Autophagic clearance of Sin Nombre hantavirus glycoprotein Gn promotes virus replication in cells

Journal of Virology

Volumn 86, Issue 14, 2012, Pages 7520-7529

  Hussein, Islam T M ^a   Cheng, Erdong ^a   Ganaie, Safder S ^a   Werle, Michael J ^a   Sheema, Sheema ^a   Haque, Absarul ^a   Mir, Muhammad A ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; VIRUS GLYCOPROTEIN GC; VIRUS GLYCOPROTEIN GN; WORTMANNIN;

ARTICLE; ATG7 GENE; AUTOPHAGY; BCLN 1 GENE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC REGULATION; HANTAVIRUS PULMONARY SYNDROME; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIN NOMBRE VIRUS; STEADY STATE; VIRAL CLEARANCE; VIRUS GENE; VIRUS PATHOGENESIS; VIRUS REPLICATION;

ADENINE; ANDROSTADIENES; ANIMALS; AUTOPHAGY; CELL LINE; CERCOPITHECUS AETHIOPS; CHROMONES; GLYCOPROTEINS; HELA CELLS; HUMANS; MORPHOLINES; PROTEOLYSIS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIN NOMBRE VIRUS; UBIQUITIN-ACTIVATING ENZYMES; VERO CELLS; VIRAL ENVELOPE PROTEINS; VIRUS REPLICATION;

HANTAVIRUS; SIN NOMBRE VIRUS;

EID: 84863740424     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.07204-11     Document Type: Article

References (45)

1. Alff PJ, et al. 2006. The pathogenic NY-1 hantavirus G1 cytoplasmic tail inhibits RIG-I- and TBK-1-directed interferon responses. J. Virol. 80: 9676-9686.
2. Alff PJ, Sen N, Gorbunova E, Gavrilovskaya IN, Mackow ER. 2008. The NY-1 hantavirus Gn cytoplasmic tail coprecipitates TRAF3 and inhibits cellular interferon responses by disrupting TBK1-TRAF3 complex formation. J. Virol. 82:9115-9122.
3. Battisti AJ, et al. 2011. Structural studies of Hantaan virus. J. Virol. 85:835- 841.
4. Ciechanover A. 2006. The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human diseases and drug targeting. Neurology 66:S7-19.
5. Deretic V, Levine B. 2009. Autophagy, immunity, and microbial adaptations. Cell Host Microbe 5:527-549.
6. Easterbrook JD, Klein SL. 2008. Immunological mechanisms mediating hantavirus persistence in rodent reservoirs. PLoS Pathog. 4:e1000172. doi: 10.1371/journal.ppat.1000172.
7. Gavrilovskaya IN, Shepley M, Shaw R, Ginsberg MH, Mackow ER. 1998. β3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure. Proc. Natl. Acad. Sci. U. S. A. 95:7074-7079.
8. Geimonen E, Fernandez I, Gavrilovskaya IN, Mackow ER. 2003. Tyrosine residues direct the ubiquitination and degradation of the NY-1 hantavirus G1 cytoplasmic tail. J. Virol. 77:10760-10868.
9. 134.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1α to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. Proc. Natl. Acad. Sci. U. S. A. 94:843- 848.
10. Hepojoki J, Strandin T, Vaheri A, Lankinen H. 2010. Interactions and oligomerization of hantavirus glycoproteins. J. Virol. 84:227-242.
11. Hepojoki J, et al. 2010. Cytoplasmic tails of hantavirus glycoproteins interact with the nucleocapsid protein. J. Gen. Virol. 91:2341-2350.
12. Jackson WT, et al. 2005. Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol. 3:e156. doi:10.1371/journal.pbio.0030156.
13. Jonsson CB, Figueiredo LT, Vapalahti O. 2010. A global perspective on hantavirus ecology, epidemiology, and disease. Clin. Microbiol. Rev. 23: 412-441.
14. Kimura S, Noda T, Yoshimori T. 2007. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescenttagged LC3. Autophagy 3:452-460.
15. Klionsky DJ, et al. 2008. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4:151-175.
16. Ku B, et al. 2008. Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine gamma-herpesvirus 68. PLoS Pathog. 4:e25. doi:10.1371/journal.ppat.0040025.
17. Kyei GB, et al. 2009. Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J. Cell Biol. 186:255-268.
18. Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A. 2007. Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 315:1398-1401.
19. Levine B. 2007. Cell biology: autophagy and cancer. Nature 446:745-747.
20. Levine B, Deretic V. 2007. Unveiling the roles of autophagy in innate and adaptive immunity. Nat. Rev. Immunol. 7:767-777.
21. Levine B, Mizushima N, Virgin HW. 2011. Autophagy in immunity and inflammation. Nature 469:323-335.
22. Levine JR, et al. 2010. Antagonism of type I interferon responses by new world hantaviruses. J. Virol. 84:11790-11801.
23. Liang XH, et al. 1998. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J. Virol. 72:8586-8596.
24. Liu Y, et al. 2005. Autophagy regulates programmed cell death during the plant innate immune response. Cell 121:567-577.
25. Lober C, Anheier B, Lindow S, Klenk HD, Feldmann H. 2001. The Hantaan virus glycoprotein precursor is cleaved at the conserved pentapeptide WAASA. Virology 289:224-229.
26. Matthys V, Gorbunova EE, Gavrilovskaya IN, Pepini T, Mackow ER. 2011. The C-terminal 42 residues of the TULV Gn protein regulate interferon induction. J. Virol. 85:4752-4760.
27. Mir MA, Duran WA, Hjelle BL, Ye C, Panganiban AT. 2008. Storage of cellular 5' mRNA caps in P bodies for viral cap-snatching. Proc. Natl. Acad. Sci. U. S. A. 105:19294-19299.
28. Mir MA, Panganiban AT. 2008. A protein that replaces the entire cellular eIF4F complex. EMBO J. 27:3129-3139.
29. Orvedahl A, et al. 2007. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe 1:23-35.
30. Orvedahl A, Levine B. 2008. Autophagy and viral neurovirulence. Cell Microbiol. 10:1747-1756.
31. Orvedahl A, et al. 2010. Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host Microbe 7:115-127.
32. Pattingre S, et al. 2005. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122:927-939.
33. Richly H, et al. 2005. A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting. Cell 120:73-84.
34. Rubinsztein DC. 2006. The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 443:780-786.
35. Sagar B, Marres HA, Hartman EH. 2010. Hypopharyngeal reconstruction with an anterolateral thigh flap after laryngopharyngeal resection: results of a retrospective study on 20 patients. J. Plast. Reconstr. Aesthet. Surg. 63:970-975.
36. Sato K, et al. 2007. Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 67:9677-9684.
37. Schmaljohn CM. 1996. Molecular biology of hantaviruses. Plenum Press, New York, NY.
38. Schmaljohn CS, Hooper JW. 2001. Bunyaviridae: the viruses and their replication, p 1581-1602. In Knipe DM, et al. (ed), Fields virology, 4th ed, vol 2. Lippincott, Williams, & Wilkins, Philadelphia, PA.
39. Schonrich G, et al. 2008. Hantavirus-induced immunity in rodent reservoirs and humans. Immunol. Rev. 225:163-189.
40. Sen N, Sen A, Mackow ER. 2007. Degrons at the C terminus of the pathogenic but not the nonpathogenic hantavirus G1 tail direct proteasomal degradation. J. Virol. 81:4323- 4330.
41. Shelly S, Lukinova N, Bambina S, Berman A, Cherry S. 2009. Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus. Immunity 30:588-598.
42. Spiropoulou CF, Goldsmith CS, Shoemaker TR, Peters CJ, Compans RW. 2003. Sin Nombre virus glycoprotein trafficking. Virology 308: 48- 63.
43. Stoltz M, Ahlm C, Lundkvist A, Klingstrom J. 2007. Lambda interferon (IFN-λ) in serum is decreased in hantavirus-infected patients, and in vitro-established infection is insensitive to treatment with all IFNs and inhibits IFN-γ-induced nitric oxide production. J. Virol. 81:8685- 8691.
44. Wang H, Alminaite A, Vaheri A, Plyusnin A. 2010. Interaction between hantaviral nucleocapsid protein and the cytoplasmic tail of surface glycoprotein Gn. Virus Res. 151:205-212.
45. Wong J, et al. 2008. Autophagosome supports coxsackievirus B3 replication in host cells. J. Virol. 82:9143-9153.