Glial cell line-derived neurotrophic factor is constitutively produced by human testicular peritubular cells and may contribute to the spermatogonial stem cell niche in man

Human Reproduction

Volumn 25, Issue 9, 2010, Pages 2181-2187

  Spinnler, K ^a   Kohn F M ^b   Schwarzer, U ^c   Mayerhofer, A ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b Andrologicum   (Germany)

^c Praxis for Urology and Andrology   (Germany)

Author keywords

glial cell line derived neurotrophic factor; human testis; neurotrophin; peritubular cells; stem cells niche

Indexed keywords

CYCLIC AMP; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR ALPHA 1; MESSENGER RNA; TRYPTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LASER MICRODISSECTION; MACROPHAGE; MALE; MAST CELL; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMINIFEROUS TUBULE; SPERMATOGENESIS; SPERMATOGONIUM; STEM CELL NICHE; TESTIS BIOPSY; TESTIS CELL; TESTIS DISEASE; TESTIS FIBROSIS;

EID: 77955969896     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/deq170     Document Type: Article

References (29)

1. Airaksinen MS, Saarma M. The GDNF family: signaling, biological functions and therapeutic value. Nat Rev Neurosci 2002;3:383-394.
2. Albrecht M, Rämsch R, Köhn FM, Schwarzer JU, Mayerhofer A. Isolation and cultivation of human testicular peritubular cells: a new model for the investigation of fibrotic processes in the human testis and male infertility. J Clin Endocrinol Metab 2006;91:1956-1960.
3. Buageaw A, Sukhwani M, Ben-Yehudah A, Ehmcke J, Rawe VY, Pholpramool C, Orwig KE, Schlatt S. GDNF family receptor alpha 1 phenotype of spermatogonial stem cells in immature mouse testes. Biol Reprod 2005;73:1011-1016.
4. Frungieri MB, Calandra RS, Lustig L, Meineke V, Köhn FM, Vogt HJ, Mayerhofer A. Number, distribution pattern, and identification of macrophages in the testes of infertile men. Fertil Steril 2002a;78:298-306.
5. Frungieri MB, Weidinger S, Meineke V, Köhn FM, Mayerhofer A. Proliferative action of mast-cell tryptase is mediated by PAR2, COX-2, prostaglandins, and PPAR. Natl Acad Sci USA 2002b;99:15072-15077.
6. Gassei K, Ehmcke J, Dhir R, Schlatt S. Magnetic activated cell sorting allows isolation of spermatogonia from adult primate testes and reveals distinct GFRa1-positive subpopulations in men. J Med Primatol 2010;39:83-91.
7. Grosse J, Bulling A, Brucker C, Berg U, Amsterdam A, Mayerhofer A, Gratzl M. Synaptosome-associated protein of 25 kilodaltons in oocytes and steroid-producing cells of rat and human ovary: molecular analysis and regulation by gonadotropins. Biol Reprod 2000;63:643-650.
8. Hermann BP, Sukhwani M, Lin CC, Sheng Y, Tomko J, Rodriguez M, Shuttleworth JJ, McFarland D, Hobbs RM, Pandolfi PP et al. Characterization, cryopreservation and ablation of spermatogonial stem cells in adult rhesus macaques. Stem Cells 2007;25:2330-2338.
9. Hofmann MC. Gdnf signaling pathways within the mammalian spermatogonial stem cell niche. Mol Cell Endocrinol 2008;288:95-103.
10. Katoh-SembaR,TsuzukiM,Miyazaki N, YoshidaA,NakajimaH,Nakagawa C, Kitajima S, Matsuda M. Distribution and immunohistochemical localization of GDNF protein in selected neural and non-neural tissues of rats during development and changes in unilateral 6-hydroxydopamine lesions. Neurosci Res 2007;59:277-287.
11. Kubota H, Avarbock MR, Brinster RL. Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells. Proc Natl Acad Sci USA 2004;101:16489-16494.
12. Maki CB, Pacchiarotti J, Ramos T, Pascual M, Pham J, Kinjo J, Anorve S, Izadyar F. Phenotypic and molecular characterization of spermatogonial stem cells in adult primate testes. Hum Reprod 2009;24:1480-1491.
13. Mayerhofer A, Frungieri MB, Fritz S, Bulling A, Jessberger B, Vogt HJ. Evidence for catecholaminergic, neuronlike cells in the adult human testis: changes associated with testicular pathologies. J Androl 1999;20:341-347.
14. Mayerhofer A, Kunz L, Krieger A, Proskocil B, Spindel E, Amsterdam A, Dissen GA, Ojeda SR, Wessler I. FSH regulates acetycholine production by ovarian granulosa cells. Reprod Biol Endocrinol 2006;17:4-37.
15. Meineke V, Frungieri MB, Jessberger B, Vogt H, Mayerhofer A. Human testicular mast cells contain tryptase: increased mast cell number and altered distribution in the testes of infertile men. Fertil Steril 2000; 74:239-244.
16. Meng X, Lindahl M, Hyvonen M, Parvinen M, De Rooij DG, Hess M, Raatikainen-Ahokas A, Sainio K, Rauvala H, Lakso M et al. Regulation of cell fate decision of undifferentiated spermatogonia by GDNF. Science 2000;287:1489-1493.
17. Mizrak SC, Chikhovskaya JV, Sadri-Ardekani H, Van Daalen S, Korver CM, Hovingh SE, Roepers-Gajadien HL, Raya A, Fluiter K, De Reijke ThM et al. Embryonic stem cell-like cells derived from adult human testis. Hum Reprod 2010;25:158-167.
18. Naughton CK, Jain S, Strickland AM, Gupta A, Milbrandt J. Glial cell-line derived neurotrophic factor-mediated RET signaling regulates spermatogonial stem cell fate. Biol Reprod 2006;74:314-321.
19. Oatley JM, Brinster RL. Regulation of spermatogonial stem cell self-renewal in mammals. Annu Rev Cell Dev Biol 2008;24:263-286.
20. Oatley JM, Reeves JJ, Mclean DJ. Biological activity of cryopreserved bovine spermatogonial stem cells during in vitro culture. Biol Reprod 2004; 1:942-947.
21. Ryu B-Y, Kubota H, Avarbock MR, Brinster RL. Conservation of spermatogonial stem cell self-renewal signaling between mouse and rat. Proc Natl Acad Sci USA 2005;102:14302-14307.
22. Schell C, Albrecht M, Mayer C, Schwarzer JU, Frungieri MB, Mayerhofer A. Exploring human testicular peritubular cells: identification of secretory products and regulation by tumor necrosis factor-a. Endocrinology 2008;149:1678-1686.
23. Schell C, Albrecht M, Spillner S, Mayer C, Kunz L, Köhn FM, Schwarzer U, Mayerhofer A. 15-deoxy-delta-Prostaglandin-J2 (15dPGJ2) induces hypertrophy and loss of contractility in human testicular peritubular cells: implications for human male fertility. Endocrinology 2010;151:1257-1268.
24. Simon L, Ekman GC, Tyagi G, Hess RA, Murphy KM, Cooke PS. Common and distinct factors regulate expression of mRNA for ETV5 and GDNF, Sertoli cell proteins essential for spermatogonial stem cell maintenance. Exp Cell Res 2007;313:3090-3099.
25. Sommersberg B, Bulling A, Salzer U, Fröhlich U, Garfield RE, Amsterdam A, Mayerhofer A. Gap junction communication and connexin 43 gene expression in a rat granulosa cell line: regulation by follicle-stimulating hormone. Biol Reprod 2000;63:1661-1668.
26. Spiess AN, Feig C, Schulze W, Chalmel F, Cappallo-Obermann H, Primig M, Kirchhoff C. Cross-platform gene expression signature of human spermatogenic failure reveals inflammatory-like response. Hum Reprod 2007;22:2936-2946.
27. Tadokoro Y, Yomogida K, Ohta H, Tohda A, Nishimune Y. Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway. Mech Dev 2002;113:29-39.
28. Wu X, Schmidt JA, Avarbock MR, Tobias JW, Carlson CA, Kolon TF, Ginsberg JP, Brinster RL. Prepubertal human spermatogonia and mouse gonocytes share conserved gene expression of germline stem cell regulatory molecules. PNAS 2009;51:21672-21677.
29. Yoshida S, Sukeno M, Nabeshima Y. A vasculature-associated niche for undifferentiated spermatogonia in the mouse testis. Science 2007; 317:1722-1726.