Leucine stimulates insulin secretion via down-regulation of surface expression of adrenergic α2A receptor through the mTOR (mammalian target of rapamycin) pathway: Implication in new-onset diabetes in renal transplantation

Journal of Biological Chemistry

Volumn 287, Issue 29, 2012, Pages 24795-24806

  Yang, Jun ^a   Dolinger, Michael ^a   Ritaccio, Gabrielle ^a   Mazurkiewicz, Joseph ^a   Conti, David ^a   Zhu, Xinjun ^a   Huang, Yunfei ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; INSULIN; MAMMALS;

CLINICAL MANAGEMENT; GLUCOSE HOMEOSTASIS; RENAL TRANSPLANTATION; RENAL TRANSPLANTS; RETROSPECTIVE ANALYSIS; SENSING MECHANISM; STIMULATORY EFFECTS; SURFACE EXPRESSION;

ANTIBIOTICS;

ALPHA 2A ADRENERGIC RECEPTOR; CLONIDINE; INSULIN; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG POTENTIATION; ENZYME ACTIVATION; FEMALE; GOTO KAKIZAKI RAT; HUMAN; HUMAN CELL; HYPERTENSION; INSULIN RELEASE; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; METABOLIC REGULATION; MONOTHERAPY; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; RETROSPECTIVE STUDY; SIGNAL TRANSDUCTION;

MAMMALIA; RATTUS;

EID: 84863788721     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.344259     Document Type: Article

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