Spy1 is frequently overexpressed in malignant gliomas and critically regulates the proliferation of glioma cells

Journal of Molecular Neuroscience

Volumn 47, Issue 3, 2012, Pages 485-494

  Zhang, Li ^a   Shen, Aiguo ^a   Ke, Qing ^b   Zhao, Wei ^a   Yan, Meijuan ^a   Cheng, Chun ^a  

^a NANTONG UNIVERSITY   (China)

^b HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

Glioma; Prognosis; Proliferation; Spy1

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1B; PROTEIN; PROTEIN SPY1; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURVIVAL; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GLIOMA; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; WESTERN BLOTTING;

ADULT; BRAIN NEOPLASMS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; MALE;

EID: 84863869748     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-012-9709-5     Document Type: Article

References (40)

1. Barnes EA, Porter LA, Lenormand JL, Dellinger RW, Donoghue DJ (2003) Human Spy1 promotes survival of mammalian cells following DNA damage. Cancer Res 63:3701-3707 (Pubitemid 36793055)
2. Bhattacharjee RN, Banks GC, Trotter KW, Lee HL, Archer TK (2001) Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodeling. Mol Cell Biol 21:5417-5425 (Pubitemid 32702446)
3. Brown NR, Noble ME, Endicott JA, Johnson LN (1999) The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. Nat Cell Biol 1:438-443 (Pubitemid 129502811)
4. Cheng A, Xiong W, Ferrell JE Jr, Solomon MJ (2005) Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. Cell Cycle 4:155-165 (Pubitemid 41038945)
5. Dinarina A, Perez LH, Davila A, Schwab M, Hunt T, Nebreda AR (2005) Characterization of a new family of cyclin-dependent kinase activators. Biochem J 386:349-355 (Pubitemid 40343793)
6. Ferby I, Blazquez M, Palmer A, Eritja R, Nebreda AR (1999) A novel p34(cdc2)-binding and activating protein that is necessary and sufficient to trigger G(2)/M progression in Xenopus oocytes. Genes Dev 13:2177-2189 (Pubitemid 29407356)
7. Furnari FB, Huang HJ, Cavenee WK (1996) Molecular biology of malignant degeneration of astrocytoma. Pediatr Neurosurg 24:41-49 (Pubitemid 26198323)
8. Gastwirt RF, Slavin DA, McAndrew CW, Donoghue DJ (2006) Spy1 expression prevents normal cellular responses to DNA damage: inhibition of apoptosis and checkpoint activation. J Biol Chem 281:35425-35435 (Pubitemid 46043250)
9. Golipour A, Myers D, Seagroves T, Murphy D, Evan GI, Donoghue DJ et al (2008) The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis. Cancer Res 68:3591-3600
10. Karaiskou A, Perez LH, Ferby I, Ozon R, Jessus C, Nebreda AR (2001) Differential regulation of Cdc2 and Cdk2 by RINGO and cyclins. J Biol Chem 276:36028-36034
11. Ke Q, Ji J, Cheng C, Zhang Y, Lu M, Wang Y et al (2009) Expression and prognostic role of Spy1 as a novel cell cycle protein in hepatocellular carcinoma. Exp Mol Pathol 87:167-172
12. King RW, Deshaies RJ, Peters JM, Kirschner MW (1996) How proteolysis drives the cell cycle. Science 274:1652-1659 (Pubitemid 26414887)
13. Kirla RM, Haapasalo HK, Kalimo H, Salminen EK (2003) Low expression of p27 indicates a poor prognosis in patients with high-grade astrocytomas. Cancer 97:644-648 (Pubitemid 36125841)
14. Kleihues P, Sobin LH (2000) World Health Organization classification of tumors. Cancer 88:2887 (Pubitemid 30417954)
15. Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC et al (2002) The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61:215-225, discussion 226-219
16. Lenormand JL, Dellinger RW, Knudsen KE, Subramani S, Donoghue DJ (1999) Speedy: a novel cell cycle regulator of the G2/M transition. EMBO J 18:1869-1877 (Pubitemid 29158530)
17. Louis DN (1994) The p53 gene and protein in human brain tumors. J Neuropathol Exp Neurol 53:11-21
18. Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK et al (2001) Malignant glioma: genetics and biology of a grave matter. Genes Dev 15:1311-1333
19. McAndrew CW, Gastwirt RF, Meyer AN, Porter LA, Donoghue DJ (2007) Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27. Cell Cycle 6:1937-1945
20. Morgan DO (1996) The dynamics of cyclin dependent kinase structure. Curr Opin Cell Biol 8:767-772
21. Morgan DO (1997) Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu Rev Cell Dev Biol 13:261-291
22. Morris GF, Mathews MB (1989) Regulation of proliferating cell nuclear antigen during the cell cycle. J Biol Chem 264:13856-13864 (Pubitemid 19198480)
23. Nebreda AR (2006) CDK activation by non-cyclin proteins. Curr Opin Cell Biol 18:192-198
24. Nho RS, Sheaff RJ (2003) p27kip1 contributions to cancer. Prog Cell Cycle Res 5:249-259
25. Ohgaki H, Kleihues P (2005) Epidemiology and etiology of gliomas. Acta Neuropathol 109:93-108 (Pubitemid 40287792)
26. Pines J (1995) Cyclins and cyclin-dependent kinases: a biochemical view. Biochem J 308(Pt 3):697-711
27. Porter LA, Dellinger RW, Tynan JA, Barnes EA, Kong M, Lenormand JL et al (2002) Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2. J Cell Biol 157:357-366 (Pubitemid 34839801)
28. Porter LA, Kong-Beltran M, Donoghue DJ (2003) Spy1 interacts with p27Kip1 to allow G1/S progression. Mol Biol Cell 14:3664-3674 (Pubitemid 37151617)
29. Rasheed BK, Wiltshire RN, Bigner SH, Bigner DD (1999) Molecular pathogenesis of malignant gliomas. Curr Opin Oncol 11:162-167 (Pubitemid 29229607)
30. Reilly KM, Jacks T (2001) Genetically engineered mouse models of astrocytoma: GEMs in the rough? Semin Cancer Biol 11:177-191
31. Rich JN, Hans C, Jones B, Iversen ES, McLendon RE, Rasheed BK et al (2005) Gene expression profiling and genetic markers in glioblastoma survival. Cancer Res 65:4051-4058 (Pubitemid 40775641)
32. Sanson M, Thillet J, Hoang-Xuan K (2004) Molecular changes in gliomas. Curr Opin Oncol 16:607-613 (Pubitemid 39482982)
33. Sherr CJ (1996) Cancer cell cycles. Science 274:1672-1677
34. Sherr CJ, Roberts JM (1995) Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9:1149-1163
35. Sherr CJ, Roberts JM (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13:1501-1512 (Pubitemid 29297917)
36. Solomon MJ, Kaldis P (1998) Regulation of CDKs by phosphorylation. Results Probl Cell Differ 22:79-109
37. Uhrbom L, Kastemar M, Johansson FK, Westermark B, Holland EC (2005) Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis. Cancer Res 65:2065-2069 (Pubitemid 40490109)
38. Wong AJ, Bigner SH, Bigner DD, Kinzler KW, Hamilton SR, Vogelstein B (1987) Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci U S A 84:6899-6903
39. Xiao A, Wu H, Pandolfi PP, Louis DN, Van Dyke T (2002) Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell 1:157-168 (Pubitemid 41039162)
40. Zucchi I, Mento E, Kuznetsov VA, Scotti M, Valsecchi V, Simionati B et al (2004) Gene expression profiles of epithelial cells microscopically isolated from a breast-invasive ductal carcinoma and a nodal metastasis. Proc Natl Acad Sci U S A 101:18147-18152 (Pubitemid 40054088)