Angiotensin-(1-7) inhibits neuronal activity of dorsolateral periaqueductal gray via a nitric oxide pathway

Neuroscience Letters

Volumn 522, Issue 2, 2012, Pages 156-161

  Xing, Jihong ^a,b   Kong, Jian ^a   Lu, Jian ^b   Li, Jianhua ^b  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Angiotensin (1 7); Mas receptor; Midbrain PAG; Nitric oxide

Indexed keywords

ANGIOTENSIN[1-7]; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR MAS; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; MALE; MEMBRANE POTENTIAL; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION;

ANGIOTENSIN I; ANIMALS; CITRULLINE; FEMALE; MALE; NEURONS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; PERIAQUEDUCTAL GRAY; PROTO-ONCOGENE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; THIOUREA;

EID: 84863873052     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.06.031     Document Type: Article

References (33)

1. Bandler R., Carrive P., Zhang S.H. Integration of somatic and autonomic reactions within the midbrain periaqueductal gray: viscerotopic, somatotopic and functional organization. Progress in Brain Research 1991, 87:269-305.
2. Becker L.K., Etelvino G.M., Walther T., Santos R.A.S., Campagnole-Santos M.J. Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain. American Journal of Physiology 2007, 293:H1416-H1424.
3. Behbehani M.M. Functional characteristics of the midbrain periaqueductal gray. Progress in Neurobiology 1995, 46:575-605.
4. Brooks V.L. Interactions between angiotensin II and the sympathetic nervous system in the long-term control of arterial pressure. Clinical and Experimental Pharmacology and Physiology 1997, 24:83-90.
5. Bruner C.A., Kuslikis B.I., Fink G.D. Effect of inhibition of central angiotensin pressor mechanisms on blood pressure in spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology 1987, 9:298-304.
6. Campagnole-Santos M.J., Heringer S.B., Batista E.N., Khosla M.C., Santos R.A. Differential baroreceptor reflex modulation by centrally infused angiotensin peptides. American Journal of Physiology 1992, 263:R89-R94.
7. Chang Y.Z., Gu Y.H. Role of brain angiotensin II system in subfornical organ-pressor responses. Acta Physiologica Sinica 1999, 51:38-44.
8. Costa M.A., Verrilli M.A., Gomez K.A., Nakagawa P., Peña C., Arranz C., Gironacci M.M. Angiotensin-(1-7) upregulates cardiac nitric oxide synthase in spontaneously hypertensive rats. American Journal of Physiology 2010, 299:H1205-H1211.
9. Craig A.D. Distribution of brainstem projections from spinal lamina I neurons in the cat and the monkey. Journal of Comparative Neurology 1995, 361:225-248.
10. D'Amico M., Di Filippo C., Berrino L., Rossi F. AT1 receptors mediate pressor responses induced by angiotensin II in the periaqueductal gray area of rats. Life Sciences 1997, 61:PL17-PL20.
11. Doobay M.F., Talman L.S., Obr T.D., Tian X., Davisson R.L., Lazartigues E. Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin angiotensin system. American Journal of Physiology 2007, 292:R373-R381.
12. Feng Y., Xia H., Cai Y., Halabi C.M., Becker L.K., Santos R.A., Speth R.C., Sigmund C.D., Lazartigues E. Brain-selective overexpression of human angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. Circulation Research 2010, 106:373-382.
13. Ferrario C.M., Trask A.J., Jessup J.A. Advances in the biochemical and functional roles of angiotensin converting enzyme 2 and angiotensin-(1-7) in the regulation of cardiovascular function. American Journal of Physiology 2005, 289:H2281-H2290.
14. Keay K.A., Feil K., Gordon B.D., Herbert H., Bandler R. Spinal afferents to functionally distinct periaqueductal gray columns in the rat - an anterograde and retrograde tracing study. Journal of Comparative Neurology 1997, 385:207-229.
15. Li D.-P., Pan H.-L. Angiotensin II attenuates synaptic GABA release and excites paraventricular-rostral ventrolateral medulla output neurons. Journal of Pharmacology and Experimental Therapeutics 2005, 313:1035-1045.
16. Li D.P., Chen S.R., Pan H.L. Journal of Neuroscience 2003, 23:5041-5049.
17. Li Z., Ferguson A.V. Subfornical organ efferents to paraventricular nucleus utilize angiotensin as a neurotransmitter. American Journal of Physiology 1993, 265:R302-R309.
18. Lopez Verrilli M.A., Pirola C.J., Pascual M.M., Dominici F.P., Turyn D., Gironacci M.M. Angiotensin-(1-7) through AT2 receptors mediates tyrosine hydroxylase degradation via the ubiquitin-proteasome pathway. Journal of Neurochemistry 2009, 109:326-335.
19. Lovick T.A., Adamec R. The periaqueductal gray (PAG). Neural Plasticity 2009.
20. Lu J., Xing J., Li J. Prostaglandin E2 (PGE2) inhibits glutamatergic synaptic transmission in dorsolateral periaqueductal gray (dl-PAG). Brain Research 2007, 1162:38-47.
21. McGaraughty S., Chu K.L., Bitner R.S., Martino B., El Kouhen R., Han P., Nikkel A.L., Burgard E.C., Faltynek C.R., Jarvis F. Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM. Journal of Neurophysiology 2003, 90:2702-2710.
22. Modgil A., Zhang Q., Pingili A., Singh N., Yao F., Ge J., Guo L., Xuan C., O'Rourke S.T., Sun C. Angiotensin-(1-7) attenuates the chronotropic response to angiotensin II via stimulation of PTEN in the spontaneously hypertensive rat neurons. American Journal of Physiology 2012, 302:H1116-H1122.
23. Peach M.J. Renin-angiotensin system: biochemistry and mechanisms of action. Physiological Reviews 1977, 57:313-370.
24. Prado W.A., Pelegrini-da-Silva A., Martins A.R. Microinjection of renin-angiotensin system peptides in discrete sites within the rat periaqueductal gray matter elicits antinociception. Brain Research 2003, 972:207-215.
25. Santos R.A.S., Silva A.C.S., Maric C. Angiotensin-(1-7) is an endogenous ligand for the G 425 protein-coupled receptor Mas. PNAS 2003, 100:8258-8263.
26. Sewards T.V., Sewards M.A. The awareness of thirst: proposed neural correlates. Consciousness and Cognition 2000, 9:463-487.
27. Steckelings U.M., Obermuller N., Bottari S.P., Qadri F., Veltmar A., Unger T. Brain angiotensin: receptors, actions and possible role in hypertension. Pharmacology and Toxicology 1992, 70:S23-S27.
28. Swanson L.W. Brain Maps: Structure of the Rat Brain 1998, Elsevier, New York.
29. Verberne A.J.M., Guyenet P.G. Midbrain central gray: influence on medullary sympathoexcitatory neurons and the baroreflex in rats. American Journal of Physiology 1992, 263:R24-R33.
30. Xing J., Li D.-P., Li J. Role of GABA receptors in nitric oxide inhibition of dorsolateral periaqueductal gray neurons. Neuropharmacology 2008, 54:734-744.
31. Xing J., Lu J., Li J. Angiotensin II inhibits GABAergic synaptic transmission in dorsolateral periaqueductal gray neurons. Neuroscience Letters 2009, 455:8-13.
32. Yamazato M., Yamazato Y., Sun C., Diez-Freire C., Raizada M.K. Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats. Hypertension 2007, 49:926-931.
33. Yang R., Yin J., Li Y., Zimmerman M.C., Schultz H.D. Angiotensin-(1-7) increases neuronal potassium current via a nitric oxide-dependent mechanism. American Journal of Physiology 2011, 300:C58-C64.