Proteomic identification of adam12 as a regulator for tgf-β1-induced differentiation of human mesenchymal stem cells to smooth muscle cells

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Kim, Young Mi ^a   Kim, Jaeyoon ^b   Heo, Soon Chul ^a   Shin, Sang Hun ^a   Do, Eun Kyoung ^a   Suh, Dong Soo ^a   Kim, Ki Hyung ^a   Yoon, Man Soo ^a   Lee, Taehoon G ^b   Kim, Jae Ho ^a  

^a Pusan National University School of Medicine   (South Korea)

^b NovaCell Technology Inc   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

A DISINTGERIN AND METALLOPROTEASE 12; ADAM PROTEIN; ALPHA SMOOTH MUSCLE ACTIN; BIOLOGICAL MARKER; CAVEOLIN 1; MESSENGER RNA; METHYL BETA CYCLODEXTRIN; PROTEOME; SHORT HAIRPIN RNA; SMAD2 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; GENE SILENCING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPID RAFT; MESENCHYMAL STEM CELL; NUCLEOTIDE SEQUENCE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; REGULATORY MECHANISM; SMOOTH MUSCLE FIBER; TANDEM MASS SPECTROMETRY;

ACTINS; ADAM PROTEINS; ADIPOSE TISSUE; CAVEOLIN 1; CELL DIFFERENTIATION; CHOLESTEROL; HUMANS; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; MESENCHYMAL STROMAL CELLS; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTEOMICS; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84863765644     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040820     Document Type: Article

References (52)

1. Prockop DJ, Kota DJ, Bazhanov N, Reger RL, (2010) Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs). J Cell Mol Med 14: 2190-2199.
2. Pittenger MF, Martin BJ, (2004) Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 95: 9-20.
3. Chamberlain G, Fox J, Ashton B, Middleton J, (2007) Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25: 2739-2749.
4. Caplan AI, (2007) Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol 213: 341-347.
5. Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, et al. (2008) A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3: 301-313.
6. Cai X, Lin Y, Hauschka PV, Grottkau BE, (2011) Adipose stem cells originate from perivascular cells. Biol Cell 103: 435-447.
7. Corselli M, Chen CW, Crisan M, Lazzari L, Peault B, (2010) Perivascular ancestors of adult multipotent stem cells. Arterioscler Thromb Vasc Biol 30: 1104-1109.
8. Liu C, Nath KA, Katusic ZS, Caplice NM, (2004) Smooth muscle progenitor cells in vascular disease. Trends Cardiovasc Med 14: 288-293.
9. Owens GK, Kumar MS, Wamhoff BR, (2004) Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84: 767-801.
10. Derynck R, Akhurst RJ, Balmain A, (2001) TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 29: 117-129.
11. Massague J, Blain SW, Lo RS, (2000) TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103: 295-309.
12. Shi Y, Massague J, (2003) Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113: 685-700.
13. Kinner B, Zaleskas JM, Spector M, (2002) Regulation of smooth muscle actin expression and contraction in adult human mesenchymal stem cells. Exp Cell Res 278: 72-83.
14. Wang D, Park JS, Chu JS, Krakowski A, Luo K, et al. (2004) Proteomic profiling of bone marrow mesenchymal stem cells upon transforming growth factor beta1 stimulation. J Biol Chem 279: 43725-43734.
15. Davani S, Marandin A, Mersin N, Royer B, Kantelip B, et al. (2003) Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model. Circulation 108: II253-II258.
16. Yoon YS, Wecker A, Heyd L, Park JS, Tkebuchava T, et al. (2005) Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J Clin Invest 115: 326-338.
17. Gojo S, Gojo N, Takeda Y, Mori T, Abe H, et al. (2003) In vivo cardiovasculogenesis by direct injection of isolated adult mesenchymal stem cells. Exp Cell Res 288: 51-59.
18. Jeon ES, Moon HJ, Lee MJ, Song HY, Kim YM, et al. (2006) Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-{beta}-dependent mechanism. J Cell Sci 119: 4994-5005.
19. Jeon ES, Park WS, Lee MJ, Kim YM, Han J, et al. (2008) A Rho kinase/myocardin-related transcription factor-A-dependent mechanism underlies the sphingosylphosphorylcholine-induced differentiation of mesenchymal stem cells into contractile smooth muscle cells. Circ Res 103: 635-642.
20. Jacobsen J, Wewer UM, (2009) Targeting ADAM12 in human disease: head, body or tail? Curr Pharm Des 15: 2300-2310.
21. Cao Y, Kang Q, Zhao Z, Zolkiewska A, (2002) Intracellular processing of metalloprotease disintegrin ADAM12. J Biol Chem 277: 26403-26411.
22. Horiuchi K, Le Gall S, Schulte M, Yamaguchi T, Reiss K, et al. (2007) Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx. Mol Biol Cell 18: 176-188.
23. Loechel F, Fox JW, Murphy G, Albrechtsen R, Wewer UM, (2000) ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3. Biochem Biophys Res Commun 278: 511-515.
24. Atfi A, Dumont E, Colland F, Bonnier D, L'helgoualc'h A, et al. (2007) The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor. J Cell Biol 178: 201-208.
25. Le Pabic H, L'Helgoualc'h A, Coutant A, Wewer UM, Baffet G, et al. (2005) Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells. J Hepatol 43: 1038-1044.
26. Solomon E, Li H, Muggy SD, Syta E, Zolkiewska A, (2010) The role of SnoN in transforming growth factor beta1-induced expression of metalloprotease-disintegrin ADAM12. J Biol Chem 285: 21969-21977.
27. Jacobson K, Mouritsen OG, Anderson RG, (2007) Lipid rafts: at a crossroad between cell biology and physics. Nat Cell Biol 9: 7-14.
28. Simons K, Toomre D, (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1: 31-39.
29. Brown DA, Rose JK, (1992) Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68: 533-544.
30. Anderson RG, Jacobson K, (2002) A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains. Science 296: 1821-1825.
31. Munro S, (2003) Lipid rafts: elusive or illusive? Cell 115: 377-388.
32. Parton RG, Simons K, (2007) The multiple faces of caveolae. Nat Rev Mol Cell Biol 8: 185-194.
33. Zheng YZ, Foster LJ, (2009) Contributions of quantitative proteomics to understanding membrane microdomains. J Lipid Res 50: 1976-1985.
34. Sargiacomo M, Sudol M, Tang Z, Lisanti MP, (1993) Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells. J Cell Biol 122: 789-807.
35. Bradford MM, (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
36. Elias JE, Gygi SP, (2007) Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Nat Methods 4: 207-214.
37. Griffin NM, Yu J, Long F, Oh P, Shore S, et al. (2010) Label-free, normalized quantification of complex mass spectrometry data for proteomic analysis. Nat Biotechnol 28: 83-89.
38. Old WM, Meyer-Arendt K, Aveline-Wolf L, Pierce KG, Mendoza A, et al. (2005) Comparison of label-free methods for quantifying human proteins by shotgun proteomics. Mol Cell Proteomics 4: 1487-1502.
39. Ilangumaran S, Hoessli DC, (1998) Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane. Biochem J 335 (Pt 2): 433-440.
40. Matthews V, Schuster B, Schutze S, Bussmeyer I, Ludwig A, et al. (2003) Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J Biol Chem 278: 38829-38839.
41. Zhang T, Zhang X, Sun Z, (2010) Global network analysis of lipid-raft-related proteins reveals their centrality in the network and their roles in multiple biological processes. J Mol Biol 402: 761-773.
42. Le Pabic H, Bonnier D, Wewer UM, Coutand A, Musso O, et al. (2003) ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling. Hepatology 37: 1056-1066.
43. Ruan XZ, Varghese Z, Fernando R, Moorhead JF, (1998) Cytokine regulation of low-density lipoprotein receptor gene transcription in human mesangial cells. Nephrol Dial Transplant 13: 1391-1397.
44. Zhou S, (2011) TGF-beta regulates beta-catenin signaling and osteoblast differentiation in human mesenchymal stem cells. J Cell Biochem 112: 1651-1660.
45. Worapamorn W, Tam SP, Li H, Haase HR, Bartold PM, (2002) Cytokine regulation of syndecan-1 and-2 gene expression in human periodontal fibroblasts and osteoblasts. J Periodontal Res 37: 273-278.
46. Tellier E, Canault M, Rebsomen L, Bonardo B, Juhan-Vague I, et al. (2006) The shedding activity of ADAM17 is sequestered in lipid rafts. Exp Cell Res 312: 3969-3980.
47. Murai T, Maruyama Y, Mio K, Nishiyama H, Suga M, et al. (2011) Low cholesterol triggers membrane microdomain-dependent CD44 shedding and suppresses tumor cell migration. J Biol Chem 286: 1999-2007.
48. Wakatsuki S, Kurisaki T, Sehara-Fujisawa A, (2004) Lipid rafts identified as locations of ectodomain shedding mediated by Meltrin beta/ADAM19. J Neurochem 89: 119-123.
49. Albrechtsen R, Stautz D, Sanjay A, Kveiborg M, Wewer UM, (2011) Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity. Exp Cell Res 317: 195-209.
50. Yamaguchi H, Takeo Y, Yoshida S, Kouchi Z, Nakamura Y, et al. (2009) Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells. Cancer Res 69: 8594-8602.
51. Stautz D, Sanjay A, Hansen MT, Albrechtsen R, Wewer UM, et al. (2010) ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity. Exp Cell Res 316: 55-67.
52. Sundberg C, Thodeti CK, Kveiborg M, Larsson C, Parker P, et al. (2004) Regulation of ADAM12 cell-surface expression by protein kinase C epsilon. J Biol Chem 279: 51601-51611.