High levels of the extracellular matrix proteoglycan decorin are associated with inhibition of testicular function

International Journal of Andrology

Volumn 35, Issue 4, 2012, Pages 550-561

  Adam, M ^a   Urbanski, H F ^b,c   Garyfallou, V T ^b   Welsch, U ^a   Kohn F M ^d   Ullrich Schwarzer, J ^e   Strauss, L ^f   Poutanen, M ^f   Mayerhofer, A ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d Andrologicum Munich   (Germany)

^e Praxis Urology Andrology   (Germany)

^f UNIVERSITY OF TURKU   (Finland)

Author keywords

Development; Fibrosis; Infertility; Inflammation; Mouse < animal models; Primates < animal models; Proteoglycan; Testis

Indexed keywords

DECORIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CELL COUNT; CONNECTIVE TISSUE; CONTROLLED STUDY; CORRELATION ANALYSIS; FIBROSIS; HUMAN; MALE; NONHUMAN; POSTNATAL DEVELOPMENT; PREPUBERTY; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; TESTIS; TESTIS FUNCTION;

ANIMALS; CELLS, CULTURED; DECORIN; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX PROTEINS; FIBROSIS; HUMANS; INFERTILITY, MALE; INFLAMMATION; MACACA MULATTA; MALE; MICE; MICE, TRANSGENIC; SIGNAL TRANSDUCTION; TESTIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84863879971     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2011.01225.x     Document Type: Article

References (48)

1. Adam M, Schwarzer JU, Kohn FM, Strauss L, Poutanen M & Mayerhofer M. (2011) Mast cell tryptase stimulates production of decorin by human testicular peritubular cells: possible role in male infertility with growth factor signaling? Hum Reprod 26, 2613-2625.
2. Albrecht M, Ramsch R, Kohn FM, Schwarzer JU & Mayerhofer A. (2006) Isolation and cultivation of human testicular peritubular cells: a new model for the investigation of fibrotic processes in the human testis and male infertility. J Clin Endocrinol Metab 91, 1956-1960.
3. Basciani S, Mariani S, Spera G & Gnessi L. (2010) Role of platelet-derived growth factors in the testis. Endocr Rev.31: 916-939.
4. Davidoff MS, Breucker H, Holstein AF & Seidl K. (1990) Cellular architecture of the lamina propria of human seminiferous tubules. Cell Tissue Res 262, 253-261.
5. Dobashi M, Fujisawa M, Naito I, Yamazaki T, Okada H & Kamidono S. (2003) Distribution of type IV collagen subtypes in human testes and their association with spermatogenesis. Fertil Steril 80(Suppl 2), 755-760.
6. Dodge GR, Diaz A, Sanz-Rodriguez C, Reginato AM & Jimenez SA. (1998) Effects of interferon-gamma and tumor necrosis factor alpha on the expression of the genes encoding aggrecan, biglycan, and decorin core proteins in cultured human chondrocytes. Arthritis Rheum 41, 274-283.
7. Fadic R, Mezzano V, Alvarez K, Cabrera D, Holmgren J & Brandan E. (2006) Increase in decorin and biglycan in Duchenne Muscular Dystrophy: role of fibroblasts as cell source of these proteoglycans in the disease. J Cell Mol Med 10, 758-769.
8. Frungieri MB, Urbanski HF, Hohne-Zell B & Mayerhofer A. (2000) Neuronal elements in the testis of the rhesus monkey: ontogeny, characterization and relationship to testicular cells. Neuroendocrinology 71, 43-50.
9. Frungieri MB, Calandra RS, Lustig L, Meineke V, Kohn FM, Vogt HJ & Mayerhofer A. (2002) Number, distribution pattern, and identification of macrophages in the testes of infertile men. Fertil Steril 78, 298-306.
10. Gambichler T, Kreuter A, Skrygan M, Burkert B, Altmeyer P & Schieren G. (2009) Decorin is significantly overexpressed in nephrogenic systemic fibrosis. Am J Clin Pathol 132, 139-143.
11. Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K & Iozzo RV. (2009) Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol 185, 743-754.
12. Gulkesen KH, Erdogru T, Sargin CF & Karpuzoglu G. (2002) Expression of extracellular matrix proteins and vimentin in testes of azoospermic man: an immunohistochemical and morphometric study. Asian J Androl 4, 55-60.
13. Haider SG, Talati J & Servos G. (1999) Ultrastructure of peritubular tissue in association with tubular hyalinization in human testis. Tissue Cell 31, 90-98.
14. Haigh M, Scott JE. (1986) A method of processing tissue sections for staining with cu-promeronic blue and other dyes, using CEC techniques, for light and electron microscopy. Basic Appl Histochem 30, 479-486.
15. Iacob D, Cai J, Tsonis M, Babwah A, Chakraborty C, Bhattacharjee RN & Lala PK. (2008) Decorin-mediated inhibition of proliferation and migration of the human trophoblast via different tyrosine kinase receptors. Endocrinology 149, 6187-6197.
16. Iozzo RV. (1997) The family of the small leucine-rich proteoglycans: key regulators of matrix assembly and cellular growth. Crit Rev Biochem Mol Biol 32, 141-174.
17. Iozzo RV. (1999) The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins. J Biol Chem 274, 18843-18846.
18. Jarvelainen H, Puolakkainen P, Pakkanen S, Brown EL, Hook M, Iozzo RV, Sage EH & Wight TN. (2006) A role for decorin in cutaneous wound healing and angiogenesis. Wound Repair Regen 14, 443-452.
19. Li X, Nokkala E, Yan W, Streng T, Saarinen N, Warri A, Huhtaniemi I, Santti R, Makela S & Poutanen M. (2001) Altered structure and function of reproductive organs in transgenic male mice overexpressing human aromatase. Endocrinology 142, 2435-2442.
20. Li X, Makela S, Streng T, Santti R & Poutanen M. (2003) Phenotype characteristics of transgenic male mice expressing human aromatase under ubiquitin C promoter. J Steroid Biochem Mol Biol 86, 469-476.
21. Li X, Strauss L, Kaatrasalo A, Mayerhofer A, Huhtaniemi I, Santti R, Makela S & Poutanen M. (2006) Transgenic mice expressing p450 aromatase as a model for male infertility associated with chronic inflammation in the testis. Endocrinology 147, 1271-1277.
22. Lemos DR, Downs JL & Urbanski HF. (2006) Twenty-four-hour rhythmic gene expression in the rhesus macaque adrenal gland. Mol Endocrinol 20, 1164-1176.
23. Mauviel A, Santra M, Chen YQ, Uitto J & Iozzo RV. (1995) Transcriptional regulation of decorin gene expression. Induction by quiescence and repression by tumor necrosis factor-alpha. J Biol Chem 270, 11692-11700.
24. Meineke V, Frungieri MB, Jessberger B, Vogt H & Mayerhofer A. (2000) Human testicular mast cells contain tryptase: increased mast cell number and altered distribution in the testes of infertile men. Fertil Steril 74, 239-244.
25. Miqueloto CA & Zorn TM. (2007) Characterization and distribution of hyaluronan and the proteoglycans decorin, biglycan and 'perlecan in the developing embryonic mouse gonad. J Anat 211, 16-25.
26. Nili N, Cheema AN, Giordano FJ, Barolet AW, Babaei S, Hickey R et al. (2003) Decorin inhibition of PDGF-stimulated vascular smooth muscle cell function: potential mechanism for inhibition of intimal hyperplasia after balloon angioplasty. Am J Pathol 163, 869-878.
27. Nurmio M, Toppari J, Zaman F, Andersson AM, Paranko J, Soder O & Jahnukainen K. (2007) Inhibition of tyrosine kinases PDGFR and C-Kit by imatinib mesylate interferes with postnatal testicular development in the rat. Int J Androl 30, 366-376. discussion 376.
28. Orgel JP, Eid A, Antipova O, Bella J & Scott JE. (2009) Decorin core protein (decoron) shape complements collagen fibril surface structure and mediates its binding. PLoS ONE 4, e7028.
29. Parkin JD, San Antonio JD, Pedchenko V, Hudson B, Jensen ST & Savige J. (2011) Mapping structural landmarks, ligand binding sites and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions and variation in phenotypes in inherited diseases affecting basement membranes. Hum Mutat 32, 127-143.
30. Pelliniemi LJ, Paranko J, Grund SK, Frojdman K, Foidart JM & Lakkala-Paranko T. (1984) Extracellular matrix in testicular differentiation. Ann N Y Acad Sci 438, 405-416.
31. Pollanen PP, Kallajoki M, Risteli L, Risteli J & Suominen JJ. (1985) Laminin and type IV collagen in the human testis. Int J Androl 8, 337-347.
32. Reed CC & Iozzo RV. (2002) The role of decorin in collagen fibrillogenesis and skin homeostasis. Glycoconj J 19, 249-255.
33. Santamaria L, Martinez-Onsurbe P, Paniagua R & Nistal M. (1990) Laminin, type IV collagen, and fibronectin in normal and cryptorchid human testes. An immunohistochemical study. Int J Androl 13, 135-146.
34. Schaefer L & Iozzo RV. (2008) Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction. J Biol Chem 283, 21305-21309.
35. Schell C & Albrecht M, Mayer C, Schwarzer JU, Frungieri MB, Mayerhofer A. (2008) Exploring human testicular peritubular cells: identification of secretory products and regulation by tumor necrosis factor-alpha. Endocrinology 149, 1678-1686.
36. Schell C, Albrecht M, Spillner S, Mayer C, Kunz L, Kohn FM, Schwarzer U & Mayerhofer A. (2010) 15-Deoxy-delta 12-14-prostaglandin-J2 induces hypertrophy and loss of contractility in human testicular peritubular cells: implications for human male fertility. Endocrinology 151, 1257-1268.
37. Scott JE & Bosworth TR. (1990) A comparative biochemical and ultrastructural study of proteoglycan-collagen interactions in corneal stroma. Functional and metabolic implications. Biochem J 270, 491-497.
38. Scott JE & Thomlinson AM. (1998) The structure of interfibrillar proteoglycan bridges (shape modules') in extracellular matrix of fibrous connective tissues and their stability in various chemical environments. J Anat 192 (Pt 3) 391-405.
39. Siu MK & Cheng CY. (2008) Extracellular matrix and its role in spermatogenesis. Adv Exp Med Biol 636, 74-91.
40. Soto-Suazo M, San Martin S, Ferro ES & Zorn TM. (2002) Differential expression of glycosaminoglycans and proteoglycans in the migratory pathway of the primordial germ cells of the mouse. Histochem Cell Biol 118, 69-78.
41. Spinnler K, Kohn FM, Schwarzer U & Mayerhofer A. (2002) Glial cell line-derived neurotrophic factor is constitutively produced by human testicular peritubular cells and may contribute to the spermatogonial stem cell niche in man. Hum Reprod 25, 2181-2187.
42. van Straaten JF, Coers W, Noordhoek JA, Huitema S, Flipsen JT, Kauffman HF, Timens W & Postma DS. (1999) Proteoglycan changes in the extracellular matrix of lung tissue from patients with pulmonary emphysema. Mod Pathol 12, 697-705.
43. Strauss L, Kallio J, Desai N, Pakarinen P, Miettinen T, Gylling H, Albrecht M, Makela S, Mayerhofer A & Poutanen M. (2009) Increased exposure to estrogens disturbs maturation, steroidogenesis, and cholesterol homeostasis via estrogen receptor alpha in adult mouse Leydig cells. Endocrinology 150, 2865-2872.
44. Takaba H. (1990) [A morphological study of the testes in patients with idiopathic male infertility--immunohistochemical analysis of collagens and laminin in human testes]. Hinyokika Kiyo 36, 1173-1180.
45. Ungefroren H, Ergun S, Krull B & Holstein AF. (1995) Expression of the small proteoglycans biglycan and decorin in the adult human testis. Biol Reprod 52, 1095-1105.
46. Urbanski HF, Noriega NC, Lemos DR & Kohama SG. (2009) Gene expression profiling in the rhesus macaque: experimental design considerations. Methods 49, 26-31.
47. Yan YC, Sun YP & Zhang ML. (1998) Testis epidermal growth factor and spermatogenesis. Arch Androl 40, 133-146.
48. Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC & Iozzo RV. (2005) Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis. J Biol Chem 280, 32468-32479.