectrometry. J. Pharm. Biomed. Anal. 2009, 50, 475.
2. T. Liu, F. Du, Y. Wan, F. Zhu, J. Xing,. Rapid identification of phase I and II metabolites of artemisinin antimalarials using LTQ Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange technique. J. Mass Spectrom. 2011, 46, 725.
3. G. Chen, I. Daaro, B. N. Pramanik, J. J. Piwinski,. Structural characterization of in vitro rat liver microsomal metabolites of antihistamine desloratadine using LTQ Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange HR-LC/MS. J. Mass Spectrom. 2009, 44, 203.
4. S. Beuck, W. Schanzer, M. Thevis,. Investigation of the in vitro metabolism of the emerging drug candidates S107 for doping-preventive purposes. J. Mass Spectrom. 2011, 46, 112.
5. D. Q. Liu, C. E. Hop,. Strategies for characterization of drug metabolites using liquid chromatography tandem mass spectrometry in conjunction with chemical derivatization and on-line H/D exchange approaches. J. Pharm. Biomed. Anal. 2005, 37, 1.
6. W. Lam, R. Ramanathan,. In electrospray ionization source hydrogen/deuterium exchange LC-MS and LC-MS/MS for characterization of metabolites. J. Am. Soc. Mass Spectrom. 2002, 13, 345.
7. C. Gillis, R. N. Brogden,. Ketorolac: a reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management. Drugs 1997, 53, 139.
8. D. J. Reinhart,. Minimizing the adverse effects of ketorolac. Drug Saf. 2000, 22, 487.
9. A. Escousse, G. Rifle, C. Sgro, C. Mousson, G. Zanetta, D. Chevet,. Azathioprine toxicity, 6-mercaptopurine accumulation and the "poor" 6-thiopurine methylator phenotype. Eur. J. Clin. Pharmacol. 1995, 48, 309.
10. P. Zimniak,. Detoxification reactions: relevance to aging. Ageing Res. Rev. 2008, 7, 281.
11. D. Jun, U. Mroszczak, A. Wu, T. L. Ling, H. Sevelius, L. Bynum,. Pharmacokinetic of ketorolac and p-hydroxy ketorolac following oral and intramuscular administration of ketorolac tromethamine. Pharm. Res. 1989, 6, 62.
12. E. J. Mroszczak, F. W. Lee, D. Combs,. Ketorolac tromethamine absorption, distribution, metabolism, excretion and pharmacokinetics in animals and humans. Drug Metab. Dispos. 1987, 15 618.
13. E. J. Mroszczak, D. Jung, J. Yee, L. Bynum, H. Sevelius, I. Massey,. Ketorolac tromethamine pharmacokinetics and metabolism after intravenous, intramuscular and oral administration in humans and animals. Pharmacotherapy 1990, 10, 33.
14. R. E. Kauffman, M. W. L. Lai, H. G. Uy, M. K. Aravind,. Enantiomer selective pharmacokinetics and metabolism of ketorolac in children. Clin. Pharmacol. Ther. 1999, 65, 382.
15. S. Patri, A. K. Patni, S. Sunil, I. Arshad, H. Khuroo, T. Monif, S. Rana, S. Kumar, R. Jain,. A validated high-performance liquid chromatography tandem mass spectrometric (LC-MS/MS) method for simultaneous determination of R (+) and S (-) ketorolac in human plasma and its application to a bioequivalence study. Chromatography Research Int'l 2011. DOI: 10.4061/2011/214793
16. A. T. Wu, I. J. Massey,. Simultaneous determination of Ketorolac and its hydroxylated metabolite in plasma by high performance liquid chromatography. J. Chromatogr. B 1990, 534, 241.
17. M. Vakily, B. Corrigan, F. Jamali,. The problem of racemization in the stereospecific assay and pharmacokinetic evaluation of ketorolac in human and rats. Pharm. Res. 1995, 12, 1652.
18. D. J. Jones, A. R. Bjorksten,. Detection of ketorolac enantiomers in human plasma using enantioselective liquid chromatography. J. Chromatogr. B 1994, 661, 165.
19. M. J. Diaz-Perez, J. C. Chen, A. F. Aubry, I. W. Wainer,. The direct determination of the enantiomers of ketorolac and parahydroxyl ketorolac in plasma and urine using enantioselective liquid chromatography on a human serum albumin based chiral stationary phase. Chirality 1994, 6, 283.
20. B. Raju, M. Ramesh, R. M. Borkar, R. Padiya, S. K. Banerjee, R. Srinivas,. Development and validation of liquid chromatography-mass spectrometric method (LC-MS) for simultaneous determination of moxifloxacin and ketorolac in rat plasma: Application to pharmacokinetic study. Biomed. Chromatogr. 2012, DOI: 10.1002/bmc.2701
21. B. Raju, V. Ramesh, A. Sudhakar, M. Ramesh, V. U. M. Sarma, S. Chandrasekhar, R. Srinivas,. Diastereomeric differentiation of norbornene amino acid peptides by electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2009, 23, 2965.
22. n experiments: Development of a validated specific stability-indicating LC-MS method. J. Pharm. Biomed. Anal. 2011, 56, 560.
23. n). J. Am. Soc. Mass Spectrom. 2011, 23, 703.