What is the Efficiency of ATP Signaling from Erythrocytes to Regulate Distribution of O2 Supply Within the Microvasculature?

Microcirculation

Volumn 19, Issue 5, 2012, Pages 440-450

  Ellis, Christopher G ^a   Milkovich, Stephanie ^a   Goldman, Daniel ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Capillary; Erythrocyte; Microvascular regulation; O2 supply; O2 dependent ATP release

Indexed keywords

ADENOSINE TRIPHOSPHATE; OXYGEN; PURINERGIC P2Y RECEPTOR;

BLOOD FLOW; CAPILLARY; ENDOTHELIUM CELL; ERYTHROCYTE; ERYTHROCYTE FUNCTION AND CHARACTERISTICS; HEMATOCRIT; HYPERPOLARIZATION; INTRACELLULAR SIGNALING; MICROVASCULATURE; OXYGEN SATURATION; OXYGEN SUPPLY; OXYGEN TISSUE LEVEL; OXYGEN TRANSPORT; PRIORITY JOURNAL; REVIEW; VASCULAR RESISTANCE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOOD FLOW VELOCITY; ENDOTHELIUM, VASCULAR; ERYTHROCYTE MEMBRANE; HUMANS; MICROCIRCULATION; MICROVESSELS; OXYGEN; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION; VASCULAR RESISTANCE;

EID: 84863747159     PISSN: 10739688     EISSN: 15498719     Source Type: Journal    
DOI: 10.1111/j.1549-8719.2012.00196.x     Document Type: Review

References (53)

1. Al-Khazraji BK, Novielli NM, Goldman D, Medeiros PJ, Jackson DN. A simple "streak length method" for quantifying and characterizing red blood cell velocity profiles and blood flow in rat skeletal muscle arterioles. Microcirculation 19: 327-335, 2012.
2. Arciero JC, Carlson BE, Secomb TW. Theoretical model of metabolic blood flow regulation: roles of ATP release by red blood cells and conducted responses. Am J Physiol Heart Circ Physiol 295: H1562-H1571, 2008.
3. Bagher P, Segal SS. Regulation of blood flow in the microcirculation: role of conducted vasodilation. Acta Physiol (Oxf) 202: 271-284, 2011.
4. Bateman RM, Sharpe MD, Goldman D, Lidington D, Ellis CG. Inhibiting nitric oxide overproduction during hypotensive sepsis increases local oxygen consumption in rat skeletal muscle. Crit Care Med 36: 225-231, 2008.
5. Bolon ML, Kidder GM, Simon AM, Tyml K. Lipopolysaccharide reduces electrical coupling in microvascular endothelial cells by targeting connexin40 in a tyrosine-, ERK1/2-, PKA-, and PKC-dependent manner. J Cell Physiol 211: 159-166, 2007.
6. Collins DM, McCullough WT, Ellsworth ML. Conducted vascular responses: communication across the capillary bed. Microvasc Res 56: 43-53, 1998.
7. Dietrich HH. Effect of locally applied epinephrine and norepinephrine on blood flow and diameter in capillaries of rat mesentery. Microvasc Res 38: 125-135, 1989.
8. Dietrich HH, Ellsworth ML, Sprague RS, Dacey RG Jr. Red blood cell regulation of microvascular tone through adenosine triphosphate. Am J Physiol Heart Circ Physiol 278: H1294-H1298, 2000.
9. Dietrich HH, Horiuchi T, Xiang C, Hongo K, Falck JR, Dacey RG Jr. Mechanism of ATP-induced local and conducted vasomotor responses in isolated rat cerebral penetrating arterioles. J Vasc Res 46: 253-264, 2009.
10. Dietrich HH, Tyml K. Capillary as a communicating medium in the microvasculature. Microvasc Res 43: 87-99, 1992.
11. 2+. Am J Physiol Heart Circ Physiol 285: H26-H37, 2003.
12. 2 extraction in sepsis. Am J Physiol Heart Circ Physiol 282: H156-H164, 2002.
13. Ellis CG, Goldman D, Hanson M, Stephenson AH, Milkovich S, Benlamri A, Ellsworth ML, Sprague RS. Defects in oxygen supply to skeletal muscle of prediabetic ZDF rats. Am J Physiol Heart Circ Physiol 298: H1661-H1670, 2010.
14. Ellis CG, Jagger J, Sharpe M. The microcirculation as a functional system. Crit Care 9(Suppl. 4): S3-S8, 2005.
15. Ellis CG, Wrigley SM, Groom AC. Heterogeneity of red blood cell perfusion in capillary networks supplied by a single arteriole in resting skeletal muscle. Circ Res 75: 357-368, 1994.
16. Ellsworth ML, Ellis CG, Goldman D, Stephenson AH, Dietrich HH, Sprague RS. Erythrocytes: oxygen sensors and modulators of vascular tone. Physiology (Bethesda) 24: 107-116, 2009.
17. Ellsworth ML, Ellis CG, Popel AS, Pittman RN. Role of microvessels in oxygen-suppy to tissue. News Physiol Sci 9: 119-123, 1994.
18. Ellsworth ML, Forrester T, Ellis CG, Dietrich HH. The erythrocyte as a regulator of vascular tone. Am J Physiol 269: H2155-H2161, 1995.
19. Ellsworth ML, Pittman RN. Arterioles supply oxygen to capillaries by diffusion as well as by convection. Am J Physiol 258: H1240-H1243, 1990.
20. Ellsworth ML, Sprague RS. Regulation of blood flow distribution in skeletal muscle: role of erythrocyte-released ATP. J Physiol 2012 May 14. [Epub ahead of print].
21. Frisbee JC. Hypertension-independent microvascular rarefaction in the obese Zucker rat model of the metabolic syndrome. Microcirculation 12: 383-392, 2005.
22. Ghonaim NW, Lau LW, Goldman D, Ellis CG, Yang J. A micro-delivery approach for studying microvascular responses to localized oxygen delivery. Microcirculation 18: 646-654, 2011.
23. Golub AS, Song BK, Pittman RN. The rate of O loss from mesenteric arterioles is not unusually high. Am J Physiol Heart Circ Physiol 301: H737-H745, 2011.
24. Hanson MS, Ellsworth ML, Achilleus D, Stephenson AH, Bowles EA, Sridharan M, Adderley S, Sprague RS. Insulin inhibits low oxygen-induced ATP release from human erythrocytes: implication for vascular control. Microcirculation 16: 424-433, 2009.
25. Hester RL, Hammer LW. Venular-arteriolar communication in the regulation of blood flow. Am J Physiol Regul Integr Comp Physiol 282: R1280-R1285, 2002.
26. Jackson DN, Moore AW, Segal SS. Blunting of rapid onset vasodilatation and blood flow restriction in arterioles of exercising skeletal muscle with ageing in male mice. J Physiol 588: 2269-2282, 2010.
27. Jackson WF, Duling BR. The oxygen sensitivity of hamster cheek pouch arterioles. In vitro and in situ studies. Circ Res 53: 515-525, 1983.
28. 2 delivery mediated by hemoglobin oxygenation. Am J Physiol Heart Circ Physiol 280: H2833-H2839, 2001.
29. Japee SA, Ellis CG, Pittman RN. Flow visualization tools for image analysis of capillary networks. Microcirculation 11: 39-54, 2004.
30. Japee SA, Pittman RN, Ellis CG. A new video image analysis system to study red blood cell dynamics and oxygenation in capillary networks. Microcirculation 12: 489-506, 2005.
31. Knowles AF. The GDA1_CD39 superfamily: NTPDases with diverse functions. Purinergic Signal 7: 21-45, 2011.
32. Krogh A. The supply of oxygen to the tissues and the regulation of the capillary circulation. J Physiol 52: 457-474, 1919.
33. Kurjiaka DT, Segal SS. Conducted vasodilation elevates flow in arteriole networks of hamster striated muscle. Am J Physiol 269: H1723-H1728, 1995.
34. Lam C, Tyml K, Martin C, Sibbald W. Microvascular perfusion is impaired in a rat model of normotensive sepsis. J Clin Invest 94: 2077-2083, 1994.
35. Lidington D, Ouellette Y, Tyml K. Communication of agonist-induced electrical responses along "capillaries"in vitro can be modulated by lipopolysaccharide, but not nitric oxide. J Vasc Res 39: 405-413, 2002.
36. Loffler M, Morote-Garcia JC, Eltzschig SA, Coe IR, Eltzschig HK. Physiological roles of vascular nucleoside transporters. Arterioscler Thromb Vasc Biol 27: 1004-1013, 2007.
37. Melani A, Corti F, Stephan H, Muller CE, Donati C, Bruni P, Vannucchi MG, Pedata F. Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum. Exp Neurol 233: 193-204, 2012.
38. Moschandreou TE, Ellis CG, Goldman D. Influence of tissue metabolism and capillary oxygen supply on arteriolar oxygen transport: a computational model. Math Biosci 232: 1-10, 2011.
39. Poole DC, Brown MD, Hudlicka O. Counterpoint: there is not capillary recruitment in active skeletal muscle during exercise. J Appl Physiol 104: 891-893; discussion 893-894, 2008.
40. Roy TK, Pries AR, Secomb TW. Theoretical comparison of wall-derived and erythrocyte-derived mechanisms for metabolic flow regulation in heterogeneous microvascular networks. Am J Physiol Heart Circ Physiol 302: H1945-H1952, 2012.
41. Segal SS. Cell-to-cell communication coordinates blood flow control. Hypertension 23: 1113-1120, 1994.
42. Segal SS. Regulation of blood flow in the microcirculation. Microcirculation 12: 33-45, 2005.
43. Song H, Tyml K. Evidence for sensing and integration of biological signals by the capillary network. Am J Physiol 265: H1235-H1242, 1993.
44. Sprague RS, Ellswoth ML. Erythrocyte-derived ATP and perfusion distribution: Role of intracellular and intercellular communication. Microcirculation 19: : 430-439, 2012.
45. Sprague RS, Ellsworth ML, Stephenson AH, Kleinhenz ME, Lonigro AJ. Deformation-induced ATP release from red blood cells requires CFTR activity. Am J Physiol 275: H1726-H1732, 1998.
46. Sridharan M, Sprague RS, Adderley SP, Bowles EA, Ellsworth ML, Stephenson AH. Diamide decreases deformability of rabbit erythrocytes and attenuates low oxygen tension-induced ATP release. Exp Biol Med (Maywood) 235: 1142-1148, 2010.
47. 2 during nonhypoxic and hypoxic ventilation. Am J Physiol 265: H537-H542, 1993.
48. Wan J, Ristenpart WD, Stone HA. Dynamics of shear-induced ATP release from red blood cells. Proc Natl Acad Sci U S A 105: 16432-16437, 2008.
49. Weibel ER. The Pathway for Oxygen. Cambridge, MA: Harvard University Press, 1984.
50. Welsh DG, Segal SS. Endothelial and smooth muscle cell conduction in arterioles controlling blood flow. Am J Physiol 274: H178-H186, 1998.
51. Wolfle SE, Chaston DJ, Goto K, Sandow SL, Edwards FR, Hill CE. Non-linear relationship between hyperpolarisation and relaxation enables long distance propagation of vasodilatation. J Physiol 589: 2607-2623, 2011.
52. Woodward HN, Anwar A, Riddle S, Taraseviciene-Stewart L, Fragoso M, Stenmark KR, Gerasimovskaya EV. PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells. Am J Physiol Lung Cell Mol Physiol 297: L954-L964, 2009.
53. Yoon YS, Uchida S, Masuo O, Cejna M, Park JS, Gwon HC, Kirchmair R, Bahlman F, Walter D, Curry C, Hanley A, Isner JM, Losordo DW. Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor. Circulation 111: 2073-2085, 2005.