Inhibition of tyrosine kinases PDGFR and C-Kit by imatinib mesylate interferes with postnatal testicular development in the rat

International Journal of Andrology

Volumn 30, Issue 4, 2007, Pages 366-376

  Nurmio, Mirja ^a   Toppari, Jorma ^a   Zaman, Farasat ^b   Andersson, Anna Maria ^c   Paranko, Jorma ^a   Söder, Olle ^b   Jahnukainen, Kirsi ^a,b  

^a UNIVERSITY OF TURKU   (Finland)

^b KAROLINSKA INSTITUTE   (Sweden)

^c Rigshospitalet   (Denmark)

Author keywords

Germ cell; Imatinib; Rat; STI571; Testis; Tyrosine kinase

Indexed keywords

FOLLITROPIN; IMATINIB; LUTEINIZING HORMONE; PLATELET DERIVED GROWTH FACTOR; PROTEIN TYROSINE KINASE; STEM CELL FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; GERM LINE; IMMATURITY; MALE; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; SPERMATOGENESIS; SPERMATOGONIUM; SPERMATOZOON COUNT; STATISTICAL SIGNIFICANCE; STEM CELL; TESTIS DEVELOPMENT;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DISEASE MODELS, ANIMAL; MALE; PIPERAZINES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SERTOLI CELLS; SPERMATOGENESIS; TESTICULAR NEOPLASMS; TESTIS;

EID: 34547866697     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2007.00755.x     Document Type: Article

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