Inhalative nanomedicine-opportunities and challenges

Inhalation Toxicology

Volumn 21, Issue SUPPL. 1, 2009, Pages 137-143

  Bur, Michael ^a   Henning, Andreas ^a   Hein, Stephanie ^a   Schneider, Marc ^a   Lehr, Claus Michael ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Inhalation; Nano particles

Indexed keywords

CHITOSAN; DRUG CARRIER; INSULIN; NANOPARTICLE; NUCLEOTIDE; PEPTIDE; POLYGLACTIN; PROTEIN; TRIPOLYPHOSPHATE;

AEROSOL; CONTROLLED RELEASE FORMULATION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; HUMAN; LUNG CLEARANCE; MACROPHAGE; MUCOCILIARY CLEARANCE; NANOENCAPSULATION; NANOMEDICINE; NONHUMAN; PARTICLE SIZE; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW;

ADMINISTRATION, INHALATION; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; HUMANS; LUNG; MUCOCILIARY CLEARANCE; NANOMEDICINE; NANOPARTICLES; PROTEINS; TECHNOLOGY, PHARMACEUTICAL;

EID: 70350651977     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370902962283     Document Type: Review

References (45)

1. Abu-Dahab, R., Schaefer, U.F., Lehr, C.M. 2001. Lectin-functionalized liposomes for pulmonary drug delivery: Effect of nebulization on stability and bioadhesion. European Journal of Pharmaceutical Sciences 14 1:37-46. (Pubitemid 32655413)
2. Anabousi, S., Bakowsky, U., Schneider, M., Huwer, H., Lehr, C.M., Ehrhardt, C. 2006. In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer. European Journal of Pharmaceutical Sciences 29 5:367-374.
3. Anabousi, S., Kleemann, E., Bakowsky, U., Kissel, T., Schmehl, T., Gessler, T., Seeger, W., Lehr, C.M., Ehrhardt, G. 2006. Effect of PEGylation on the stability of liposomes during nebulisation and in lung surfactant. Journal of Nanoscience and Nanotechnology 6 9-10:3010-3016.
4. Anabousi, S., Laue, M., Lehr, C.M., Bakowsky, U., Ehrhardt, C. 2005. Assessing transferrin modification of liposomes by atomic force microscopy and transmission electron microscopy. European Journal of Pharmaceutics and Biopharmaceutics 60 2:295-303.
5. Azarmi, S., Loebenberg, R., Roa, W.H., Tai, S., Finlay, W.H. 2008. Formulation and in vivo evaluation of effervescent inhalable carrier particles for pulmonary delivery of nanoparticles. Drug Development and Industrial Pharmacy 34 9:943-947.
6. Bowden, D.H. 1987. Macrophages, dust, and pulmonary diseases. Experimental Lung Research 12 2:89-107.
7. Brown, J.S., Zeman, K.L., Bennett, W.D. 2002. Ultrafine particle deposition and clearance in the healthy and obstructed lung. American Journal of Respiratory and Critical Care Medicine 166 9:1240-1247.
8. Dietz, A.B., Bulur, P.A., Emery, R.L., Winters, J.L., Epps, D.E., Zubair, A.C., Vuk-Pavlovic, S. 2006. A novel source of viable peripheral blood mononuclear cells from leukoreduction system chambers. Transfusion 46 12:2083-2089.
9. Erdmann, E. 2006. Worldwide spread of lifestyle diseases and its importance for cardiovascular events. Drugs of Today 42 suppl. C:5-8.
10. Foster, W.M., Langenback, E., Bergofsky, E.H. 1980. Measurement of tracheal and bronchial mucus velocities in man: Relation to lung clearance. Journal of Applied Physiology Respiratory Environmental and Exercise Physiology 48 6:965-971.
11. Gehr, P., Bachofen, M., Weibel, E.R. 1978. The normal human lung: ultrastructure and morphometric estimation of diffusion capacity. Respiration Physiology 32 2:121-140.
12. Gehr, P., Blank, F., Rothen-Rutishauser, B.M. 2006. Fate of inhaled particles after interaction with the lung surface. Paediatric Respiratory Reviews 7 suppl. 1.
13. Gehr, P., Geiser, M., Hof, V.I., Schurch, S., Waber, U., Baumann, M. 1993. Surfactant and inhaled particles in the conducting airways: Structural, stereological, and biophysical aspects. Microscopy Research and Technique 26 5:423-436.
14. Geiser, M., Rothen-Rutishauser, B., Kapp, N., Schuerch, S., Kreyling, W., Schulz, H., Semmler, M., Im Hof V., Heyder, J., Gehr, P, . 2005. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environmental Health Perspectives 113 11:1555-1560.
15. Gerber, V., Gehr, P., Straub, R., Frenz, M., King, M., Im Hof, V. 1997. Mucus quality on horse tracheal epithelium: Microscopic grading based on transparency. Respiration Physiology 107 1:67-74.
16. Grenha, A., Remunan-Lopez, C., Carvalho, E.L.S., Seijo, B. 2008. Microspheres containing lipid/chitosan nanoparticles complexes for pulmonary delivery of therapeutic proteins. European Journal of Pharmaceutics and Biopharmaceutics 69 1:83-93.
17. Heinemann, L. 2004. Current status of the development of inhaled insulin. British Journal of Diabetes and Vascular Disease 4 5:295-301.
18. Henning, A., Schneider, M., Bur, M., Blank, F., Gehr, P., Lehr, C.M. 2008. Embryonic chicken trachea as a new in vitro model for the investigation of mucociliary particle clearance in the airways. AAPS PharmSciTech 9 2:521-527.
19. Hirota, K., Hasegawa, T., Hinata, H., Ito, F., Inagawa, H., Kochi, C., Soma, G.I., Makino, K., Terada, H. 2007. Optimum conditions for efficient phagocytosis of rifampicin-loaded PLGA microspheres by alveolar macrophages. Journal of Controlled Release 119 1:69-76.
20. Kaewamatawong, T., Kawamura, N., Okajima, M., Sawada, M., Morita, T., Shimada, A. 2005. Acute pulmonary toxicity caused by exposure to colloidal silica: Particle size dependent pathological changes in mice. Toxicologic Pathology 33 7:745-751.
21. Kneuer, C., Sameti, M., Bakowsky, U., Schiestel, T., Schirra, H., Schmidt, H., Lehr, C.M. 2000. A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro. Bioconjugate Chemistry 11 6:926-932.
22. Kneuer, C., Sameti, M., Haltner, E.G., Schiestel, T., Schirra, H., Schmidt, H., Lehr, C.M. 2000. Silica nanoparticles modified with aminosilanes as carriers for plasmid DNA. International Journal of Pharmaceutics 196 2:257-261.
23. Kumar, M.N.V.R., Mohapatra, S.S., Kong, X., Jena, P.K., Bakowsky, U., Lehr, C.M. 2004. Cationic poly(lactide-co-glycolide) nanoparticles as efficient in vivo gene transfection agents. Journal of Nanoscience and Nanotechnology 4 8:990-994.
24. Lai, S.K., O'hanlon, E.D., Man, S.T., Cone, R., Hanes, J. 2005. Real-Time Transport of Polymer Nanoparticles in Cervical Vaginal Mucus. AIChE Annual Meeting, Conference Proceedings, p 14298.
25. Lehnert, B.E., Valdez, Y.E., Tietjen, G.L. 1989. Alveolar macrophage-particle relationships during lung clearance. American Journal of Respiratory Cell and Molecular Biology 1 2:145-154.
26. Liu, J., Gong, T., Fu, H., Wang, C., Wang, X., Chen, Q., Zhang, Q., He, Q., Zhang, Z. 2008. Solid lipid nanoparticles for pulmonary delivery of insulin. International Journal of Pharmaceutics 356 1-2:333-344.
27. Lundqvist, M., Stigler, J., Elia, G., Lynch, I., Cedervall, T., Dawson, K.A. 2008. Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts. Proceedings of the National Academy of Sciences of the United States of America 105 38:14265-14270.
28. Luten, J., Van Nostrum, C.F., De Smedt, S.C., Hennink, W.E. 2008. Biodegradable polymers as non-viral carriers for plasmid DNA delivery. Journal of Controlled Release 126 2:97-110.
29. Mace, K., Bowman, E.D., Vautravers, P., Shields, P.G., Harris, C.C., Pfeifer, A.M.A. 1998. Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues. European Journal of Cancer 34 6:914-920.
30. Mbawuike, I.N., Herscowitz, H.B. 1989. MH-S, a murine alveolar macrophage cell line: Morphological, cytochemical, and functional characteristics. Journal of Leukocyte Biology 46 2:119-127.
31. Moeller, W., Brown, D.M., Kreyling, W.G., Stone, V. 2005. Ultrafine particles cause cytoskeletal dysfunctions in macrophages: Role of intracellular calcium. Particle and Fibre Toxicology 2.
32. Moeller, W., Haeußinger, K., Winkler-Heil, R., Stahlhofen, W., Meyer, T., Hofmann, W., Heyder, J. 2004. Mucociliary and long-term particle clearance in the airways of healthy nonsmoker subjects. Journal of Applied Physiology 97 6:2200-2206.
33. Nafee, N., Taetz, S., Schneider, M., Schaefer, U.F., Lehr, C.M. 2007. Chitosancoated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotids. Nanomedicine 3 3:173-183.
34. Patton, J.S. 1996. Mechanisms of macromolecule absorption by the lungs. Advanced Drug Delivery Reviews 19 1:3-36.
35. Sakagami, M. 2006. In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery. Advanced Drug Delivery Reviews 58 9-10:1030-1060.
36. Scheuch, G., Kohlhaeufl, M.J., Brand, P., Siekmeier, R. 2006. Clinical perspectives on pulmonary systemic and macromolecular delivery. Advanced Drug Delivery Reviews 58 9-10:996-1008.
37. Schulze, C., Kroll, A., Lehr, C.M., Schaefer, U.F., Becker, K., Schnekenburger, J., Schulze Isfort, C., Landsiedel, R., Wohlleben, W . 2008. Not ready to use- Overcoming pitfalls when dispersing nanoparticles in physiological media. Nanotoxicology 2 2:51-61.
38. Schurch, S., Gehr, P., Im Hof, V., Geiser, M., Green, F. 1990. Surfactant displaces particles toward the epithelium in airways and alveoli. Respiration Physiology 80 1:17-32.
39. Taetz, S., Nafee, N., Beisner, J., Piotrowska, K., Baldes, C., Muedter, T.E., Huwer, H., Schneider, M., Schaefer, U.F., Klotz, U., Lehr, C.M. 2008. The influence of chitosan content in cationic chitosan/PLGA nanoparticles on the delivery efficiency of antisense 2'-O-methyl-RNA directed against telomerase in lung cancer cells. European Journal of Pharmaceutics and Biopharmaceutics 72 2:358-369.
40. Torchilin, V. 2008. Antibody-modified liposomes for cancer chemotherapy. Expert Opinion on Drug Delivery 5 9:1003-1025.
41. Tronde, A., Norden, B., Marchner, H., Wendel, A.K., Lennernaes, H., Bengtsson, U.H. 2003. Pulmonary absorption rate and bioavailability of drugs in vivo in rats: Structure-absorption relationships and physicochemical profiling of inhaled drugs. Journal of Pharmaceutical Sciences 92 6:1216-1233.
42. Valberg, P.A., Jensen, W.A., Rose, R.M. 1990. Cell organelle motions in bronchoalveolar lavage macrophages from smokers and nonsmokers. American Review of Respiratory Disease 141 5 I:1272-1279.
43. Weibel, E.R. 1973. Morphological basis of alveolar-capillary gas exchange. Physiological Reviews 53 2:419-495.
44. Yamamoto, H., Kuno, Y., Sugimoto, S., Takeuchi, H., Kawashima, Y. 2005. Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions. Journal of Controlled Release 102 2:373-381.
45. Zlochiver, S., Radai, M.M., Barak-Shinar, D., Ben-Gal, T., Yaari, V., Strasberg, B., Abboud, S. 2005. Monitoring lung resistivity changes in congestive heart failure patients using the bioimpedance technique. Congestive Heart Failure (Greenwich, Conn) 11 6:289-293.